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Comparing BWI76_RS27025 FitnessBrowser__Koxy:BWI76_RS27025 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P00944 Xylose isomerase; D-xylulose keto-isomerase; EC 5.3.1.5 from Escherichia coli (strain K12) (see paper)
91% identity, 100% coverage: 1:440/440 of query aligns to 1:440/440 of P00944
- H101 (= H101) active site
1a0cA Xylose isomerase from thermoanaerobacterium thermosulfurigenes
50% identity, 99% coverage: 4:438/440 of query aligns to 3:436/437 of 1a0cA
- active site: H100 (= H101), D103 (= D104), W138 (= W139), E231 (= E232), K233 (= K234), E267 (= E268), H270 (= H271), D295 (= D296), D306 (= D307), D308 (= D309), D338 (= D339)
- binding cobalt (ii) ion: E231 (= E232), E267 (= E268), E267 (= E268), H270 (= H271), D295 (= D296), D306 (= D307), D308 (= D309), D338 (= D339)
1a0eA Xylose isomerase from thermotoga neapolitana
51% identity, 99% coverage: 4:437/440 of query aligns to 3:435/443 of 1a0eA
- active site: H100 (= H101), D103 (= D104), W138 (= W139), E231 (= E232), K233 (= K234), E267 (= E268), H270 (= H271), D295 (= D296), D306 (= D307), D308 (= D309), D338 (= D339)
- binding cobalt (ii) ion: E231 (= E232), E267 (= E268), E267 (= E268), H270 (= H271), D295 (= D296), D308 (= D309), D338 (= D339)
1a0dA Xylose isomerase from bacillus stearothermophilus
52% identity, 99% coverage: 4:439/440 of query aligns to 2:435/437 of 1a0dA
- active site: H98 (= H101), D101 (= D104), W136 (= W139), E229 (= E232), K231 (= K234), E265 (= E268), H268 (= H271), D293 (= D296), D304 (= D307), D306 (= D309), D336 (= D339)
- binding manganese (ii) ion: E229 (= E232), E265 (= E268), E265 (= E268), H268 (= H271), D293 (= D296), D304 (= D307), D306 (= D309), D336 (= D339)
5nhcA Crystal structure of xylose isomerase from piromyces e2 in complex with two co2+ ions and xylulose (see paper)
49% identity, 99% coverage: 2:436/440 of query aligns to 2:435/436 of 5nhcA
- active site: H101 (= H101), D104 (= D104), W139 (= W139), E232 (= E232), K234 (= K234), E268 (= E268), H271 (= H271), D296 (= D296), D307 (= D307), D309 (= D309), D339 (= D339)
- binding cobalt (ii) ion: E232 (= E232), E268 (= E268), E268 (= E268), H271 (= H271), D296 (= D296), D307 (= D307), D309 (= D309), D339 (= D339)
- binding 4-hydroxyproline: G290 (= G290), L292 (≠ F292), G328 (≠ A328), G330 (= G330), V332 (≠ T332)
- binding d-xylulose: W49 (= W49), H101 (= H101), W188 (= W188), E232 (= E232), E268 (= E268), H271 (= H271), D339 (= D339)
5nhaA Crystal structure of xylose isomerase from piromyces sp. E2 in complex with two mn2+ ions and sorbitol (see paper)
49% identity, 99% coverage: 2:436/440 of query aligns to 2:435/436 of 5nhaA
- active site: H101 (= H101), D104 (= D104), W139 (= W139), E232 (= E232), K234 (= K234), E268 (= E268), H271 (= H271), D296 (= D296), D307 (= D307), D309 (= D309), D339 (= D339)
- binding manganese (ii) ion: E232 (= E232), E268 (= E268), E268 (= E268), H271 (= H271), D296 (= D296), D307 (= D307), D309 (= D309), D339 (= D339)
- binding sorbitol: W49 (= W49), H101 (= H101), W188 (= W188), E232 (= E232), D339 (= D339)
5nh9A Crystal structure of xylose isomerase from piromyces e2 in complex with two mn2+ ions and xylose (see paper)
49% identity, 99% coverage: 2:436/440 of query aligns to 2:435/436 of 5nh9A
- active site: H101 (= H101), D104 (= D104), W139 (= W139), E232 (= E232), K234 (= K234), E268 (= E268), H271 (= H271), D296 (= D296), D307 (= D307), D309 (= D309), D339 (= D339)
- binding manganese (ii) ion: E232 (= E232), E268 (= E268), E268 (= E268), H271 (= H271), D296 (= D296), D307 (= D307), D309 (= D309), D339 (= D339)
- binding D-xylose: W49 (= W49), H101 (= H101), W188 (= W188), E232 (= E232), E268 (= E268), H271 (= H271), D339 (= D339)
- binding beta-D-xylopyranose: G63 (= G63), K65 (≠ F65), S66 (≠ N66), K203 (≠ R203), K206 (≠ R206), H257 (≠ F257), D288 (≠ A288), A289 (≠ L289)
5nh7A Crystal structure of xylose isomerase from piromyces e2 in complex with two mg2+ ions and xylose (see paper)
49% identity, 99% coverage: 2:436/440 of query aligns to 2:435/436 of 5nh7A
- active site: H101 (= H101), D104 (= D104), W139 (= W139), E232 (= E232), K234 (= K234), E268 (= E268), H271 (= H271), D296 (= D296), D307 (= D307), D309 (= D309), D339 (= D339)
- binding magnesium ion: E232 (= E232), E268 (= E268), E268 (= E268), H271 (= H271), D296 (= D296), D307 (= D307), D309 (= D309), D339 (= D339)
- binding D-xylose: W49 (= W49), H101 (= H101), W188 (= W188), E232 (= E232), E268 (= E268), H271 (= H271), D339 (= D339)
- binding beta-D-xylopyranose: G63 (= G63), K65 (≠ F65), S66 (≠ N66)
- binding alpha-D-xylopyranose: P21 (= P21), D40 (= D40), Y97 (= Y97), K136 (= K136), E350 (≠ Y350)
5nh6A Crystal structure of xylose isomerase from piromyces e2 complexed with one mg2+ ion and xylitol (see paper)
49% identity, 99% coverage: 2:436/440 of query aligns to 2:435/436 of 5nh6A
- active site: H101 (= H101), D104 (= D104), W139 (= W139), E232 (= E232), K234 (= K234), E268 (= E268), H271 (= H271), D296 (= D296), D307 (= D307), D309 (= D309), D339 (= D339)
- binding magnesium ion: E232 (= E232), E268 (= E268), D296 (= D296), D339 (= D339)
- binding Xylitol: W49 (= W49), H101 (= H101), W188 (= W188), E232 (= E232), E268 (= E268), H271 (= H271), D339 (= D339)
5nh5A Crystal structure of native xylose isomerase from piromyces e2 (see paper)
49% identity, 99% coverage: 2:436/440 of query aligns to 2:435/436 of 5nh5A
- active site: H101 (= H101), D104 (= D104), W139 (= W139), E232 (= E232), K234 (= K234), E268 (= E268), H271 (= H271), D296 (= D296), D307 (= D307), D309 (= D309), D339 (= D339)
- binding calcium ion: E232 (= E232), E268 (= E268), D296 (= D296), D339 (= D339)
- binding fe (ii) ion: E232 (= E232), E268 (= E268), D296 (= D296), D339 (= D339)
- binding magnesium ion: E232 (= E232), E268 (= E268), D296 (= D296), D339 (= D339)
5nh4A Crystal structure of xylose isomerase from piromyces e2 in complex with one mg2+ ions and glycerol (see paper)
49% identity, 99% coverage: 2:436/440 of query aligns to 2:435/436 of 5nh4A
- active site: H101 (= H101), D104 (= D104), W139 (= W139), E232 (= E232), K234 (= K234), E268 (= E268), H271 (= H271), D296 (= D296), D307 (= D307), D309 (= D309), D339 (= D339)
- binding magnesium ion: E232 (= E232), E268 (= E268), D296 (= D296), D339 (= D339)
5yn3A Crystal structure of xylose isomerase from piromyces sp. E2 (see paper)
49% identity, 99% coverage: 2:436/440 of query aligns to 1:434/435 of 5yn3A
- active site: H100 (= H101), D103 (= D104), W138 (= W139), E231 (= E232), K233 (= K234), E267 (= E268), H270 (= H271), D295 (= D296), D306 (= D307), D308 (= D309), D338 (= D339)
- binding glycerol: H100 (= H101), W187 (= W188), E231 (= E232), D295 (= D296)
- binding manganese (ii) ion: E231 (= E232), E267 (= E268), E267 (= E268), H270 (= H271), D295 (= D296), D306 (= D307), D308 (= D309), D338 (= D339)
4xkmA Crystal structure of xylose isomerase from an human intestinal tract microbe bacteroides thetaiotaomicron
50% identity, 99% coverage: 2:436/440 of query aligns to 1:434/435 of 4xkmA
- active site: F23 (= F24), E29 (≠ D30), H100 (= H101), D103 (= D104), W138 (= W139), E231 (= E232), K233 (= K234), E267 (= E268), H270 (= H271), D295 (= D296), D306 (= D307), D308 (= D309), D338 (= D339)
- binding manganese (ii) ion: E231 (= E232), E267 (= E268), E267 (= E268), H270 (= H271), D295 (= D296), D306 (= D307), D308 (= D309), D338 (= D339)
6intA Xylose isomerase from paenibacillus sp. R4 (see paper)
47% identity, 99% coverage: 4:439/440 of query aligns to 1:412/413 of 6intA
- active site: H74 (= H101), D77 (= D104), W112 (= W139), E205 (= E232), K207 (= K234), E241 (= E268), H244 (= H271), D269 (= D296), D280 (= D307), D282 (= D309), D313 (= D339)
- binding calcium ion: G166 (= G193), E178 (= E205), E205 (= E232), E241 (= E268), E241 (= E268), H244 (= H271), D269 (= D296), D280 (= D307), D282 (= D309), D313 (= D339)
8awyA Millisecond cryo-trapping by the spitrobot crystal plunger, serial measurement xylose isomerase with 2,3-butanediol at 50ms (see paper)
28% identity, 70% coverage: 43:351/440 of query aligns to 9:296/387 of 8awyA
- binding Meso-2,3-Butanediol: H53 (= H101), T89 (= T141), W136 (= W188), E180 (= E232), D286 (= D339)
- binding magnesium ion: H53 (= H101), N91 (= N143), F93 (= F145), E180 (= E232), E216 (= E268), D244 (= D296), D286 (= D339)
4zb0A A dehydrated form of glucose isomerase collected at room temperature. (see paper)
28% identity, 70% coverage: 43:351/440 of query aligns to 9:296/387 of 4zb0A
- active site: H53 (= H101), D56 (= D104), M87 (≠ W139), E180 (= E232), K182 (= K234), E216 (= E268), H219 (= H271), D244 (= D296), D254 (= D307), D256 (= D309), D286 (= D339)
- binding beta-D-fructofuranose: W19 (= W54), D107 (= D159), R108 (≠ P160), D109 (≠ E161), Q255 (≠ T308)
- binding alpha-D-glucopyranose: H53 (= H101), T89 (= T141), W136 (= W188), E180 (= E232), D286 (= D339)
- binding manganese (ii) ion: E180 (= E232), A200 (≠ G252), R204 (≠ Q256), E216 (= E268), E216 (= E268), H219 (= H271), D244 (= D296), D254 (= D307), D256 (= D309), D286 (= D339)
1oadA Glucose isomerase from streptomyces rubiginosus in p21212 crystal form (see paper)
28% identity, 70% coverage: 43:351/440 of query aligns to 9:296/387 of 1oadA
- active site: H53 (= H101), D56 (= D104), M87 (≠ W139), E180 (= E232), K182 (= K234), E216 (= E268), H219 (= H271), D244 (= D296), D254 (= D307), D256 (= D309), D286 (= D339)
- binding magnesium ion: E180 (= E232), E216 (= E268), D244 (= D296), D286 (= D339)
- binding manganese (ii) ion: E216 (= E268), H219 (= H271), D254 (= D307), D256 (= D309)
- binding 2-methylpentane-1,2,4-triol: W15 (= W49), H53 (= H101), F93 (= F145), W136 (= W188), E180 (= E232), D286 (= D339)
4qehA Room temperature x-ray structure of d-xylose isomerase in complex with two mg2+ ions and l-ribose (see paper)
28% identity, 70% coverage: 43:351/440 of query aligns to 10:297/388 of 4qehA
- active site: H54 (= H101), D57 (= D104), M88 (≠ W139), E181 (= E232), K183 (= K234), E217 (= E268), H220 (= H271), D245 (= D296), D255 (= D307), D257 (= D309), D287 (= D339)
- binding beta-L-ribofuranose: W16 (= W49), H54 (= H101), W137 (= W188), E181 (= E232), D287 (= D339)
- binding magnesium ion: E181 (= E232), E217 (= E268), E217 (= E268), H220 (= H271), D245 (= D296), D255 (= D307), D257 (= D309), D287 (= D339)
4qeeA Room temperature x-ray structure of d-xylose isomerase in complex with two ni2+ ions and l-ribose (see paper)
28% identity, 70% coverage: 43:351/440 of query aligns to 10:297/388 of 4qeeA
- active site: H54 (= H101), D57 (= D104), M88 (≠ W139), E181 (= E232), K183 (= K234), E217 (= E268), H220 (= H271), D245 (= D296), D255 (= D307), D257 (= D309), D287 (= D339)
- binding alpha-L-ribofuranose: W16 (= W49), H54 (= H101), F94 (= F145), E181 (= E232), D287 (= D339)
4qe4A Room temperature x-ray structure of d-xylose isomerase in complex with two ni2+ ions and l-ribulose (see paper)
28% identity, 70% coverage: 43:351/440 of query aligns to 10:297/388 of 4qe4A
- active site: H54 (= H101), D57 (= D104), M88 (≠ W139), E181 (= E232), K183 (= K234), E217 (= E268), H220 (= H271), D245 (= D296), D255 (= D307), D257 (= D309), D287 (= D339)
- binding beta-L-ribulofuranose: W16 (= W49), H54 (= H101), W137 (= W188), E181 (= E232), D287 (= D339)
Query Sequence
>BWI76_RS27025 FitnessBrowser__Koxy:BWI76_RS27025
MQTYFDQLDRVRYEGPKSANPLAFRHYNPDELVLGKRMEDHLRFAACYWHTFCWNGADMF
GVGSFNRPWQQPGEAMEMAKRKADVAFEFFHKLNVPYYCFHDVDVSPEGASLKEYANNFA
QMVDVLAEKQQQSGVKLLWGTANCFTNPRYGAGAATNPDPEVFSWAATQVVTAMDATHKL
GGENYVLWGGREGYETLLNTDLRQEREQIGRFMQLVVEHKHKIGFQGTLLIEPKPQEPTK
HQYDYDASTVYGFLKQFGLEKEIKLNIEANHATLAGHTFHHEIATAIALGLFGSVDANRG
DPQLGWDTDQFPNSVEENALVMYEILKAGGFTTGGLNFDAKVRRQSTDKYDLFYGHIGAM
DTMALALKVAARMIEGGELDKRVAKRYAGWNGELGQQILKGQMNLADIAQYATQHNLAPQ
HQSGHQELLENVVNRYLFDR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory