Comparing BWI76_RS12880 FitnessBrowser__Koxy:BWI76_RS12880 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1gl3A Aspartate beta-semialdehyde dehydrogenase in complex with NADP and substrate analogue s-methyl cysteine sulfoxide (see paper)
55% identity, 99% coverage: 1:369/372 of query aligns to 1:367/367 of 1gl3A
P0A9Q9 Aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Escherichia coli (strain K12) (see 2 papers)
55% identity, 99% coverage: 1:369/372 of query aligns to 1:367/367 of P0A9Q9
5bntC X-ray crystal structure of a aspartate-semialdehyde dehydrogenase bound to NADP from pseudomonas aeruginosa
53% identity, 99% coverage: 1:368/372 of query aligns to 2:368/371 of 5bntC
P44801 Aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 2 papers)
52% identity, 99% coverage: 1:368/372 of query aligns to 1:369/371 of P44801
1pquA Crystal structure of the h277n mutant of aspartate semialdehyde dehydrogenase from haemophilus influenzae bound with NADP, s-methyl cysteine sulfoxide and cacodylate (see paper)
52% identity, 99% coverage: 1:368/372 of query aligns to 1:369/371 of 1pquA
4r5mA Crystal structure of vc-aspartate beta-semialdehyde-dehydrogenase with NADP and 4-nitro-2-phosphono-benzoic acid (see paper)
51% identity, 98% coverage: 3:368/372 of query aligns to 2:366/369 of 4r5mA
1mb4A Crystal structure of aspartate semialdehyde dehydrogenase from vibrio cholerae with NADP and s-methyl-l-cysteine sulfoxide (see paper)
51% identity, 98% coverage: 3:368/372 of query aligns to 2:366/369 of 1mb4A
3pzrA Crystals structure of aspartate beta-semialdehyde dehydrogenase from vibrio cholerae with NADP and product of s-carbamoyl-l-cysteine (see paper)
51% identity, 98% coverage: 3:368/372 of query aligns to 2:366/370 of 3pzrA
Q9KQG2 Aspartate-semialdehyde dehydrogenase 1; ASA dehydrogenase 1; ASADH 1; Aspartate-beta-semialdehyde dehydrogenase 1; EC 1.2.1.11 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see paper)
51% identity, 98% coverage: 3:368/372 of query aligns to 2:366/370 of Q9KQG2
7tcmA Crystal structure of aspartate-semialdehyde dehydrogenase from acinetobacter baumannii in complex with NADP
51% identity, 98% coverage: 3:368/372 of query aligns to 4:368/373 of 7tcmA
1tb4A Crystal structure of aspartate-semialdehyde dehydrogenase from haemophilus influenzae with a bound periodate (see paper)
51% identity, 99% coverage: 1:368/372 of query aligns to 1:355/357 of 1tb4A
1ta4A Crystal structure of aspartate-semialdehyde dehydrogenase from haemophilus influenzae with a bound arsenate (see paper)
51% identity, 99% coverage: 1:368/372 of query aligns to 1:355/357 of 1ta4A
1nx6A Crystal structure of aspartate semialdehyde dehydrogenase from haemophilus influenzae as a tetrahedral hemithiocetal reaction intermediate with phosphate at 2.15 a (see paper)
51% identity, 99% coverage: 1:368/372 of query aligns to 1:355/357 of 1nx6A
1pqpA Crystal structure of the c136s mutant of aspartate semialdehyde dehydrogenase from haemophilus influenzae bound with aspartate semialdehyde and phosphate (see paper)
51% identity, 99% coverage: 1:368/372 of query aligns to 1:355/357 of 1pqpA
Q04797 Aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Bacillus subtilis (strain 168) (see paper)
26% identity, 96% coverage: 3:358/372 of query aligns to 6:330/346 of Q04797
3tz6A Crystal structure of aspartate semialdehyde dehydrogenase complexed with inhibitor smcs (cys) and phosphate from mycobacterium tuberculosis h37rv (see paper)
26% identity, 79% coverage: 4:296/372 of query aligns to 4:276/342 of 3tz6A
Sites not aligning to the query:
2r00C Crystal structure of aspartate semialdehyde dehydrogenase ii complexed with asa from vibrio cholerae (see paper)
24% identity, 79% coverage: 4:296/372 of query aligns to 6:265/336 of 2r00C
Sites not aligning to the query:
P23247 Aspartate-semialdehyde dehydrogenase 2; ASA dehydrogenase 2; ASADH 2; Aspartate-beta-semialdehyde dehydrogenase 2; EC 1.2.1.11 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see paper)
24% identity, 79% coverage: 4:296/372 of query aligns to 7:266/337 of P23247
4r54A Complex crystal structure of sp-aspartate-semialdehyde-dehydrogenase with 3-carboxy-ethyl-phthalic acid (see paper)
24% identity, 95% coverage: 4:358/372 of query aligns to 4:330/357 of 4r54A
4r41A Complex crystal structure of 4-nitro-2-phosphono-benzoic acid with sp- aspartate-semialdehyde dehydrogenase and nicotinamide-dinucleotide (see paper)
24% identity, 95% coverage: 4:358/372 of query aligns to 4:330/357 of 4r41A
>BWI76_RS12880 FitnessBrowser__Koxy:BWI76_RS12880
MKQVGIVGWRGMVGSVLLQRMIEENDFDNISAHFFSTSSAGAAGPVIDGISYTLKDANSV
SALAEMDIIITCQGGDYTKAIYPNLLNHGWGGYWIDAASALRMDEKACIILDPVNRNNID
RAIKEGIKLFVGGNCSITLSLMGLAGLIKADLIEWMSVMTYQSASGAGAQYVRELIAQSA
YISRHLSPDELASSGSVLPLVNKVSELINSADMPTQNFGAPLMGSIIPWIDSDLGDGNSR
EEWKGEAETNKILGLSPGTIPVNGLCIRVGVIRCHSAAITLKLKREVNEEEFAELVMNSH
PWVNYVPNNKEESVSTLTPAHISGSLKVGIGRYKKMSLNNEPIYSVLTVGDQLLWGAAEP
LRRMLNILSGKA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory