Comparing BWI76_RS15390 FitnessBrowser__Koxy:BWI76_RS15390 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3rpdA The structure of a b12-independent methionine synthase from shewanella sp. W3-18-1 in complex with selenomethionine.
86% identity, 98% coverage: 4:340/343 of query aligns to 5:341/345 of 3rpdA
Q56837 2-hydroxypropyl-CoM lyase; Aliphatic epoxide carboxylation component I; Epoxide carboxylase component I; Epoxyalkane:CoM transferase; EaCoMT; EC 4.4.1.23 from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) (see paper)
31% identity, 98% coverage: 5:340/343 of query aligns to 10:369/376 of Q56837
P25665 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Escherichia coli (strain K12) (see 3 papers)
27% identity, 97% coverage: 6:338/343 of query aligns to 427:752/753 of P25665
Sites not aligning to the query:
P80877 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; Superoxide-inducible protein 9; SOI9; EC 2.1.1.14 from Bacillus subtilis (strain 168) (see 2 papers)
24% identity, 97% coverage: 4:337/343 of query aligns to 429:755/762 of P80877
Sites not aligning to the query:
O50008 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1; Cobalamin-independent methionine synthase 1; AtMS1; Vitamin-B12-independent methionine synthase 1; EC 2.1.1.14 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
24% identity, 98% coverage: 4:340/343 of query aligns to 431:761/765 of O50008
Sites not aligning to the query:
Q9X112 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
23% identity, 99% coverage: 4:342/343 of query aligns to 403:734/734 of Q9X112
Sites not aligning to the query:
1xdjA Crystal structure of t. Maritima cobalamin-independent methionine synthase complexed with zn2+ and homocysteine (see paper)
23% identity, 99% coverage: 4:341/343 of query aligns to 392:722/722 of 1xdjA
Sites not aligning to the query:
1t7lA Crystal structure of cobalamin-independent methionine synthase from t. Maritima (see paper)
23% identity, 99% coverage: 4:341/343 of query aligns to 404:734/734 of 1t7lA
Sites not aligning to the query:
1xpgA Crystal structure of t. Maritima cobalamin-independent methionine synthase complexed with zn2+ and methyltetrahydrofolate (see paper)
24% identity, 91% coverage: 4:314/343 of query aligns to 404:707/734 of 1xpgA
Sites not aligning to the query:
3bq5A Crystal structure of t. Maritima cobalamin-independent methionine synthase complexed with zn2+ and homocysteine (monoclinic) (see paper)
25% identity, 91% coverage: 4:314/343 of query aligns to 396:686/709 of 3bq5A
Q8CWX6 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see paper)
23% identity, 98% coverage: 4:340/343 of query aligns to 414:743/745 of Q8CWX6
1u22A A. Thaliana cobalamine independent methionine synthase (see paper)
23% identity, 98% coverage: 4:339/343 of query aligns to 430:746/746 of 1u22A
Sites not aligning to the query:
1u1jA A. Thaliana cobalamine independent methionine synthase (see paper)
23% identity, 98% coverage: 4:339/343 of query aligns to 430:746/746 of 1u1jA
Sites not aligning to the query:
1u1hA A. Thaliana cobalamine independent methionine synthase (see paper)
23% identity, 98% coverage: 4:339/343 of query aligns to 430:746/746 of 1u1hA
Q9UT19 Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
23% identity, 91% coverage: 4:314/343 of query aligns to 436:737/764 of Q9UT19
Sites not aligning to the query:
4ztxA Neurospora crassa cobalamin-independent methionine synthase complexed with zn2+ (see paper)
22% identity, 99% coverage: 4:343/343 of query aligns to 434:767/768 of 4ztxA
3t0cA Crystal structure of streptococcus mutans mete complexed with zinc (see paper)
23% identity, 97% coverage: 4:335/343 of query aligns to 414:733/737 of 3t0cA
P82610 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme; EC 2.1.1.14 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 4 papers)
22% identity, 91% coverage: 4:314/343 of query aligns to 440:741/767 of P82610
Sites not aligning to the query:
4qquA Crystal structure of the cobalamin-independent methionine synthase enzyme in a closed conformation (see paper)
22% identity, 91% coverage: 4:314/343 of query aligns to 439:740/766 of 4qquA
Sites not aligning to the query:
4l61A Crystal structure of the candida albicans methionine synthase in complex with methionine (see paper)
23% identity, 91% coverage: 4:314/343 of query aligns to 431:730/755 of 4l61A
>BWI76_RS15390 FitnessBrowser__Koxy:BWI76_RS15390
MKKLLPTSTAGSLPKPSWLAEPEKLWSAWKLHDQELIDGKKDALSLSLFDQLRAGIDIVS
DGEQTRQHFVTTFIEHLSGVDFEKREVVKIRNRYDASVPTVVGAVERQKPVFVEDARFLR
QLTKQPIKWALPGPMTMIDTLYDAHYKSREKLAWEFAKILNQEAKELEAAGVDIIQFDEP
AFNVFFDEVNDWGIAALERAIEGLKCETAVHICYGYGIKANTDWKKTLGTEWRQYEEAFP
KLQTSNIDIISLECHNSRVPMDLLELIRGKKVMVGAIDVATNTIETPEEVAATLRKALQF
VEADKLYPSTNCGMAPLSRRVAAGKLQALSAGAEIIRRELQGK
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory