SitesBLAST
Comparing CA265_RS02820 CA265_RS02820 acyl-CoA dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
51% identity, 96% coverage: 14:383/384 of query aligns to 9:378/378 of 5ol2F
- active site: L124 (= L129), T125 (= T130), G241 (= G246), G374 (≠ R379)
- binding calcium ion: E29 (= E34), E33 (≠ A38), R35 (≠ H40)
- binding coenzyme a persulfide: L238 (= L243), R242 (= R247), E362 (= E367), G363 (= G368)
- binding flavin-adenine dinucleotide: F122 (≠ W127), L124 (= L129), T125 (= T130), P127 (≠ A132), T131 (≠ S136), F155 (≠ W160), I156 (= I161), T157 (= T162), E198 (= E203), R267 (= R272), F270 (= F275), L274 (≠ I279), F277 (= F282), Q335 (= Q340), L336 (≠ I341), G338 (= G343), G339 (= G344), Y361 (≠ G366), T364 (= T369), E366 (= E371)
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
50% identity, 98% coverage: 6:383/384 of query aligns to 2:379/380 of 4l1fA
- active site: L125 (= L129), T126 (= T130), G242 (= G246), E363 (= E367), R375 (= R379)
- binding coenzyme a persulfide: T132 (≠ S136), H179 (≠ K183), F232 (= F236), M236 (= M240), E237 (≠ K241), L239 (= L243), D240 (= D244), R243 (= R247), Y362 (≠ G366), E363 (= E367), G364 (= G368), R375 (= R379)
- binding flavin-adenine dinucleotide: F123 (≠ W127), L125 (= L129), T126 (= T130), G131 (= G135), T132 (≠ S136), F156 (≠ W160), I157 (= I161), T158 (= T162), R268 (= R272), Q270 (= Q274), F271 (= F275), I275 (= I279), F278 (= F282), L281 (≠ I285), Q336 (= Q340), I337 (= I341), G340 (= G344), I358 (≠ L362), Y362 (≠ G366), T365 (= T369), Q367 (≠ E371)
- binding 1,3-propandiol: L5 (≠ E9), Q10 (= Q14)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
50% identity, 97% coverage: 9:382/384 of query aligns to 2:373/374 of 5lnxD
- active site: L122 (= L129), T123 (= T130), G239 (= G246), E358 (= E367), K370 (≠ R379)
- binding flavin-adenine dinucleotide: L122 (= L129), T123 (= T130), G128 (= G135), S129 (= S136), F153 (≠ W160), T155 (= T162), R265 (= R272), Q267 (= Q274), F268 (= F275), I272 (= I279), N275 (≠ F282), I278 (= I285), Q331 (= Q340), I332 (= I341), G335 (= G344), Y357 (≠ G366), T360 (= T369), E362 (= E371)
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
47% identity, 97% coverage: 11:383/384 of query aligns to 9:381/384 of 1jqiA
- active site: G377 (≠ R379)
- binding acetoacetyl-coenzyme a: L95 (= L97), F125 (≠ W127), S134 (= S136), F234 (= F236), M238 (= M240), Q239 (≠ K241), L241 (= L243), D242 (= D244), R245 (= R247), Y364 (≠ G366), E365 (= E367), G366 (= G368)
- binding flavin-adenine dinucleotide: F125 (≠ W127), L127 (= L129), S128 (≠ T130), G133 (= G135), S134 (= S136), W158 (= W160), T160 (= T162), R270 (= R272), F273 (= F275), L280 (≠ F282), Q338 (= Q340), I339 (= I341), G342 (= G344), I360 (≠ L362), T367 (= T369), E369 (= E371), I370 (= I372)
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
47% identity, 97% coverage: 11:383/384 of query aligns to 36:408/412 of P15651
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
47% identity, 97% coverage: 10:381/384 of query aligns to 7:378/378 of 4n5fA
- active site: L126 (= L129), T127 (= T130), G243 (= G246), E364 (= E367), R376 (= R379)
- binding dihydroflavine-adenine dinucleotide: L126 (= L129), T127 (= T130), G132 (= G135), S133 (= S136), F157 (≠ W160), T159 (= T162), T210 (= T213), Y363 (≠ G366), T366 (= T369), E368 (= E371), M372 (≠ I375)
7y0aC Crystal structure of human short-chain acyl-coa dehydrogenase
47% identity, 97% coverage: 11:383/384 of query aligns to 12:384/387 of 7y0aC
- binding flavin-adenine dinucleotide: F128 (≠ W127), L130 (= L129), S131 (≠ T130), G136 (= G135), S137 (= S136), W161 (= W160), T163 (= T162), T214 (= T213), R273 (= R272), F276 (= F275), L280 (≠ I279), L283 (≠ F282), V285 (≠ A284), Q341 (= Q340), I342 (= I341), G345 (= G344), I363 (≠ L362), Y367 (≠ G366), T370 (= T369), E372 (= E371), L376 (≠ I375)
8sgsA Short-chain specific acyl-CoA dehydrogenase, mitochondrial (see paper)
47% identity, 97% coverage: 11:383/384 of query aligns to 6:378/381 of 8sgsA
- binding coenzyme a: S131 (= S136), A133 (= A138), N177 (≠ S182), F231 (= F236), M235 (= M240), L238 (= L243), I312 (≠ T317), E362 (= E367), G363 (= G368)
- binding flavin-adenine dinucleotide: F122 (≠ W127), L124 (= L129), S125 (≠ T130), G130 (= G135), S131 (= S136), W155 (= W160), T157 (= T162), R267 (= R272), F270 (= F275), L274 (≠ I279), L277 (≠ F282), Q335 (= Q340), I336 (= I341), G338 (= G343), G339 (= G344), I357 (≠ L362), I360 (= I365), Y361 (≠ G366), T364 (= T369), E366 (= E371)
7y0bA Crystal structure of human short-chain acyl-coa dehydrogenase
47% identity, 97% coverage: 11:383/384 of query aligns to 9:381/385 of 7y0bA
- binding (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol: M343 (≠ Y345), T347 (≠ K349), E348 (≠ D350)
- binding flavin-adenine dinucleotide: F125 (≠ W127), L127 (= L129), S128 (≠ T130), G133 (= G135), S134 (= S136), W158 (= W160), T160 (= T162), R270 (= R272), F273 (= F275), L280 (≠ F282), V282 (≠ A284), Q338 (= Q340), I339 (= I341), G342 (= G344), I360 (≠ L362), Y364 (≠ G366), T367 (= T369), E369 (= E371), I370 (= I372), L373 (≠ I375)
P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 3 papers)
47% identity, 97% coverage: 11:383/384 of query aligns to 36:408/412 of P16219
- G90 (= G65) to S: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908005
- E104 (= E79) natural variant: Missing (in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs387906308)
- 152:161 (vs. 127:136, 40% identical) binding in other chain
- R171 (≠ V146) to W: 69% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1800556
- WIT 185:187 (= WIT 160:162) binding in other chain
- A192 (≠ G167) to V: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940874
- G209 (= G184) to S: 86% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1799958
- R297 (= R272) binding
- Q308 (= Q283) binding in other chain
- R325 (≠ E300) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908006
- S353 (= S328) to L: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28941773
- QILGG 365:369 (≠ QIFGG 340:344) binding
- R380 (≠ K355) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940875
- TSE 394:396 (= TSE 369:371) binding in other chain
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
2vigB Crystal structure of human short-chain acyl coa dehydrogenase
46% identity, 97% coverage: 11:383/384 of query aligns to 3:368/371 of 2vigB
- active site: L121 (= L129), S122 (≠ T130), G231 (= G246), E352 (= E367), G364 (≠ R379)
- binding coenzyme a persulfide: S128 (= S136), F221 (= F236), M225 (= M240), Q226 (≠ K241), L228 (= L243), D229 (= D244), R232 (= R247), E352 (= E367), G353 (= G368), I357 (= I372)
- binding flavin-adenine dinucleotide: L121 (= L129), S122 (≠ T130), G127 (= G135), S128 (= S136), W152 (= W160), T154 (= T162), R257 (= R272), F260 (= F275), L264 (≠ I279), L267 (≠ F282), Q325 (= Q340), I326 (= I341), G329 (= G344), I347 (≠ L362), Y351 (≠ G366), T354 (= T369), E356 (= E371)
3pfdC Crystal structure of an acyl-coa dehydrogenase from mycobacterium thermoresistibile bound to reduced flavin adenine dinucleotide solved by combined iodide ion sad mr (see paper)
46% identity, 96% coverage: 15:383/384 of query aligns to 3:369/369 of 3pfdC
- active site: L116 (= L129), S117 (≠ T130), T233 (≠ G246), E353 (= E367), R365 (= R379)
- binding dihydroflavine-adenine dinucleotide: Y114 (≠ W127), L116 (= L129), S117 (≠ T130), G122 (= G135), S123 (= S136), W147 (= W160), I148 (= I161), T149 (= T162), R259 (= R272), F262 (= F275), V266 (≠ I279), N269 (≠ F282), Q326 (= Q340), L327 (≠ I341), G330 (= G344), I348 (≠ L362), Y352 (≠ G366), T355 (= T369), Q357 (≠ E371)
4m9aB Crystal structure of acyl-coa dehydrogenase from burkholderia thailandensis e264
44% identity, 97% coverage: 10:381/384 of query aligns to 5:376/376 of 4m9aB
- active site: L124 (= L129), T125 (= T130), G241 (= G246), E362 (= E367), R374 (= R379)
- binding dihydroflavine-adenine dinucleotide: F122 (≠ W127), T125 (= T130), G130 (= G135), S131 (= S136), F155 (≠ W160), T157 (= T162), T208 (= T213), Y361 (≠ G366), T364 (= T369), E366 (= E371), M370 (≠ I375)
1ukwB Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
44% identity, 98% coverage: 5:382/384 of query aligns to 1:377/379 of 1ukwB
- active site: L124 (= L129), S125 (≠ T130), T241 (≠ G246), E362 (= E367), R374 (= R379)
- binding cobalt (ii) ion: D145 (= D150), H146 (≠ D151)
- binding flavin-adenine dinucleotide: F122 (≠ W127), L124 (= L129), S125 (≠ T130), G130 (= G135), S131 (= S136), W155 (= W160), S157 (≠ T162), K200 (= K205), L357 (= L362), Y361 (≠ G366), E362 (= E367), T364 (= T369), E366 (= E371), L370 (≠ I375)
1ukwA Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
44% identity, 98% coverage: 5:382/384 of query aligns to 1:377/379 of 1ukwA
- active site: L124 (= L129), S125 (≠ T130), T241 (≠ G246), E362 (= E367), R374 (= R379)
- binding flavin-adenine dinucleotide: F122 (≠ W127), L124 (= L129), S125 (≠ T130), G130 (= G135), S131 (= S136), W155 (= W160), S157 (≠ T162), L357 (= L362), Y361 (≠ G366), E362 (= E367), T364 (= T369), E366 (= E371), L370 (≠ I375)
1bucA Three-dimensional structure of butyryl-coa dehydrogenase from megasphaera elsdenii (see paper)
45% identity, 98% coverage: 6:383/384 of query aligns to 2:383/383 of 1bucA
- active site: L128 (= L129), T129 (= T130), G246 (= G246), E367 (= E367), G379 (≠ R379)
- binding acetoacetyl-coenzyme a: L96 (= L97), F126 (≠ W127), G134 (= G135), T135 (≠ S136), T162 (= T162), N182 (≠ S182), H183 (≠ K183), F236 (= F236), M240 (= M240), M241 (≠ K241), L243 (= L243), D244 (= D244), T317 (= T317), Y366 (≠ G366), E367 (= E367), G368 (= G368)
- binding flavin-adenine dinucleotide: F126 (≠ W127), L128 (= L129), T129 (= T130), G134 (= G135), T135 (≠ S136), F160 (≠ W160), T162 (= T162), Y366 (≠ G366), T369 (= T369), E371 (= E371), M375 (≠ I375)
Q06319 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; BCAD; SCAD; EC 1.3.8.1 from Megasphaera elsdenii (see paper)
45% identity, 98% coverage: 6:383/384 of query aligns to 2:383/383 of Q06319
- E367 (= E367) active site, Proton acceptor; mutation to Q: Loss of activity.
2d29A Structural study on project id tt0172 from thermus thermophilus hb8
46% identity, 98% coverage: 7:383/384 of query aligns to 4:384/386 of 2d29A
- active site: L126 (= L129), T127 (= T130), G247 (= G246), E368 (= E367), R380 (= R379)
- binding flavin-adenine dinucleotide: L126 (= L129), T127 (= T130), G132 (= G135), S133 (= S136), F157 (≠ W160), I158 (= I161), T159 (= T162), L363 (= L362), T370 (= T369), E372 (= E371)
7w0jE Acyl-coa dehydrogenase, tfu_1647
44% identity, 99% coverage: 5:383/384 of query aligns to 2:382/382 of 7w0jE
- binding [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-azanyl-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate: S127 (≠ T130), W157 (= W160), R270 (= R272), Q272 (= Q274), F273 (= F275), I277 (= I279), F280 (= F282), I283 (= I285), Q339 (= Q340), L340 (≠ I341), G343 (= G344), Y365 (≠ G366), E366 (= E367), T368 (= T369), Q370 (≠ E371), I371 (= I372)
8i4rA Crystal structure of acyl-coa dehydrogenase complexed with acetyl-coa from thermobifida fusca
44% identity, 99% coverage: 5:383/384 of query aligns to 1:381/381 of 8i4rA
- binding acetyl coenzyme *a: S132 (= S136), T134 (≠ A138), R180 (≠ K183), R234 (≠ K237), L237 (≠ M240), R238 (≠ K241), L240 (= L243), D241 (= D244), R244 (= R247), E365 (= E367), G366 (= G368), R377 (= R379)
- binding flavin-adenine dinucleotide: Y123 (≠ W127), L125 (= L129), S126 (≠ T130), G131 (= G135), S132 (= S136), W156 (= W160), I157 (= I161), T158 (= T162), I360 (≠ L362), T367 (= T369), Q369 (≠ E371)
Query Sequence
>CA265_RS02820 CA265_RS02820 acyl-CoA dehydrogenase
MSVSFDFSETETQQSVKAMVRDFAEKNIRPHIMEWDEAQHFPVELFKQLGELGLMGVLVP
EEYGGSGLGYQEYVDVIVEVARVCGSIGLSLAAHNSLCTGHILAFANPEQKQRWLPKLAT
AEWIGAWGLTEANTGSDALRMMTTAVEDGDDYIINGAKNWITHGKSGDIAVVMVRTGEQG
SSKGISAIVVERGTPGFTAGKKENKLGMRASETTEMIFDNCRVPKANLLGNVGEGFKQAM
KVLDGGRISIAALALGIAKGAFDAAVAYSKQRQQFGQPISSFQAISFKLADMATEIEAAE
LLIRQAADLKNRHLPMTKESAMAKYFASEVSVRVATDAVQIFGGYGYTKDFPVEKFYRDS
KLCTIGEGTSEIQKIVIAREVLQG
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory