Comparing BWI76_RS24585 BWI76_RS24585 glycerol dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5xn8A Structure of glycerol dehydrogenase crystallised as a contaminant
93% identity, 100% coverage: 1:365/365 of query aligns to 1:365/365 of 5xn8A
4mcaA Crystal structure of glycerol dehydrogenase from serratia to 1.9a
76% identity, 100% coverage: 1:365/365 of query aligns to 1:365/367 of 4mcaA
8gobA Crystal structure of glycerol dehydrogenase in the presence of NAD+ (see paper)
58% identity, 99% coverage: 1:363/365 of query aligns to 1:363/367 of 8gobA
8goaA Crystal structure of glycerol dehydrogenase in the absence of NAD+ (see paper)
58% identity, 99% coverage: 1:363/365 of query aligns to 1:363/367 of 8goaA
5zxlA Structure of glda from e.Coli (see paper)
58% identity, 99% coverage: 1:363/365 of query aligns to 1:363/367 of 5zxlA
P0A9S5 Glycerol dehydrogenase; GDH; GLDH; (R)-aminopropanol dehydrogenase; 1,2-propanediol dehydrogenase; D-1-amino-2-propanol oxidoreductase; EC 1.1.1.6; EC 1.1.1.75 from Escherichia coli (strain K12) (see paper)
58% identity, 99% coverage: 1:363/365 of query aligns to 1:363/367 of P0A9S5
Q9WYQ4 Glycerol dehydrogenase; GDH; GLDH; EC 1.1.1.6 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
51% identity, 99% coverage: 1:360/365 of query aligns to 1:358/364 of Q9WYQ4
1kq3A Crystal structure of a glycerol dehydrogenase (tm0423) from thermotoga maritima at 1.5 a resolution (see paper)
51% identity, 99% coverage: 1:360/365 of query aligns to 2:359/364 of 1kq3A
P32816 Glycerol dehydrogenase; GDH; GLDH; GlyDH; EC 1.1.1.6 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see 2 papers)
50% identity, 99% coverage: 3:362/365 of query aligns to 5:364/370 of P32816
1jq5A Bacillus stearothermophilus glycerol dehydrogenase complex with NAD+ (see paper)
50% identity, 99% coverage: 3:362/365 of query aligns to 4:363/366 of 1jq5A
1jqaA Bacillus stearothermophilus glycerol dehydrogenase complex with glycerol (see paper)
50% identity, 99% coverage: 3:362/365 of query aligns to 3:358/361 of 1jqaA
3uhjA Crystal structure of a probable glycerol dehydrogenase from sinorhizobium meliloti 1021
43% identity, 99% coverage: 1:361/365 of query aligns to 1:356/357 of 3uhjA
O13702 Glycerol dehydrogenase 1; GDH; GLDH; EC 1.1.1.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
42% identity, 99% coverage: 3:362/365 of query aligns to 64:424/450 of O13702
1ta9B Crystal structure of glycerol dehydrogenase from schizosaccharomyces pombe
42% identity, 99% coverage: 3:362/365 of query aligns to 8:368/394 of 1ta9B
5fb3F Structure of glycerophosphate dehydrogenase in complex with NADPH (see paper)
28% identity, 68% coverage: 80:328/365 of query aligns to 66:307/337 of 5fb3F
Sites not aligning to the query:
P31005 NAD-dependent methanol dehydrogenase; MDH; MEDH; Type 3 alcohol dehydrogenase; EC 1.1.1.244 from Bacillus methanolicus (see 3 papers)
27% identity, 70% coverage: 72:327/365 of query aligns to 74:353/381 of P31005
Sites not aligning to the query:
Q9YER2 Glycerol-1-phosphate dehydrogenase [NAD(P)+]; G1P dehydrogenase; G1PDH; Gro1PDH; Enantiomeric glycerophosphate synthase; sn-glycerol-1-phosphate dehydrogenase; EC 1.1.1.261 from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) (see paper)
29% identity, 65% coverage: 88:325/365 of query aligns to 93:318/352 of Q9YER2
4rgqB Crystal structure of the methanocaldococcus jannaschii g1pdh with NADPH and dhap (see paper)
25% identity, 79% coverage: 32:318/365 of query aligns to 8:296/333 of 4rgqB
4rgvA Crystal structure of the methanocaldococcus jannaschii g1pdh (see paper)
26% identity, 63% coverage: 88:318/365 of query aligns to 67:291/328 of 4rgvA
3ce9A Crystal structure of glycerol dehydrogenase (np_348253.1) from clostridium acetobutylicum at 2.37 a resolution
27% identity, 40% coverage: 40:186/365 of query aligns to 40:179/349 of 3ce9A
Sites not aligning to the query:
>BWI76_RS24585 BWI76_RS24585 glycerol dehydrogenase
MLKVIQSPAKYLQGPDASTLFGQYAKNLADSFFVIADDFVMKLAGEKVLEGLHSHNISCH
AERFNGECSHVEINRLIAILKQHGCRGVVGIGGGKTLDTAKAIGYYQKLPVVVIPTIAST
DAPTSALSVIYTEAGEFEEYLIYPKNPDMVVMDTAIIAKAPVRLLVAGMGDALSTWFEAK
ACYDARATSMAGGQSTAAALSLAHLCYDTLLAEGEKARLAAQAGVVTDALERIVEANTYL
SGIGFESSGLAAAHAIHNGFTILEECHHLYHGEKVAFGTLAQLVLQNSPMEEIETVLNFC
HTVGLPVTLAQMGVKEGIDEKIQAVAKATCAEGETIHNMPFPVSAQSAHAAILTADLLGQ
QWLAR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory