Comparing BWI76_RS12865 FitnessBrowser__Koxy:BWI76_RS12865 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7rsfA Acetylornithine deacetylase from escherichia coli
33% identity, 92% coverage: 21:377/389 of query aligns to 27:378/380 of 7rsfA
4o23A Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
31% identity, 86% coverage: 49:382/389 of query aligns to 46:376/376 of 4o23A
4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril (see paper)
31% identity, 85% coverage: 49:380/389 of query aligns to 46:374/375 of 4pqaA
5vo3A Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
32% identity, 53% coverage: 53:258/389 of query aligns to 54:263/380 of 5vo3A
Sites not aligning to the query:
P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 3 papers)
32% identity, 53% coverage: 53:258/389 of query aligns to 50:259/377 of P44514
Sites not aligning to the query:
7uoiA Crystallographic structure of dape from enterococcus faecium
28% identity, 86% coverage: 28:363/389 of query aligns to 32:364/383 of 7uoiA
7t1qA Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
27% identity, 85% coverage: 49:378/389 of query aligns to 46:376/377 of 7t1qA
7lgpB Dape enzyme from shigella flexneri
32% identity, 49% coverage: 68:258/389 of query aligns to 65:260/377 of 7lgpB
Q8P8J5 N-acetyl-L-citrulline deacetylase; ACDase; Acetylcitrulline deacetylase; EC 3.5.1.- from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see paper)
28% identity, 95% coverage: 7:377/389 of query aligns to 10:362/366 of Q8P8J5
2f7vA Structure of acetylcitrulline deacetylase complexed with one co (see paper)
28% identity, 95% coverage: 7:377/389 of query aligns to 11:357/360 of 2f7vA
3pfoA Crystal structure of a putative acetylornithine deacetylase (rpa2325) from rhodopseudomonas palustris cga009 at 1.90 a resolution
31% identity, 51% coverage: 66:265/389 of query aligns to 99:301/426 of 3pfoA
Sites not aligning to the query:
4h2kA Crystal structure of the catalytic domain of succinyl-diaminopimelate desuccinylase from haemophilus influenzae (see paper)
38% identity, 30% coverage: 53:168/389 of query aligns to 52:170/258 of 4h2kA
Sites not aligning to the query:
4op4B Crystal structure of the catalytic domain of dape protein from v.Cholerea in the zn bound form (see paper)
38% identity, 34% coverage: 34:165/389 of query aligns to 33:165/265 of 4op4B
Sites not aligning to the query:
Q8C165 N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Peptidase M20 domain-containing protein 1; PM20D1; EC 3.5.1.114; EC 3.5.1.14 from Mus musculus (Mouse) (see paper)
30% identity, 52% coverage: 11:211/389 of query aligns to 60:279/503 of Q8C165
Sites not aligning to the query:
7m6uB Crystal structure of a circular permutation and computationally designed pro-enzyme of carboxypeptidase g2 (see paper)
27% identity, 59% coverage: 53:281/389 of query aligns to 4:222/392 of 7m6uB
Sites not aligning to the query:
P06621 Carboxypeptidase G2; CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase; EC 3.4.17.11 from Pseudomonas sp. (strain RS-16) (see paper)
27% identity, 66% coverage: 27:281/389 of query aligns to 63:312/415 of P06621
Sites not aligning to the query:
1cg2A Carboxypeptidase g2 (see paper)
27% identity, 66% coverage: 27:281/389 of query aligns to 38:287/389 of 1cg2A
Sites not aligning to the query:
Q03154 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Homo sapiens (Human) (see 6 papers)
27% identity, 54% coverage: 64:274/389 of query aligns to 73:293/408 of Q03154