Comparing BWI76_RS18685 FitnessBrowser__Koxy:BWI76_RS18685 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 17 hits to proteins with known functional sites (download)
6dvvA 2.25 angstrom resolution crystal structure of 6-phospho-alpha- glucosidase from klebsiella pneumoniae in complex with NAD and mn2+. (see paper)
71% identity, 99% coverage: 4:441/442 of query aligns to 3:434/435 of 6dvvA
Q97LM4 Maltose-6'-phosphate glucosidase MalH; 6-phospho-alpha-glucosidase; 6-phospho-glucosidase; Maltose-6-phosphate hydrolase; EC 3.2.1.122 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see paper)
67% identity, 99% coverage: 4:441/442 of query aligns to 3:440/441 of Q97LM4
P54716 Maltose-6'-phosphate glucosidase; 6-phospho-alpha-D-glucosidase; 6-phosphoryl-O-alpha-D-glucopyranosyl:phosphoglucohydrolase; EC 3.2.1.122 from Bacillus subtilis (strain 168) (see paper)
65% identity, 100% coverage: 2:441/442 of query aligns to 3:441/449 of P54716
1u8xX Crystal structure of glva from bacillus subtilis, a metal-requiring, NAD-dependent 6-phospho-alpha-glucosidase (see paper)
65% identity, 100% coverage: 2:441/442 of query aligns to 1:432/436 of 1u8xX
6vc6B 2.1 angstrom resolution crystal structure of 6-phospho-alpha- glucosidase from gut microorganisms in complex with NAD and mn2+
47% identity, 99% coverage: 4:442/442 of query aligns to 2:440/440 of 6vc6B
6wbtA 2.52 angstrom resolution crystal structure of 6-phospho-alpha- glucosidase from gut microorganisms in complex with NAD and glucose- 6-phosphate
47% identity, 99% coverage: 7:442/442 of query aligns to 6:442/442 of 6wbtA
5c3mB Crystal structure of gan4c, a gh4 6-phospho-glucosidase from geobacillus stearothermophilus
31% identity, 98% coverage: 11:441/442 of query aligns to 7:410/411 of 5c3mB
1up6A Structure of the 6-phospho-beta glucosidase from thermotoga maritima at 2.55 angstrom resolution in the tetragonal form with manganese, NAD+ and glucose-6-phosphate (see paper)
29% identity, 98% coverage: 7:437/442 of query aligns to 4:409/413 of 1up6A
1up7A Structure of the 6-phospho-beta glucosidase from thermotoga maritima at 2.4 angstrom resolution in the tetragonal form with NAD and glucose-6-phosphate (see paper)
29% identity, 98% coverage: 7:437/442 of query aligns to 5:410/414 of 1up7A
Q9AI65 Alpha-glucosidase; EC 3.2.1.20 from Erwinia rhapontici (Pectobacterium rhapontici) (see paper)
22% identity, 98% coverage: 6:438/442 of query aligns to 5:448/453 of Q9AI65
Sites not aligning to the query:
P39130 Alpha-galacturonidase; EC 3.2.1.67 from Bacillus subtilis (strain 168) (see paper)
23% identity, 74% coverage: 73:398/442 of query aligns to 74:406/446 of P39130
3fefA Crystal structure of putative glucosidase lpld from bacillus subtilis
23% identity, 74% coverage: 73:398/442 of query aligns to 68:400/434 of 3fefA
3u95A Crystal structure of a putative alpha-glucosidase from thermotoga neapolitana (see paper)
24% identity, 85% coverage: 7:380/442 of query aligns to 3:407/468 of 3u95A
7ctmA Crystal structure of thermotoga maritima alpha-glucuronidase (tm0752) in complex with nadh and d-glucuronic acid (see paper)
23% identity, 79% coverage: 34:380/442 of query aligns to 33:408/469 of 7ctmA
Sites not aligning to the query:
6kcxA Crystal structure of citrate complex of alpha-glucuronidase (tm0752) from thermotoga maritima (see paper)
23% identity, 79% coverage: 34:380/442 of query aligns to 33:408/470 of 6kcxA
7br4A Structure of deletion mutant of alpha-glucuronidase (tm0752) from thermotoga maritima (see paper)
23% identity, 76% coverage: 34:368/442 of query aligns to 33:391/468 of 7br4A
Sites not aligning to the query:
1vjtA Crystal structure of alpha-glucosidase (tm0752) from thermotoga maritima at 2.50 a resolution
23% identity, 79% coverage: 34:380/442 of query aligns to 34:409/471 of 1vjtA
Sites not aligning to the query:
>BWI76_RS18685 FitnessBrowser__Koxy:BWI76_RS18685
MKNKFVVTIAGGGSTYTPGIVMMLLENMDRFPLSEIRLYDNHRDRQSVIGEACAILVAER
YPQVAFSFTTDPQEAFTGVDFVMAHIRVGLYEMREKDEKIPLKHGVIGQETCGPGGIAYG
MRSIAGVLELVDYMETYSPGAWMLNYSNPAAIVAEATRRLRPTAKIINICDMPVAIEGLF
ADILGLKSRKEMNVRYFGLNHFGWWTSITDKAGNDLMPALKNHVAELGYCSPKEDFQHKA
PSWIETFKKVKDVFALDTDTLPNTYLKYYFYADYEVAHSDPDFTRANEVIAGREKEVFDM
AREIVARQSGKAAHFHAGAHATFIVDLACAIAFNTQERMLLIVENNGAIANFDDTAMVEV
PCLVGVNGPEPLAMGKIPLFQKGMMEQQVAVEKLVVDAWVEGSYQKLWQAMTLSKTVPSA
SVAKAILDELIVANRGYWPELR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory