Comparing BWI76_RS24830 FitnessBrowser__Koxy:BWI76_RS24830 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P23522 5-keto-4-deoxy-D-glucarate aldolase; KDGluc aldolase; KDGlucA; 2-dehydro-3-deoxy-D-glucarate aldolase; 2-keto-3-deoxy-D-glucarate aldolase; 5-dehydro-4-deoxy-D-glucarate aldolase; Alpha-keto-beta-deoxy-D-glucarate aldolase; EC 4.1.2.20 from Escherichia coli (strain K12) (see paper)
93% identity, 100% coverage: 1:256/256 of query aligns to 1:256/256 of P23522
1dxfA 2-dehydro-3-deoxy-galactarate aldolase from escherichia coli in complex with pyruvate (see paper)
93% identity, 99% coverage: 4:256/256 of query aligns to 1:253/253 of 1dxfA
1dxeA 2-dehydro-3-deoxy-galactarate aldolase from escherichia coli (see paper)
93% identity, 99% coverage: 4:256/256 of query aligns to 1:253/253 of 1dxeA
2v5kA Class ii aldolase hpch - magnesium - oxamate complex (see paper)
50% identity, 91% coverage: 8:239/256 of query aligns to 12:244/260 of 2v5kA
Q47098 4-hydroxy-2-oxo-heptane-1,7-dioate aldolase; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; HHED aldolase; 4-hydroxy-2-ketoheptane-1,7-dioate aldolase; HKHD aldolase; EC 4.1.2.52 from Escherichia coli (see 3 papers)
50% identity, 91% coverage: 8:239/256 of query aligns to 3:235/262 of Q47098
4b5vA Crystal structures of divalent metal dependent pyruvate aldolase, hpai, in complex with 4-hydroxyl-2-ketoheptane-1,7-dioate (see paper)
50% identity, 91% coverage: 8:239/256 of query aligns to 3:235/251 of 4b5vA
4b5tA Crystal structures of divalent metal dependent pyruvate aldolase, hpai, in complex with ketobutyrate (see paper)
50% identity, 91% coverage: 8:239/256 of query aligns to 3:235/251 of 4b5tA
4b5sA Crystal structures of divalent metal dependent pyruvate aldolase, hpai, in complex with pyruvate (see paper)
50% identity, 91% coverage: 8:239/256 of query aligns to 3:235/251 of 4b5sA
7et9A Crystal structure of abhpai-zn-pyruvate complex, class ii aldolase, hpai from acinetobacter baumannii (see paper)
45% identity, 97% coverage: 8:255/256 of query aligns to 6:253/254 of 7et9A
7etiA Crystal structure of abhpai-zn-pyruvate-4-hydroxybenzaldehyde complex, class ii aldolase, hpai from acinetobacter baumannii (see paper)
45% identity, 97% coverage: 8:255/256 of query aligns to 6:253/253 of 7etiA
7etfA Crystal structure of abhpai-mn-pyruvate-succinic semialdehyde complex, class ii aldolase, hpai from acinetobacter baumannii (see paper)
45% identity, 97% coverage: 8:255/256 of query aligns to 6:253/253 of 7etfA
7eteA Crystal structure of abhpai-mg-(4r)-kdgal complex, class ii aldolase, hpai from acinetobacter baumannii (see paper)
45% identity, 97% coverage: 8:255/256 of query aligns to 6:253/253 of 7eteA
7etdA Crystal structure of abhpai-zn-(4s)-kdglu complex, class ii aldolase, hpai from acinetobacter baumannii (see paper)
45% identity, 97% coverage: 8:255/256 of query aligns to 6:253/253 of 7etdA
7etcA Crystal structure of abhpai-zn-(4r)-kdgal complex, class ii aldolase, hpai from acinetobacter baumannii (see paper)
45% identity, 97% coverage: 8:255/256 of query aligns to 6:253/253 of 7etcA
7etbA Crystal structure of abhpai-mn-pyruvate complex, class ii aldolase, hpai from acinetobacter baumannii (see paper)
45% identity, 97% coverage: 8:255/256 of query aligns to 6:253/253 of 7etbA
7etaA Crystal structure of abhpai-co-pyruvate complex, class ii aldolase, hpai from acinetobacter baumannii (see paper)
45% identity, 97% coverage: 8:255/256 of query aligns to 6:253/253 of 7etaA
7ethA Crystal structure of abhpai-zn-pyruvate-propionaldehyde complex, class ii aldolase, hpai from acinetobacter baumannii (see paper)
45% identity, 97% coverage: 8:255/256 of query aligns to 4:251/251 of 7ethA
2vwtA Crystal structure of yfau, a metal ion dependent class ii aldolase from escherichia coli k12 - mg-pyruvate product complex (see paper)
43% identity, 99% coverage: 3:255/256 of query aligns to 2:255/256 of 2vwtA
P76469 2-keto-3-deoxy-L-rhamnonate aldolase; KDR aldolase; 2-dehydro-3-deoxyrhamnonate aldolase; 2-keto-3-deoxy acid sugar aldolase; EC 4.1.2.53 from Escherichia coli (strain K12) (see paper)
43% identity, 99% coverage: 3:255/256 of query aligns to 2:255/267 of P76469
7o5rA Crystal structure of holo-swhpa-mn (hydroxyketoacid aldolase) from sphingomonas wittichii rw1 (see paper)
31% identity, 95% coverage: 8:250/256 of query aligns to 2:244/251 of 7o5rA
>BWI76_RS24830 FitnessBrowser__Koxy:BWI76_RS24830
MNNDIFPNKFKAALAAHQVQIGCWSALASPISTEVLGLAGFDWLVLDGEHAPNDISTFIP
QLMALKGSASAPVVRVPTNEPVIIKRLLDIGFYNFLIPFVETEEQAVNAVASTRYPPEGI
RGVSVSHRANMFGTVPDYFAQSNKNITILVQIESQQGVDNVDAIAATPGVDGIFVGPSDL
AAALGHLGNASHPEVQEAIQHIFASAKKHGKPSGILAPVEADARRYLEWGATFVAVGSDL
GVFRSATQKLADSFKK
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory