Comparing BWI76_RS16115 FitnessBrowser__Koxy:BWI76_RS16115 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 8 hits to proteins with known functional sites (download)
P14407 Fumarate hydratase class I, anaerobic; D-tartrate dehydratase; Fumarase B; EC 4.2.1.2; EC 4.2.1.81 from Escherichia coli (strain K12) (see paper)
86% identity, 99% coverage: 1:548/551 of query aligns to 1:548/548 of P14407
E9AE57 Fumarate hydratase 2; Fumarase 2; LmFH-2; EC 4.2.1.2 from Leishmania major (see paper)
65% identity, 93% coverage: 25:537/551 of query aligns to 53:565/568 of E9AE57
Q4QAU9 Fumarate hydratase 1, mitochondrial; Fumarase 1; LmFH-1; EC 4.2.1.2 from Leishmania major (see paper)
62% identity, 95% coverage: 14:538/551 of query aligns to 21:549/549 of Q4QAU9
6msoA Crystal structure of mitochondrial fumarate hydratase from leishmania major in a complex with inhibitor thiomalate (see paper)
62% identity, 95% coverage: 14:538/551 of query aligns to 12:540/540 of 6msoA
6unzA Crystal structure of cytosolic fumarate hydratase from leishmania major (see paper)
65% identity, 93% coverage: 25:537/551 of query aligns to 33:536/539 of 6unzA
6uoiA Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with malonate (see paper)
65% identity, 93% coverage: 25:537/551 of query aligns to 28:532/535 of 6uoiA
6msnA Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with inhibitor thiomalate (see paper)
65% identity, 93% coverage: 25:537/551 of query aligns to 26:529/532 of 6msnA
6uqnB Crystal structure of r173a variant of cytosolic fumarate hydratase from leishmania major in a complex with fumarate and s-malate (see paper)
65% identity, 93% coverage: 25:537/551 of query aligns to 26:529/532 of 6uqnB
>BWI76_RS16115 FitnessBrowser__Koxy:BWI76_RS16115
MSTKPFVYQEAFPLAKDKTEYYLLSKEHVSIAEFEGQEILKVDPQALTLLAQQAFHDAAF
MLRVSHQKQVAQILLDPEASDNDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIMGKKGQR
VWTGGGDEAALARGVYNTYTEDNLRYSQNAPLDMYKEVNTGTNLPAQIDLYATDGEEYKF
LCIAKGGGSANKTYLYQETKALITPAKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAES
TLKTVKLASTHYYDELPTEGNEHGQAFRDIQLEQELLAEAQNLGLGAQFGGKYFAHDIRV
IRLPRHGASCPVGMGVSCSADRNIKAKINRHGIWIEKLESNPGQYIPEHLRQQGEGRVVS
INLNQPMSEILAQLSAHPVSTRLTLNGTIIVARDIAHAKLKELIDNGEELPQYVKDHPIY
YAGPAKTPEGYASGSLGPTTAGRMDSYVDLLQSHGASMVMLAKGNRSQQVTDACHKHGGF
YLGSIGGPAAVLAQQSIKSLECVAYPELGMEAIWKIEVENFPAFILVDDKGNDFFQQIQN
KQCAGCSQQRG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory