Comparing BWI76_RS18945 FitnessBrowser__Koxy:BWI76_RS18945 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5abtA S.Enterica hisa mutant d7n, g102a, v106m, d176a
87% identity, 100% coverage: 1:244/245 of query aligns to 1:244/246 of 5abtA
5ab3A S.Enterica hisa mutant d7n, d10g, dup13-15, q24l, g102a (see paper)
83% identity, 100% coverage: 1:244/245 of query aligns to 1:241/241 of 5ab3A
3zs4A Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase with bound prfar
35% identity, 98% coverage: 1:239/245 of query aligns to 4:239/244 of 3zs4A
5dn1A Crystal structure of phosphoribosyl isomerase a from streptomyces coelicolor (see paper)
35% identity, 98% coverage: 2:240/245 of query aligns to 6:237/240 of 5dn1A
P16250 Phosphoribosyl isomerase A; 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; N-(5'-phosphoribosyl)anthranilate isomerase; PRAI; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; EC 5.3.1.16; EC 5.3.1.24 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
35% identity, 98% coverage: 2:240/245 of query aligns to 6:237/240 of P16250
2y88A Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase (variant d11n) with bound prfar (see paper)
34% identity, 98% coverage: 1:239/245 of query aligns to 4:239/244 of 2y88A
4tx9A Crystal structure of hisap from streptomyces sviceus with degraded profar (see paper)
36% identity, 98% coverage: 2:240/245 of query aligns to 11:242/246 of 4tx9A
2y85A Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase with bound rcdrp (see paper)
33% identity, 98% coverage: 1:239/245 of query aligns to 4:230/234 of 2y85A
1h5yB Hisf protein from pyrobaculum aerophilum (see paper)
33% identity, 84% coverage: 2:206/245 of query aligns to 7:208/253 of 1h5yB
Sites not aligning to the query:
Q9X0C7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; EC 5.3.1.16 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
29% identity, 96% coverage: 1:235/245 of query aligns to 2:233/241 of Q9X0C7
7ac8A Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex. (see paper)
29% identity, 85% coverage: 2:209/245 of query aligns to 6:208/252 of 7ac8A
Sites not aligning to the query:
Q9X0C6 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
29% identity, 85% coverage: 2:209/245 of query aligns to 6:208/253 of Q9X0C6
1gpwC Structural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex. (see paper)
28% identity, 84% coverage: 2:208/245 of query aligns to 6:207/253 of 1gpwC
Sites not aligning to the query:
7qc8A Imidazole glycerol phosphate synthase subunit HisF (see paper)
30% identity, 84% coverage: 2:208/245 of query aligns to 6:207/250 of 7qc8A
3zr4E Structural evidence for ammonia tunneling across the (beta-alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex (see paper)
27% identity, 85% coverage: 2:209/245 of query aligns to 6:199/244 of 3zr4E
Sites not aligning to the query:
2wjzE Crystal structure of (hish) k181a y138a mutant of imidazoleglycerolphosphate synthase (hish hisf) which displays constitutive glutaminase activity (see paper)
27% identity, 85% coverage: 2:209/245 of query aligns to 6:194/237 of 2wjzE
P60664 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Escherichia coli (strain K12) (see paper)
27% identity, 96% coverage: 2:237/245 of query aligns to 6:243/258 of P60664
Sites not aligning to the query:
5d2tA Directed evolutionary changes in kemp eliminase ke07 - crystal 3 wild type
27% identity, 76% coverage: 2:186/245 of query aligns to 4:184/251 of 5d2tA
Sites not aligning to the query:
6dnjA Directed evolutionary changes in kemp eliminase ke07 - crystal 28 round 5 (see paper)
26% identity, 83% coverage: 2:205/245 of query aligns to 5:206/250 of 6dnjA
1ox4B Towards understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerophosphate synthase (see paper)
22% identity, 90% coverage: 18:237/245 of query aligns to 261:523/538 of 1ox4B
Sites not aligning to the query:
>BWI76_RS18945 FitnessBrowser__Koxy:BWI76_RS18945
MIIPALDLIDGTVVRLHQGDYGQQRDYGNDPLPRLQSYAAQGAEVLHLVDLTGAKDPAKR
QIPLLKKLVAGVNVPVQVGGGVRTEQDVAALLEAGVARVVVGSTAVKSPEVVKGWFKRFG
PQHLVLALDVRIDAEGRKQVAVSGWQENSGVTLEELVESYQSVGLQHVLCTDISRDGTLA
GSNVSLYEEVCARYPQVAFQSSGGIGDLNDIAALLGTGVRGVIVGRALLEGKFNVTEAIQ
CWQNG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory