Comparing BWI76_RS20650 FitnessBrowser__Koxy:BWI76_RS20650 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P08839 Phosphoenolpyruvate-protein phosphotransferase; Phosphotransferase system, enzyme I; EC 2.7.3.9 from Escherichia coli (strain K12) (see 2 papers)
95% identity, 100% coverage: 1:575/575 of query aligns to 1:575/575 of P08839
2hwgA Structure of phosphorylated enzyme i of the phosphoenolpyruvate:sugar phosphotransferase system (see paper)
95% identity, 99% coverage: 2:573/575 of query aligns to 1:572/572 of 2hwgA
P23533 Phosphoenolpyruvate-protein phosphotransferase; Phosphotransferase system, enzyme I; EC 2.7.3.9 from Staphylococcus carnosus (strain TM300) (see paper)
51% identity, 99% coverage: 2:568/575 of query aligns to 5:569/573 of P23533
2wqdA Crystal structure of enzyme i of the phosphoenolpyruvate:sugar phosphotransferase system in the dephosphorylated state (see paper)
50% identity, 99% coverage: 1:569/575 of query aligns to 3:570/570 of 2wqdA
2xz7A Crystal structure of the phosphoenolpyruvate-binding domain of enzyme i in complex with phosphoenolpyruvate from the thermoanaerobacter tengcongensis pep-sugar phosphotransferase system (pts) (see paper)
60% identity, 55% coverage: 253:571/575 of query aligns to 5:323/324 of 2xz7A
2xz9A Crystal structure from the phosphoenolpyruvate-binding domain of enzyme i in complex with pyruvate from the thermoanaerobacter tengcongensis pep-sugar phosphotransferase system (pts) (see paper)
60% identity, 55% coverage: 256:571/575 of query aligns to 1:316/317 of 2xz9A
5lu4A C4-type pyruvate phosphate dikinase: conformational intermediate of central domain in the swiveling mechanism (see paper)
26% identity, 65% coverage: 157:531/575 of query aligns to 426:841/850 of 5lu4A
Sites not aligning to the query:
1kc7A Pyruvate phosphate dikinase with bound mg-phosphonopyruvate (see paper)
25% identity, 66% coverage: 154:531/575 of query aligns to 421:859/872 of 1kc7A
Sites not aligning to the query:
P22983 Pyruvate, phosphate dikinase; Pyruvate, orthophosphate dikinase; EC 2.7.9.1 from Clostridium symbiosum (Bacteroides symbiosus) (see 4 papers)
25% identity, 66% coverage: 154:531/575 of query aligns to 422:860/874 of P22983
Sites not aligning to the query:
5jvjB C4-type pyruvate phosphate dikinase: different conformational states of the nucleotide binding domain in the dimer (see paper)
25% identity, 65% coverage: 157:531/575 of query aligns to 353:786/797 of 5jvjB
Sites not aligning to the query:
Q02KR1 Phosphoenolpyruvate synthase; PEP synthase; Pyruvate, water dikinase; EC 2.7.9.2 from Pseudomonas aeruginosa (strain UCBPP-PA14) (see paper)
25% identity, 67% coverage: 146:530/575 of query aligns to 377:777/791 of Q02KR1
5jvlA C4-type pyruvate phospate dikinase: nucleotide binding domain with bound atp analogue (see paper)
24% identity, 65% coverage: 157:531/575 of query aligns to 426:863/874 of 5jvlA
Sites not aligning to the query:
Q39735 Pyruvate, phosphate dikinase, chloroplastic; Cold-sensitive pyruvate, orthophosphate dikinase; Pyruvate, orthophosphate dikinase; EC 2.7.9.1 from Flaveria bidentis (Coastal plain yellowtops) (Ethulia bidentis) (see 2 papers)
24% identity, 65% coverage: 157:531/575 of query aligns to 505:942/953 of Q39735
Sites not aligning to the query:
O23404 Pyruvate, phosphate dikinase 1, chloroplastic; Pyruvate, orthophosphate dikinase 1; EC 2.7.9.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 65% coverage: 156:531/575 of query aligns to 514:951/963 of O23404
P11155 Pyruvate, phosphate dikinase 1, chloroplastic; Pyruvate, orthophosphate dikinase 1; EC 2.7.9.1 from Zea mays (Maize) (see 7 papers)
24% identity, 65% coverage: 157:531/575 of query aligns to 499:936/947 of P11155
Sites not aligning to the query:
1vbgA Pyruvate phosphate dikinase from maize (see paper)
24% identity, 65% coverage: 157:531/575 of query aligns to 426:863/874 of 1vbgA
Sites not aligning to the query:
5jvlB C4-type pyruvate phospate dikinase: nucleotide binding domain with bound atp analogue (see paper)
25% identity, 60% coverage: 187:531/575 of query aligns to 123:509/520 of 5jvlB
Sites not aligning to the query:
1vbhA Pyruvate phosphate dikinase with bound mg-pep from maize (see paper)
24% identity, 65% coverage: 157:531/575 of query aligns to 417:851/862 of 1vbhA
Sites not aligning to the query:
P37349 PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM; Dihydroxyacetone kinase subunit M; EC 2.7.1.121 from Escherichia coli (strain K12) (see paper)
30% identity, 36% coverage: 14:221/575 of query aligns to 258:462/472 of P37349
Sites not aligning to the query:
5fbuA Crystal structure of rifampin phosphotransferase rph-lm from listeria monocytogenes in complex with rifampin-phosphate (see paper)
32% identity, 15% coverage: 152:239/575 of query aligns to 656:732/733 of 5fbuA
Sites not aligning to the query:
>BWI76_RS20650 FitnessBrowser__Koxy:BWI76_RS20650
MISGILASPGIAFGKALLLKEDEIVIDRKKISADKVDQEVERFLNGRTKASAQLEVIKTK
AGETFGEEKEAIFEGHIMLLEDEELEQEIIALIKDKHMTADAAANEVIEGQATALEELDD
EYLKERAADVRDIGKRLLRNILGLAIIDLSAIQDEVILVAADLTPSETAQLNLNKVLGFI
TDAGGRTSHTSIMARSLELPAIVGTGSVTSQVKNGDYLVLDAVNNQVLVNPSDQQIEELR
NLQAQVAEEKAELAKLKDLPAITLDGHQVEVCANIGTVRDVEGAERNGAEGVGLYRTEFL
FMDRDSLPTEEEQFAAYKAVAEACGSQAVIVRTMDIGGDKELPYMNFPKEENPFLGWRAV
RIAMDRKEILRDQVRAILRASAFGKLRIMFPMIISVEEVRALKKEIEIYKQELRDEGKAF
DESIEIGVMVETPAAATIARHLAKEVDFFSIGTNDLTQYTLAVDRGNDMISHLYQPMSPS
VLTLIKQVIDASHAEGKWTGMCGELAGDERATLLLLGMGLDEFSMSAISIPRIKKIIRNT
NFEDAKVLAEQALAQPTTDELMTLVNKFIEEKTIC
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory