Comparing BWI76_RS21470 BWI76_RS21470 gluconolaconase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 19 hits to proteins with known functional sites (download)
7pldB Caulobacter crescentus xylonolactonase with (r)-4-hydroxy-2- pyrrolidone (see paper)
34% identity, 98% coverage: 2:284/290 of query aligns to 3:283/289 of 7pldB
7plbB Caulobacter crescentus xylonolactonase with d-xylose (see paper)
34% identity, 98% coverage: 2:284/290 of query aligns to 3:283/289 of 7plbB
Q9A9Z1 D-xylonolactone lactonase; Xylono-1,5-lactonase; EC 3.1.1.110 from Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus) (see paper)
34% identity, 98% coverage: 2:284/290 of query aligns to 3:283/289 of Q9A9Z1
4gnaA Mouse smp30/gnl-xylitol complex (see paper)
32% identity, 90% coverage: 16:275/290 of query aligns to 16:282/297 of 4gnaA
4gn9A Mouse smp30/gnl-glucose complex (see paper)
32% identity, 90% coverage: 16:275/290 of query aligns to 16:282/297 of 4gn9A
4gn8A Mouse smp30/gnl-1,5-ag complex (see paper)
32% identity, 90% coverage: 16:275/290 of query aligns to 16:282/297 of 4gn8A
Sites not aligning to the query:
4gn7A Mouse smp30/gnl (see paper)
32% identity, 90% coverage: 16:275/290 of query aligns to 16:282/297 of 4gn7A
3g4hA Crystal structure of human senescence marker protein-30 (zinc bound) (see paper)
32% identity, 90% coverage: 16:275/290 of query aligns to 16:282/297 of 3g4hA
4gncA Human smp30/gnl-1,5-ag complex (see paper)
32% identity, 90% coverage: 16:275/290 of query aligns to 17:283/298 of 4gncA
Sites not aligning to the query:
Q15493 Regucalcin; RC; Gluconolactonase; GNL; Senescence marker protein 30; SMP-30; EC 3.1.1.17 from Homo sapiens (Human) (see 2 papers)
32% identity, 90% coverage: 16:275/290 of query aligns to 18:284/299 of Q15493
5gx1A Luciferin-regenerating enzyme collected with serial synchrotron rotational crystallography with accumulated dose of 1.1 mgy (1st measurement) (see paper)
26% identity, 89% coverage: 16:273/290 of query aligns to 17:290/307 of 5gx1A
5d9bA Luciferin-regenerating enzyme solved by siras using xfel (refined against native data) (see paper)
26% identity, 89% coverage: 16:273/290 of query aligns to 17:290/307 of 5d9bA
3e5zA X-ray structure of the putative gluconolactonase in protein family pf08450. Northeast structural genomics consortium target drr130.
30% identity, 53% coverage: 104:256/290 of query aligns to 135:277/290 of 3e5zA
Sites not aligning to the query:
7rizA Crystal structure of rpa3624, a beta-propeller lactonase from rhodopseudomonas palustris, with active-site bound 2-hydroxyquinoline (see paper)
31% identity, 37% coverage: 147:254/290 of query aligns to 169:284/306 of 7rizA
Sites not aligning to the query:
3dr2A Structural and functional analyses of xc5397 from xanthomonas campestris: a gluconolactonase important in glucose secondary metabolic pathways (see paper)
26% identity, 66% coverage: 61:252/290 of query aligns to 127:288/299 of 3dr2A
Sites not aligning to the query:
7risA Crystal structure of rpa3624, a beta-propeller lactonase from rhodopseudomonas palustris, with active-site bound phosphate (see paper)
30% identity, 37% coverage: 147:254/290 of query aligns to 160:271/293 of 7risA
Sites not aligning to the query:
8dk0A Crystal structure of rpa3624, a beta-propeller lactonase from rhodopseudomonas palustris, with active-site bound (s)gamma- valerolactone (see paper)
30% identity, 37% coverage: 147:254/290 of query aligns to 164:271/293 of 8dk0A
Sites not aligning to the query:
8djzA Crystal structure of rpa3624, a beta-propeller lactonase from rhodopseudomonas palustris, with active-site bound product (see paper)
30% identity, 37% coverage: 147:254/290 of query aligns to 164:271/293 of 8djzA
Sites not aligning to the query:
8djfA Crystal structure of rpa3624, a beta-propeller lactonase from rhodopseudomonas palustris, with active-site bound tetrahedral intermediate (see paper)
30% identity, 37% coverage: 147:254/290 of query aligns to 164:271/293 of 8djfA
Sites not aligning to the query:
>BWI76_RS21470 BWI76_RS21470 gluconolaconase
MAEPQPLFDYTGHLPECPTWSEAEQALYWADIMECEIHRYDVRTGEHQVLQFPEEPGCFA
LRAKGGFIVALRSGIWLTDAHGLLQRKVCDNPSNPQLARFNDGGTDRDGRFYAGTFWGPG
DFNGALLMRIDSDLSPQVIQCDIHGANGLAFSEDKRWMYTSDTPNAVIYRTPLDKRGEAG
KREVFRRFHPGEGIPDGAAIDAEGCYWSAMFDGWRIARFSPTGEQLEEHRLPVRCPTMVC
FGGTDMKTLYITTTRENMDAEEVAKYPLSGAIFTLPVSVAGMKKLPFIER
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory