SitesBLAST

P0AAJ3 Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit; Anaerobic formate dehydrogenase iron-sulfur subunit; Formate dehydrogenase-N subunit beta; FDH-N subunit beta from Escherichia coli (strain K12) (see paper)
34% identity, 80% coverage: 3:167/205 of query aligns to 28:201/294 of P0AAJ3

query
sites
P0AAJ3

A

A

Q

E

Y

V

G

A

F

K

F

L

I

I

D

D

S

V

A

S

R

T

C
|
C

T

I

G

G

C
|
C

K

K

T

A

C
|
C

E

Q

L

V

A

A

C
|
C

K

S

D

E

Y

W

K

N

N

D

L

I

T

R

P

D

D

E

V

V

S

G

-

H

-

C

-

V

-

G

-

V

F

Y

H

D

R

N

I

P

Y

A

E

D

Y

L

A

S

G

A

G

K

D

S

W

W

Q

T

-

V

-

M

-

R

-

F

-

S

-

E

-

T

E

E

D

Q

N

N

G

G

V

-

W

-

N

-

Q

-

N

K

V

L

F

E

A

W

Y

L

Y

I

L

R

S

K

I

D

A

G

C
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C

N

M

H

H

C
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C

E

E

D

D

P

P

A

G

C
|
C

T

L

K

K

V

A

C
|
C

P

P

S

S

-

A

G

G

A

A

M

I

H

I

K

Q

R

Y

D

A

D

N

G

G

F

I

V

V

V

D

V

F

N

Q

E

S

E

E

V

N

C
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C

I

I

G

G

C
|
C

R

G

Y

Y

C
|
C

H

I

M

A

A

G

C
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C

P

P

Y

F

G

N

A

I

P

P

Q

R

Y

L

N

N

A

K

A

E

K

D

G

N

H

R

M

V

T

Y

K

K

C
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C

D

T

G

L

C
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C

Y

V

D

D

R

R

V

V

A

S

D

V

G

G

K

Q

K

E

P

P

I

A

C
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C

V

V

E

K

S

T

C
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C

P

P

L

T

R

G

A

A

L

I

D

H

F

F

G

G

P

T

I

K

E

K

E

E

L

M

R

L

E

E

K

L

H

A

G

E

Q

Q

L

R

A

V

A

A

C39 (= C14) binding
C42 (= C17) binding
C45 (= C20) binding
C49 (= C24) binding
C100 (= C67) binding
C103 (= C70) binding
C108 (= C75) binding
C112 (= C79) binding
C133 (= C99) binding
C136 (= C102) binding
C139 (= C105) binding
C143 (= C109) binding
C160 (= C126) binding
C163 (= C129) binding
C175 (= C141) binding
C179 (= C145) binding

2vpyF Polysulfide reductase with bound quinone inhibitor, pentachlorophenol (pcp) (see paper)
37% identity, 75% coverage: 4:157/205 of query aligns to 3:147/193 of 2vpyF

query
sites
2vpyF

Q

R

Y

Y

G

A

F

M

F

A

I

I

D

D

S

L

A

S

R

L

C
|
C

T
x
V

G
|
G

C
|
C

K
x
A

T
x
A

C
|
C

E

A

L

V

A

A

C
|
C

K

K

D

M

Y

E

K
x
N

N

E

L

V

T

P

P

P

D

G

V

V

S

F

F

N

H
x
L

R

W

I
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I

Y

R

E

E

Y

R

A

E

G

V

G

G

D

E

W

Y

Q

P

E

-

D

-

N

-

G

-

V

-

W

-

N

-

Q

-

N

N

V

L

F

V

A

V

Y

E

Y

F

L

R

S
x
P

I

E

A
x
Q

C
|
C

N
x
L

H
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H

C
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C

E

E

D

N

P
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P

A
x
P

C
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C

T

V

K

P

V

V

C
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C

P
|
P

S
x
T

G

G

A

A

M
x
S

H

Y

K

Q

R

T

D

K

D

D

G

G

F

L

V
|
V

V

L

V

V

N

D

E

P

E

K

V

K

C
|
C

I
|
I

G
x
A

C
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C

R
x
G

Y
x
A

C
|
C

H

I

M

A

A

A

C
|
C

P
|
P

Y
|
Y

G

D

A

A

P

-

Q
x
R

Y

Y

N

L

A

H

A

P

K

A

G

G

H

Y

M
x
V

T

S

K

K

C
|
C

D
x
T

G
x
F

C
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C

Y

A

D

H

R

R

V

L

A

E

D

K

G

G

K

K

K

V

P
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P

I
x
A

C
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C

V

V

E

E

S

T

C
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C

P

P

L
x
T

R

Y

A
x
C

L
x
R

D

T

F

F

G

G

P

D

I

L

E

E

E

D

binding pentachlorophenol: I91 (= I100), C93 (= C102)
binding iron/sulfur cluster: C13 (= C14), V14 (≠ T15), G15 (= G16), C16 (= C17), A17 (≠ K18), A18 (≠ T19), C19 (= C20), C23 (= C24), N27 (≠ K28), L36 (≠ H37), I38 (= I39), P55 (≠ S64), Q57 (≠ A66), C58 (= C67), L59 (≠ N68), H60 (= H69), C61 (= C70), P64 (= P73), P65 (≠ A74), C66 (= C75), C70 (= C79), P71 (= P80), T72 (≠ S81), S75 (≠ M84), V83 (= V92), C90 (= C99), I91 (= I100), A92 (≠ G101), C93 (= C102), G94 (≠ R103), A95 (≠ Y104), C96 (= C105), C100 (= C109), P101 (= P110), Y102 (= Y111), R105 (≠ Q115), V113 (≠ M123), C116 (= C126), T117 (≠ D127), F118 (≠ G128), C119 (= C129), P129 (= P139), A130 (≠ I140), C131 (= C141), C135 (= C145), T137 (≠ L147), C139 (≠ A149), R140 (≠ L150)

Sites not aligning to the query:

binding iron/sulfur cluster: 189, 190

2vpxB Polysulfide reductase with bound quinone (uq1) (see paper)
37% identity, 75% coverage: 4:157/205 of query aligns to 3:147/193 of 2vpxB

query
sites
2vpxB

Q

R

Y

Y

G

A

F

M

F

A

I

I

D

D

S

L

A

S

R

L

C
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C

T
x
V

G
|
G

C
|
C

K

A

T
x
A

C
|
C

E

A

L

V

A

A

C
|
C

K

K

D

M

Y

E

K
x
N

N

E

L

V

T

P

P

P

D

G

V

V

S

F

F
x
N

H
x
L

R

W

I
|
I

Y

R

E

E

Y

R

A

E

G

V

G

G

D

E

W

Y

Q

P

E

-

D

-

N

-

G

-

V

-

W

-

N

-

Q

-

N

N

V

L

F

V

A

V

Y

E

Y

F

L

R

S
x
P

I

E

A
x
Q

C
|
C

N
x
L

H
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H

C
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C

E

E

D

N

P
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P

A

P

C
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C

T

V

K

P

V

V

C
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C

P
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P

S
x
T

G

G

A
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A

M
x
S

H

Y

K

Q

R

T

D

K

D

D

G

G

F

L

V
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V

V

L

V

V

N

D

E

P

E

K

V

K

C
|
C

I
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I

G
x
A

C
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C

R
x
G

Y
x
A

C
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C

H

I

M

A

A

A

C
|
C

P

P

Y
|
Y

G

D

A

A

P

-

Q
x
R

Y

Y

N

L

A

H

A

P

K

A

G

G

H

Y

M
x
V

T

S

K
|
K

C
|
C

D
x
T

G
x
F

C
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C

Y

A

D

H

R

R

V

L

A

E

D

K

G

G

K

K

K

V

P
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P

I
x
A

C
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C

V

V

E

E

S

T

C
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C

P

P

L
x
T

R

Y

A
x
C

L
x
R

D

T

F

F

G

G

P

D

I

L

E

E

E

D

binding iron/sulfur cluster: C13 (= C14), V14 (≠ T15), G15 (= G16), C16 (= C17), A18 (≠ T19), C19 (= C20), C23 (= C24), N27 (≠ K28), N35 (≠ F36), L36 (≠ H37), I38 (= I39), P55 (≠ S64), Q57 (≠ A66), C58 (= C67), L59 (≠ N68), H60 (= H69), C61 (= C70), P64 (= P73), C66 (= C75), C70 (= C79), P71 (= P80), T72 (≠ S81), A74 (= A83), S75 (≠ M84), V83 (= V92), C90 (= C99), I91 (= I100), A92 (≠ G101), C93 (= C102), G94 (≠ R103), A95 (≠ Y104), C96 (= C105), C100 (= C109), Y102 (= Y111), R105 (≠ Q115), R105 (≠ Q115), V113 (≠ M123), K115 (= K125), C116 (= C126), T117 (≠ D127), F118 (≠ G128), C119 (= C129), P129 (= P139), A130 (≠ I140), C131 (= C141), C135 (= C145), T137 (≠ L147), C139 (≠ A149), R140 (≠ L150)
binding ubiquinone-1: I91 (= I100), C93 (= C102)

2vpwF Polysulfide reductase with bound menaquinone (see paper)
37% identity, 75% coverage: 4:157/205 of query aligns to 3:147/193 of 2vpwF

query
sites
2vpwF

Q

R

Y

Y

G

A

F

M

F

A

I

I

D

D

S

L

A

S

R

L

C
|
C

T
x
V

G
|
G

C
|
C

K
x
A

T
x
A

C
|
C

E

A

L

V

A

A

C
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C

K

K

D

M

Y

E

K
x
N

N

E

L

V

T

P

P

P

D

G

V

V

S

F

F

N

H
x
L

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I
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I

Y

R

E

E

Y

R

A

E

G

V

G

G

D

E

W

Y

Q

P

E

-

D

-

N

-

G

-

V

-

W

-

N

-

Q

-

N

N

V

L

F

V

A

V

Y

E

Y

F

L

R

S
x
P

I

E

A
x
Q

C
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C

N
x
L

H
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H

C
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C

E

E

D

N

P
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P

A
x
P

C
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C

T

V

K

P

V

V

C
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C

P
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P

S
x
T

G

G

A

A

M
x
S

H

Y

K

Q

R

T

D

K

D

D

G

G

F

L

V
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V

V

L

V

V

N

D

E

P

E

K

V

K

C
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C

I
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I

G
x
A

C
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C

R
x
G

Y
x
A

C
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C

H

I

M

A

A

A

C
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C

P
|
P

Y
|
Y

G

D

A

A

P

-

Q
x
R

Y

Y

N

L

A

H

A

P

K

A

G

G

H

Y

M
x
V

T

S

K

K

C
|
C

D
x
T

G
x
F

C
|
C

Y

A

D

H

R

R

V

L

A

E

D

K

G

G

K

K

K

V

P
|
P

I
x
A

C
|
C

V

V

E

E

S

T

C
|
C

P

P

L
x
T

R

Y

A
x
C

L
x
R

D

T

F

F

G

G

P

D

I

L

E

E

E

D

binding menaquinone-7: I91 (= I100), C93 (= C102)
binding iron/sulfur cluster: C13 (= C14), V14 (≠ T15), G15 (= G16), C16 (= C17), A17 (≠ K18), A18 (≠ T19), C19 (= C20), C23 (= C24), N27 (≠ K28), L36 (≠ H37), I38 (= I39), P55 (≠ S64), Q57 (≠ A66), C58 (= C67), L59 (≠ N68), H60 (= H69), C61 (= C70), P64 (= P73), P65 (≠ A74), C66 (= C75), C70 (= C79), P71 (= P80), T72 (≠ S81), S75 (≠ M84), V83 (= V92), C90 (= C99), I91 (= I100), A92 (≠ G101), C93 (= C102), G94 (≠ R103), A95 (≠ Y104), C96 (= C105), C100 (= C109), P101 (= P110), Y102 (= Y111), R105 (≠ Q115), R105 (≠ Q115), V113 (≠ M123), C116 (= C126), T117 (≠ D127), F118 (≠ G128), C119 (= C129), P129 (= P139), A130 (≠ I140), C131 (= C141), C135 (= C145), T137 (≠ L147), C139 (≠ A149), R140 (≠ L150)

Sites not aligning to the query:

binding iron/sulfur cluster: 189, 190

2ivfB Ethylbenzene dehydrogenase from aromatoleum aromaticum (see paper)
35% identity, 82% coverage: 27:194/205 of query aligns to 89:268/337 of 2ivfB

query
sites
2ivfB

Y

Y

K

E

N

G

L

K

T

G

P

Q

D

T

V

V

S

H

F

F

H

H

R

P

I

T

Y

S

E

K

Y

S

A

T

G

G

G

K

D

D

-

P

-

A

-

W

-

G

-

Y

-

N

W

W

Q

D

E

E

D

D

N

Q

G

G

-

G

V

K

W

W

N

-

Q

P

N

N

V

P

F

F

A

F

Y

F

Y

Y

L

L

S

A

I

R

A
x
M

C
|
C

N
|
N

H
|
H

C
|
C

E

T

D

N

P
|
P

A

A

C
|
C

T

L

K

A

V

A

C
|
C

P

P

S
x
T

G

G

A

A

M
x
I

H

Y

K

K

R

R

D

E

D

D

-

N

G

G

F

I

V
|
V

V

L

V

V

N

D

E

Q

E

E

V

R

C
|
C

I
x
K

G
|
G

C
x
H

R
|
R

Y
x
H

C
|
C

H

V

M

E

A

A

C
|
C

P

P

Y
|
Y

G

K

A
|
A

P
x
I

Q

Y

Y

F

N

N

A

P

A

V

K

S

G

Q

H

T

M
x
S

T

E

K
|
K

C
|
C

D
x
I

G
x
L

C
|
C

Y

Y

D

P

R

R

V

I

A

E

D

K

G

G

K

I

K

A

P
x
N

I
x
A

C
|
C

V

N

E

R

S

Q

C
|
C

P

P

L
x
G

R

R

A
x
V

L
x
R

D

A

F

F

G

G

P

Y

I

L

E

D

L

T

R

T

E

S

K

H

H

V

G

H

Q

K

L

L

A

V

-

K

-

W

-

K

A

V

V

A

A

L

P

P

L

L

P

H

S

A

A

E

H

Y

F

G

T

T

K

G

P

P

S

N

I

I

V

Y

I

Y

K

V

P

P

N

P

A

M

N

G

S

A

R

R

P

G

T

F

G

G

D

E

binding fe3-s4 cluster: C148 (= C79), T150 (≠ S81), I153 (≠ M84), C169 (= C99), K170 (≠ I100), G171 (= G101), H172 (≠ C102), R173 (= R103), H174 (≠ Y104), C175 (= C105), S193 (≠ M123)
binding protoporphyrin ix containing fe: T150 (≠ S81), K170 (≠ I100), H172 (≠ C102)
binding iron/sulfur cluster: M135 (≠ A66), C136 (= C67), N137 (= N68), H138 (= H69), C139 (= C70), P142 (= P73), C144 (= C75), V162 (= V92), C179 (= C109), Y181 (= Y111), A183 (= A113), I184 (≠ P114), K195 (= K125), C196 (= C126), I197 (≠ D127), L198 (≠ G128), C199 (= C129), N209 (≠ P139), A210 (≠ I140), C211 (= C141), C215 (= C145), G217 (≠ L147), V219 (≠ A149), R220 (≠ L150)

Sites not aligning to the query:

binding iron/sulfur cluster: 13, 14, 15, 16, 17, 18, 19, 23, 27, 38, 39, 41

6cz7B The arsenate respiratory reductase (arr) complex from shewanella sp. Ana-3 (see paper)
28% identity, 92% coverage: 4:191/205 of query aligns to 2:220/234 of 6cz7B

query
sites
6cz7B

Q

R

Y

L

G

G

F

M

F

V

I

I

D

D

S

L

A

Q

R

K

C
|
C

T
x
V

G
|
G

C
|
C

K
x
G

T
x
G

C
|
C

E

S

L

L

A

A

C
|
C

K

K

D

T

Y

E

K
x
N

N

N

L

T

T

N

P

D

D

G

V

I

S

H

F
x
W

H
x
S

R

H

I

H

Y

I

E

A

Y

T

A

T

G

E

G

G

D

T

W

F

Q

P

E

D

D

-

N

-

G

-

V

-

W

-

N

-

Q

-

N

-

V

V

F

K

A

Y

Y

T

Y
|
Y

L

I

S
x
P

I

T

A
x
L

C
|
C

N
|
N

H
|
H

C
|
C

E

D

D

D

P
x
A

A
x
P

C
|
C

T

V

K

K

V

V

C
|
C

P
|
P

S
x
T

G

G

A

A

M
|
M

H

H

K

K

R

D

D

K

D

R

G

G

F

L

V
x
T

V

L

V

Q

N

N

E

N

E

D

V

E

C
|
C

I
|
I

G
|
G

C
|
C

R
x
K

Y
x
K

C
|
C

H

M

M

N

A

A

C
|
C

P

P

Y
|
Y

G

G

A
x
V

P
x
I

Q

S

Y

F

N

N

A

A

K

T

G

P

H

H

-

R

-

W

-

Q

-

D

-

S

-

E

-

V

-

A

-

N

-

G

-

T

-

V

-

S

-

P

-

L

-

M

-

L

-

K

-

R

-

T

-

G

-

A

-

T

-

A

-

T

-

P

-

N

-

E

-

N

-

P

-

E

-

R

-

G

-

D

-

T

-

Y

-

P

-

M

-

I

-

R

-

P

-

K

-

R

-

T

M
x
T

T

E

K
|
K

C
|
C

D

T

G
x
F

C
|
C

Y

D

D

H

R

R

V

L

A

D

D

K

G

G

K

L

K

N

P

P

I
x
A

C
|
C

V

V

E

D

S

A

C
|
C

P
|
P

L

S

R

E

A

A

L
x
R

D

V

F

I

G

G

P

D

I

L

E

D

L

P

R

Q

E

S

K

K

H

V

G

S

Q

Q

L

L

A

I

A

K

V

L

A

H

P

-

L

-

P

-

S

-

A

-

H

-

F

-

T

-

K

K

P

P

S

-

I

M

V

Q

I

L

K

K

P

P

N

E

A

A

N

G

S

T

R

G

P

P

binding iron/sulfur cluster: C12 (= C14), V13 (≠ T15), G14 (= G16), C15 (= C17), G16 (≠ K18), G17 (≠ T19), C18 (= C20), C22 (= C24), N26 (≠ K28), W34 (≠ F36), S35 (≠ H37), Y52 (= Y62), P54 (≠ S64), L56 (≠ A66), C57 (= C67), N58 (= N68), H59 (= H69), C60 (= C70), A63 (≠ P73), P64 (≠ A74), C65 (= C75), C69 (= C79), P70 (= P80), T71 (≠ S81), M74 (= M84), T82 (≠ V92), C89 (= C99), I90 (= I100), G91 (= G101), C92 (= C102), K93 (≠ R103), K94 (≠ Y104), C95 (= C105), C99 (= C109), Y101 (= Y111), V103 (≠ A113), I104 (≠ P114), T161 (≠ M123), K163 (= K125), C164 (= C126), F166 (≠ G128), C167 (= C129), A178 (≠ I140), C179 (= C141), C183 (= C145), P184 (= P146), R188 (≠ L150)

Q7WTT9 Arsenate respiratory reductase iron-sulfur subunit ArrB; Arsenate respiratory reductase small subunit; ARR small subunit from Shewanella sp. (strain ANA-3) (see paper)
28% identity, 92% coverage: 4:191/205 of query aligns to 2:220/234 of Q7WTT9

query
sites
Q7WTT9

Q

R

Y

L

G

G

F

M

F

V

I

I

D

D

S

L

A

Q

R

K

C
|
C

T

V

G

G

C
|
C

K

G

T

G

C
|
C

E

S

L

L

A

A

C
|
C

K

K

D

T

Y

E

K

N

N

N

L

T

T

N

P

D

D

G

V

I

S

H

F

W

H

S

R

H

I

H

Y

I

E

A

Y

T

A

T

G

E

G

G

D

T

W

F

Q

P

E

D

D

-

N

-

G

-

V

-

W

-

N

-

Q

-

N

-

V

V

F

K

A

Y

Y

T

Y

Y

L

I

S

P

I

T

A

L

C
|
C

N

N

H

H

C
|
C

E

D

D

D

P

A

A

P

C
|
C

T

V

K

K

V

V

C
|
C

P

P

S

T

G

G

A

A

M

M

H

H

K

K

R

D

D

K

D

R

G

G

F

L

V

T

V

L

V

Q

N

N

E

N

E

D

V

E

C
|
C

I

I

G

G

C
|
C

R

K

Y

K

C
|
C

H

M

M

N

A

A

C
|
C

P

P

Y

Y

G

G

A

V

P

I

Q

S

Y

F

N

N

A

A

K

T

G

P

H

H

-

R

-

W

-

Q

-

D

-

S

-

E

-

V

-

A

-

N

-

G

-

T

-

V

-

S

-

P

-

L

-

M

-

L

-

K

-

R

-

T

-

G

-

A

-

T

-

A

-

T

-

P

-

N

-

E

-

N

-

P

-

E

-

R

-

G

-

D

-

T

-

Y

-

P

-

M

-

I

-

R

-

P

-

K

-

R

-

T

M

T

T

E

K

K

C
|
C

D

T

G

F

C
|
C

Y

D

D

H

R

R

V

L

A

D

D

K

G

G

K

L

K

N

P

P

I

A

C
|
C

V

V

E

D

S

A

C
|
C

P

P

L

S

R

E

A

A

L

R

D

V

F

I

G

G

P

D

I

L

E

D

L

P

R

Q

E

S

K

K

H

V

G

S

Q

Q

L

L

A

I

A

K

V

L

A

H

P

-

L

-

P

-

S

-

A

-

H

-

F

-

T

-

K

K

P

P

S

-

I

M

V

Q

I

L

K

K

P

P

N

E

A

A

N

G

S

T

R

G

P

P

C12 (= C14) binding
C15 (= C17) binding
C18 (= C20) binding
C22 (= C24) binding
C57 (= C67) binding
C60 (= C70) binding
C65 (= C75) binding
C69 (= C79) binding
C89 (= C99) binding
C92 (= C102) binding
C95 (= C105) binding
C99 (= C109) binding
C164 (= C126) binding
C167 (= C129) binding
C179 (= C141) binding
C183 (= C145) binding

5ch7B Crystal structure of the perchlorate reductase pcrab - phe164 gate switch intermediate - from azospira suillum ps (see paper)
26% identity, 97% coverage: 4:201/205 of query aligns to 7:280/329 of 5ch7B

query
sites
5ch7B

Q

Q

Y

L

G

T

F

Y

F

V

I

T

D

D

S

L

A

N

R

K

C
|
C

T
x
I

G
|
G

C
|
C

K
x
Q

T
|
T

C
|
C

E

T

L

V

A

A

C
|
C

K

K

D
x
K

-

L

-
x
W

-

T

-
x
T

-

G

-

P

-

G

-

Q

-

D

-

F

-

M

-

Y

Y

W

K
x
R

N

N

L
x
V

-

E

-

T

T

A

P

P

D

G

V

L

S

G

F

Y

H

P

R

R

I

N

Y

W

E

Q

Y

T

A

K

G

G

-

G

-

Y

-

K

-

N

-

G

-

E

-

L

-

Q

-

K

-

G

-

K

-

I

-

P

-

M

-

I

-

D

-

Y

-

G

-

I

-

P

-

F

-

E

-

F

-

D

-

Y

-

A

-

G

-

R

-

L

-

F

-

E

-

G

-

K

-

P

-

G

-

R

-

V

-

R

-

P

-

S

-

P

-

T

-
x
P

-
x
R

-

S

-

A

-

P

D

N

W
|
W

Q

D

E

E

D

D

N

Q

G

G

V

A

-

G

-

E

W

Y

N

P

Q

N

N

N

V

S

F

F

A

-

Y

F

Y

Y

L

L

S
x
P

I

R

A
x
M

C
|
C

N
|
N

H
|
H

C
|
C

E

T

D

K

P
|
P

A

A

C
|
C

T

L

K

E

V

A

C
|
C

P

P

S

N

G

E

A

A

M
x
I

H

Y

K

K

R

R

D

E

-

Q

D

D

G

G

F

I

V

V

V

I

N

H

E

Q

E

D

V

K

C
|
C

I
x
K

G
|
G

C
x
A

R
x
Q

Y
x
A

C
|
C

H

V

M

Q

A

S

C
|
C

P

P

Y

Y

G

A

A

K

P
|
P

Q

Y

Y

F

N

N

A

P

A

L

K

T

G

N

H

K

M
x
A

T

N

K
|
K

C
|
C

D
x
I

G
|
G

C
|
C

Y

F

D

P

R

R

V

I

A

E

D

Q

G

G

K

V

K

A

P
|
P

I
x
A

C
|
C

V

V

E

A

S

Q

C
|
C

P
x
V

L
x
G

R

R

A

A

L

M

D

H

F

V

G

G

P

F

I

V

E

D

L

V

R

N

E

S

K

S

-

V

-

Y

-

K

-

L

H

I

G

K

Q

Q

L

Y

A

K

A

V

V

A

A

L

P

P

L

L

P

H

S

P

A

E

H

F

F

G

T

T

K

E

P

P

S

N

I

V

V

F

I

Y

K

V

P

P

-

P

-

V

-

L

-

G

-

P

-

R

-

I

-

E

N

M

A

A

N

N

S

G

R

E

P

P

T

S

G

T

D

D

T

P

T

K

G

I

Y

P

L

L

A

A

N

Q

binding fe3-s4 cluster: C145 (= C79), I150 (≠ M84), C166 (= C99), K167 (≠ I100), G168 (= G101), A169 (≠ C102), Q170 (≠ R103), A171 (≠ Y104), C172 (= C105), A190 (≠ M123)
binding iron/sulfur cluster: C17 (= C14), I18 (≠ T15), G19 (= G16), C20 (= C17), Q21 (≠ K18), T22 (= T19), C23 (= C20), C27 (= C24), W31 (vs. gap), R43 (≠ K28), R43 (≠ K28), V45 (≠ L30), P130 (≠ S64), M132 (≠ A66), C133 (= C67), N134 (= N68), H135 (= H69), C136 (= C70), P139 (= P73), C141 (= C75), C176 (= C109), P181 (= P114), K192 (= K125), C193 (= C126), I194 (≠ D127), G195 (= G128), C196 (= C129), P206 (= P139), A207 (≠ I140), C208 (= C141), C212 (= C145), V213 (≠ P146), G214 (≠ L147)
binding sulfite ion: K29 (≠ D26), T33 (vs. gap), P106 (vs. gap), R107 (vs. gap), W112 (= W47)

3egwB The crystal structure of the narghi mutant narh - c16a
40% identity, 48% coverage: 56:153/205 of query aligns to 173:271/509 of 3egwB

query
sites
3egwB

Q

E

N

N

V

T

F

F

A

M

Y

M

Y

Y

L

L

S
x
P

I

R

A
x
L

C
|
C

N
x
E

H
|
H

C
|
C

E

L

D

N

P
|
P

A

A

C
|
C

T

V

K

A

V

T

C
|
C

P

P

S
|
S

G

G

A

A

M
x
I

H

Y

K

K

R

R

D

E

-

E

D

D

G

G

F

I

V
|
V

V

L

V

I

N

D

E

Q

E

D

V

K

C
|
C

I
x
R

G
|
G

C
x
W

R
|
R

Y
x
M

C
|
C

H

I

M

T

A

G

C
|
C

P

P

Y
|
Y

G

K

A

K

P
x
I

Q

Y

Y

F

N

N

A

W

A

K

K

S

G

G

H

K

M
x
S

T

E

K
|
K

C
|
C

D
x
I

G
x
F

C
|
C

Y

Y

D

P

R

R

V

I

A

E

D

A

G

G

K

Q

K

P

P
x
T

I
x
V

C
|
C

V

S

E

E

S

T

C
|
C

P
x
V

L
x
G

R

R

A
x
I

L
x
R

D

Y

F

L

G

G

binding fe3-s4 cluster: P181 (≠ S64), C196 (= C79), S198 (= S81), I201 (≠ M84), C217 (= C99), R218 (≠ I100), G219 (= G101), W220 (≠ C102), R221 (= R103), M222 (≠ Y104), C223 (= C105), S241 (≠ M123), C263 (= C145), V264 (≠ P146), G265 (≠ L147), I267 (≠ A149), R268 (≠ L150)
binding protoporphyrin ix containing fe: W220 (≠ C102), R221 (= R103)
binding iron/sulfur cluster: L183 (≠ A66), C184 (= C67), E185 (≠ N68), H186 (= H69), C187 (= C70), P190 (= P73), C192 (= C75), V210 (= V92), C227 (= C109), Y229 (= Y111), I232 (≠ P114), K243 (= K125), C244 (= C126), I245 (≠ D127), F246 (≠ G128), C247 (= C129), T257 (≠ P139), V258 (≠ I140), C259 (= C141)

Sites not aligning to the query:

binding fe3-s4 cluster: 17, 18, 19, 20, 21, 22
binding protoporphyrin ix containing fe: 88, 89
binding iron/sulfur cluster: 26, 30, 41, 42

P11349 Respiratory nitrate reductase 1 beta chain; Nitrate reductase A subunit beta; Quinol-nitrate oxidoreductase subunit beta; EC 1.7.5.1 from Escherichia coli (strain K12) (see 2 papers)
40% identity, 48% coverage: 56:153/205 of query aligns to 173:271/512 of P11349

query
sites
P11349

Q

E

N

N

V

T

F

F

A

M

Y

M

Y

Y

L

L

S

P

I

R

A

L

C
|
C

N

E

H

H

C
|
C

E

L

D

N

P

P

A

A

C
|
C

T

V

K

A

V

T

C
|
C

P

P

S

S

G

G

A

A

M

I

H

Y

K

K

R

R

D

E

-

E

D

D

G

G

F

I

V

V

V

L

V

I

N

D

E

Q

E

D

V

K

C
|
C

I

R

G

G

C

W

R

R

Y

M

C
|
C

H

I

M

T

A

G

C
|
C

P

P

Y

Y

G

K

A

K

P

I

Q

Y

Y

F

N

N

A

W

A

K

K

S

G

G

H

K

M

S

T

E

K

K

C
|
C

D

I

G

F

C
|
C

Y

Y

D

P

R

R

V

I

A

E

D

A

G

G

K

Q

K

P

P

T

I

V

C
|
C

V

S

E

E

S

T

C
|
C

P

V

L

G

R

R

A

I

L

R

D

Y

F

L

G

G

C184 (= C67) binding
C187 (= C70) binding
C192 (= C75) binding
C196 (= C79) binding
C217 (= C99) binding
C223 (= C105) binding
C227 (= C109) binding
C244 (= C126) binding
C247 (= C129) binding
C259 (= C141) binding
C263 (= C145) binding

Sites not aligning to the query:

16 binding
19 binding
22 binding
26 binding

1h0hB Tungsten containing formate dehydrogenase from desulfovibrio gigas (see paper)
31% identity, 75% coverage: 6:159/205 of query aligns to 3:170/214 of 1h0hB

query
sites
1h0hB

G

G

F
|
F

F

F

I

V

D

D

S

T

A

T

R

R

C
|
C

T
|
T

G
x
A

C
|
C

K
x
R

T
x
G

C
|
C

E

Q

L

V

A

A

C
|
C

K

K

D

Q

-

W

-
x
H

-

G

-

N

-

P

-

A

-

T

-

P

-

T

-

E

-

N

-

T

-

G

Y

F

K

H

N

Q

L

N

T

P

P

P

D

D

V

F

S

N

F

F

H

H

R

-

I

T

Y

Y

E
x
K

Y

L

A

V

G

R

G

M

D

H

W

E

Q

Q

E

E

D

I

N

D

G

G

V

-

W

-

N

-

Q

-

N

R

V

I

F

D

A

W

Y

L

Y

F

L

F

S
x
P

I

D

A
x
Q

C
|
C

N
x
R

H
|
H

C
|
C

E

I

D

A

P

P

A
x
P

C
|
C

T

K

K

A

V

T

C

A

-

D

-

M

-

E

-

D

P

E

S

S

G

A

A

I

M

I

H

H

K

D

R

D

D

A

D

T

G

G

F

C

V
|
V

V

L

V

F

N

T

E

P

E

K

V

T

C

K

I

D

G

L

C

E

R

D

Y

Y

C

E

H

S

M

V

-

I

-

S

A

A

C
|
C

P

P

Y
|
Y

G

D

A
x
V

P
|
P

Q

R

Y

K

N

V

A

A

A

E

K

S

G

N

H

Q

M

M

T

A

K
|
K

C
|
C

D
|
D

G
x
M

C
|
C

Y

I

D

D

R

R

V

I

A

T

D

N

G

G

K

L

K

R

P

P

I
x
A

C
|
C

V

V

E

T

S

S

C
|
C

P
|
P

L

T

R

G

A
|
A

L
x
M

D

N

F

F

G

G

P

D

I

L

E

S

E

E

L

M

R

E

binding iron/sulfur cluster: F4 (= F7), C11 (= C14), T12 (= T15), A13 (≠ G16), C14 (= C17), R15 (≠ K18), G16 (≠ T19), C17 (= C20), C21 (= C24), H25 (vs. gap), K50 (≠ E41), P69 (≠ S64), Q71 (≠ A66), C72 (= C67), R73 (≠ N68), H74 (= H69), C75 (= C70), P79 (≠ A74), C80 (= C75), V101 (= V92), C120 (= C109), Y122 (= Y111), V124 (≠ A113), P125 (= P114), K136 (= K125), C137 (= C126), D138 (= D127), M139 (≠ G128), C140 (= C129), A151 (≠ I140), C152 (= C141), C156 (= C145), P157 (= P146), A160 (= A149), M161 (≠ L150)

Q8GC87 Formate dehydrogenase subunit beta; FDH subunit beta; Formate dehydrogenase small subunit from Megalodesulfovibrio gigas (strain ATCC 19364 / DSM 1382 / NCIMB 9332 / VKM B-1759) (Desulfovibrio gigas) (see paper)
31% identity, 75% coverage: 6:159/205 of query aligns to 4:171/215 of Q8GC87

query
sites
Q8GC87

G

G

F

F

I

V

D

D

S

T

A

T

R

R

C
|
C

T

T

G

A

C
|
C

K

R

T

G

C
|
C

E

Q

L

V

A

A

C
|
C

K

K

D

Q

-

W

-

H

-

G

-

N

-

P

-

A

-

T

-

P

-

T

-

E

-

N

-

T

-

G

Y

F

K

H

N

Q

L

N

T

P

P

P

D

D

V

F

S

N

F

F

H

H

R

-

I

T

Y

Y

E

K

Y

L

A

V

G

R

G

M

D

H

W

E

Q

Q

E

E

D

I

N

D

G

G

V

-

W

-

N

-

Q

-

N

R

V

I

F

D

A

W

Y

L

Y

F

L

F

S

P

I

D

A

Q

C
|
C

N

R

H

H

C
|
C

E

I

D

A

P

P

A

P

C
|
C

T

K

K

A

V

T

C

A

-

D

-

M

-

E

-

D

P

E

S

S

G

A

A

I

M

I

H

H

K

D

R

D

D

A

D

T

G

G

F

C

V

V

V

L

V

F

N

T

E

P

E

K

V

T

C

K

I

D

G

L

C

E

R

D

Y

Y

C

E

H

S

M

V

-

I

-

S

A

A

C
|
C

P

P

Y

Y

G

D

A

V

P

P

Q

R

Y

K

N

V

A

A

A

E

K

S

G

N

H

Q

M

M

T

A

K

K

C
|
C

D

D

G

M

C
|
C

Y

I

D

D

R

R

V

I

A

T

D

N

G

G

K

L

K

R

P

P

I

A

C
|
C

V

V

E

T

S

S

C
|
C

P

P

L

T

R

G

A

A

L

M

D

N

F

F

G

G

P

D

I

L

E

S

E

E

L

M

R

E

C12 (= C14) binding
C15 (= C17) binding
C18 (= C20) binding
C22 (= C24) binding
C73 (= C67) binding
C76 (= C70) binding
C81 (= C75) binding
C121 (= C109) binding
C138 (= C126) binding
C141 (= C129) binding
C153 (= C141) binding
C157 (= C145) binding

8bqgB W-formate dehydrogenase from desulfovibrio vulgaris - soaking with formate 1 min (see paper)
30% identity, 74% coverage: 7:158/205 of query aligns to 4:169/214 of 8bqgB

query
sites
8bqgB

F
|
F

F

F

I

V

D

D

S

L

A

S

R

R

C
|
C

T
|
T

G
x
A

C
|
C

K
x
R

T
x
G

C
|
C

E

Q

L

I

A

A

C
|
C

K

K

D

Q

Y

W

K
|
K

N

N

L

L

T

P

-

A

-

E

-

T

-

R

-

N

-

T

-

G

-

S

-

H

-

Q

-

N

-

P

P

P

D

D

V

L

S

S

F

Y

H

V

-

T

-

L

-
x
K

-

T

-

V

R

R

I

F

Y

T

E

E

Y

K

A

S

-

R

-

K

-

G

-

P

G

G

G

I

D

D

W

W

Q

-

E

-

D

-

N

-

G

-

V

-

W

-

N

-

Q

-

N

-

V

-

F

-

A

-

Y

L

Y

F

L

F

S

P

I

E

A
x
Q

C
|
C

N
x
R

H
|
H

C
|
C

E

V

D

E

P

P

A
x
P

C
|
C

-

K

-

G

-

Q

T

A

K

D

V

V

C

D

P

L

S

E

G

G

A

A

M

V

H

V

K

K

R

D

D

E

D

T

G

T

F

G

V

A

V
|
V

V

L

N

F

E

T

E

E

V

L

C

T

-

A

-

K

I

V

G

D

C

G

R

E

Y

S

C

V

H

R

M

S

A

A

C
|
C

P

P

Y
|
Y

G

D

A
x
I

P
|
P

Q

R

Y

I

N

D

A

P

A

V

K

T

G

K

H

R

M

L

T

S

K
|
K

C
|
C

D
|
D

G
x
M

C
|
C

Y

N

D

D

R

R

V

V

A

Q

D

N

G

G

K

L

P
|
P

I
x
A

C
|
C

V

V

E

K

S

T

C
|
C

P
|
P

L
x
T

R

G

A
x
T

L
x
M

D

N

F

F

G

G

P

D

I

E

E

Q

E

E

L

M

binding iron/sulfur cluster: F4 (= F7), C11 (= C14), T12 (= T15), A13 (≠ G16), C14 (= C17), R15 (≠ K18), G16 (≠ T19), C17 (= C20), C21 (= C24), K25 (= K28), K50 (vs. gap), Q72 (≠ A66), C73 (= C67), R74 (≠ N68), H75 (= H69), C76 (= C70), P80 (≠ A74), C81 (= C75), V102 (= V93), C120 (= C109), Y122 (= Y111), I124 (≠ A113), P125 (= P114), K136 (= K125), C137 (= C126), D138 (= D127), M139 (≠ G128), C140 (= C129), P150 (= P139), A151 (≠ I140), C152 (= C141), C156 (= C145), P157 (= P146), T158 (≠ L147), T160 (≠ A149), M161 (≠ L150)

7qv7B Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
31% identity, 79% coverage: 10:171/205 of query aligns to 10:180/183 of 7qv7B

query
sites
7qv7B

D

N

S

P

A

A

R

K

C
|
C

T
x
I

G
|
G

C
|
C

K
|
K

T
x
A

C
|
C

E

E

L

V

A

A

C
|
C

K

-

D

-

Y

-

K

-

N

-

L

-

T

-

P

-

D

-

V

F

S

A

F

V

H
|
H

R

N

I

R

Y

N

E

N

Y

H

A

V

G

G

G

A

D

T

W

V

Q

-

E

-

D

-

N

-

G

G

V

T

W

V

N

S

Q

I

N

P

V

V

F

I

A

P

Y
x
R

Y

L

-

H

-

L

-

I

-

K

-

T

-

E

-

H

-

G

-

T

L

M

S

P

I

I

A

Q

C
|
C

N
x
R

H
|
H

C
|
C

E

E

D

D

P
x
A

A

P

C
|
C

T

A

K

N

V

V

C
|
C

P

T

S

V

G

G

A
|
A

M
x
I

H

-

K

K

R

R

D

E

D

G

G

N

F

A

V

I

V

V

N

D

E

E

E

K

V

L

C
|
C

I
|
I

G

G

C
|
C

R

K

Y

S

C
|
C

H

L

M

L

A

A

C
|
C

P

P

Y

F

G

G

A

A

-
x
I

-

E

-

L

P

P

Q

Q

Y

Y

N

E

A

D

A

G

K

R

G

E

H

V

M

F

T

Q

-

I

-

N

-

L

-

K

-

L

-

V

-

Q

-

E

-

P

-

R

-

I

-

A

-

Y

K

K

C
|
C

D
|
D

G
x
L

C
|
C

Y

N

D

D

R

L

V

-

A

-

D

-

G

-

K

G

K

E

P
|
P

I
x
A

C
|
C

V

V

E

K

S

A

C
|
C

P
|
P

L

E

R

N

A
|
A

L
|
L

D

T

F

L

G

V

P

M

I

P

E

T

E

E

L

M

R

K

E

K

K

A

H

R

G

N

Q

K

L

E

A

A

V

L

A

S

P

F

L

L

binding iron/sulfur cluster: C14 (= C14), I15 (≠ T15), G16 (= G16), C17 (= C17), K18 (= K18), A19 (≠ T19), C20 (= C20), C24 (= C24), H28 (= H37), R48 (≠ Y61), C63 (= C67), R64 (≠ N68), H65 (= H69), C66 (= C70), A69 (≠ P73), C71 (= C75), C75 (= C79), A79 (= A83), I80 (≠ M84), C94 (= C99), I95 (= I100), C97 (= C102), C100 (= C105), C104 (= C109), I109 (vs. gap), C139 (= C126), D140 (= D127), L141 (≠ G128), C142 (= C129), P148 (= P139), A149 (≠ I140), C150 (= C141), C154 (= C145), P155 (= P146), A158 (= A149), L159 (= L150)

6f0kB Alternative complex iii (see paper)
25% identity, 75% coverage: 4:157/205 of query aligns to 723:918/961 of 6f0kB

query
sites
6f0kB

Q

Q

Y

W

G

A

F

M

F

V

I

I

D

D

S

L

A

N

R

A

C
|
C

T
|
T

G
|
G

C
|
C

K
x
N

T
x
A

C
|
C

E

I

L

V

A

A

C
|
C

K

-

D

D

Y

S

K

E

N

N

L

N

T

I

P

P

D

M

V

V

S

G

F

K

H

N

R

E

I

V

Y

G

E

R

Y

G

A

R

G

E

G

M

D

H

W
|
W

Q
x
L

E

R

D

-

N

-

G

-

V

-

W

-

N

-

Q

-

N

-

V
x
I

F

D

A

R

Y

Y

Y

F

L

V

S

S

-

D

-

E

-

A

-

H

-

A

-

D

-

P

-

Q

-

I

-

V

-

Q

-

P

I

V

A

P

C
|
C

N
x
M

H
|
H

C
|
C

E

E

D

N

P

A

A
x
P

C
|
C

T

E

K

S

V

V

C
|
C

P

P

S
x
V

G
x
A

A

A

M

T

H

V

K

H

R

S

D

P

D

D

G

G

F

L

V
x
N

V

E

V
x
M

N

V

E

Y

E
x
N

V
x
R

C
|
C

I
|
I

G
|
G

C
x
T

R
|
R

Y
|
Y

C
|
C

H

S

M

N

A

N

C
|
C

P

P

Y

Y

G

K

A

V

P
x
R

Q

R

Y

F

N

N

-

W

-

F

-

N

-

W

-

V

-

K

-

T

-

L

-

P

-

I

-

Q

-

V

-

Q

-

M

-

A

-

Q

-

N

-

P

-

D

-

V

-

T

-

V

A

R

A

F

K

R

G

G

H

V

M
|
M

T

E

K

K

C
|
C

D

T

G
x
Y

C
|
C

Y

V

D

Q

R

R

V

I

A
x
R

D

E

G

A

-
x
Q

-
x
R

-

Q

-

A

-
x
N

-

I

-

E

K

K

K

R

P

P

I

L

-

R

-

D

-

G

-

E

-

V

-

K

-

T

-
x
A

C
|
C

V

Q

E

Q

S

A

C
|
C

P

P

L

A

R

E

A

A

L

I

D

T

F

F

G

G

P

D

I

L

E

N

E

D

binding fe3-s4 cluster: C803 (= C79), V805 (≠ S81), M818 (≠ V94), C823 (= C99), I824 (= I100), G825 (= G101), T826 (≠ C102), R827 (= R103), Y828 (= Y104), C829 (= C105), M869 (= M123)
binding heme c: A806 (≠ G82), N821 (≠ E97), R822 (≠ V98), R880 (≠ A134), Q883 (vs. gap), R884 (vs. gap), N887 (vs. gap)
binding iron/sulfur cluster: C733 (= C14), T734 (= T15), G735 (= G16), C736 (= C17), N737 (≠ K18), A738 (≠ T19), C739 (= C20), C743 (= C24), W765 (= W47), L766 (≠ Q48), I768 (≠ V58), C791 (= C67), M792 (≠ N68), H793 (= H69), C794 (= C70), P798 (≠ A74), C799 (= C75), N816 (≠ V92), C833 (= C109), R838 (≠ P114), C872 (= C126), Y874 (≠ G128), C875 (= C129), A901 (vs. gap), C902 (= C141), C906 (= C145)

Sites not aligning to the query:

binding heme c: 719

7qv7A Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
28% identity, 81% coverage: 10:175/205 of query aligns to 8:173/174 of 7qv7A

query
sites
7qv7A

D

D

S

P

A

K

R

R

C
|
C

T
x
L

G
|
G

C
|
C

K
x
Y

T

T

C
|
C

E

I

L

A

A

A

C
|
C

K

A

-

F

-

V

-
x
H

D

E

Y

E

K

Q

N

G

L

L

T

Q

P

P

D

F

V

P

S

R

F
x
L

H

Y

R

L

I

T

Y

Y

E

T

Y

S

A

E

G

G

G

-

D

-

W

-

Q

-

E

-

D

-

N

-

G

-

V

-

W

-

N

-

Q

-

N

-

V

-

F

-

A

-

Y

-

Y

I

L

M

S

P

I

I

A

Q

C
|
C

N
x
R

H

H

C
|
C

E

E

D

D

P

A

A
x
P

C
|
C

T

A

K

E

V

V

C
|
C

P

P

S

V

G

E

A

A

M
x
I

H

K

K

K

R

E

D

G

D

N

G

A

F

-

V

I

N

D

E

E

E

K

V

A

C
|
C

I
|
I

G
|
G

C
|
C

R

K

Y

T

C
|
C

H

L

M

L

A

A

C
|
C

P

S

Y

F

G

G

A

A

P
x
I

Q

D

Y
x
F

-

S

-

V

-

Q

-

D

-

S

-

L

-

E

-

Q

-

S

-

I

-

F

-

K

-

D

-

I

-

K

-

E

N

N

A

L

A

M

K

R

G

I

H

V

M
x
A

T

V

K

K

C
|
C

D
|
D

G
x
L

C
|
C

Y

N

D

F

R

R

V

-

A

-

D

-

G

E

K

E

K

G

P
|
P

I
x
A

C
|
C

V

V

E

Q

S

F

C
|
C

P
|
P

L
x
T

R

K

A

A

L

L

D

K

F

L

G

V

P

D

I

G

E

D

E

E

L

I

R

N

E

K

-

M

-

V

K

K

H

N

G

K

Q

R

L

T

A

V

A

N

V

V

A

E

P

S

L

L

P

L

S

S

A

V

H

Y

binding iron/sulfur cluster: C12 (= C14), L13 (≠ T15), G14 (= G16), C15 (= C17), Y16 (≠ K18), C18 (= C20), C22 (= C24), H26 (vs. gap), L37 (≠ F36), C51 (= C67), R52 (≠ N68), C54 (= C70), P58 (≠ A74), C59 (= C75), C63 (= C79), I68 (≠ M84), C82 (= C99), I83 (= I100), G84 (= G101), C85 (= C102), C88 (= C105), C92 (= C109), I97 (≠ P114), F99 (≠ Y116), A122 (≠ M123), C125 (= C126), D126 (= D127), L127 (≠ G128), C128 (= C129), P135 (= P139), A136 (≠ I140), C137 (= C141), C141 (= C145), P142 (= P146), T143 (≠ L147)

6x6uB Wor5 from pyrococcus furiosus, taurine-bound (see paper)
33% identity, 68% coverage: 7:145/205 of query aligns to 5:125/167 of 6x6uB

query
sites
6x6uB

F

I

F

L

I

I

D

T

S

P

A
x
D

R

K

C
|
C

T
x
S

G
|
G

C
|
C

K
x
R

T

L

C
|
C

E

E

L

V

A

T

C
|
C

K

S

D

-

Y

-

K

-

N

-

L

-

T

-

P

-

D

-

V

-

S

-

F

-

H

-

R

-

I

-

Y

L

E

E

Y
x
H

A

E

G

G

G

I

D

I

W

W

Q

P

E

E

D

A

N

S

G
x
R

V
x
I

W

-

N

-

Q

-

N

R

V
|
V

F

F

A

E

Y

L

Y

F

L

P

S

G

I

I

-

N

-

V

-
x
P

-

H

A

T

C
|
C

N
x
V

H
x
Q

C
|
C

E

P

D

D

P

Y

A
x
P

C
|
C

T

V

K

N

V

A

C
|
C

P
|
P

S

T

G

N

A

A

M
x
L

H

S

-

V

K

D

R

E

D

K

D

T

G

G

F

A

V

V

N

N

E

E

V

K

C
|
C

I
|
I

G
x
T

C
|
C

R
x
G

Y
x
A

C
|
C

H

V

M

L

A

A

C
|
C

P

P

Y

G

G

K

A
x
V

P
|
P

Q

R

Y

I

N

P

A

A

A

G

K

K

G

G

H

S

M

V

T

V

K

I

C
|
C

D
|
D

G
x
L

C
|
C

Y

-

D

-

R

-

V

-

A

-

D

-

G

G

K

G

K

N

P
|
P

I
x
K

C
|
C

V

V

E

E

S

I

C
|
C

binding phosphate ion: D10 (≠ A12)
binding iron/sulfur cluster: C12 (= C14), S13 (≠ T15), G14 (= G16), C15 (= C17), R16 (≠ K18), C18 (= C20), C22 (= C24), H26 (≠ Y42), R36 (≠ G52), I37 (≠ V53), V39 (= V58), P49 (vs. gap), C52 (= C67), V53 (≠ N68), Q54 (≠ H69), C55 (= C70), P59 (≠ A74), C60 (= C75), C64 (= C79), P65 (= P80), L69 (≠ M84), C85 (= C99), I86 (= I100), T87 (≠ G101), C88 (= C102), G89 (≠ R103), A90 (≠ Y104), C91 (= C105), C95 (= C109), V99 (≠ A113), P100 (= P114), C112 (= C126), D113 (= D127), L114 (≠ G128), C115 (= C129), P119 (= P139), K120 (≠ I140), C121 (= C141), C125 (= C145)

Sites not aligning to the query:

8c0zC Cryoem structure of a tungsten-containing aldehyde oxidoreductase from aromatoleum aromaticum (see paper)
30% identity, 72% coverage: 6:152/205 of query aligns to 4:133/158 of 8c0zC

query
sites
8c0zC

G

S

F

L

F

H

I

I

D

D

S

P

A

A

R

K

C
|
C

T
|
T

G
|
G

C
|
C

K
x
L