SitesBLAST – Find functional sites

 

SitesBLAST

Comparing BWI76_RS19230 FitnessBrowser__Koxy:BWI76_RS19230 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
30% identity, 88% coverage: 23:233/241 of query aligns to 17:213/215 of 4ymtC

query
sites
4ymtC
S
 
S
G
 
G
L
 
L
A
 
I
V
 
M
T
 
T
A
 
L
E
 
K
L
 
L
F
 
T
L
 
F
L
 
L
S
 
A
I
 
V
V
 
T
P
 
I
G
 
G
M
 
V
A
 
L
L
 
M
A
 
G
I
 
L
A
 
F
M
 
I
A
 
A
V
 
L
G
 
M
Q
 
K
V
 
M
Y
 
S
G
 
S
P
 
I
R
 
K
G
 
P
L
 
I
A
 
K
L
 
L
P
 
V
I
 
A
R
 
S
A
 
S
F
 
Y
T
 
I
Y
 
E
F
 
V
F
 
I
R
 
R
S
 
G
T
 
T
P
|
P
L
|
L
Y
 
L
L
 
V
Q
 
Q
L
 
L
M
 
L
L
 
L
I
 
I
Y
 
Y
Y
 
N
G
 
G
L
 
L
S
 
M
Q
 
Q
F
 
F
D
 
G
I
 
-
V
 
-
Q
 
-
T
 
-
G
 
-
W
 
-
M
 
M
N
 
N
D
 
I
Q
 
P
P
 
A
F
 
F
W
 
T
L
 
-
L
 
-
F
 
-
R
 
-
D
 
-
A
 
-
T
 
-
F
 
-
C
 
A
A
 
G
T
 
V
L
 
S
A
 
A
L
 
L
V
 
A
L
 
I
N
|
N
T
 
S
A
 
S
A
 
A
Y
|
Y
V
 
V
A
 
A
E
 
E
L
 
I
L
 
I
-
 
R
A
 
A
G
 
G
M
 
I
M
 
Q
V
 
A
T
 
V
F
 
D
P
 
P
R
 
G
Q
 
Q
E
 
N
W
 
E
I
 
-
A
 
A
G
 
A
E
 
R
A
 
S
Y
 
L
G
 
G
M
 
M
G
 
T
K
 
H
W
 
A
Q
 
M
I
 
A
I
 
M
R
 
R
R
 
Y
L
 
V
V
 
I
L
 
I
P
 
P
A
 
Q
T
 
A
L
 
I
R
 
K
R
 
N
G
 
I
I
 
L
P
 
P
A
 
A
L
 
L
N
 
G
N
 
N
E
|
E
M
 
F
V
 
I
F
 
V
L
x
M
L
 
L
H
x
K
A
x
E
T
 
S
S
 
A
L
 
I
A
 
V
S
 
S
T
 
V
V
 
I
T
 
G
L
 
F
L
 
A
D
 
D
I
 
L
T
 
T
G
 
R
V
 
Q
A
 
A
R
 
D
A
 
I
F
 
I
Y
 
Q
A
 
S
M
 
V
T
 
T
Y
 
Y
S
 
R
P
 
Y
F
 
F
I
 
E
P
 
P
F
 
Y
L
 
I
M
 
I
A
 
I
A
 
A
A
 
A
L
 
I
Y
 
Y
L
 
-
L
 
-
C
 
-
T
 
-
F
 
F
L
 
V
L
 
M
I
 
T
F
 
L
T
 
T
F
 
F
A
 
S
R
 
K
A
 
L
-
 
L
-
 
S
-
 
L
-
 
F
E
 
E
R
 
R
R
 
R

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
30% identity, 88% coverage: 23:233/241 of query aligns to 17:213/214 of 4ymwC

query
sites
4ymwC
S
 
S
G
 
G
L
 
L
A
 
I
V
 
M
T
 
T
A
 
L
E
 
K
L
 
L
F
 
T
L
 
F
L
 
L
S
 
A
I
 
V
V
 
T
P
 
I
G
 
G
M
 
V
A
 
L
L
 
M
A
 
G
I
 
L
A
 
F
M
 
I
A
 
A
V
 
L
G
 
M
Q
 
K
V
 
M
Y
 
S
G
 
S
P
 
I
R
 
K
G
 
P
L
 
I
A
 
K
L
 
L
P
 
V
I
 
A
R
 
S
A
 
S
F
 
Y
T
 
I
Y
 
E
F
 
V
F
 
I
R
 
R
S
 
G
T
 
T
P
 
P
L
 
L
Y
 
L
L
 
V
Q
 
Q
L
 
L
M
 
L
L
 
L
I
 
I
Y
 
Y
Y
 
N
G
 
G
L
 
L
S
 
M
Q
 
Q
F
 
F
D
 
G
I
 
-
V
 
-
Q
 
-
T
 
-
G
 
-
W
 
-
M
 
M
N
 
N
D
 
I
Q
 
P
P
 
A
F
 
F
W
 
T
L
 
-
L
 
-
F
 
-
R
 
-
D
 
-
A
 
-
T
 
-
F
 
-
C
 
A
A
 
G
T
 
V
L
 
S
A
 
A
L
 
L
V
 
A
L
 
I
N
|
N
T
 
S
A
 
S
A
 
A
Y
|
Y
V
 
V
A
 
A
E
 
E
L
 
I
L
 
I
-
 
R
A
 
A
G
 
G
M
 
I
M
 
Q
V
 
A
T
 
V
F
 
D
P
 
P
R
 
G
Q
 
Q
E
 
N
W
 
E
I
 
-
A
 
A
G
 
A
E
 
R
A
 
S
Y
 
L
G
 
G
M
 
M
G
 
T
K
 
H
W
 
A
Q
 
M
I
 
A
I
 
M
R
 
R
R
 
Y
L
 
V
V
 
I
L
 
I
P
 
P
A
 
Q
T
 
A
L
 
I
R
 
K
R
 
N
G
 
I
I
 
L
P
 
P
A
 
A
L
 
L
N
 
G
N
 
N
E
|
E
M
 
F
V
 
I
F
 
V
L
 
M
L
 
L
H
 
K
A
x
E
T
 
S
S
 
A
L
 
I
A
 
V
S
 
S
T
 
V
V
 
I
T
 
G
L
 
F
L
 
A
D
 
D
I
 
L
T
 
T
G
 
R
V
 
Q
A
 
A
R
 
D
A
 
I
F
 
I
Y
 
Q
A
 
S
M
 
V
T
 
T
Y
 
Y
S
 
R
P
 
Y
F
 
F
I
 
E
P
 
P
F
 
Y
L
 
I
M
 
I
A
 
I
A
 
A
A
 
A
L
 
I
Y
 
Y
L
 
-
L
 
-
C
 
-
T
 
-
F
 
F
L
 
V
L
 
M
I
 
T
F
 
L
T
 
T
F
 
F
A
 
S
R
 
K
A
 
L
-
 
L
-
 
S
-
 
L
-
 
F
E
 
E
R
 
R
R
 
R

Query Sequence

>BWI76_RS19230 FitnessBrowser__Koxy:BWI76_RS19230
MNLQTFIDAIPSFLWSDGNGAASGLAVTAELFLLSIVPGMALAIAMAVGQVYGPRGLALP
IRAFTYFFRSTPLYLQLMLIYYGLSQFDIVQTGWMNDQPFWLLFRDATFCATLALVLNTA
AYVAELLAGMMVTFPRQEWIAGEAYGMGKWQIIRRLVLPATLRRGIPALNNEMVFLLHAT
SLASTVTLLDITGVARAFYAMTYSPFIPFLMAAALYLLCTFLLIFTFARAERRWLAFIRR
G

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory