SitesBLAST
Comparing BWI76_RS21985 FitnessBrowser__Koxy:BWI76_RS21985 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P37685 Aldehyde dehydrogenase B; Acetaldehyde dehydrogenase; EC 1.2.1.4 from Escherichia coli (strain K12) (see paper)
65% identity, 99% coverage: 6:506/506 of query aligns to 12:512/512 of P37685
- R197 (≠ E191) mutation to E: Less than 10% of wild-type acetaldehyde dehydrogenase activity.
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
43% identity, 94% coverage: 22:497/506 of query aligns to 7:478/489 of 4o6rA
- active site: N150 (= N165), K173 (= K188), E248 (= E262), C282 (= C301), E383 (= E402), E460 (= E479)
- binding adenosine monophosphate: I146 (= I161), V147 (≠ I162), K173 (= K188), G206 (= G220), G210 (= G224), Q211 (≠ E225), F224 (= F238), G226 (= G240), S227 (= S241), T230 (≠ V244), R233 (≠ H247)
7radA Crystal structure analysis of aldh1b1
42% identity, 94% coverage: 22:497/506 of query aligns to 16:487/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I161), I159 (= I162), P160 (= P163), W161 (= W164), N162 (= N165), M167 (= M170), K185 (= K188), E188 (= E191), G218 (= G220), G222 (= G224), A223 (≠ E225), T237 (= T239), G238 (= G240), S239 (= S241), V242 (= V244), E261 (= E262), L262 (= L263), C295 (= C301), E392 (= E402), F394 (= F404)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (≠ A116), E117 (≠ L120), F163 (= F166), E285 (= E288), F289 (= F295), N450 (≠ H460), V452 (≠ Y462)
7mjdA Crystal structure analysis of aldh1b1
42% identity, 94% coverage: 22:497/506 of query aligns to 16:487/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I161), I159 (= I162), P160 (= P163), W161 (= W164), N162 (= N165), M167 (= M170), K185 (= K188), E188 (= E191), G218 (= G220), G222 (= G224), F236 (= F238), T237 (= T239), G238 (= G240), S239 (= S241), V242 (= V244), E261 (= E262), L262 (= L263), C295 (= C301), E392 (= E402), F394 (= F404)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ L120), E285 (= E288), F289 (= F295), N450 (≠ H460), V452 (≠ Y462)
7mjcA Crystal structure analysis of aldh1b1
42% identity, 94% coverage: 22:497/506 of query aligns to 16:487/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (= I161), I159 (= I162), P160 (= P163), W161 (= W164), N162 (= N165), K185 (= K188), E188 (= E191), G218 (= G220), G222 (= G224), T237 (= T239), G238 (= G240), S239 (= S241), V242 (= V244), E261 (= E262), L262 (= L263), C295 (= C301), E392 (= E402), F394 (= F404)
4go4A Crystal structure of pnpe in complex with nicotinamide adenine dinucleotide
43% identity, 94% coverage: 22:497/506 of query aligns to 6:476/487 of 4go4A
- active site: N149 (= N165), K172 (= K188), E247 (= E262), C281 (= C301), E381 (= E402), E458 (= E479)
- binding nicotinamide-adenine-dinucleotide: I145 (= I161), V146 (≠ I162), W148 (= W164), N149 (= N165), F154 (≠ M170), K172 (= K188), G205 (= G220), G209 (= G224), Q210 (≠ E225), F223 (= F238), T224 (= T239), G225 (= G240), S226 (= S241), T229 (≠ V244), E247 (= E262), G249 (= G264), C281 (= C301), E381 (= E402), F383 (= F404)
P05091 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Homo sapiens (Human) (see 5 papers)
43% identity, 94% coverage: 22:496/506 of query aligns to 40:510/517 of P05091
- E337 (≠ A319) to V: in dbSNP:rs1062136
- E496 (≠ K482) to K: in allele ALDH2*3; dbSNP:rs769724893
- E504 (≠ Q490) to K: in AMEDS; allele ALDH2*2; drastic reduction of enzyme activity; dbSNP:rs671
Sites not aligning to the query:
5l13A Structure of aldh2 in complex with 2p3 (see paper)
43% identity, 94% coverage: 22:496/506 of query aligns to 17:487/494 of 5l13A
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (= F166), M168 (= M170), W171 (= W173), F290 (= F295), C295 (≠ V300), C296 (= C301), C297 (≠ T302), D451 (≠ H460), F453 (≠ Y462)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
43% identity, 94% coverage: 22:496/506 of query aligns to 17:487/494 of 4kwgA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (= F166), M168 (= M170), C295 (≠ V300), C296 (= C301), C297 (≠ T302), D451 (≠ H460), F453 (≠ Y462)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
43% identity, 94% coverage: 22:496/506 of query aligns to 17:487/494 of 4kwfA