Comparing BWI76_RS17500 FitnessBrowser__Koxy:BWI76_RS17500 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q51742 Ornithine carbamoyltransferase, anabolic; OTCase; EC 2.1.3.3 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see 3 papers)
27% identity, 80% coverage: 18:332/395 of query aligns to 5:273/315 of Q51742
Sites not aligning to the query:
Q8P8J2 N-acetylornithine carbamoyltransferase; N-acetyl-L-ornithine transcarbamylase; AOTCase; Acetylornithine transcarbamylase; EC 2.1.3.9 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see 3 papers)
29% identity, 79% coverage: 18:331/395 of query aligns to 1:296/339 of Q8P8J2
Sites not aligning to the query:
3l02A Crystal structure of n-acetyl-l-ornithine transcarbamylase e92a mutant complexed with carbamyl phosphate and n-succinyl-l-norvaline (see paper)
29% identity, 79% coverage: 21:331/395 of query aligns to 2:294/332 of 3l02A
Sites not aligning to the query:
3m4jA Crystal structure of n-acetyl-l-ornithine transcarbamylase complexed with palao (see paper)
29% identity, 79% coverage: 21:331/395 of query aligns to 2:294/332 of 3m4jA
Sites not aligning to the query:
3kzoA Crystal structure of n-acetyl-l-ornithine transcarbamylase complexed with carbamyl phosphate and n-acetyl-l-norvaline (see paper)
29% identity, 79% coverage: 21:331/395 of query aligns to 2:294/332 of 3kzoA
Sites not aligning to the query:
3kznA Crystal structure of n-acetyl-l-ornithine transcarbamylase complexed with n-acetyl-l-ornirthine (see paper)
29% identity, 79% coverage: 21:331/395 of query aligns to 2:294/332 of 3kznA
Sites not aligning to the query:
3kzmA Crystal structure of n-acetyl-l-ornithine transcarbamylase complexed with carbamyl phosphate (see paper)
29% identity, 79% coverage: 21:331/395 of query aligns to 2:294/332 of 3kzmA
Sites not aligning to the query:
3kzkA Crystal structure of acetylornithine transcarbamylase complexed with acetylcitrulline (see paper)
29% identity, 79% coverage: 21:331/395 of query aligns to 2:294/334 of 3kzkA
Sites not aligning to the query:
P00481 Ornithine transcarbamylase, mitochondrial; OTCase; Ornithine carbamoyltransferase, mitochondrial; EC 2.1.3.3 from Rattus norvegicus (Rat) (see 2 papers)
24% identity, 91% coverage: 13:373/395 of query aligns to 32:340/354 of P00481
Sites not aligning to the query:
Q837U7 Putrescine carbamoyltransferase; PTC; PTCase; Agmatine catabolism protein B; Putrescine transcarbamoylase; Putrescine transcarbamylase; EC 2.1.3.6 from Enterococcus faecalis (strain ATCC 700802 / V583) (see paper)
24% identity, 89% coverage: 20:372/395 of query aligns to 2:306/339 of Q837U7
4a8hA Crystal structure of putrescine transcarbamylase from enterococcus faecalis with n-(phosphonoacetyl)-putrescine (see paper)
24% identity, 89% coverage: 20:372/395 of query aligns to 2:306/340 of 4a8hA
Q81M99 Ornithine carbamoyltransferase; OTCase; EC 2.1.3.3 from Bacillus anthracis
27% identity, 81% coverage: 18:336/395 of query aligns to 9:280/316 of Q81M99
Sites not aligning to the query:
4nf2A Crystal structure of anabolic ornithine carbamoyltransferase from bacillus anthracis in complex with carbamoyl phosphate and l- norvaline
27% identity, 81% coverage: 18:336/395 of query aligns to 5:276/307 of 4nf2A
Sites not aligning to the query:
7nouA Crystal structure of mycobacterium tuberculosis argf in complex with (3,5-dichlorophenyl)boronic acid.
26% identity, 89% coverage: 21:372/395 of query aligns to 4:302/308 of 7nouA
7nosA Crystal structure of mycobacterium tuberculosis argf in complex with 4-bromo-6-(trifluoromethyl)-1h-benzo[d]imidazole.
26% identity, 89% coverage: 21:372/395 of query aligns to 4:302/308 of 7nosA
7norA Crystal structure of mycobacterium tuberculosis argf in complex with 2-fluoro-4-hydroxybenzonitrile.
26% identity, 89% coverage: 21:372/395 of query aligns to 4:302/308 of 7norA
7nnyA Crystal structure of mycobacterium tuberculosis argf in complex with naphthalen-1-ol.
26% identity, 89% coverage: 21:372/395 of query aligns to 4:302/308 of 7nnyA
7nnwA Crystal structure of mycobacterium tuberculosis argf in complex with methyl 4-hydroxy-3-iodobenzoate.
26% identity, 89% coverage: 21:372/395 of query aligns to 4:302/308 of 7nnwA
7nnvA Crystal structure of mycobacterium tuberculosis argf in complex with carbamoyl phosphate.
26% identity, 89% coverage: 21:372/395 of query aligns to 4:302/308 of 7nnvA
P9WIT9 Ornithine carbamoyltransferase; OTCase; EC 2.1.3.3 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
26% identity, 89% coverage: 21:372/395 of query aligns to 3:301/307 of P9WIT9
>BWI76_RS17500 FitnessBrowser__Koxy:BWI76_RS17500
MKTVNELIKDINQLNSHLSEKDFLLTWEQTPDELKQVLDVAAALKTLRAENIATKVFNSG
LGISVFRDNSTRTRFSYASALNLLGLAQQDLDEGKSQIAHGETVRETANMISFCADAIGI
RDDMFLGAGNAYMREVGEALDDGHKQGVLPQRPALINLQCDIDHPTQSMADLAWLREHFG
SLENLKGKKIAMTWAYSPSYGKPLSVPQGIIGLMTRFGMEVTLAHPEGYDLIPDVIEVAK
NNAQASGGSFRQVNSMEEAFKDADIVYPKSWAPYKVMEKRTELLRANDHEGLKALEKACL
EQNAGHKDWHCTEEMMKHTRDGEALYMHCLPADITGVSCEAGEVTEGVFEKYRIPTYKEA
SWKPYIIAAMIVCRKYANPGKVLEQLLKDAQKRIK
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory