Comparing BWI76_RS19670 FitnessBrowser__Koxy:BWI76_RS19670 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 13 hits to proteins with known functional sites (download)
P33018 S-formylglutathione hydrolase YeiG; FGH; EC 3.1.2.12 from Escherichia coli (strain K12) (see paper)
81% identity, 100% coverage: 1:277/278 of query aligns to 1:277/278 of P33018
3i6yA Structure of an esterase from the oil-degrading bacterium oleispira antarctica (see paper)
62% identity, 100% coverage: 1:278/278 of query aligns to 2:278/278 of 3i6yA
3s8yA Bromide soaked structure of an esterase from the oil-degrading bacterium oleispira antarctica (see paper)
62% identity, 99% coverage: 1:276/278 of query aligns to 2:276/277 of 3s8yA
Q8LAS8 S-formylglutathione hydrolase; AtSFGH; Esterase D; EC 3.1.2.12 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
55% identity, 97% coverage: 8:276/278 of query aligns to 12:282/284 of Q8LAS8
P10768 S-formylglutathione hydrolase; FGH; Esterase D; Methylumbelliferyl-acetate deacetylase; EC 3.1.2.12; EC 3.1.1.56 from Homo sapiens (Human) (see 4 papers)
50% identity, 100% coverage: 1:278/278 of query aligns to 3:282/282 of P10768
3fcxB Crystal structure of human esterase d (see paper)
50% identity, 99% coverage: 1:276/278 of query aligns to 1:274/275 of 3fcxB
Sites not aligning to the query:
3fcxA Crystal structure of human esterase d (see paper)
49% identity, 100% coverage: 1:278/278 of query aligns to 3:268/268 of 3fcxA
3e4dA Structural and kinetic study of an s-formylglutathione hydrolase from agrobacterium tumefaciens (see paper)
47% identity, 99% coverage: 1:276/278 of query aligns to 2:277/278 of 3e4dA
P40363 S-formylglutathione hydrolase; FGH; EC 3.1.2.12 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
44% identity, 99% coverage: 1:276/278 of query aligns to 1:296/299 of P40363
4flmA S-formylglutathione hydrolase w197i variant containing copper (see paper)
43% identity, 99% coverage: 1:276/278 of query aligns to 1:285/288 of 4flmA
6wcxA Fphf, staphylococcus aureus fluorophosphonate-binding serine hydrolases f, substrate bound (see paper)
24% identity, 87% coverage: 18:258/278 of query aligns to 9:238/255 of 6wcxA
6vhdA Fphf, staphylococcus aureus fluorophosphonate-binding serine hydrolases f, kt129 bound (see paper)
24% identity, 87% coverage: 18:258/278 of query aligns to 9:238/255 of 6vhdA
7l0aA Crystal structure of s-formylglutathione hydrolase (frmb) from staphylococcus aureus, apoenzyme (see paper)
26% identity, 58% coverage: 21:180/278 of query aligns to 18:167/249 of 7l0aA
>BWI76_RS19670 FitnessBrowser__Koxy:BWI76_RS19670
MELLEEHRCFEGRQQRWRHDSATLNCAMTFSIFLPPANADAPPPVLYWLSGLTCNDENFT
TKAGAQRVAAELGIALVMPDTSPRGDNVADDSAYDLGKGAGFYLNATQAPWSAHFRMYDY
LRDELPQLIAREFTLSGRCAISGHSMGGHGALVMALKNPGRFVSVSAFAPIVNPTQVPWG
QKAFTAYLGADEAAWQAWDSCALMQASSESDAIPTLIDQGDSDAFLAEQLQPAVLAETAR
QKSWPLTLRIQPGYDHSYYFIASFIEDHLRFHARYLLA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory