Comparing BWI76_RS26315 FitnessBrowser__Koxy:BWI76_RS26315 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4ptnA Crystal structure of yage, a kdg aldolase protein in complex with magnesium cation coordinated l-glyceraldehyde (see paper)
31% identity, 91% coverage: 6:278/299 of query aligns to 7:280/298 of 4ptnA
4onvA Crystal structure of yage, a kdg aldolase protein in complex with 2- keto-3-deoxy gluconate
31% identity, 91% coverage: 6:278/299 of query aligns to 7:280/298 of 4onvA
4oe7D Crystal structure of yage, a kdg aldolase protein, in complex with aldol condensed product of pyruvate and glyoxal
31% identity, 91% coverage: 6:278/299 of query aligns to 7:280/298 of 4oe7D
4oe7B Crystal structure of yage, a kdg aldolase protein, in complex with aldol condensed product of pyruvate and glyoxal
31% identity, 91% coverage: 6:278/299 of query aligns to 7:280/298 of 4oe7B
4oe7A Crystal structure of yage, a kdg aldolase protein, in complex with aldol condensed product of pyruvate and glyoxal
31% identity, 91% coverage: 6:278/299 of query aligns to 7:280/298 of 4oe7A
3nevA Crystal structure of yage, a prophage protein from e. Coli k12 in complex with kdgal (see paper)
31% identity, 91% coverage: 6:278/299 of query aligns to 7:280/298 of 3nevA
Q9X1K9 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
28% identity, 98% coverage: 4:295/299 of query aligns to 3:293/294 of Q9X1K9
1o5kA Crystal structure of dihydrodipicolinate synthase (tm1521) from thermotoga maritima at 1.80 a resolution
28% identity, 98% coverage: 4:295/299 of query aligns to 4:294/295 of 1o5kA
4dxvA Crystal structure of dihydrodipicolinate synthase from acinetobacter baumannii complexed with mg and cl ions at 1.80 a resolution
29% identity, 97% coverage: 6:295/299 of query aligns to 6:290/291 of 4dxvA
3u8gA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with oxalic acid at 1.80 a resolution
29% identity, 97% coverage: 6:295/299 of query aligns to 6:290/291 of 3u8gA
3tdfA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with 2-ketobutanoic acid at 1.99 a resolution
29% identity, 97% coverage: 6:295/299 of query aligns to 6:290/291 of 3tdfA
3tceA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with 5-hydroxylysine at 2.6 a resolution
29% identity, 97% coverage: 6:295/299 of query aligns to 6:290/291 of 3tceA
3rk8A Crystal structure of the chloride inhibited dihydrodipicolinate synthase from acinetobacter baumannii complexed with pyruvate at 1.8 a resolution
29% identity, 97% coverage: 6:295/299 of query aligns to 6:290/291 of 3rk8A
3pueB Crystal structure of the complex of dhydrodipicolinate synthase from acinetobacter baumannii with lysine at 2.6a resolution
29% identity, 97% coverage: 6:295/299 of query aligns to 6:290/291 of 3pueB
Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
29% identity, 96% coverage: 10:295/299 of query aligns to 10:292/294 of Q8UGL3
3s8hA Structure of dihydrodipicolinate synthase complexed with 3- hydroxypropanoic acid(hpa)at 2.70 a resolution
33% identity, 70% coverage: 10:219/299 of query aligns to 10:216/292 of 3s8hA
Sites not aligning to the query:
3puoA Crystal structure of dihydrodipicolinate synthase from pseudomonas aeruginosa(psdhdps)complexed with l-lysine at 2.65a resolution (see paper)
33% identity, 70% coverage: 10:219/299 of query aligns to 10:216/292 of 3puoA
Sites not aligning to the query:
4i7wA Agrobacterium tumefaciens dhdps with lysine and pyruvate
28% identity, 96% coverage: 10:295/299 of query aligns to 10:292/294 of 4i7wA
7kkdB Dihydrodipicolinate synthase (dhdps) from c.Jejuni, n84a mutant with pyruvate bound in the active site and r,r-bislysine bound at the allosteric site
27% identity, 97% coverage: 6:296/299 of query aligns to 18:304/306 of 7kkdB
7kg2A Dihydrodipicolinate synthase (dhdps) from c.Jejuni, h59k mutant with pyruvate bound in the active site and l-histidine bound at the allosteric site
27% identity, 97% coverage: 6:296/299 of query aligns to 8:294/296 of 7kg2A
>BWI76_RS26315 FitnessBrowser__Koxy:BWI76_RS26315
MQSRYITPAITVFDEQGRLDPDGNFRLYDFIKNSVSGFVVMGSTGEFFSLDMKTSRQIIQ
MAAEFPRQGIKAYAGASRMDIDECVELANYADECGLDGVMIISPWYFRLTDEGIYTFYSQ
IARRTAAKIFIYNFPERTGYSVSPEVCLRLAREFPNIIGLKDTIPDTNHTSQVIRQVKSE
LPYFEVYAGYDNNFAHNVLSGGNGCIGGLSNICPELFRDWMQAFSDNDLPQIRRYQQKVD
GLMDIYAVNDPFIPTFKKALQLRGIIQSDRCTPPFSSLATCQTESIQRILSRAGIEINA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory