Comparing BWI76_RS23880 FitnessBrowser__Koxy:BWI76_RS23880 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3a8iA Crystal structure of et-ehred-5-ch3-thf complex (see paper)
89% identity, 99% coverage: 2:363/364 of query aligns to 1:362/363 of 3a8iA
1worA Crystal structure of t-protein of the glycine cleavage system (see paper)
42% identity, 91% coverage: 3:334/364 of query aligns to 2:330/362 of 1worA
1wopA Crystal structure of t-protein of the glycine cleavage system (see paper)
42% identity, 91% coverage: 3:334/364 of query aligns to 2:330/362 of 1wopA
Sites not aligning to the query:
1wooA Crystal structure of t-protein of the glycine cleavage system (see paper)
42% identity, 91% coverage: 3:334/364 of query aligns to 2:330/362 of 1wooA
Sites not aligning to the query:
P48728 Aminomethyltransferase, mitochondrial; Glycine cleavage system T protein; GCVT; EC 2.1.2.10 from Homo sapiens (Human) (see 4 papers)
33% identity, 98% coverage: 3:357/364 of query aligns to 34:395/403 of P48728
Sites not aligning to the query:
1wsvA Crystal structure of human t-protein of glycine cleavage system (see paper)
33% identity, 98% coverage: 3:357/364 of query aligns to 3:364/371 of 1wsvA
Sites not aligning to the query:
2gagA Heteroteterameric sarcosine: structure of a diflavin metaloenzyme at 1.85 a resolution (see paper)
28% identity, 98% coverage: 2:356/364 of query aligns to 574:955/965 of 2gagA
Sites not aligning to the query:
Q46337 Sarcosine oxidase subunit alpha; Sarcosine oxidase subunit A; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit alpha; Tetrameric sarcosine oxidase subunit alpha; TSOX subunit alpha; EC 1.5.3.24 from Corynebacterium sp. (strain P-1) (see 2 papers)
29% identity, 98% coverage: 2:356/364 of query aligns to 576:957/967 of Q46337
Sites not aligning to the query:
Q50LF0 Sarcosine oxidase subunit alpha; Sarcosine oxidase subunit A; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit alpha; Tetrameric sarcosine oxidase subunit alpha; TSOX subunit alpha; EC 1.5.3.24 from Corynebacterium sp. (strain U-96) (see 2 papers)
28% identity, 98% coverage: 2:356/364 of query aligns to 574:955/965 of Q50LF0
Sites not aligning to the query:
3ad7A Heterotetrameric sarcosine oxidase from corynebacterium sp. U-96 in complex with methylthio acetate (see paper)
28% identity, 98% coverage: 2:356/364 of query aligns to 573:954/963 of 3ad7A
Sites not aligning to the query:
1vrqA Crystal structure of heterotetrameric sarcosine oxidase from corynebacterium sp. U-96 in complex with folinic acid (see paper)
28% identity, 98% coverage: 2:356/364 of query aligns to 573:954/963 of 1vrqA
Sites not aligning to the query:
Q63342 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Rattus norvegicus (Rat) (see 2 papers)
26% identity, 92% coverage: 24:357/364 of query aligns to 507:841/857 of Q63342
Sites not aligning to the query:
4pabB Crystal structure of the precursor form of rat dmgdh complexed with tetrahydrofolate (see paper)
26% identity, 92% coverage: 24:357/364 of query aligns to 470:804/824 of 4pabB
Sites not aligning to the query:
Q9UI17 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Homo sapiens (Human) (see 4 papers)
26% identity, 88% coverage: 36:357/364 of query aligns to 521:848/866 of Q9UI17
Sites not aligning to the query:
1pj7A Structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folinic acid (see paper)
26% identity, 88% coverage: 36:356/364 of query aligns to 489:818/827 of 1pj7A
Sites not aligning to the query:
1pj6A Crystal structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folic acid (see paper)
26% identity, 88% coverage: 36:356/364 of query aligns to 490:819/828 of 1pj6A
Sites not aligning to the query:
Q9AGP8 Dimethylglycine oxidase; DMGO; EC 1.5.3.10 from Arthrobacter globiformis (see 2 papers)
26% identity, 88% coverage: 36:356/364 of query aligns to 492:821/830 of Q9AGP8
Sites not aligning to the query:
3gsiA Crystal structure of d552a dimethylglycine oxidase mutant of arthrobacter globiformis in complex with tetrahydrofolate (see paper)
26% identity, 88% coverage: 36:356/364 of query aligns to 489:818/827 of 3gsiA
Sites not aligning to the query:
Q8GAI3 4-methylaminobutanoate oxidase (formaldehyde-forming); MABO; Demethylating gamma-N-methylaminobutyrate oxidase; Gamma-N-methylaminobutyrate oxidase 1; EC 1.5.3.19 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans) (see paper)
25% identity, 88% coverage: 35:356/364 of query aligns to 489:814/824 of Q8GAI3
Sites not aligning to the query:
3tfjA Dmsp-dependent demethylase from p. Ubique - with cofactor thf (see paper)
21% identity, 93% coverage: 21:357/364 of query aligns to 32:369/369 of 3tfjA
>BWI76_RS23880 FitnessBrowser__Koxy:BWI76_RS23880
MAQQTPLFEQHTLCGARMVDFHGWMMPLHYGSQIDEHHAVRGDAGMFDVSHMTIVDFHGS
RIREFLRYLLANDVAKLTVPGKALYSGMLTASGGVIDDLIVYFLSEDYFRLVVNSATREK
DLAWIAQQSESYGLEITVRDDLSLIAVQGPRAKEKAATLFTDAQRQAVEGMKPFFGVQAG
DLFIATTGYTGEAGYEIALPNEQAVDFWRGLLDAGVKPCGLGARDTLRLEAGMNLYGQEM
DEGVSPLAANMGWTIAWEPTDRDFIGREALEMQREKGTEQLVGLVMTEKGVLRGGLPVRF
SDADGNQKEGIITSGTFSPTLGYSIALARVPEGIGETAVVQIRNREMPVKVTKPVFVRNG
KAVV
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory