Comparing BWI76_RS24715 FitnessBrowser__Koxy:BWI76_RS24715 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 3 papers)
27% identity, 96% coverage: 10:406/415 of query aligns to 3:418/425 of O59010
2nwwA Crystal structure of gltph in complex with tboa (see paper)
28% identity, 93% coverage: 19:406/415 of query aligns to 3:407/407 of 2nwwA
6x15A Inward-facing state of the glutamate transporter homologue gltph in complex with l-aspartate and sodium ions (see paper)
27% identity, 96% coverage: 10:406/415 of query aligns to 3:416/419 of 6x15A
6bauA Crystal structure of gltph r397c in complex with l-cysteine (see paper)
28% identity, 93% coverage: 19:406/415 of query aligns to 4:408/408 of 6bauA
6bavA Crystal structure of gltph r397c in complex with s-benzyl-l-cysteine (see paper)
28% identity, 93% coverage: 19:406/415 of query aligns to 4:408/409 of 6bavA
6x14A Inward-facing state of the glutamate transporter homologue gltph in complex with tfb-tboa (see paper)
27% identity, 95% coverage: 12:406/415 of query aligns to 2:413/413 of 6x14A
5e9sA Crystal structure of substrate-bound glutamate transporter homologue glttk (see paper)
26% identity, 96% coverage: 10:406/415 of query aligns to 1:418/427 of 5e9sA
6xwnB Structure of glutamate transporter homologue glttk in the presence of tboa inhibitor (see paper)
27% identity, 96% coverage: 10:406/415 of query aligns to 1:418/426 of 6xwnB
6bmiA Crystal structure of gltph r397c in complex with l-serine (see paper)
29% identity, 71% coverage: 19:313/415 of query aligns to 4:315/396 of 6bmiA
Sites not aligning to the query:
6zgbA Glutamate transporter homologue glttk in complex with a photo cage compound (see paper)
26% identity, 95% coverage: 12:406/415 of query aligns to 1:416/425 of 6zgbA
6r7rA Crystal structure of the glutamate transporter homologue glttk in complex with d-aspartate (see paper)
26% identity, 93% coverage: 22:406/415 of query aligns to 6:407/416 of 6r7rA
6zl4A The structure of glutamate transporter homologue glttk in complex with the photo switchable compound (cis) (see paper)
26% identity, 93% coverage: 22:406/415 of query aligns to 10:415/424 of 6zl4A
Sites not aligning to the query:
7awmA Structure of the thermostabilized eaat1 cryst mutant in complex with l-asp, three sodium ions and the allosteric inhibitor ucph101 (see paper)
27% identity, 60% coverage: 149:395/415 of query aligns to 154:393/412 of 7awmA
Sites not aligning to the query:
P56564 Excitatory amino acid transporter 1; Glial high affinity glutamate transporter; High-affinity neuronal glutamate transporter; GluT-1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Mus musculus (Mouse) (see paper)
26% identity, 70% coverage: 124:415/415 of query aligns to 218:504/543 of P56564
Sites not aligning to the query:
P43003 Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Homo sapiens (Human) (see 3 papers)
25% identity, 66% coverage: 141:415/415 of query aligns to 233:504/542 of P43003
Sites not aligning to the query:
5mjuA Structure of the thermostabilized eaat1 cryst mutant in complex with the competititve inhibitor tfb-tboa and the allosteric inhibitor ucph101 (see paper)
27% identity, 60% coverage: 149:395/415 of query aligns to 147:379/397 of 5mjuA
Sites not aligning to the query:
P43007 Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4 from Homo sapiens (Human) (see 4 papers)
29% identity, 60% coverage: 149:395/415 of query aligns to 222:469/532 of P43007
Sites not aligning to the query:
O35874 Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4 from Mus musculus (Mouse) (see 2 papers)
29% identity, 60% coverage: 149:395/415 of query aligns to 222:469/532 of O35874
Sites not aligning to the query:
7bcsA Asct2 in the presence of the inhibitor lc-bpe (position "down") in the outward-open conformation. (see paper)
28% identity, 70% coverage: 106:395/415 of query aligns to 145:431/442 of 7bcsA
7bcqA Asct2 in the presence of the inhibitor lc-bpe (position "up") in the outward-open conformation. (see paper)
28% identity, 70% coverage: 106:395/415 of query aligns to 145:431/442 of 7bcqA
Sites not aligning to the query:
>BWI76_RS24715 FitnessBrowser__Koxy:BWI76_RS24715
MATQSPRSTLLRRLAQGSLVKQILIGLVLGVLLATVSKPAAVAVGLLGTLFVGALKAVAP
VLVLMLVMASIANHQQGQKTSIRPILFLYLLGTFAAALTAVVFSFIFPSTLHLNAAAESI
TPPSGIVEVLRGLLMSMVSNPIDALLNANYIGILVWAVGLGFALRHGNETTKNLINDVSH
AVTFIVKVVIRFAPLGIFGLVASTLATTGFETLWGYAQLLLVLVGCMLLVALVINPLLVF
WKIRRNPYPLVLLCLRESGVYAFFTRSSAANIPVNMALSEKLNLDRDTYSVSIPLGATIN
MAGAAITITVLTLAAVHTLNVPVDLPTALLLSVVASLCACGASGVAGGSLLLIPLACNMF
GIPNDVAMQVVAVGFIIGVLQDSCETALNSSTDVLFTAAACIAEDEQIAKNALRN
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory