SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing CA265_RS03655 FitnessBrowser__Pedo557:CA265_RS03655 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P0A717 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Escherichia coli (strain K12) (see 4 papers)
29% identity, 79% coverage: 24:241/277 of query aligns to 35:254/315 of P0A717

query
sites
P0A717

F

F

A

S

G

D

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G

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E

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D129 (= D116) to A: in mutant PRSA1; alters the binding of divalent cations, especially magnesium. Little alteration in the affinity for ribose 5-phosphate and 27-fold decrease of the affinity for ATP. Absence of inhibition by AMP
D220 (= D207) mutation to E: 4-fold decrease in the affinity binding for Rib-5-P in the presence of magnesium ions. In the presence of cobalt ions, it shows a 15-fold decrease in the affinity binding for Rib-5-P.; mutation to F: With magnesium or manganese ions, the affinity binding values for ATP and Rib-5-P are comparable to those of the wild-type.
D221 (= D208) mutation to A: The affinity binding for ATP is comparable to those of the wild-type, apart from a slight decrease in the presence of manganese ions. The affinity binding for Rib-5-P is greatly decreased in the presence of both manganese and cobalt ions but only about 2-fold in the presence of magnesium ions.
D224 (= D211) mutation to A: With magnesium or manganese ions, the affinity binding values for ATP and Rib-5-P are comparable to those of the wild-type.; mutation to S: With magnesium or manganese ions, the affinity binding values for ATP and Rib-5-P are comparable to those of the wild-type.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

6asvC E. Coli prpp synthetase (see paper)
29% identity, 79% coverage: 24:241/277 of query aligns to 33:252/311 of 6asvC

query
sites
6asvC

F

F

A

S

G

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G

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binding phosphate ion: D168 (= D155), D218 (= D207), D219 (= D208), D222 (= D211), T223 (≠ G212), G224 (= G213), T226 (= T215), L227 (≠ F216)

4s2uA Crystal structure of the phosphorybosylpyrophosphate synthetase from e. Coli
29% identity, 79% coverage: 24:241/277 of query aligns to 34:253/308 of 4s2uA

query
sites
4s2uA

F

F

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S

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G

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binding magnesium ion: D223 (= D211), T227 (= T215)

7xmvA E.Coli phosphoribosylpyrophosphate (prpp) synthetase type a(amp/adp) filament bound with adp, amp and r5p (see paper)
29% identity, 79% coverage: 24:241/277 of query aligns to 33:246/307 of 7xmvA

query
sites
7xmvA

F
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F

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G
x
D

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E
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E

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L

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A

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K

A

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G

A

A

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K

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F

L

A

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H

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S

binding adenosine-5'-diphosphate: F33 (= F24), D35 (≠ G26), E37 (= E28), R94 (= R84), R97 (= R87), H129 (= H118)
binding adenosine monophosphate: R97 (= R87), V99 (≠ M89), R100 (≠ I90), E131 (= E120), F145 (vs. gap), S147 (= S122), V173 (≠ K160), A177 (≠ K164)
binding 5-O-phosphono-alpha-D-ribofuranose: D212 (= D207), D213 (= D208), M214 (≠ I209), D216 (= D211), T217 (≠ G212), G219 (= G214), T220 (= T215)

7xmuA E.Coli phosphoribosylpyrophosphate (prpp) synthetase type a filament bound with adp, pi and r5p (see paper)
29% identity, 79% coverage: 24:241/277 of query aligns to 33:246/307 of 7xmuA

query
sites
7xmuA

F
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F

A

S

G
x
D

G

G

E
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E

P

V

H

S

I

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K

Q

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D

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D

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K

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A

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A

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E

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K

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K

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A

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K

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S

S

binding adenosine-5'-diphosphate: F33 (= F24), D35 (≠ G26), E37 (= E28), R94 (= R84), Q95 (= Q85), R97 (= R87), R97 (= R87), R100 (≠ I90), H129 (= H118), E131 (= E120), F145 (vs. gap), S147 (= S122), V173 (≠ K160)
binding 5-O-phosphono-alpha-D-ribofuranose: D168 (= D155), D212 (= D207), M214 (≠ I209), D216 (= D211), T217 (≠ G212)

P9WKE3 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
28% identity, 66% coverage: 60:241/277 of query aligns to 80:264/326 of P9WKE3

query
sites
P9WKE3

I

I

T

M

V

I

D

D

A

A

L

L

K

K

R

R

M

G

G

S

V

A

K

K

E

R

I

I

H

T

L

A

F

V

I

M

P

P

Y

F

F

Y

P

P

A

Y

A

A

R

R

Q

Q

D

D

R

K

V

K

M

H

I

R

P

G

G

R

E

E

P

P

L

I

S

S

V

A

K

R

V

L

Y

I

A

A

D

D

I

L

N

K

A

T

M

A

A

G

L

A

A

D

N

R

V

I

T

V

I

T

F

V

D

D

P

L

H

H

S

T

E

D

V

Q

S

I

P

Q

A

G

L

F

N

D

N

G

C

P

V

V

T

D

-

H

I

M

S

R

N

G

H

Q

E

N

F

L

I

L

K

T

Q

G

V

Y

I

I

A

R

K

D

I

N

G

Y

T

P

D

D

-

G

-

N

V

M

K

V

L

V

I

V

S

S

P

P

D

D

G

S

G

G

A

R

L

V

K

R

K

I

I

A

Y

E

K

K

V

W

S

A

E

D

F

A

L

L

D

G

G

G

A

V

E

P

V

L

I

A

E

F

C

I

S

H

K

K

S

T

R

R

D

D

V

P

K

R

T

V

G

P

K

N

L

Q

S

V

G

V

F

S

K

N

V

R

Y

V

A

V

E

G

D

D

L

V

A

A

G

G

A

R

D

T

C

C

L

V

I

L

V

I

D

D

I

M

C

I

D

D

G

T

G

G

T

T

F

I

I

A

G

G

L

A

S

V

E

A

A

L

L

L

K

H

A

N

K

D

N

G

A

A

G

G

K

D

L

V

Y

I

L

I

A

A

I

A

S

T

H

H

G

G

I

V

F

L

S

S

Sites not aligning to the query:

29 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

6nfeA Crystal structure of ribose-phosphate pyrophosphokinase from legionella pneumophila with bound amp, adp, and ribose-5-phosphate
27% identity, 75% coverage: 53:260/277 of query aligns to 64:268/298 of 6nfeA

query
sites
6nfeA

N

N

D

N

L

L

G

M

L

E

I

L

C

L

I

I

T

M

V

A

D

D

A

A

L

L

K

R

R

R

M

S

G

S

V

A

K

G

E

R

I

I

H

T

L

A

F

V

I

V

P

P

Y

Y

F

F

P

G

A

Y

A

A

R
|
R

Q
|
Q

D

D

R
|
R

V

R

M
x
V

I

R

P

S

G

A

E

R

-

V

P

P

L

I

S

T

V

A

K

K

V

V

Y

V

A

A

D

D

I

M

N

A

A

S

M

V

A

G

L

I

A

C

N

R

V

V

T

L

I

T

F

V

D

D

P

L

H
|
H

S

A

E

D

V

Q

S

I

P

Q

A

G

L

F

N

Y

N

M

C

P

V

V

-

D

-

N

T

V

I
x
Y

S

S

N

T

H

P

E

V

F

L

I

L

K

E

Q

D

V

I

I

T

A

K

K

Q

I

K

G

L

T

N

D

N

V

I

K

M

L

I

I

V

S

S

P

P

D

D

G

V

G

G

A

G

L

V

K

V

K
x
R

I

A

Y

R

K
x
A

V

V

S

A

E
x
K

F

R

L

L

D

N

G

D

A

A

E

E

V

L

I

S

E

I

C

I

S

D

K

K

S

R

R

R

D

E

V

V

K

-

T

-

G

-

K

-

L

-

S

-

G

-

F

M

K

H

V

I

Y

I

A

G

E

E

D

P

L

-

A

A

G

N

A

K

D

N

C

C

L

I

I

I

V

V

D
|
D

I
|
I

C

V

D
|
D

G
x
T

G
x
A

G

G

T
|
T

F

L

I

C

G

T

L

A

S

A

E

H

A

E

L

L

K

K

A

K

K

N

N

G

A

A

G

K

K

S

L

V

Y

R

L

A

A

Y

I

I

S

T

H

H

G

P

I

V

F

L

S

S

K

G

G

P

F

A

D

V

E

N

L

N

D

I

K

K

Y

H

-

S

-

G

F

L

E

D

Q

E

I

V

F

V

T

V

T

T

D

D

S

T

I

I

binding adenosine-5'-diphosphate: R95 (= R84), Q96 (= Q85), H130 (= H118)
binding adenosine monophosphate: R98 (= R87), V100 (≠ M89), Y146 (≠ I132), R175 (≠ K161), A178 (≠ K164), K181 (≠ E167)
binding 5-O-phosphono-alpha-D-ribofuranose: H130 (= H118), D213 (= D207), D214 (= D208), I215 (= I209), D217 (= D211), T218 (≠ G212), A219 (≠ G213), T221 (= T215)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 34, 36, 38

Q97Z86 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
24% identity, 83% coverage: 16:246/277 of query aligns to 24:255/291 of Q97Z86

query
sites
Q97Z86

L

L

I

V

E

K

Y

V

K

E

S

N

F

K

L

I

F

F

A

P

G

D

G

G

E

E

P

S

H

Y

I

I

K

R

I

V

S

P

N

S

F

I

-

R

D

D

A

E

L

V

P

L

I

L

T

V

I

Q

T

T

H

T

R

D

I

Y

N

P

S

Q

F

D

N

K

D

H

L

L

G

I

L

E

I

L

C

F

I

L

T

I

V

A

D

E

A

T

L

I

K

R

R

D

M

L

G

G

V

A

K

K

E

K

I

L

H

T

L

A

F

I

I

V

P

P

Y

Y

F

L

P

A

A

Y

A

S

R

R

Q

Q

D

D

R

R

V

R

M

F

I

K

P

D

G

G

E

E

P

A

L

I

S

S

V

I

K

K

V

T

Y

I

A

L

D

H

I

I

I

L

N

S

A

E

M

V

A

G

L

V

A

N

N

T

V

L

T

V

I

V

F

V

D

E

P

P

H

H

S

K

E

P

V

E

S

E

P

L

A

S

L

Y

L

F

N

K

N

G

C

E

V

L

T

K

I

I

S

V

N

H

-

P

H

Y

E

H

F

Q

I

I

K

A

Q

R

V

K

I

I

A

K

K

E

I

I

G

I

T

E

D

D

V

P

K

F

L

I

I

L

S

A

P

P

D

D

G

R

G

G

A

A

L

L

K

D

K

R

I

A

Y

R

K

K

V

I

S

A

E

E

F

E

L

I

D

N

G

-

A

A

E

P

V

Y

I

S

E

Y

C

I

S

E

K

K

S

E

R

R

D

D

V

R

K

T

T

T

G

G

K

E

L

V

S

R

G

I

F

K

K

E

V

A

Y

P

A

N

E

I

D

N

L

L

A

K

G

G

A

K

D

D

C

V

L

V

I

I

V

I

D

D

I

I

C

I

D
x
S

G
x
T

G
|
G

T
|
T

F

I

I

V

G

Q

L

A

S

T

E

R

A

L

L

A

K

Y

A

S

K

L

N

G

A

A

G

K

K

S

L

V

Y

T

L

A

A

A

I

A

S

I

H

H

G

L

I

L

F

L

S

V

K

G

G

G

F

A

D

K

E

E

STGGT 220:224 (≠ DGGGT 211:215) binding

6nfeB Crystal structure of ribose-phosphate pyrophosphokinase from legionella pneumophila with bound amp, adp, and ribose-5-phosphate
27% identity, 75% coverage: 53:260/277 of query aligns to 64:269/299 of 6nfeB

query
sites
6nfeB

N

N

D

N

L

L

G

M

L

E

I

L

C

L

I

I

T

M

V

A

D

D

A

A

L

L

K

R

R

R

M

S

G

S

V

A

K

G

E

R

I

I

H

T

L

A

F

V

I

V

P

P

Y

Y

F

F

P

G

A

Y

A

A

R
|
R

Q
|
Q

D

D

R

R

V

R

M

V

I

R

P

S

G

A

E

R

-

V

P

P

L

I

S

T

V

A

K

K

V

V

Y

V

A

A

D

D

I

M

N

A

A

S

M

V

A

G

L

I

A

C

N

R

V

V

T

L

I

T

F

V

D

D

P

L

H
|
H

S

A

E

D

V

Q

S

I

P

Q

A

G

L

F

N

Y

N

M

C

P

V

V

-

D

-

N

T

V

I

Y

S

S

N

T

H

P

E

V

F

L

I

L

K

E

Q

D

V

I

I

T

A

K

K

Q

I

K

G

L

T

N

D

N

V

I

K

M

L

I

I

V

S

S

P

P

D

D

G

V

G

G

A

G

L

V

K

V

K

R

I

A

Y

R

K

A

V

V

S

A

E

K

F

R

L

L

D

N

G

D

A

A

E

E

V

L

I

S

E

I

C

I

S

D

K

K

S

R

R

R

D

S

V

-

K

-

T

-

G

-

K

-

L

-

S

E

G

V

F

M

K

H

V

I

Y

I

A

G

E

E

D

P

L

-

A

A

G

N

A

K

D

N

C

C

L

I

I

I

V

V

D
|
D

I
|
I

C

V

D
|
D

G
x
T

G
x
A

G

G

T
|
T

F

L

I

C

G

T

L

A

S

A

E

H

A

E

L

L

K

K

A

K

K

N

N

G

A

A

G

K

K

S

L

V

Y

R

L

A

A

Y

I

I

S

T

H

H

G

P

I

V

F

L

S

S

K

G

G

P

F

A

D

V

E

N

L

N

D

I

K

K

Y

H

-

S

-

G

F

L

E

D

Q

E

I

V

F

V

T

V

T

T

D

D

S

T

I

I

binding adenosine-5'-diphosphate: R95 (= R84), Q96 (= Q85), H130 (= H118)
binding 5-O-phosphono-alpha-D-ribofuranose: H130 (= H118), D214 (= D207), D215 (= D208), I216 (= I209), D218 (= D211), T219 (≠ G212), A220 (≠ G213), T222 (= T215)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 34, 36, 38

3lpnA Crystal structure of the phosphoribosylpyrophosphate (prpp) synthetase from thermoplasma volcanium in complex with an atp analog (ampcpp). (see paper)
28% identity, 74% coverage: 58:261/277 of query aligns to 65:265/284 of 3lpnA

query
sites
3lpnA

I

M

C

I

I

L

T

T

V

L

D

S

A

A

L

I

K

Q

R

D

M

Y

G

R

V

T

K

K

E

S

I

V

H

N

L

I

F

I

I

A

P

P

Y

Y

F

Y

P

G

A

Y

A

A

R
|
R

Q
|
Q

D
x
H

R

Q

V

R

M
x
Y

I

K

P

N

G

G

E

E

P

P

L

I

S

S

V

S

K

Q

V

I

Y

L

A

T

D

E

I

I

I

Y

N

S

A

S

M

Y

A

S

L

N

A

S

N

I

V

A

T

T

I

V

F

-

D

D

P

I

H
|
H

S
x
D

E

E

V

-

S

-

P

K

A

T

L

L

L

S

N

Y

N

S

C

K

V

V

T

K

I

F

S

S

N

D

-

L

-

H

-

A

H

N

E

D

F

A

I

I

K

V

Q

R

V

Y

I

Y

A

K

K

N

I

V

G

D

T

V

D

D

V

Y

K

-

L

V

I

V

S

S

P

P

D

D

G

D

G

G

A

G

L

L

K

A

K

R

I

V

Y

A

K

D

V

I

S

S

E

A

F

K

L

L

D

G

G

K

A

K

E

H

V

F

I

F

E

I

C

E

S

K

K

K

S

R

R

I

D

D

V

D

K

R

T

T

G

V

K

E

L

M

S

-

G

-

F

-

K

K

V

V

Y

P

A

N

E

V

D

D

L

V

A

N

G

G

A

K

D

K

C

L

L

L

I

I

V

V

D

D

I

I

C

I

D
x
S

G
x
T

G
|
G

G

G

T
|
T

F

I

I

A

G

K

L

S

S

S

E

G

A

L

L

L

K

R

A

E

K

K

N

G

A

A

G

S

K

K

L

I

Y

Y

L

V

A

S

I

A

S

V

H

H

G

G

I

L

F

F

S

V

K

N

G

G

F

S

D

E

-

N

E

K

L

I

D

L

K

Q

Y

N

F

A

E

D

Q

E

I

I

F

H

T

V

T

T

D

D

S

T

I

V

K

E

binding diphosphomethylphosphonic acid adenosyl ester: R91 (= R84), Q92 (= Q85), H93 (≠ D86), Y96 (≠ M89), H124 (= H118), D125 (≠ S119)
binding sulfate ion: S214 (≠ D211), T215 (≠ G212), G216 (= G213), T218 (= T215)

Sites not aligning to the query:

P14193 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PPRibP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Bacillus subtilis (strain 168) (see 4 papers)
24% identity, 90% coverage: 24:272/277 of query aligns to 41:291/317 of P14193

query
sites
P14193

F

F

A

S

G

D

G

G

E

E

P

V

H

Q

I

I

K

N

I

I

S

E

N

E

N

S

F

I

D

R

A

G

A

C

L

D

P

C

I

Y

T

I

I

I

T

Q

H

S

R

T

I

S

N

D

S

P

F

V

N

N

D

E

-

H

L

I

G

M

L

E

I

L

C

L

I

I

T

M

V

V

D

D

A

A

L

L

K

K

R

R

M

A

G

S

V

A

K

K

E

T

I

I

H

N

L

I

F

V

I

I

P

P

Y

Y

F

Y

P

G

A

Y

A

A

R
|
R

Q
|
Q

D

D

R

R

V

K

M

A

I

R

P

S

G

R

E

E

P

P

L

I

S

T

V

A

K

K

V

L

Y

F

A

A

D

N

I

L

N

E

A

T

M

A

A

G

L

A

A

T

N

R

V

V

T

I

I

A

F

L

D

D

P

L

H

H

S

A

E

P

V

Q

S

I

P

Q

A

G

L

F

N

D

N

I

C

P

V

I

T

-

I

-

S

-

N

D

H

H

E

L

F

M

I

G

K

V

Q

P

V

I

I

L

-

G

-

E

-

Y

-

F

-

E

A

G

K

K

I

N

G

L

T

E

D

D

V

I

K

V

L

I

I

V

S

S

P

P

D

D

G

H

G

G

A

G

L

V

K

T

K

R

I

A

Y

R

K

K

V

L

S

A

E

D

F

R

L

L

D

K

G

A

A

P

-

I

E

A

V

I

I

I

E

D

C
x
K

S

R

K
x
R

S

P

R
|
R

D

P

V

-

K

-

T

-

G

-

K
x
N

L

V

S

A

G
x
E

F

V

K

M

V

N

Y

I

A

V

E

G

D

N

L

I

A

E

G

G

A

K

D

T

C

A

L

I

I

L

V

I

D

D

I

I

C

I

D
|
D

G
x
T

G
x
A

G
|
G

T
|
T

F

I

I

T

G

L

L

A

S

A

E

N

A

A

L

L

K

V

A

E

K

N

N

G

A

A

G

K

K

E

L

V

Y

Y

L

A

A

C

I

C

S

T

H

H

G

P

I

V

F

L

S

S

K

G

G

P

F

A

D

V

E

E

L

R

-

I

-

N

D

N

K

S

Y

T

F

I

E

K

Q

E

I

L

F

V

T

V

T

T

D

N

S

S

I

I

K

K

E

L

V

P

D

E

H

E

K

K

G

K

V

I

T

E

Q

R

I

F

K

K

RQ 102:103 (= RQ 84:85) binding
K198 (≠ C177) mutation to A: Strong decrease of the Vmax value compared to that of the wild-type. The affinity binding for ATP and Rib-5-P are slightly altered compared to the wild-type. The cooperativity of ADP binding is reduced.
R200 (≠ K179) mutation to A: Strong decrease of the Vmax value compared to that of the wild-type enzyme. The affinity binding for ATP and Rib-5-P are slightly altered compared to the wild-type.
R202 (= R181) mutation to A: 3-fold decrease in the affinity binding for ATP. Slight decrease of the Vmax value.
N204 (≠ K187) mutation to A: 4.5-fold decrease in the affinity binding for ATP. Slight decrease of the Vmax value.
E207 (≠ G190) mutation to A: 2.5-fold decrease in the affinity binding for ATP. Slight decrease of the Vmax value.
DTAGT 228:232 (≠ DGGGT 211:215) binding

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

3mbiA Crystal structure of the phosphoribosylpyrophosphate (prpp) synthetase from thermoplasma volcanium in complex with adp-mg2+ and ribose 5- phosphate (see paper)
28% identity, 74% coverage: 58:261/277 of query aligns to 67:267/287 of 3mbiA

query
sites
3mbiA

I

M

C

I

I

L

T

T

V

L

D

S

A

A

L

I

K

Q

R

D

M

Y

G

R

V

T

K

K

E

S

I

V

H

N

L

I

F

I

I

A

P

P

Y

Y

F

Y

P

G

A

Y

A

A

R
|
R

Q
|
Q

D
x
H

R

Q

V

R

M
x
Y

I

K

P

N

G

G

E

E

P

P

L

I

S

S

V

S

K

Q

V

I

Y

L

A

T

D

E

I

I

I

Y

N

S

A

S

M

Y

A

S

L

N

A

S

N

I

V

A

T

T

I

V

F

-

D

D

P

I

H
|
H

S

D

E

E

V

-

S

-

P

K

A

T

L

L

L

S

N

Y

N

S

C

K

V

V

T

K

I

F

S

S

N

D

-

L

-

H

-

A

H

N

E

D

F

A

I

I

K

V

Q

R

V

Y

I

Y

A

K

K

N

I

V

G

D

T

V

D

D

V

Y

K

-

L

V

I

V

S

S

P

P

D

D

G

D

G

G

A

G

L

L

K

A

K

R

I

V

Y

A

K

D

V

I

S

S

E

A

F

K

L

L

D

G

G

K

A

K

E

H

V

F

I

F

E

I

C

E

S
x
K

K

K

S
x
R

R

I

D

D

V

D

K

R

T

T

G

V

K

E

L

M

S

-

G

-

F

-

K

K

V

V

Y

P

A

N

E

V

D

D

L

V

A

N

G

G

A

K

D

K

C

L

L

L

I

I

V

V

D

D

I

I

C

I

D
x
S

G
x
T

G
|
G

G

G

T
|
T

F

I

I

A

G

K

L

S

S

S

E

G

A

L

L

L

K

R

A

E

K

K

N

G

A

A

G

S

K

K

L

I

Y

Y

L

V

A

S

I

A

S

V

H

H

G

G

I

L

F

F

S

V

K

N

G

G

F

S

D

E

-

N

E

K

L

I

D

L

K

Q

Y

N

F

A

E

D

Q

E

I

I

F

H

T

V

T

T

D

D

S

T

I

V

K

E

binding adenosine-5'-diphosphate: R93 (= R84), Q94 (= Q85), Y98 (≠ M89), H126 (= H118), K186 (≠ S178), R188 (≠ S180)
binding magnesium ion: H95 (≠ D86), H126 (= H118)
binding phosphate ion: R188 (≠ S180), S216 (≠ D211), T217 (≠ G212), G218 (= G213), T220 (= T215)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 34, 36, 38

3mbiD Crystal structure of the phosphoribosylpyrophosphate (prpp) synthetase from thermoplasma volcanium in complex with adp-mg2+ and ribose 5- phosphate (see paper)
28% identity, 74% coverage: 58:261/277 of query aligns to 65:265/285 of 3mbiD

query
sites
3mbiD

I

M

C

I

I

L

T

T

V

L

D

S

A

A

L

I

K

Q

R

D

M

Y

G

R

V

T

K

K

E

S

I

V

H

N

L

I

F

I

I

A

P

P

Y

Y

F

Y

P

G

A

Y

A

A

R
|
R

Q
|
Q

D

H

R

Q

V

R

M
x
Y

I

K

P

N

G

G

E

E

P

P

L

I

S

S

V

S

K

Q

V

I

Y

L

A

T

D

E

I

I

I

Y

N

S

A

S

M

Y

A

S

L

N

A

S

N

I

V

A

T

T

I

V

F

-

D

D

P

I

H
|
H

S

D

E

E

V

-

S

-

P

K

A

T

L

L

L

S

N

Y

N

S

C

K

V

V

T

K

I

F

S

S

N

D

-

L

-

H

-

A

H

N

E

D

F

A

I

I

K

V

Q

R

V

Y

I

Y

A

K

K

N

I

V

G

D

T

V

D

D

V

Y

K

-

L

V

I

V

S

S

P

P

D

D

G

D

G

G

A

G

L

L

K

A

K

R

I

V

Y

A

K

D

V

I

S

S

E

A

F

K

L

L

D

G

G

K

A

K

E

H

V

F

I

F

E

I

C

E

S
x
K

K

K

S
x
R

R

I

D

D

V

D

K

R

T

T

G

V

K

E

L

M

S

-

G

-

F

-

K

K

V

V

Y

P

A

N

E

V

D

D

L

V

A

N

G

G

A

K

D

K

C

L

L

L

I

I

V

V

D
|
D

I
|
I

C

I

D
x
S

G
x
T

G
|
G

G

G

T
|
T

F

I

I

A

G

K

L

S

S

S

E

G

A

L

L

L

K

R

A

E

K

K

N

G

A

A

G

S

K

K

L

I

Y

Y

L

V

A

S

I

A

S

V

H

H

G

G

I

L

F

F

S

V

K

N

G

G

F

S

D

E

-

N

E

K

L

I

D

L

K

Q

Y

N

F

A

E

D

Q

E

I

I

F

H

T

V

T

T

D

D

S

T

I

V

K

E

binding adenosine-5'-diphosphate: R91 (= R84), Q92 (= Q85), Y96 (≠ M89), H124 (= H118), K184 (≠ S178), R186 (≠ S180)
binding 5-O-phosphono-alpha-D-ribofuranose: R91 (= R84), H124 (= H118), K184 (≠ S178), R186 (≠ S180), D210 (= D207), D211 (= D208), I212 (= I209), S214 (≠ D211), T215 (≠ G212), G216 (= G213), T218 (= T215)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 32, 34, 36

Q97CA5 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) (see paper)
28% identity, 74% coverage: 58:261/277 of query aligns to 65:265/286 of Q97CA5

query
sites
Q97CA5

I

M

C

I

I

L

T

T

V

L

D

S

A

A

L

I

K

Q

R

D

M

Y

G

R

V

T

K

K

E

S

I

V

H

N

L

I

F

I

I

A

P

P

Y

Y

F

Y

P

G

A

Y

A

A

R
|
R

Q
|
Q

D
x
H

R

Q

V

R

M

Y

I

K

P

N

G

G

E

E

P

P

L

I

S

S

V

S

K

Q

V

I

Y

L

A

T

D

E

I

I

I

Y

N

S

A

S

M

Y

A

S

L

N

A

S

N

I

V

A

T

T

I

V

F

-

D

D

P

I

H

H

S

D

E

E

V

-

S

-

P

K

A

T

L

L

L

S

N

Y

N

S

C

K

V

V

T

K

I

F

S

S

N

D

-

L

-

H

-

A

H

N

E

D

F

A

I

I

K

V

Q

R

V

Y

I

Y

A

K

K

N

I

V

G

D

T

V

D

D

V

Y

K

-

L

V

I

V

S

S

P

P

D

D

G

D

G

G

A

G

L

L

K

A

K

R

I

V

Y

A

K

D

V

I

S

S

E

A

F

K

L

L

D

G

G

K

A

K

E

H

V

F

I

F

E

I

C

E

S

K

K

K

S
x
R

R

I

D

D

V

D

K

R

T

T

G

V

K

E

L

M

S

-

G

-

F

-

K

K

V

V

Y

P

A

N

E

V

D

D

L

V

A

N

G

G

A

K

D

K

C

L

L

L

I

I

V

V

D
|
D

D

D

I

I

C

I

D
x
S

G
x
T

G
|
G

T
|
T

F

I

I

A

G

K

L

S

S

S

E

G

A

L

L

L

K

R

A

E

K

K

N

G

A

A

G

S

K

K

L

I

Y

Y

L

V

A

S

I

A

S

V

H

H

G

G

I

L

F

F

S

V

K

N

G

G

F

S

D

E

-

N

E

K

L

I

D

L

K

Q

Y

N

F

A

E

D

Q

E

I

I

F

H

T

V

T

T

D

D

S

T

I

V

K

E

RQH 91:93 (≠ RQD 84:86) binding
R186 (≠ S180) binding
D210 (= D207) binding
STGGT 214:218 (≠ DGGGT 211:215) binding

Sites not aligning to the query:

34:36 binding

Q58761 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
28% identity, 92% coverage: 17:271/277 of query aligns to 27:279/284 of Q58761

query
sites
Q58761

I

V

E

E

Y

Y

K

K

S

R

F

F

L

-

F

-

A

P

G
x
D

G
x
N

E
|
E

P

I

H

Y

I

V

K

R

I

I

S

V

N

D

N

E

F

I

D

N

A

D

L

E

P

A

I

V

T

I

I

I

T

N

H

T

R

Q

I

K

N

N

S

Q

F

N

N

D

D

A

L

I

G

V

L

E

I

T

C

I

I

L

T

L

V

C

D

D

A

A

L

L

K

R

R

D

M

E

G

G

V

V

K

K

E

K

I

I

H

T

L

L

F

V

I

A

P

P

Y

Y

F

L

P

A

A

Y

A

A

R

R

Q

Q

D

D

R

K

V

K

M

F

I

N

P

P

G

G

E

E

P

A

L

I

S

S

V

I

K

R

V

A

Y

L

A

A

D

K

I

I

I

Y

N

S

A

N

M

I

A

V

L

D

A

K

N

L

V

I

T

T

I

I

F

-

D

N

P

P

H

H

S

E

E

T

-

H

-

I

-

K

-

D

-

F

V

T

S

I

P

P

A

F

L

I

L

Y

N

G

N

D

C

A

V

V

T

P

I

-

S

K

N

L

H

A

E

E

F

Y

I

V

K

K

Q

D

V

K

I

L

A

-

K

-

I

-

G

-

T

N

D

D

V

P

K

I

L

V

I

L

S

A

P

P

D

D

G

K

G

G

A

A

L

L

K

E

K

F

I

A

Y

K

K

T

V

A

S

S

E

K

F

I

L

L

D

N

G

-

A

A

E

E

V

Y

I

D

E

Y

C

L

S

E

K

K

S

T

R

R

D

L

V

S

K

P

T

T

G

E

K

I

L

Q

S

I

G

A

F

P

K

K

V

T

Y

L

A

-

E

-

D

D

L

A

A

K

G

D

A

R

D

D

C

V

L

F

I

I

V

V

D
|
D

D

D

I

I

C

I

D
x
S

G
x
T

G
|
G

T
|
T

F

M

I

A

G

T

L

A

S

V

E

K

A

L

L

L

K

K

A

E

K

Q

N

G

A

A

G

K

K

K

L

I

Y

I

L

A

A

A

I

C

S

V

H

H

G

P

I

V

F

L

S

I

K

G

G

-

F

-

D

D

E

A

L

L

D

N

K

K

Y

L

F

Y

-

S

-

A

-

G

-

V

E

E

Q

E

I

V

F

V

T

G

T

T

D

D

S

T

-

Y

I

L

K

S

E

E

V

V

D

S

H

K

K

V

G

S

V

V

T

A

Q

E

I

V

DNE 34:36 (≠ GGE 26:28) binding
D212 (= D207) binding
STGGT 216:220 (≠ DGGGT 211:215) binding

4twbA Sulfolobus solfataricus ribose-phosphate pyrophosphokinase (see paper)
23% identity, 83% coverage: 16:246/277 of query aligns to 24:242/278 of 4twbA

query
sites
4twbA

L

L

I

V

E

K

Y

V

K

E

S

N

F

K

L

I

F
|
F

A

P

G
x
D

G

G

E
|
E

P

S

H

Y

I

I

K

R

I

V

S

P

N

S

F

I

-

R

D

D

A

E

L

V

P

L

I

L

T

V

I

Q

T

T

H

T

R

D

I

Y

N

P

S

Q

F

D

N

K

D

H

L

L

G

I

L

E

I

L

C

F

I

L

T

I

V

A

D

E

A

T

L

I

K

R

R

D

M

L

G

G

V

A

K

K

E

K

I

L

H

T

L

A

F

I

I

V

P

P

Y

Y

F

L

P

A

A

Y

A

S

R
|
R

Q

Q

D

D

R

R

V

R

M
x
F

I

K

P

D

G

G

E

E

P

A

L

I

S

S

V

I

K

K

V

T

Y

I

A

L

D

H

I

I

I

L

N

S

A

E

M

V

A

G

L

V

A

N

N

T

V

L

T

V

I

V

F

V

D

E

P

P

H
|
H

S

K

E

P

V

E

S

E

P

L

A

S

L

Y

L

F

N

K

N

G

C

E

V

L

T

K

I

I

S

V

N

H

-

P

H

Y

E

H

F

Q

I

I

K

A

Q

R

V

K

I

I

A

K

K

E

I

I

G

I

T

E

D

D

V

P

K

F

L

I

I

L

S

A

P

P

D

D

G

R

G

G

A

A

L

L

K

D

K

R

I

A

Y

R

K

K

V

I

S

A

E

E

F

E

L

I

D

N

G

-

A

A

E

P

V

Y

I

S

E

Y

C

I

S

E

K

K

S

E

R

R

D

N

V

I

K

-

T

-

G

-

K

-

L

-

S

-

G

-

F

-

K

-

V

-

Y

-

A

-

E

-

D

N

L

L

A

K

G

G

A

K

D

D

C

V

L

V

I

I

V

I

D

D

I

I

C

I

D

S

G

T

G

G

T

T

F

I

I

V

G

Q

L

A

S

T

E

R

A

L

L

A

K

Y

A

S

K

L

N

G

A

A

G

K

K

S

L

V

Y

T

L

A

A

A

I

A

S

I

H

H

G

L

I

L

F

L

S

V

K

G

G

G

F

A

D

K

E

E

binding adenosine monophosphate: F32 (= F24), D34 (≠ G26), E36 (= E28), R93 (= R84), F98 (≠ M89), H127 (= H118)

1dkuA Crystal structures of bacillus subtilis phosphoribosylpyrophosphate synthetase: molecular basis of allosteric inhibition and activation. (see paper)
24% identity, 86% coverage: 24:261/277 of query aligns to 33:263/295 of 1dkuA

query
sites
1dkuA

F

F

A

S

G

D

G

G

E

E

P

V

H

Q

I

I

K

N

I

I

S

E

N

E

N

S

F

I

D

R

A

G

A

C

L

D

P

C

I

Y

T

I

I

I

T

Q

H

S

R

T

I

S

N

D

S

P

F

V

N

N

D

E

-

H

L

I

G

M

L

E

I

L

C

L

I

I

T

M

V

V

D

D

A

A

L

L

K

K

R

R

M

A

G

S

V

A

K

K

E

T

I

I

H

N

L

I

F

V

I

I

P

P

Y

Y

F

Y

P

G

A

Y

A

A

R
|
R

Q

Q

D

D

R

R

V
x
K

M

A

I

R

P
x
S

G
x
R

E

E

P

P

L

I

S

T

V

A

K

K

V

L

Y

F

A

A

D

N

I

L

N

E

A

T

M

A

A

G

L

A

A

T

N

R

V

V

T

I

I

A

F

L

D

D

P

L

H
|
H

S

A

E

P

V

Q

S

I

P

Q

A

G

L

F

N

D

N

I

C

P

V

I

T

-

I

-

S

-

N
x
D

H

H

E

L

F

M

I

G

K

V

Q

P

V

I

I

L

-

G

-

E

-

Y

-

F

-

E

A

G

K

K

I

N

G

L

T

E

D

D

V

I

K

V

L

I

I

V

S

S

P

P

D

D

G

H

G

G

A

G

L

V

K

T

K

R

I

A

Y

R

K

K

V

L

S

A

E

D

F

R

L

L

D

K

G

-

A

A

E

P

V

I

I

A

E

I

C

I

S

D

K

K

S

R

R

M

D

N

V

I

K

-

T

-

G

-

K

-

L

-

S

-

G

-

F

-

K

-

V

-

Y

-

A

V

E

G

D

N

L

I

A

E

G

G

A

K

D

T

C

A

L

I

I

L

V

I

D

D

I

I

C

I

D

D

G

T

G

A

G

G

T

T

F

I

I

T

G

L

L

A

S

A

E

N

A

A

L

L

K

V

A

E

K

N

N

G

A

A

G

K

K

E

L

V

Y

Y

L

A

A

C

I

C

S

T

H

H

G

P

I

V

F

L

S

S

K

G

G

P

F

A

D

V

E

E

L

R

-

I

-

N

D

N

K

S

Y

T

F

I

E

K

Q

E

I

L

F

V

T

V

T

T

D

N

S

S

I

I

K

K

binding methyl phosphonic acid adenosine ester: R94 (= R84), H128 (= H118)
binding phosphomethylphosphonic acid adenosyl ester: K98 (≠ V88), S101 (≠ P91), R102 (≠ G92), D141 (≠ N134)

Sites not aligning to the query:

binding phosphomethylphosphonic acid adenosyl ester: 290, 291, 292, 295

1u9zA Crystal structure of phosphoribosyl diphosphate synthase complexed with amp and ribose 5-phosphate (see paper)
27% identity, 92% coverage: 17:271/277 of query aligns to 27:269/274 of 1u9zA

query
sites
1u9zA

I

V

E

E

Y

Y

K

K

S

R

F
|
F

L

-

F

-

A

P

G
x
D

G

N

E
|
E

P

I

H

Y

I

V

K

R

I

I

S

V

N

D

N

E

F

I

D

N

A

D

L

E

P

A

I

V

T

I

I

I

T

N

H

T

R

Q

I

K

N

N

S

Q

F

N

N

D

D

A

L

I

G

V

L

E

I

T

C

I

I

L

T

L

V

C

D

D

A

A

L

L

K

R

R

D

M

E

G

G

V

V

K

K

E

K

I

I

H

T

L

L

F

V

I

A

P

P

Y

Y

F

L

P

A

A

Y

A

A

R
|
R

Q
|
Q

D

D

R

K

V

K

M
x
F

I

N

P

P

G

G

E

E

P

A

L

I

S

S

V

I

K

R

V

A

Y

L

A

A

D

K

I

I

I

Y

N

S

A

N

M

I

A

V

L

D

A

K

N

L

V

I

T

T

I

I

F

-

D

N

P

P

H
|
H

S

E

E

T

-

H

-

I

-

K

-

D

-

F

V

T

S

I

P

P

A

F

L

I

L

Y

N

G

N

D

C

A

V

V

T

P

I

-

S

K

N

L

H

A

E

E

F

Y

I

V

K

K

Q

D

V

K

I

L

A

-

K

-

I

-

G

-

T

N

D

D

V

P

K

I

L

V

I

L

S

A

P

P

D
|
D

G

K

G

G

A

A

L

L

K

E

K

F

I

A

Y

K

K

T

V

A

S

S

E

K

F

I

L

L

D

N

G

A

A

E

-

Y

E

D

V

Y

I

L

E

E

C

I

S

A

-

P

K

K

S

T

R

L

D

D

V

A

K

K

T

-

G

-

K

-

L

-

S

-

G

-

F

-

K

-

V

-

Y

-

A

-

E

-

D

-

L

-

A

-

G

D

A

R

D

D

C

V

L

F

I

I

V

V

D
|
D

D

D

I

I

C
x
I

D
x
S

G
x
T

G
|
G

G

G

T
|
T

F

M

I

A

G

T

L

A

S

V

E

K

A

L

L

L

K

K

A

E

K

Q

N

G

A

A

G

K

K

K

L

I

Y

I

L

A

A

A

I

C

S

V

H

H

G

P

I

V

F

L

S

I

K

G

G

-

F

-

D

D

E

A

L

L

D

N

K

K

Y

L

F

Y

-

S

-

A

-

G

-

V

E

E

Q

E

I

V

F

V

T

G

T

T

D

D

S

T

-

Y

I

L

K

S

E

E

V

V

D

S

H

K

K

V

G

S

V

V

T

A

Q

E

I

V

binding adenosine monophosphate: F32 (= F22), D34 (≠ G26), E36 (= E28), R92 (= R84), Q93 (= Q85), F97 (≠ M89), H125 (= H118)
binding ribose-5-phosphate: D163 (= D155), D202 (= D207), I205 (≠ C210), S206 (≠ D211), T207 (≠ G212), G208 (= G213), T210 (= T215)

1ibsB Phosphoribosyldiphosphate synthetase in complex with cadmium ions (see paper)
24% identity, 90% coverage: 24:272/277 of query aligns to 35:274/299 of 1ibsB

query
sites
1ibsB

F

F

A

S

G

D

G

G

E

E

P

V

H

Q

I

I

K

N

I

I

S

E

N

E

N

S

F

I

D

R

A

G

A

C

L

D

P

C

I

Y

T

I

I

I

T

Q

H

S

R

T

I

S

N

D

S

P

F

V

N

N

D

E

-

H

L

I

G

M

L

E

I

L

C

L

I

I

T

M

V

V

D

D

A

A

L

L

K

K

R

R

M

A

G

S

V

A

K

K

E

T

I

I

H

N

L

I

F

V

I

I

P

P

Y

Y

F

Y

P

G

A

Y

A

A

R
|
R

Q
|
Q

D

D

R
|
R

V

K

M

-

I

-

P

S

G

R

E

E

P

P

L

I

S

T

V

A

K

K

V

L

Y

F

A

A

D

N

I

L

N

E

A

T

M

A

A

G

L

A

A

T

N

R

V

V

T

I

I

A

F

L

D

D

P

L

H

H

S

A

E

P

V

Q

S

I

P

Q

A

G

L

F

N

D

N

I

C

P

V

I

T

-

I

-

S

-

N

D

H

H

E

L

F

M

I

G

K

V

Q

P

V

I

I

L

-

G

-

E

-

Y

-

F

-

E

A

G

K

K

I

N

G

L

T

E

D

D

V

I

K

V

L

I

I

V

S

S

P

P

D

D

G

H

G

G

A

G

L

V

K

T

K

R

I

A

Y

R

K

K

V

L

S

A

E

D

F

R

L

L

D

K

G

-

A

A

E

P

V

I

I

A

E

I

C

I

S

D

K

K

S

R

R

M

D

N

V

I

K

-

T

-

G

-

K

-

L

-

S

-

G

-

F

-

K

-

V

-

Y

-

A

V

E

G

D

N

L

I

A

E

G

G

A

K

D

T

C

A

L

I

I

L

V

I

D

D

I

I

C

I

D

D

G

T

G

A

G

G

T

T

F

I

I

T

G

L

L

A

S

A

E

N

A

A

L

L

K

V

A

E

K

N

N

G

A

A

G

K

K

E

L

V

Y

Y

L

A

A

C

I

C

S

T

H

H

G

P

I

V

F

L

S

S

K

G

G

P

F

A

D

V

E

E

L

R

-

I

-

N

D

N

K

S

Y

T

F

I

E

K

Q

E

I

L

F

V

T

V

T

T

D

N

S

S

I

I

K

K

E

L

V

P

D

E

H

E

K

K

G

K

V

I

T

E

Q

R

I

F

K

K

binding methyl phosphonic acid adenosine ester: R96 (= R84), Q97 (= Q85), R99 (= R87)

1ibsA Phosphoribosyldiphosphate synthetase in complex with cadmium ions (see paper)
24% identity, 90% coverage: 24:272/277 of query aligns to 33:272/297 of 1ibsA

query
sites
1ibsA

F

F

A

S

G

D

G

G

E

E

P

V

H

Q

I

I

K

N

I

I

S

E

N

E

N

S

F

I

D

R

A

G

A

C

L

D

P

C

I

Y

T

I

I

I

T

Q

H

S

R

T

I

S

N

D

S

P

F

V

N

N

D

E

-

H

L

I

G

M

L

E

I

L

C

L

I

I

T

M

V

V

D

D

A

A

L

L

K

K

R

R

M

A

G

S

V

A

K

K

E

T

I

I

H

N

L

I

F

V

I

I

P

P

Y

Y

F

Y

P

G

A

Y

A

A

R
|
R

Q
|
Q

D

D

R
|
R

V

K

M

-

I

-

P

S

G

R

E

E

P

P

L

I

S

T

V

A

K

K

V

L

Y

F

A

A

D

N

I

L

N

E

A

T

M

A

A

G

L

A

A

T

N

R

V

V

T

I

I

A

F

L

D

D

P

L

H
|
H

S

A

E

P

V

Q

S

I

P

Q

A

G

L

F

N

D

N

I

C

P

V

I

T

-

I

-

S

-

N

D

H

H

E

L

F

M

I

G

K

V

Q

P

V

I

I

L

-

G

-

E

-

Y

-

F

-

E

A

G

K

K

I

N

G

L

T

E

D

D

V

I

K

V

L

I

I

V

S

S

P

P

D

D

G

H

G

G

A

G

L

V

K

T

K

R

I

A

Y

R

K

K

V

L

S

A

E

D

F

R

L

L

D

K

G

-

A

A

E

P

V

I

I

A

E

I

C

I

S

D

K

K

S

R

R

M

D

N

V

I

K

-

T

-

G

-

K

-

L

-

S

-

G

-

F

-

K

-

V

-

Y

-

A

V

E

G

D

N

L

I

A

E

G

G

A

K

D

T

C

A

L

I

I

L

V

I

D

D

I

I

C

I

D
|
D

G
x
T

G
x
A

G

G

T
|
T

F

I

I

T

G

L

L

A

S

A

E

N

A

A

L

L

K

V

A

E

K

N

N

G

A

A

G

K

K

E

L

V

Y

Y

L

A

A

C

I

C

S

T

H

H

G

P

I

V

F

L

S

S

K

G

G

P

F

A

D

V

E

E

L

R

-

I

-

N

D

N

K

S

Y

T

F

I

E

K

Q

E

I

L

F

V

T

V

T

T

D

N

S

S

I

I

K

K

E

L

V

P

D

E

H

E

K

K

G

K

V

I

T

E

Q

R

I

F

K

K

binding methyl phosphonic acid adenosine ester: R94 (= R84), Q95 (= Q85), R97 (= R87), H126 (= H118)
binding sulfate ion: D209 (= D211), T210 (≠ G212), A211 (≠ G213), T213 (= T215)

Query Sequence

>CA265_RS03655 FitnessBrowser__Pedo557:CA265_RS03655
MLNLNPGFTPLGENNLIEYKSFLFAGGEPHIKISNNFDAALPITITHRINSFNDLGLICI
TVDALKRMGVKEIHLFIPYFPAARQDRVMIPGEPLSVKVYADIINAMALANVTIFDPHSE
VSPALLNNCVTISNHEFIKQVIAKIGTDVKLISPDGGALKKIYKVSEFLDGAEVIECSKS
RDVKTGKLSGFKVYAEDLAGADCLIVDDICDGGGTFIGLSEALKAKNAGKLYLAISHGIF
SKGFDELDKYFEQIFTTDSIKEVDHKGVTQIKLQKIL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory