SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing CA265_RS04075 FitnessBrowser__Pedo557:CA265_RS04075 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

5o5cB The crystal structure of dfoj, the desferrioxamine biosynthetic pathway lysine decarboxylase from the fire blight disease pathogen erwinia amylovora (see paper)
46% identity, 94% coverage: 19:502/513 of query aligns to 1:466/468 of 5o5cB

query
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5o5cB

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binding pyridoxal-5'-phosphate: G145 (= G165), T146 (= T166), H191 (= H210), T248 (= T267), D273 (= D292), A275 (= A294), D302 (= D321), H304 (= H323), K305 (= K324), T340 (= T373), T341 (= T374)

A7B1V0 Tryptophan decarboxylase; Trp decarboxylase; EC 4.1.1.105 from Ruminococcus gnavus (strain ATCC 29149 / VPI C7-9) (see paper)
30% identity, 80% coverage: 97:506/513 of query aligns to 91:490/490 of A7B1V0

query
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A7B1V0

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K306 (= K324) modified: N6-(pyridoxal phosphate)lysine

4obvC Ruminococcus gnavus tryptophan decarboxylase rumgna_01526 (alpha-fmt) (see paper)
30% identity, 79% coverage: 97:499/513 of query aligns to 76:464/471 of 4obvC

query
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4obvC

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A

F

G

T

T

T

K

V

I

L

N

N

Q

G

Q

K

F

T

Y

V

L

L

K

R

F

I

T

C

L

A

L

I

N

H

P
|
P

L
x
E

T

A

T

T

I

Q

S

E

D

D

I

M

E

Q

N

H

I

T

I

I

K

D

I

L

I

L

K

D

K

Q

H

Y

G

G

N

R

E

E

binding alpha-(fluoromethyl)-D-tryptophan: P87 (= P108), A88 (≠ I109), S90 (≠ I111), F294 (= F327), P444 (= P479), E445 (≠ L480)
binding {5-hydroxy-4-[(1E)-4-(1H-indol-3-yl)-3-oxobut-1-en-1-yl]-6-methylpyridin-3-yl}methyl dihydrogen phosphate: F83 (≠ H104), V84 (≠ L105), H105 (≠ S126), G144 (= G165), S145 (≠ T166), H177 (= H210), T234 (= T267), D259 (= D292), A261 (= A294), D288 (= D321), K291 (= K324), L321 (vs. gap), W331 (≠ V367), T338 (= T374)

4obuA Ruminococcus gnavus tryptophan decarboxylase rumgna_01526 (apo) (see paper)
29% identity, 80% coverage: 98:506/513 of query aligns to 77:462/462 of 4obuA

query
sites
4obuA

H

H

P

P

A

R

Y

F

I

F

A

S

H
x
F

L

V

N

P

C

G

P

P

I

A

V

S

I

S

P

V

A

S

V

W

A

L

A

G

E

D

V

I

M

M

I

T

S

S

A

A

I

Y

N

N

S

I

S

H

I

A

D

G

T

G

W

S

D

K

Q

L

S

A

A

P

G

M

G

V

T

N

L

C

I

I

E

E

Q

Q

K

E

L

V

I

L

E

K

W

W

T

L

C

A

D

K

Q

Q

I

V

G

G

Y

F

S

T

K

E

K

N

S

P

D

G

G

G

I

V

F

F

T

V

S

S

G

G

G
|
G

T
x
S

Q

M

S

A

N

N

L

I

M

T

G

A

L

L

L

T

L

A

A

A

R

R

D

D

H

N

Y

-

S

K

I

L

T

T

A

D

L

I

N

N

H

L

N

H

I

L

K

G

V

T

E

A

G

-

L

-

P

-

Q

-

E

-

A

-

S

-

R

-

F

-

R

-

I

-

F

Y

V

I

S

S

E

D

K

Q

A

T

H
|
H

F

S

S

S

I

V

Q

A

K

K

N

G

A

L

S

R

L

I

L

I

G

G

L

I

G

T

E

D

K

S

S

R

V

I

I

R

K

R

I

I

K

P

T

T

D

N

R

S

S

H

F

F

R

Q

M

M

N

D

T

T

V

T

L

K

L

L

E

E

D

E

A

A

I

I

K

E

R

T

E

D

I

K

A

K

Q

S

G

G

N

Y

I

I

P

P

I

F

A

V

I

V

V

I

G

G

T

T

A

A

G

G

T

T

T
|
T

D

N

F

T

G

G

N

S

V

I

D

D

P

P

L

L

K

T

E

E

L

I

A

S

S

A

I

L

S

C

K

K

K

K

Y

H

H

D

T

M

W

W

F

F

H

H

I

I

D
|
D

A

G

A
|
A

Y

Y

G

G

C

A

G

S

L

V

L

L

L

L

T

S

D

P

K

K

Y

Y

R

K

S

S

L

L

L

L

N

T

G

G

I

T

E

G

L

L

A

A

H

D

S

S

V

I

T

S

V

W

D

D

Y

A

H

H

K
|
K

S

W

F

L

F

F

Q

Q

P

T

V
x
Y

S

G

S

C

S

A

G

M

F

V

L

L

V

V

R

K

D

D

-

I

K

R

N

N

F

L

F

F

N

-

L

-

I

-

T

-

H

-

H

H

A

S

D

F

Y

H

L

V

N

N

P

P

K

E

D

-

H

-

D

-

E

-

D

-

G

-

L

-

P

-

N

-

Q

Y

V

L

N

D

K

I

S

G

I

M

Q

E

T

L

T

T

R

R

R

P

F

A

D

R

A

G

L

L

K

K

L

L

W

W

F

L

T

T

L

L

R

Q

M

V

M

L

G

G

R

S

N

D

K

L

L

I

G

G

G

S

Y

A

F

I

D

E

T

H

I

G

I

F

E

Q

T

L

A

A

A

V

K

W

I

A

A

E

D

E

L

A

L

L

H

N

A

P

D

K

S

K

D

D

F

W

E

E

L

I

M

V

N

S

E

P

S

A

D

Q

I

M

S

A

A

M

L

I

V

N

F

F

R

R

Y

Y

R

A

P

P

K

K

N

D

V

L

-

T

-

K

-

E

Q

E

L

Q

D

D

V

I

C

-

A

-

M

L

N

N

Q

E

Y

K

I

I

K

S

K

H

A

R

M

I

F

L

N

E

Q

S

G

G

K

Y

A

A

L

A

V

I

A

F

G

T

T

T

K

V

I

L

N

N

Q

G

Q

K

F

T

Y

V

L

L

K

R

F

I

T

C

L

A

L

I

N

H

P

P

L

E

T

A

T

T

I

Q

S

E

D

D

I

M

E

Q

N

H

I

T

I

I

K

D

I

L

I

L

K

D

K

Q

H

Y

G

G

N

R

E

E

-

I

Y

Y

V

T

R

E

L

M

N

K

Q

K

A

A

binding pyridoxal-5'-phosphate: F83 (≠ H104), G144 (= G165), S145 (≠ T166), H177 (= H210), T234 (= T267), D259 (= D292), A261 (= A294), K291 (= K324), Y297 (≠ V330)

Q05683 Glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform; EC 4.1.1.15 from Rattus norvegicus (Rat) (see 2 papers)
30% identity, 81% coverage: 87:499/513 of query aligns to 164:584/585 of Q05683

query
sites
Q05683

Q

Q

L

T

Y

T

T

L

S

K

H

Y

A

A

V

I

A

K

F

T

H

G

H

H

P

P

A

R

Y

Y

I

F

A

N

H

Q

L

L

N

S

C

T

P

G

I

L

V

D

I

M

P

V

A

G

V

L

A

A

A

A

E

D

V

W

M

L

I

T

S

S

A

T

I

A

N

N

S

T

S

N

I

M

D

F

T

T

W

Y

D

E

Q

I

S

A

A

P

G

V

G

F

T

V

L

L

I

L

E

E

Q

Y

K

V

L

T

I

L

E

K

W

K

T

M

C

R

D

E

Q

I

I

I

G

G

Y

W

S

P

K

G

K

G

S

S

-

G

D

D

G

G

I

I

F

F

T

S

S

P

G

G

G

G

T

A

Q

I

S

S

N

N

L

M

M

Y

G

A

L

M

L

L

L

I

A

A

R

R

D

-

H

-

Y

-

S

-

I

-

T

Y

A

K

L

M

N

F

H

P

N

E

I

V

K

K

V

E

E

K

G

G

L

M

P

-

Q

A

E

A

A

V

S

P

R

R

F

L

R

I

I

A

F

F

V

T

S

S

E

E

K

H

A

S

H

H

F

F

S

S

I

L

Q

K

K

K

N

G

A

A

S

A

L

A

L

L

G

G

L

I

G

G

E

T

K

D

S

S

V

V

I

I

K

L

I

I

K

K

T

C

D

D

R

E

S

R

F

G

R

K

M

M

N

I

T

P

V

S

L

D

L

L

E

E

D

R

A

R

I

I

K

L

R

E

E

V

I

K

A

Q

Q

K

G

G

N

F

I

V

P

P

I

F

A

L

I

V

V

S

G

A

T

T

A

A

G

G

T

T

T

T

D

V

F

Y

G

G

N

A

V

F

D

D

P

P

L

L

K

L

E

A

L

V

A

A

S

D

I

I

S

C

K

K

K

K

Y

Y

H

K

T

I

W

W

F

M

H

H

I

V

D

D

A

A

A

A

Y

W

G

G

C

G

G

G

L

L

L

L

L

M

T

S

D

R

K

K

Y

H

R

K

S

W

L

K

L

L

N

N

G

G

I

V

E

E

L

R

A

A

H

N

S

S

V

V

T

T

V

W

D

N

Y

P

H

H

K

K

S

M

F

M

F

G

Q

V

P

P

V

L

S

Q

S

C

S

S

G

A

F

L

L

L

V

V

R

R

D

E

K

E

N

G

F

L

F

M

N

Q

L

S

I

C

T

N

H

Q

-

M

H

H

A

A

D

S

Y

Y

L

L

N

F

P

Q

K

Q

D

D

H

K

D

H

E

Y

D

D

G

L

L

S

P

Y

N

D

Q

T

V

G

N

D

K

K

S

A

I

L

Q

Q

T

C

T

G

R

R

R

H

F

V

D

D

A

V

L

F

K

K

L

L

W

W

F

L

T

M

L

W

R

R

M

A

M

K

G

G

R

T

N

T

K

G

L

F

G

E

G

A

Y

H

F

I

D

D

T

K

I

C

I

L

E

E

T

L

A

A

A

E

K

Y

I

L

A

Y

D

N

L

I

L

I

H

K

A

N

D

R

S

E

D

G

F

Y

E

E

L

M

M

V

-

F

-

D

N

G

E

K

S

P

D

Q

I

H

S

T

A

N

L

V

V

C

F

F

R

W

Y

F

R

V

P

P

K

P

N

S

V

L

Q

R

L

V

-

L

-

E

-

D

-

N

-

E

-

E

-

R

-

M

-

S

D

R

V

L

C

S

A

K

M

V

N

A

Q

P

Y

V

I

I

K

K

K

A

A

R

M

M

F

M

N

E

Q

Y

G

G

K

T

A

T

L

M

V

V

A

S

-

Y

-

Q

-

P

-

L

G

G

T

D

K

K

I

V

N

N

Q

-

Q

-

F

-

Y

F

L

F

K

R

F

M

T

V

L

I

L

S

N

N

P

P

L

A

T

A

T

T

I

H

S

Q

D

D

I

I

E

D

N

F

I

L

I

I

K

E

I

E

I

I

K

E

K

R

H

L

G

G

N

Q

E

D

Sites not aligning to the query:

3 modified: Phosphoserine
6 modified: Phosphoserine
10 modified: Phosphoserine
10:17 SFGSEDGS→AFGAEDGA: No effect on glutamate decarboxylase activity.
13 modified: Phosphoserine
17 modified: Phosphoserine
30 modified: S-palmitoyl cysteine; C→A: Abolishes palmitoylation but not membrane-association; when associates with A-45. No effect on glutamate decarboxylase activity; when associated with A-45.
45 modified: S-palmitoyl cysteine; C→A: Abolishes palmitoylation but not membrane-association; when associates with A-30. No effect on glutamate decarboxylase activity; when associated with A-30.
73 C→S: No effect on palmitoylation.
75 C→S: No effect on palmitoylation.
80 C→S: No effect on palmitoylation.
82 C→S: No effect on palmitoylation.
101 C→S: No effect on palmitoylation.

Q05329 Glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform; EC 4.1.1.15 from Homo sapiens (Human) (see 3 papers)
30% identity, 81% coverage: 87:499/513 of query aligns to 164:584/585 of Q05329

query
sites
Q05329

Q

Q

L

T

Y

T

T

L

S

K

H

Y

A

A

V

I

A

K

F

T

H

G

H

H

P

P

A

R

Y

Y

I

F

A

N

H

Q

L

L

N

S

C

T

P

G

I

L

V

D

I

M

P

V

A

G

V

L

A

A

A

A

E

D

V

W

M

L

I

T

S

S

A

T

I

A

N

N

S

T

S

N

I

M

D

F

T

T

W

Y

D

E

Q

I

S

A

A

P

G

V

G

F

T

V

L

L

I

L

E

E

Q

Y

K

V

L

T

I

L

E

K

W

K

T

M

C

R

D

E

Q

I

I

I

G

G

Y

W

S

P

K

G

K

G

S

S

-

G

D

D

G

G

I

I

F

F

T

S

S

P

G

G

G

G

T

A

Q

I

S

S

N

N

L

M

M

Y

G

A

L

M

L

M

L

I

A

A

R

R

D

-

H

-

Y

-

S

-

I

-

T

F

A

K

L

M

N

F

H

P

N

E

I

V

K

K

V

E

E

K

G

G

L

M

P

-

Q

A

E

A

A

L

S

P

R

R

F

L

R

I

I

A

F

F

V

T

S

S

E

E

K

H

A

S

H

H

F

F

S

S

I

L

Q
x
K

K

K

N

G

A

A

S

A

L

A

L

L

G

G

L

I

G

G

E

T

K

D

S

S

V

V

I

I

K

L

I

I

K

K

T

C

D

D

R

E

S

R

F

G

R

K

M

M

N

I

T

P

V

S

L

D

L

L

E

E

D

R

A

R

I

I

K

L

R

E

E

A

I

K

A

Q

Q

K

G

G

N

F

I

V

P

P

I

F

A

L

I

V

V

S

G

A

T

T

A

A

G

G

T

T

T

T

D

V

F

Y

G

G

N

A

V

F

D

D

P

P

L

L

K

L

E

A

L

V

A

A

S

D

I

I

S

C

K

K

K

K

Y

Y

H

K

T

I

W

W

F

M

H

H

I

V

D

D

A

A

A

A

Y

W

G

G

C

G

G

G

L

L

L

L

L

M

T

S

D
x
R

K

K

Y

H

R

K

S

W

L

K

L

L

N

S

G

G

I

V

E

E

L

R

A

A

H

N

S

S

V

V

T

T

V

W

D

N

Y

P

H

H

K

K

S

M

F

M

F

G

Q

V

P

P

V

L

S

Q

S

C

S

S

G

A

F

L

L

L

V

V

R

R

D

E

K

E

N

G

F

L

F

M

-

Q

N

N

L

C

I

N

T

Q

H

M

H

H

A

A

D

S

Y

Y

L

L

N

F

P

Q

K

Q

D

D

H

K

D

H

E

Y

D

D

G

L

L

S

P

Y

N

D

Q

T

V

G

N

D

K

K

S

A

I

L

Q

Q

T

C

T

G

R

R

R

H

F

V

D

D

A

V

L

F

K

K

L

L

W

W

F

L

T

M

L

W

R

R

M

A

M

K

G

G

R

T

N

T

K

G

L

F

G

E

G

A

Y

H

F

V

D

D

T

K

I

C

I

L

E

E

T

L

A

A

A

E

K

Y

I

L

A

Y

D

N

L

I

L

I

H

K

A

N

D

R

S

E

D

G

F

Y

E

E

L

M

M

V

-

F

-

D

N

G

E

K

S

P

D

Q

I

H

S

T

A

N

L

V

V

C

F

F

R

W

Y

Y

R

I

P

P

K

P

N

S

V

L

Q

R

L

T

-

L

-

E

-

D

-

N

-

E

-

E

-

R

-

M

-

S

D

R

V

L

C

S

A

K

M

V

N

A

Q

P

Y

V

I

I

K

K

K

A

A

R

M

M

F

M

N

E

Q

Y

G

G

K

T

A

T

L

M

V

V

A

S

-

Y

-

Q

-

P

-

L

G

G

T

D

K

K

I

V

N

N

Q

-

Q

-

F

-

Y

F

L

F

K
x
R

F

M

T

V

L

I

L

S

N

N

P

P

L

A

T

A

T

T

I

H

S

Q

D

D

I

I

E

D

N

F

I

L

I

I

K

E

I

E

I

I

K

E

K

R

H

L

G

G

N

Q

E

D

K286 (≠ Q214) to R: in dbSNP:rs8190671
R375 (≠ D303) to Q: in dbSNP:rs8190730
R558 (≠ K473) binding

Sites not aligning to the query:

3 modified: Phosphoserine
3:13 SPGSGFWSFGS→APGAGFWAFGA: No effect on glutamate decarboxylase activity.
6 modified: Phosphoserine
10 modified: Phosphoserine
12 G → R: in dbSNP:rs8190591
13 modified: Phosphoserine
30 modified: S-palmitoyl cysteine
45 modified: S-palmitoyl cysteine
124 K → N: in dbSNP:rs8190600

Q80WP8 Acidic amino acid decarboxylase GADL1; Aspartate 1-decarboxylase; ADC; Cysteine sulfinic acid decarboxylase; CSADC; Glutamate decarboxylase-like protein 1; EC 4.1.1.11; EC 4.1.1.29 from Mus musculus (Mouse) (see paper)
30% identity, 78% coverage: 39:439/513 of query aligns to 86:479/550 of Q80WP8

query
sites
Q80WP8

V

M

T

E

Q

E

A

V

V

V

K

L

K

K

F

A

L

T

N

D

N

V

N

N

Q

E

Q

K

P

V

F

C

S

E

G

W

V

Q

S

P

P

P

S

E

K

Q

L

L

R

R

P

Q

L

L

F

L

D

D

S

-

I

L

E

E

F

M

E

R

K

D

T

T

H

G

D

E

N

S

Y

Q

D

D

A

K

L

L

L

L

K

K

E

L

V

C

E

Q

Q

D

L

V

Y

-

T

I

S

H

H

F

A

S

V

V

A

K

F

T

H

N

H

H

P

P

A

R

Y

F

I

F

A

N

H

Q

L

L

N

Y

C

A

P

G

I

L

V

D

I

Y

P

Y

A

S

V

L

A

A

A

A

E

R

V

I

M

I

I

T

S

E

A

A

I

L

N

N

S

P

S

S

I

I

D

Y

T

T

W

Y

D

E

Q

V

S

S

A

P

G

V

G

F

T

L

L

L

I

V

E

E

Q

E

K

A

L

V

I

L

E

K

W

K

T

M

C

I

D

E

Q

C

I

V

G

G

Y

W

S

-

K

K

K

E

S

G

D

D

G

G

I

I

F

F

T

N

S

P

G

G

G

G

T

S

Q

V

S

S

N

N

L

M

M

C

G

A

L

M

L

N

L

L

A

A

R

R

D

Y

H

R

Y

H

S

C

I

-

T

-

A

-

L

-

N

-

H

P

N

D

I

I

K

K

V

E

E

K

G

G

L

L

P

-

Q

S

E

G

A

L

S

P

R

R

F

L

R

I

I

L

F

F

V

T

S

S

E

A

K

E

A

C

H

H

F

Y

S

S

I

M

Q

K

K

K

N

A

A

A

S

S

L

F

L

L

G

G

L

I

G

G

E

T

K

Q

S

N

V

V

I

Y

K

F

I

V

K

E

T

T

D

D

R

G

S

R

F

G

R

K

M

M

N

I

T

P

V

E

L

D

L

L

E

E

D

K

A

Q

I

I

K

W

R

Q

E

A

I

R

A

Q

Q

E

G

G

N

A

I

V

P

P

I

F

A

L

I

V

V

C

G

A

T

T

A

S

G

G

T

T

T

T

D

V

F

L

G

G

N

A

V

F

D

D

P

P

L

L

K

D

E

E

L

I

A

A

S

E

I

V

S

C

K

E

K

R

Y

H

H

G

T

L

W

W

F

L

H

H

I

V

D

D

A

A

A

S

Y

W

G

G

C

G

G

S

L

A

L

L

L

V

T

S

D

R

K

K

Y

H

R

R

S

R

L

L

L

L

N

H

G

G

I

I

E

H

L

R

A

A

H

D

S

S

V

V

T

A

V

W

D

N

Y

P

H

H

K
|
K

S

M

F

L

F

M

Q

A

P

G

V

I

S

Q

S

C

S

S

G

A

F

L

L

L

V

V

R

K

D

D

K

K

N

S

-

D

-

L

F

L

F

K

N

K

L

C

I

Y

T

S

H

A

H

K

A

A

D

T

Y

Y

L

L

N

F

P

Q

K

Q

D

D

H

K

D

F

E

Y

D

D

G

V

L

S

P

Y

N

D

Q

T

V

G

N

D

K

K

S

S

I

I

Q

Q

T

C

T

S

R

R

R

R

F

P

D

D

A

A

L

F

K

K

L

F

W

W

F

M

T

T

L

W

R

K

M

A

M

L

G

G

R

T

N

S

K

G

L

L

G

E

G

E

Y

R

F

V

D

N

T

R

I

A

I

F

E

A

T

L

A

S

A

R

K

Y

I

L

A

V

D

D

L

E

L

I

H

K

A

K

D

R

S

E

D

G

F

F

E

K

L

L

M

L

N

M

E

E

S

P

D

E

I

Y

S

T

A

N

L

V

V

C

F

F

R

W

Y

Y

R

I

P

P

K

P

N

S

V

L

Q

R

K362 (= K324) modified: N6-(pyridoxal phosphate)lysine

6enzA Crystal structure of mouse gadl1 (see paper)
30% identity, 78% coverage: 39:439/513 of query aligns to 28:416/487 of 6enzA

query
sites
6enzA

V

M

T

E

Q

E

A

V

V

V

K

L

K

K

F

A

L

T

N

D

N

V

N

N

Q

E

Q

K

P

V

F

C

S

E

G

W

V

Q

S

P

P

P

S

E

K

Q

L

L

R

R

P

Q

L

L

F

L

D

D

S

-

I

L

E

E

F

M

E

R

K

D

T

T

H

G

D

E

N

S

Y

Q

D

D

A

K

L

L

L

L

K

K

E

L

V

C

E

Q

Q

D

L

V

Y

-

T

I

S

H

H

F

A

S

V

V

A

K

F

T

H

N

H

H

P

P

A

R

Y

F

I

F

A

N

H

Q

L

L

N

Y

C

A

P

G

I

L

V

D

I

Y

P

Y

A

S

V

L

A

A

A

A

E

R

V

I

M

I

I

T

S

E

A

A

I

L

N

N

S

P

S

S

I

I

D

Y

T

T

W

Y

D

E

Q

V

S

S

A

P

G

V

G

F

T

L

L

L

I

V

E

E

Q

E

K

A

L

V

I

L

E

K

W

K

T

M

C

I

D

E

Q

C

I

V

G

G

Y

W

S

-

K

K

K

E

S

G

D

D

G

G

I

I

F

F

T

N

S

P

G
|
G

G
|
G

T
x
S

Q

V

S

S

N

N

L

M

M

C

G

A

L

M

L

N

L

L

A

A

R

R

D

Y

H

R

Y

H

S

C

I

-

T

-

A

-

L

-

N

-

H

P

N

D

I

I

K

K

V

E

E

K

G

G

L

L

P

-

Q

S

E

G

A

L

S

P

R

R

F

L

R

I

I

L

F

F

V

T

S

S

E

A

K

E

A

C

H
|
H

F

Y

S

S

I

M

Q

K

K

K

N

A

A

A

S

S

L

F

L

L

G

G

L

I

G

G

E

T

K

Q

S

N

V

V

I

Y

K

F

I

V

K

E

T

T

D

D

R

G

S

R

F

G

R

K

M

M

N

I

T

P

V

E

L

D

L

L

E

E

D

K

A

Q

I

I

K

W

R

Q

E

A

I

R

A

Q

Q

E

G

G

N

A

I

V

P

P

I

F

A

L

I

V

V

C

G

A

T

T

A

S

G

G

T

T

T
|
T

D

V

F

L

G

G

N

A

V

F

D

D

P

P

L

L

K

D

E

E

L

I

A

A

S

E

I

V

S

C

K

E

K

R

Y

H

H

G

T

L

W

W

F

L

H

H

I

V

D
|
D

A

A

A
x
S

Y

W

G

G

C

G

G

S

L

A

L

L

L

V

T

S

D

R

K

K

Y

H

R

R

S

R

L

L

L

L

N

H

G

G

I

I

E

H

L

R

A

A

H

D

S

S

V

V

T

A

V

W

D

N

Y

P

H

H

K
|
K

S

M

F

L

F

M

Q

A

P

G

V

I

S

Q

S

C

S

S

G

A

F

L

L

L

V

V

R

K

D

D

K

K

N

S

F

D

F

L

N

L

L

K

I

K

T

C

H

Y

H

S

A

A

D

-

Y

-

L

-

N

K

P

A

K

T

D

D

H

K

D

F

E

Y

D

D

G

V

L

S

P

Y

N

D

Q

T

V

G

N

D

K

K

S

S

I

I

Q

Q

T

C

T

S

R

R

R

R

F

P

D

D

A

A

L

F

K

K

L

F

W

W

F

M

T

T

L

W

R

K

M

A

M

L

G

G

R

T

N

S

K

G

L

L

G

E

G

E

Y

R

F

V

D

N

T

R

I

A

I

F

E

A

T

L

A

S

A

R

K

Y

I

L

A

V

D

D

L

E

L

I

H

K

A

K

D

R

S

E

D

G

F

F

E

K

L

L

M

L

N

M

E

E

S

P

D

E

I

Y

S

T

A

N

L

V

V

C

F

F

R

W

Y

Y

R

I

P

P

K

P

N

S

V

L

Q

R

binding pyridoxal-5'-phosphate: G150 (= G164), G151 (= G165), S152 (≠ T166), H190 (= H210), T247 (= T267), D272 (= D292), S274 (≠ A294), K304 (= K324)

3vp6A Structural characterization of glutamic acid decarboxylase; insights into the mechanism of autoinactivation (see paper)
30% identity, 79% coverage: 92:497/513 of query aligns to 86:499/500 of 3vp6A

query
sites
3vp6A

H

Y

A

G

V

V

A

R

F

T

H

G

H

H

P

P

A

R

Y

F

I

F

A

N

H
x
Q

L
|
L

N
x
S

C

T

P

G

I

L

V

D

I

I

P

I

A

G

V

L

A

A

A

G

E

E

V

W

M

L

I

T

S

S

A

T

I

A

N

N

S

T

S

N

I

M

D
x
F

T

T

W

Y

D

E

Q

I

S

A

A

P

G

V

G

F

T

V

L

L

I

M

E

E

Q

Q

K

I

L

T

I

L

E

K

W

K

T

M

C

R

D

E

Q

I

I

V

G

G

Y

W

S

S

K

S

K

K

-

D

S

G

D

D

G

G

I

I

F

F

T

S

S

P

G

G

G

G

T

A

Q

I

S

S

N

N

L

M

M

Y

G

S

L

I

L

M

L

A

A

A

R

R

D

Y

H

K

Y

Y

S

F

I

-

T

-

A

-

L

-

N

-

H

P

N

E

I

V

K

K

V

T

E

K

G

G

L

M

P

A

Q

A

E

-

A

V

S

P

R

K

F

L

R

V

I

L

F

F

V

T

S

S

E

E

K

Q

A

S

H
|
H

F

Y

S

S

I

I

Q

K

K

K

N

A

A

G

S

A

L

A

L

L

G

G

L

F

G

G

E

T

K

D

S

N

V

V

I

I

K

L

I

I

K

K

T

C

D

N

R

E

S

R

F

G

R

K

M

I

N

I

T

P

V

A

L

D

L

F

E

E

D

A

A

K

I

I

K

L

R

E

E

A

I

K

A

Q

Q

K

G

G

N

Y

I

V

P

P

I

F

A

Y

I

V

V

N

G

A

T

T

A

A

G

G

T

T

T

T

D

V

F

Y

G

G

N

A

V

F

D

D

P

P

L

I

K

Q

E

E

L

I

A

A

S

D

I

I

S

C

K

E

K

K

Y

Y

H

N

T

L

W

W

F

L

H

H

I

V

D

D

A

A

A

A

Y

W

G

G

C

G

G

G

L

L

L

L

L

M

T

S

D

R

K

K

Y

H

R

R

S

H

L

K

L

L

N

N

G

G

I

I

E

E

L

R

A

A

H

N

S

S

V

V

T

T

V

W

D

N

Y

P

H

H

K
|
K

S

M

F

M

F

G

Q

V

P

L

V

L

S

Q

S

C

S

S

G

A

F

I

L

L

V

V

R

K

D

E

K

K

N

G

F

I

F

L

N

Q

L

G

I

C

T

N

H

Q

-

M

H

H

A

A

D

S

Y

Y

L
|
L

N

F

P

Q

K

Q

D

D

H

K

D

H

E

Y

D

D

G

V

L

S

P

Y

N

D

Q

T

V

G

N

D

K

K

S

A

I

I

Q

Q

T

C

T

G

R

R

R

H

F

V

D

D

A

I

L

F

K

K

L

F

W

W

F

L

T

M

L

W

R

K

M

A

M

K

G

G

R

T

N

V

K

G

L

F

G

E

G

N

Y

Q

F

I

D

N

T

K

I

C

I

L

E

E

T

L

A

A

A

E

K

Y

I

L

A

Y

D

A

L

K

L

I

H

K

A

N

D

R

S

E

D

E

F

F

E

E

L

M

M

V

-

F

-

N

N

G

E

E

S

P

D

E

I

H

S

T

A

N

L

V

V

C

F

F

R

W

Y

Y

R

I

P

P

K

Q

N

S

V

L

-

R

-

G

-

V

-

P

-

D

-

S

-

P

-

Q

-

R

Q

R

L

E

D

K

V

L

C

H

A

K

M

V

N

A

Q

P

Y

K

I

I

K

K

K

A

A

L

M

M

F

M

N

E

Q

S

G

G

K

T

A

T

L

M

V

V

A

G

-

Y

-

Q

-

P

-

Q

G

G

T

D

K

K

I

A

N

N

Q

-

Q

-

F

-

Y

F

L

F

K
x
R

F

M

T

V

L

I

L

S

N

N

P

P

L

A

T

A

T

T

I

Q

S

S

D

D

I

I

E

D

N

F

I

L

I

I

K

E

I

E

I

I

K

E

K

R

H

L

G

G

binding 4-oxo-4H-pyran-2,6-dicarboxylic acid: Q98 (≠ H104), L99 (= L105), S100 (≠ N106), F122 (≠ D128), H199 (= H210), K313 (= K324), L343 (= L353), R475 (≠ K473)

2okkA The x-ray crystal structure of the 65kda isoform of glutamic acid decarboxylase (gad65) (see paper)
29% identity, 81% coverage: 87:499/513 of query aligns to 77:483/483 of 2okkA

query
sites
2okkA

Q

Q

L

T

Y

T

T

L

S

K

H

Y

A

A

V

I

A

K

F

T

H

G

H

H

P

P

A

R

Y

Y

I

F

A

N

H
x
Q

L
|
L

N
x
S

C

T

P

G

I

L

V

D

I

M

P

V

A

G

V

L

A

A

A

A

E

D

V

W

M

L

I

T

S

S

A

T

I

A

N

N

S

T

S

N

I

M

D

F

T

T

W

Y

D

E

Q

I

S

A

A

P

G

V

G

F

T

V

L

L

I

L

E

E

Q

Y

K

V

L

T

I

L

E

K

W

K

T

M

C

R

D

E

Q

I

I

I

G

G

Y

W

S

P

K

G

K

G

S

S

-

G

D

D

G

G

I

I

F

F

T

S

S

P

G

G

G

G

T

A

Q

I

S

S

N

N

L

M

M

Y

G

A

L

M

L

M

L

I

A

A

R

R

D

-

H

-

Y

-

S

-

I

-

T

F

A

K

L

M

N

F

H

P

N

E

I

V

K

K

V

E

E

K

G

G

L

M

P

-

Q

A

E

A

A

L

S

P

R

R

F

L

R

I

I

A

F

F

V

T

S

S

E

E

K

H

A

S

H
|
H

F

F

S

S

I

L

Q

K

K

K

N

G

A

A

S

A

L

A

L

L

G

G

L

I

G

G

E

T

K

D

S

S

V

V

I

I

K

L

I

I

K

K

T

C

D

D

R

E

S

R

F

G

R

K

M

M

N

I

T

P

V

S

L

D

L

L

E

E

D

R

A

R

I

I

K

L

R

E

E

A

I

K

A

Q

Q

K

G

G

N

F

I

V

P

P

I

F

A

L

I

V

V

S

G

A

T

T

A

A

G

G

T

T

T

T

D

V

F

Y

G

G

N

A

V

F

D

D

P

P

L

L

K

L

E

A

L

V

A

A

S

D

I

I

S

C

K

K

K

K

Y

Y

H

K

T

I

W

W

F

M

H

H

I

V

D

D

A

A

A

A

Y

W

G

G

C

G

G

G

L

L

L

L

L

M

T

S

D

R

K

K

Y

H

R

K

S

W

L

K

L

L

N

S

G

G

I

V

E

E

L

R

A

A

H

N

S

S

V

V

T

T

V

W

D

N

Y

P

H

H

K
|
K

S

M

F

M

F

G

Q

V

P

P

V

L

S

Q

S

C

S

S

G

A

F

L

L

L

V

V

R

R

D

E

K

E

N

G

F

-

F

-

N

-

L

-

I

L

T

M

H

Q

H

N

A

C

D

N

Y

Q

L

M

N

H

P

D

K

L

D

S

H

Y

D

D

E

T

D

G

G

-

L

-

P

-

N

-

Q

-

V

-

N

D

K

K

S

A

I

L

Q

Q

T

C

T

G

R

R

R

H

F

V

D

D

A

V

L

F

K

K

L

L

W

W

F

L

T

M

L

W

R

R

M

A

M

K

G

G

R

T

N

T

K

G

L

F

G

E

G

A

Y

H

F

V

D

D

T

K

I

C

I

L

E

E

T

L

A

A

A

E

K

Y

I

L

A

Y

D

N

L

I

L

I

H

K

A

N

D

R

S

E

D

G

F

Y

E

E

L

M

M

V

-

F

-

D

N

G

E

K

S

P

D

Q

I

H

S

T

A

N

L

V

V

C

F

F

R

W

Y

Y

R

I

P

P

K

P

N

S

V

L

Q

R

L

T

D

L

V

E

C

E

A

R

M

M

N

S

Q

R

Y

L

-

S

-

K

-

V

-

A

-

P

-

V

I

I

K

K

K

A

A

R

M

M

F

M

N

E

Q

Y

G

G

K

T

A

T

L

M

V

V

A

S

-

Y

-

Q

-

P

-

L

G

G

T

D

K

K

I

V

N

N

Q

-

Q

-

F

-

Y

F

L

F

K
x
R

F

M

T

V

L

I

L

S

N

N

P

P

L

A

T

A

T

T

I

H

S

Q

D

D

I

I

E

D

N

F

I

L

I

I

K

E

I

E

I

I

K

E

K

R

H

L

G

G

N

Q

E

D

binding gamma-amino-butanoic acid: Q94 (≠ H104), L95 (= L105), L95 (= L105), S96 (≠ N106), H195 (= H210), K309 (= K324), R457 (≠ K473)

Q99259 Glutamate decarboxylase 1; 67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform; EC 4.1.1.15 from Homo sapiens (Human) (see 4 papers)
29% identity, 80% coverage: 92:499/513 of query aligns to 178:593/594 of Q99259

query
sites
Q99259

H

Y

A

G

V

V

A

R

F

T

H

G

H

H

P

P

A

R

Y

F

I

F

A

N

H
x
Q

L
|
L

N
x
S

C

T

P

G

I

L

V

D

I

I

P

I

A

G

V

L

A

A

A

G

E

E

V

W

M

L

I

T

S

S

A

T

I

A

N

N

S

T

S

N

I

M

D

F

T

T

W

Y

D

E

Q

I

S

A

A

P

G

V

G

F

T

V

L

L

I

M

E

E

Q

Q

K
x
I

L

T

I

L

E

K

W
x
K

T

M

C

R

D

E

Q

I

I

V

G

G

Y

W

S

S

K

S

K

K

-

D

S

G

D

D

G

G

I

I

F

F

T

S

S

P

G

G

G

G

T

A

Q

I

S

S

N

N

L

M

M

Y

G

S

L

I

L

M

L

A

A

A

R

R

D

Y

H

K

Y

Y

S

F

I

-

T

-

A

-

L

-

N

-

H

P

N

E

I

V

K

K

V

T

E

K

G

G

L

M

P

A

Q

A

E

-

A

V

S

P

R

K

F

L

R

V

I

L

F

F

V

T

S

S

E

E

K

Q

A

S

H

H

F

Y

S

S

I

I

Q

K

K

K

N

A

A

G

S

A

L

A

L

L

G

G

L

F

G

G

E

T

K

D

S

N

V

V

I

I

K

L

I

I

K

K

T

C

D

N

R

E

S

R

F

G

R

K

M

I

N

I

T

P

V

A

L

D

L

F

E

E

D

A

A

K

I

I

K

L

R

E

E

A

I

K

A

Q

Q

K

G

G

N

Y

I

V

P

P

I

F

A

Y

I

V

V

N

G

A

T

T

A

A

G

G

T

T

T

T

D

V

F

Y

G

G

N

A

V

F

D

D

P

P

L

I

K

Q

E

E

L

I

A

A

S

D

I

I

S

C

K

E

K

K

Y

Y

H

N

T

L

W

W

F

L

H

H

I

V

D

D

A

A

A

A

Y

W

G

G

C

G

G

G

L

L

L

L

L

M

T

S

D

R

K

K

Y

H

R

R

S

H

L

K

L

L

N

N

G

G

I

I

E

E

L

R

A

A

H

N

S

S

V

V

T

T

V

W

D

N

Y

P

H

H

K
|
K

S

M

F

M

F

G

Q

V

P

L

V

L

S

Q

S

C

S

S

G

A

F

I

L

L

V

V

R

K

D

E

K

K

N

G

F

I

F

L

N

Q

L

G

I

C

T

N

H

Q

H

M

-

C

A

A

D

G

Y

Y

L

L

N

F

P

Q

K

P

D

D

H

K

D

Q

E

Y

D

D

G

V

L

S

P

Y

N

D

Q

T

V

G

N

D

K

K

S

A

I

I

Q

Q

T

C

T

G

R

R

R

H

F

V

D

D

A

I

L

F

K

K

L

F

W

W

F

L

T

M

L

W

R

K

M

A

M

K

G

G

R

T

N

V

K

G

L

F

G

E

G

N

Y

Q

F

I

D

N

T

K

I

C

I

L

E

E

T

L

A

A

A

E

K

Y

I

L

A

Y

D

A

L

K

L

I

H

K

A

N

D

R

S

E

D

E

F

F

E

E

L

M

M

V

-

F

-

N

N

G

E

E

S

P

D

E

I

H

S

T

A

N

L

V

V

C

F

F

R

W

Y

Y

R

I

P

P

K

Q

N

S

V

L

-

R

-

G

-

V

-

P

-

D

-

S

-

P

-

Q

-
x
R

Q
x
R

L
x
E

D
x
K

V
x
L

C
x
H

A
x
K

M
x
V

N
x
A

Q
x
P

Y
x
K

I
|
I

K
|
K

K
x
A

A
x
L

M
|
M

F
x
M

N
x
E

Q
x
S

G
|
G

K
x
T

A
x
T

L
x
M

V
|
V

A
x
G

-
x
Y

-
x
Q

-
x
P

-
x
Q

G
|
G

T
x
D

K
|
K

I
x
A

N
|
N

Q

-

Q

-

F

-

Y
x
F

L
x
F

K
x
R

F
x
M

T
x
V

L
x
I

L
x
S

N
|
N

P
|
P

L
x
A

T
x
A

T
|
T

I
x
Q

S
|
S

D
|
D

I
|
I

E
x
D

N
x
F

I
x
L

I
|
I

K
x
E

I
x
E

I
|
I

K
x
E

K
x
R

H
x
L

G
|
G

N
x
Q

E
x
D

QLS 190:192 (≠ HLN 104:106) binding
I228 (≠ K142) to L: in dbSNP:rs45566933
K232 (≠ W146) natural variant: Missing (in DEE89; uncertain significance; no effect on protein abundance; no effect on splicing)
K405 (= K324) modified: N6-(pyridoxal phosphate)lysine
R532 (≠ Q439) to Q: in dbSNP:rs769402
R567 (≠ K473) binding

Sites not aligning to the query:

12 S → C: in dbSNP:rs121918345
531:594 natural variant: Missing (in DEE89; uncertain significance)

2okjB The x-ray crystal structure of the 67kda isoform of glutamic acid decarboxylase (gad67) (see paper)
29% identity, 80% coverage: 92:499/513 of query aligns to 86:501/504 of 2okjB

query
sites
2okjB

H

Y

A

G

V

V

A

R

F

T

H

G

H

H

P

P

A

R

Y

F

I

F

A

N

H
x
Q

L
|
L

N
x
S

C

T

P

G

I

L

V

D

I

I

P

I

A

G

V

L

A

A

A

G

E

E

V

W

M

L

I

T

S

S

A

T

I

A

N

N

S

T

S

N

I

M

D

F

T

T

W

Y

D

E

Q

I

S

A

A

P

G

V

G

F

T

V

L

L

I

M

E

E

Q

Q

K

I

L

T

I

L

E

K

W

K

T

M

C

R

D

E

Q

I

I

V

G

G

Y

W

S

S

K

S

K

K

-

D

S

G

D

D

G

G

I

I

F

F

T

S

S

P

G
|
G

G
|
G

T
x
A

Q

I

S

S

N

N

L

M

M

Y

G

S

L

I

L

M

L

A

A

A

R

R

D

Y

H

K

Y

Y

S

F

I

-

T

-

A

-

L

-

N

-

H

P

N

E

I

V

K

K

V

T

E

K

G

G

L

M

P

A

Q

A

E

-

A

V

S

P

R

K

F

L

R

V

I

L

F

F

V

T

S

S

E

E

K

Q

A

S

H
|
H

F

Y

S

S

I

I

Q

K

K

K

N

A

A

G

S

A

L

A

L

L

G

G

L

F

G

G

E

T

K

D

S

N

V

V

I

I

K

L

I

I

K

K

T

C

D

N

R

E

S

R

F

G

R

K

M

I

N

I

T

P

V

A

L

D

L

F

E

E

D

A

A

K

I

I

K

L

R

E

E

A

I

K

A

Q

Q

K

G

G

N

Y

I

V

P

P

I

F

A

Y

I

V

V

N

G

A

T

T

A

A

G

G

T

T

T
|
T

D

V

F

Y

G

G

N

A

V

F

D

D

P

P

L

I

K

Q

E

E

L

I

A

A

S

D

I

I

S

C

K

E

K

K

Y

Y

H

N

T

L

W

W

F

L

H

H

I

V

D
|
D

A

A

A
|
A

Y

W

G

G

C

G

G

G

L

L

L

L

L

M

T

S

D

R

K

K

Y

H

R

R

S

H

L

K

L

L

N

N

G

G

I

I

E

E

L

R

A

A

H

N

S

S

V

V

T

T

V

W

D
x
N

Y

P

H
|
H

K
|
K

S

M

F

M

F

G

Q

V

P

L

V

L

S

Q

S

C

S

S

G

A

F

I

L

L

V

V

R

K

D

E

K

K

N

G

F

I

F

L

N

Q

L

G

I

C

T

N

H

Q

H

M

-

C

A

A

D

G

Y

Y

L

L

N

F

P

Q

K

P

D

D

H

K

D

Q

E

Y

D

D

G

V

L

S

P

Y

N

D

Q

T

V

G

N

D

K

K

S

A

I

I

Q

Q

T

C

T

G

R

R

R

H

F

V

D

D

A

I

L

F

K

K

L

F

W

W

F

L

T

M

L

W

R

K

M

A

M

K

G

G

R

T

N

V

K

G

L

F

G

E

G

N

Y

Q

F

I

D

N

T

K

I

C

I

L

E

E

T

L

A

A

A

E

K

Y

I

L

A

Y

D

A

L

K

L

I

H

K

A

N

D

R

S

E

D

E

F

F

E

E

L

M

M

V

-

F

-

N

N

G

E

E

S

P

D

E

I

H

S

T

A

N

L

V

V

C

F

F

R

W

Y

Y

R

I

P

P

K

Q

N

S

V

L

-

R

-

G

-

V

-

P

-

D

-

S

-

P

-

Q

-

R

Q

R

L

E

D

K

V

L

C

H

A

K

M

V

N

A

Q

P

Y

K

I

I

K

K

K

A

A

L

M

M

F

M

N

E

Q

S

G

G

K

T

A

T

L

M

V

V

A

G

-

Y

-

Q

-

P

-

Q

G

G

T

D

K

K

I

A

N

N

Q

-

Q

-

F

-

Y

F

L

F

K
x
R

F

M

T

V

L

I

L

S

N

N

P

P

L

A

T

A

T

T

I

Q

S

S

D

D

I

I

E

D

N

F

I

L

I

I

K

E

I

E

I

I

K

E

K

R

H

L

G

G

N

Q

E

D

binding gamma-amino-butanoic acid: Q98 (≠ H104), L99 (= L105), S100 (≠ N106), R475 (≠ K473)
binding 4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]butanoic acid: L99 (= L105), G159 (= G164), G160 (= G165), A161 (≠ T166), H199 (= H210), T256 (= T267), D281 (= D292), A283 (= A294), N310 (≠ D321), H312 (= H323), K313 (= K324)

2jisB Human cysteine sulfinic acid decarboxylase (csad) in complex with plp.
26% identity, 90% coverage: 39:499/513 of query aligns to 23:486/487 of 2jisB

query
sites
2jisB

V

V

T

D

Q

E

A

A

V

I

K

Q

K

K

F

G

L

T

N

S

N

V

N

S

Q

Q

Q

K

P

V

F

C

S

E

G

W

V

K

S

E

P

P

S

E

K

E

L

L

R

K

P

Q

L

L

F

L

D

D

S

-

I

L

E

E

F

L

E

R

K

S

T

Q

H

G

D

E

N

S

Y

Q

D

K

A

Q

L

I

L

L

K

E

E

R

V

C

E

R

Q

A

L

V

Y

-

T

I

S

R

H

Y

A

S

V

V

A

K

F

T

H

G

H

H

P

P

A

R

Y

F

I

F

A

N

H

Q

L

L

N

F

C

S

P

G

I

L

V

D

I

P

P

H

A

A

V

L

A

A

A

G

E

R

V

I

M

I

I

T

S

E

A

S

I

L

N

N

S

T

S

S

I

Q

D

Y

T

T

W

Y

D

E

Q

I

S

A

A

P

G

V

G

F

T

V

L

L

I

M

E

E

Q

E

K

E

L

V

I

L

E

R

W

K

T

L

C

R

D

A

Q

L

I

V

G

G

Y

W

S

S

K

S

K

-

S

G

D

D

G

G

I

I

F

F

T

C

S

P

G
|
G

G
|
G

T
x
S

Q

I

S

S

N

N

L

M

M

Y

G

A

L

V

L

N

L

L

A

A

R

R

D

Y

H

Q

Y

R

S

Y

I

P

T

D

A

C

L

K

N

Q

H

R

N

G

I

L

K

R

V

T

E

-

G

-

L

L

P

P

Q

P

E

L

A

A

S

-

R

-

F

-

R

-

I

L

F

F

V

T

S

S

E

K

K

E

A

C

H

H

F

Y

S

S

I

I

Q

Q

K

K

N

G

A

A

S

A

L

F

L

L

G

G

L

L

G

G

E

T

K

D

S

S

V

V

I

R

K

V

I

V

K

K

T

A

D

D

R

E

S

R

F

G

R

K

M

M

N

V

T

P

V

E

L

D

L

L

E

E

D

R

A

Q

I

I

K

G

R

M

E

A

I

E

A

A

Q

E

G

G

N

A

I

V

P

P

I

F

A

L

I

V

V

S

G

A

T

T

A

S

G

G

T

T

T
|
T

D

V

F

L

G

G

N

A

V

F

D

D

P

P

L

L

K

E

E

A

L

I

A

A

S

D

I

V

S

C

K

Q

K

R

Y

H

H

G

T

L

W

W

F

L

H

H

I

V

D
|
D

A

A

A
|
A

Y

W

G

G

C

G

G

S

L

V

L

L

L

L

T

S

D

Q

K

T

Y

H

R

R

S

H

L

L

L

L

N

D

G

G

I

I

E

Q

L

R

A

A

H

D

S

S

V

V

T

A

V

W

D
x
N

Y

P

H

H

K
|
K

S

L

F

L

F

A

Q

A

P

G

V

L

S

Q

S

C

S

S

G

A

F

L

L

L

V

L

R

Q

D

D

K

T

N

S

F

-

F

-

N

N

L

L

I

L

T

K

H

R

-

C

-

H

-

G

-

S

H

Q

A

A

D

S

Y

Y

L

L

N

F

P

Q

K

Q

D

D

H

K

D

F

E

Y

D

D

G

V

L

A

P

L

N

D

Q

T

V

G

N

D

K

K

S

V

I

V

Q

Q

T
x
C

T
x
G

R

R

R

R

F

V

D

D

A

C

L

L

K

K

L

L

W

W

F

L

T

M

L

W

R

K

M

A

M

Q

G

G

R

D

N

Q

K

G

L

L

G

E

G

R

Y

R

F

I

D

D

T

Q

I

A

I

F

E

V

T

L

A

A

A

R

K

Y

I

L

A

V

D

E

L

E

L

M

H

K

A

K

D

R

S

E

D

G

F

F

E

E

L

L

M

V

N

M

E

E

S

P

D

E

I

F

S

V

A

N

L

V

V

C

F

F

R

W

Y

F

R

V

P

P

K

P

N

S

V

L

Q

R

L

G

D

K

-

Q

-

E

-

S

-

P

-

D

-

Y

-

H

-

E

-

R

V

L

C

S

A

K

M

V

N

A

Q

P

Y

V

I

L

K

K

K

E

A

R

M

M

F

V

N

K

Q

E

G

G

K

S

A

M

L

M

V

I

A

G

-

Y

-

Q

-

P

-

H

G

G

T

T

K

R

I

G

N

N

Q

-

Q

-

F

-

Y

F

L

F

K

R

F

V

T

V

L

V

L

A

N

N

P

S

L

A

T

L

T

T

I

C

S

A

D

D

I

M

E

D

N

F

I

L

I

L

K

N

I

E

I

L

K

E

K

R

H

L

G

G

N

Q

E

D

binding pyridoxal-5'-phosphate: G145 (= G164), G146 (= G165), S147 (≠ T166), T242 (= T267), D267 (= D292), A269 (= A294), N296 (≠ D321), K299 (= K324), C350 (≠ T373), G351 (≠ T374)

6zekA Crystal structure of mouse csad (see paper)
26% identity, 88% coverage: 39:487/513 of query aligns to 17:463/476 of 6zekA

query
sites
6zekA

V

V

T

D

Q

E

A

A

V

I

K

L

K

K

F

G

L

T

N

S

N

A

N

S

Q

E

Q

K

P

V

F

C

S

E

G

W

V

K

S

E

P

P

S

E

K

E

L

L

R

K

P

Q

L

L

F

L

D

D

S

-

I

L

E

E

F

L

E

Q

K

S

T

Q

H

G

D

E

N

S

Y

R

D

E

A

Q

L

I

L

L

K

E

E

R

V

C

E

R

Q

T

L

V

Y

-

T

I

S

H

H

Y

A

S

V

V

A

K

F

T

H

G

H

H

P

P

A

R

Y

F

I

F

A

N

H

Q

L

L

N

F

C

S

P

G

I

L

V

D

I

P

P

H

A

A

V

L

A

A

A

G

E

R

V

I

M

I

I

T

S

E

A

S

I

L

N

N

S

T

S

S

I

Q

D

Y

T

T

W

Y

D

E

Q

I

S

A

A

P

G

V

G

F

T

V

L

L

I

M

E

E

Q

E

K

E

L

V

I

L

E

K

W

K

T

L

C

R

D

A

Q

L

I

V

G

G

Y

W

S

N

K

S

K

-

S

G

D

D

G

G

I

V

F

F

T

C

S

P

G

G

G

G

T

S

Q

I

S

S

N

N

L

M

M

Y

G

A

L

M

L

N

L

L

A

A

R

R

D

F

H

Q

Y

R

S

Y

I

P

T

D

A

C

L

K

N

Q

H

R

N

G

I

L

K

R

V

-

E

-

G

A

L

L

P

P

Q

P

E

L

A

A

S

-

R

-

F

-

R

-

I

L

F

F

V

T

S

S

E

K

K

E

A

C

H

H

F

Y

S

S

I

I

Q

T

K

K

N

G

A

A

S

A

L

F

L

L

G

G

L

L

G

G

E

T

K

D

S

S

V

V

I

R

K

V

I

V

K

K

T

A

D

D

R

E

S

R

F

G

R

R

M

M

N

I

T

P

V

E

L

D

L

L

E

E

D

R

A

Q

I

I

K

I

R

L

E

A

I

E

A

A

Q

E

G

G

N

S

I

V

P

P

I

F

A

L

I

V

V

S

G

A

T

T

A

S

G

G

T

T

T

T

D

V

F

L

G

G

N

A

V

F

D

D

P

P

L

L

K

D

E

A

L

I

A

A

S

D

I

V

S

C

K

Q

K

R

Y

H

H

G

T

L

W

W

F

F

H

H

I

V

D

D

A

A

A

A

Y

W

G

G

C

G

G

S

L

V

L

L

L

L

T

S

D

R

K

T

Y

H

R

R

S

H

L

L

L

L

N

D

G

G

I

I

E

Q

L

R

A

A

H

D

S

S

V

V

T

A

V

W

D

N

Y

P

H

H

K

K

S

L

F

L

F

A

Q

A

P

G

V

L

S

Q

S

C

S

S

G

A

F

L

L

L

V

L

R

R

D

D

K

T

N

S

F

-

F

-

N

N

L

L

I

L

T

K

H

R

-

C

H

H

A

G

D

S

Y

Q

L

L

N

F

P

Q

K

Q

D

D

H

K

D

F

E

Y

D

D

G

V

L

A

P

L

N

D

Q

T

V

G

N

D

K

K

S

V

I

V

Q

Q

T

C

T

G

R

R

R

R

F

V

D

D

A

C

L

L

K

K

L

L

W

W

F

L

T

M

L

W

R

K

M

A

M

Q

G

G

R

G

N

Q

K

G

L

L

G

E

G

R

Y

R

F

I

D

D

T

Q

I

A

I

F

E

A

T

L

A

T

A

R

K

Y

I

L

A

V

D

E

L

E

L
x
I

H
x
K

A

K

D
x
R

S

E

D

G

F
|
F

E

E

L

L

M

V

N

M

E

E

S

P

D

E

I

F

S

V

A

N

L

V

V

C

F

F

R

W

Y

F

R

V

P

P

K

P

N

S

V

L

Q

R

-

G

-

K

-

K

-

E

-

S

-

P

-

D

-

Y

-

S

L

Q

D

R

V

L

C

S

A

Q

M

V

N

A

Q

P

Y

V

I

L

K

K

K

E

A

R

M

M

F

V

N

K

Q

K

G

G

K

T

A

M

L

M

V

I

A

-

G

G

T

Y

K

Q

I

P

N

H

Q

R

Q

A

F

N

Y

F

L

F

K

R

F

M

T

V

L

V

L

A

N

N

P

P

L

I

T

L

T

A

I

Q

S

A

D

D

I

I

E

D

binding cobalt (ii) ion: I380 (≠ L412), K381 (≠ H413), R383 (≠ D415), F386 (= F418)

4rlgD The clear crystal structure of pyridoxal-dependent decarboxylase from sphaerobacter thermophilus dsm 20745
28% identity, 84% coverage: 63:495/513 of query aligns to 45:467/470 of 4rlgD

query
sites
4rlgD

R

R

P

P

L

P

F

M

D

P

S

E

I

I

E

T

F

I

E

P

K

E

T

A

H

A

D

A

N

T

Y

E

D

A

A

T

L

L

L

L

K

Q

E

A

V

I

E

R

Q

D

L

M

Y

-

T

V

S

D

H

G

A

S

V

M

A

N

F

P

H

A

H

N

P

P

A

G

Y

Y

I

I

A

G

H

H

L

M

N

D

C

P

P

M

I

P

V

A

I

T

P

M

A

A

V

I

A

L

A

G

E

D

V

L

M

V

I

A

S

A

A

A

I

V

N

N

S

N

S

N

I

M

D

L

T

S

W

L

D

E

Q

M

S

S

A

P

G

S

G

F

T

S

L

R

I

L

E

E

Q

T

K

L

L

L

I

L

E

R

W

A

T

I

C

A

D

G

Q

L

I

F

G

G

Y

L

S

G

K

E

K

Q

S

A

D

G

G

G

I

V

F

L

T

T

S

S

G
|
G

G
|
G

T
x
S

Q

L

S

A

N

N

L

L

M

Q

G

A

L

L

L

A

L

V

A

A

R

R

D

N

H

-

Y

-

S

-

I

-

T

-

A

-

L

V

N

A

H

F

N

D

I

S

K

V

V

E

E

P

G

G

L

I

P

T

Q

G

E

L

A

A

S

Q

R

R

F

P

R

V

I

I

F

F

V

A

S
|
S

E

E

K

A

A
|
A

H
|
H

F
x
T

S

S

I

L

Q
|
Q

K

K

N

A

A

A

S

M

L

L

L

L

G

G

L

L

G

G

E

T

K

A

S

A

V

V

I

I

K

P

I

V

K

R

T

A

D

T

R

A

S

D

F

S

R

R

M

M

N

D

T

P

V

E

L

D

L

L

E

R

D

A

A

R

I

I

K

D

R

Q

E

A

I

R

A

G

Q

A

G

G

N

Q

I

H

P

P

I

F

A

C

I

V

V

V

G

A

T

T

A

A

G

G

T

T

T
|
T

D

T

F

T

G

G

N

N

V

I

D

D

P

P

L

L

K

A

E

E

L

I

A

G

S

A

I

I

S

A

K

R

K

E

Y

H

H

G

T

L

W

W

F

F

H

H

I

V

D
|
D

A

A

A
|
A

Y

Y

G

G

C

G

G

A

L

L

L

V

L

F

T

S

D

E

K

R

Y

H

R

R

S

W

L

R

L

L

N

A

G

G

I

I

E

E

L

Q

A

A

H

D

S

S

V

I

T

T

V

F

D
x
N

Y

P

H

Q

K
|
K

S

W

F

L

F

Y

Q

V

P

A

V

K

S

T

S

C

S

A

G

M

F

V

L

L

V

F

R

R

D

D

K

A

N

G

F

-

F

-

N

-

L

-

I

V

T

L

H

E

H

R

A

A

D

F

Y

R

L

I

N

P

P

P

K

Y

D

M

H

R

D

A

E

T

D

D

G

G

L

F

P

I

N

N

Q

L

V

G

N

E

K

I

S

G

I

V

Q

Q

T

G

T

T

R

R

R

H

F

A

D

D

A

V

L

V

K

K

L

L

W

W

F

L

T

T

L

L

R

Q

M

H

M

I

G

G

R

Q

N

Q

K

G

L

Y

G

A

G

R

Y

L

F

I

D

D

T

D

I

G

I

Y

E

R

T

L

A

A

A

E

K

R

I

V

A

V

D

E

L

G

L

V

H

R

A

Q

D

R

S

P

D

F

F

L

E

R

L

L

M

A

N

G

E

E

S

I

D

D

I

T

S

N

A

I

L

V

V

C

F

F

R

R

Y

G

R

E

P

P

K

D

N

W

V

L

Q

P

L

A

D

E

V

R

C

W

-

D

A

D

M

W

N

N

Q

A

Y

A

I

L

K

Q

K

A

A

L

M

L

F

L

N

R

Q

E

G

G

K

K

A

I

L

F

V

L

A

S

G

L

T

P

K

V

I

Y

N

R

Q

G

Q

G

F

R

Y

W

L

L

K

R

F

A

T

V

L

L

L

L

N

N

P

P

L

Y

T

T

T

T

I

D

S

A

D

V

I

I

E

D

N

A

I

M

I

F

K

K

I

Q

I

I

K

D

K

R

binding gamma-amino-butanoic acid: S181 (= S206), A184 (= A209), A184 (= A209), H185 (= H210), H185 (= H210), T186 (≠ F211), T186 (≠ F211), Q189 (= Q214)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G145 (= G164), G146 (= G165), S147 (≠ T166), H185 (= H210), T242 (= T267), D267 (= D292), A269 (= A294), N296 (≠ D321), K299 (= K324)

4rizC The crystal structure of y333q mutant pyridoxal-dependent decarboxylase from sphaerobacter thermophilus dsm 20745
29% identity, 78% coverage: 98:495/513 of query aligns to 83:472/476 of 4rizC

query
sites
4rizC

H

N

P

P

A

G

Y

Y

I

I

A

G

H

H

L

M

N

D

C

P

P

M

I

P

V

A

I

T

P

M

A

A

V

I

A

L

A

G

E

D

V

L

M

V

I

A

S

A

A

A

I

V

N

N

S

N

S

N

I

M

D

L

T

S

W

L

D

E

Q

M

S

S

A

P

G

S

G

F

T

S

L

R

I

L

E

E

Q

T

K

L

L

L

I

L

E

R

W

A

T

I

C

A

D

G

Q

L

I

F

G

G

Y

L

S

G

K

E

K

Q

S

A

D

G

G

G

I

V

F

L

T

T

S

S

G
|
G

G
|
G

T
x
S

Q

L

S

A

N

N

L

L

M

Q

G

A

L

L

L

A

L

V

A

A

R

R

D

N

H

-

Y

-

S

-

I

-

T

-

A

-

L

V

N

A

H

F

N

D

I

S

K

V

V

E

E

P

G

G

L

I

P

T

Q

G

E

L

A

A

S

Q

R

R

F

P

R

V

I

I

F

F

V

A

S

S

E

E

K

A

A

A

H
|
H

F

T

S

S

I

L

Q

Q

K

K

N

A

A

A

S

M

L

L

L

L

G

G

L

L

G

G

E

T

K

A

S

A

V

V

I

I

K

P

I

V

K

R

T

A

D

T

R

A

S

D

F

S

R

R

M

M

N

D

T

P

V

E

L

D

L

L

E

R

D

A

A

R

I

I

K

D

R

Q

E

A

I

R

A

G

Q

A

G

G

N

Q

I

H

P

P

I

F

A

C

I

V

V

V

G

A

T

T

A

A

G

G

T

T

T
|
T

D

T

F

T

G

G

N

N

V

I

D

D

P

P

L

L

K

A

E

E

L

I

A

G

S

A

I

I

S

A

K

R

K

E

Y

H

H

G

T

L

W

W

F

F

H

H

I

V

D
|
D

A

A

A
|
A

Y

Y

G

G

C

G

G

A

L

L

L

V

L

F

T

S

D

E

K

R

Y

H

R

R

S

W

L

R

L

L

N

A

G

G

I

I

E

E

L

Q

A

A

H

D

S

S

V

I

T

T

V

F

D
x
N

Y

P

H

Q

K
|
K

S

W

F

L

F

Y

Q

V

P

A

V

K

S

T

S

C

S

A

G

M

F

V

L

L

V

F

R

R

D

D

K

A

N

-

F

-

F

-

N

G

L

V

I

L

T

E

H

R

H

A

A

F

D

R

Y

I

L

P

N

A

P

P

K

Q

D

M

H

R

D

A

E

T

D

D

G

G

L

F

P

I

N

N

Q

L

V

G

N

E

K

I

S

G

I

V

Q

Q

T

G

T

T

R

R

R

H

F

A

D

D

A

V

L

V

K

K

L

L

W

W

F

L

T

T

L

L

R

Q

M

H

M

I

G

G

R

Q

N

Q

K

G

L

Y

G

A

G

R

Y

L

F

I

D

D

T

D

I

G

I

Y

E

R

T

L

A

A

A

E

K

R

I

V

A

V

D

E

L

G

L

V

H

R

A

Q

D

R

S

P

D

F

F

L

E

R

L

L

M

A

N

G

E

E

S

I

D

D

I

T

S

N

A

I

L

V

V

C

F

F

R

R

Y

G

R

E

P

P

K

D

N

W

V

L

Q

P

L

A

D

E

V

R

C

W

-

D

A

D

M

W

N

N

Q

A

Y

A

I

L

K

Q

K

A

A

L

M

L

F

L

N

R

Q

E

G

G

K

K

A

I

L

F

V

L

A

S

G

L

T

P

K

V

I

Y

N

R

Q

G

Q

G

F

R

Y

W

L

L

K

R

F

A

T

V

L

L

L

L

N

N

P

P

L

Y

T

T

T

T

I

D

S

A

D

V

I

I

E

D

N

A

I

M

I

F

K

K

I

Q

I

I

K

D

K

R

binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G149 (= G164), G150 (= G165), S151 (≠ T166), H189 (= H210), T246 (= T267), D271 (= D292), A273 (= A294), N300 (≠ D321), K303 (= K324)

8oraA Human holo aromatic l-amino acid decarboxylase (aadc) external aldimine with l-dopa methylester (see paper)
24% identity, 88% coverage: 49:502/513 of query aligns to 25:476/480 of 8oraA

query
sites
8oraA

N

E

N

G

Q

R

Q

Q

P

V

F

Y

S

P

G

D

V

V

S

E

P

P

S

G

K

Y

L

L

R

R

P

P

L

L

F

I

D

P

S

A

I

A

E

A

F

P

E

Q

K

E

T

P

H

-

D

D

N

T

Y

F

D

E

A

D

L

I

L

I

K

N

E

D

V

V

E

E

Q

K

L

I

Y

I

T

M

S

P

H

G

A

V

V

T

A

H

F

W

H

H

H

S

P

P

A

Y

Y

F

I

F

A

A

H
x
Y

L
x
F

N

P

C

T

P

A

I

S

V

S

I

Y

P

P

A

A

V

M

A

L

A

A

E

D

V

M

M

L

I

C

S

G

A

A

I

I

N

G

S

C

S

I

I

G

D

F

T

S

W

W

D

A

Q

A

S

S

A

P

G

A

G

C

T

T

L

E

I

L

E

E

Q

T

K

V

L

M

I

M

E

D

W

W

T

L

C

G

D

K

Q

M

I

L

G

E

Y

L

S

P

K

K

-

A

-

F

-

L

-

N

-

E

-

K

-

A

-

G

K

E

S

G

D

G

G

G

I

V

F

I

T

Q

S

G

G
x
S

G
x
A

T
x
S

Q

E

S

A

N

T

L

L

M

V

G

A

L

L

L

L

L

A

A

A

R

R

D

-

H

-

Y

-

S

-

I

-

T

T

A

K

L

V

N

I

H

H

N

R

I

L

K

Q

V

A

E

A

G

S

-

P

-

E

L

L

P

T

Q

Q

E

A

A

A

-

I

-

M

S

E

R

K

F

L

R

V

I

A

F

Y

V

S

S

S

E

D

K

Q

A

A

H
|
H

F

S

S

S

I

V

Q

E

K

R

N

A

A

G

S

L

L

I

L

G

G

G

L

V

G

K

E

L

K

K

S

A

V

-

I

-

K

-

I

I

K

P

T

S

D

D

R

G

S

N

F

F

R

A

M

M

N

R

T

A

V

S

L

A

L

L

E

Q

D

E

A

A

I

L

K

E

R

R

E

D

I

K

A

A

Q

A

G

G

N

L

I

I

P

P

I

F

A

F

I

M

V

V

G

A

T

T

A

L

G

G

T

T

T
|
T

D

T

F

C

G

C

N

S

V

F

D

D

P

N

L

L

K

L

E

E

L

V

A

G

S

P

I

I

S

C

K

N

K

K

Y

E

H

D

T

I

W

W

F

L

H

H

I

V

D
|
D

A

A

A
|
A

Y

Y

G

A

C

G

G

S

L

A

L

F

L

I

T

C

D

P

K

E

Y

F

R

R

S

H

L

L

L

L

N

N

G

G

I

V

E

E

L

F

A

A

H

D

S

S

V

F

T

N

V

F

D
x
N

Y

P

H
|
H

K
|
K

S

W

F

L

F

L

Q

V

P

N

V

F

S

D

S

C

S

S

G

A

F

M

L

W

V

V

R

K

D

K

K

R

-

T

N

D

F

L

F

T

N

G

L

A

I

F

T

R

H

L

H

D

A

P

D

T

Y

Y

L

L

N

K

P

H

K

S

D

H

H

Q

D

D

E

S

D

G

G

L

L

I

P

T

N

D

Q

Y

V

R

N

H

K

W

S

Q

I

I

Q

P

T

L

T

G

R

R

R

R

F

F

D

R

A

S

L

L

K

K

L

M

W

W

F

F

T

V

L

F

R

R

M

M

M

Y

G

G

R

V

N

K

K

G

L

L

G

Q

G

A

Y

Y

F

I

D

R

T

K

I

H

I

V

E

Q

T

L

A

S

A

H

K

E

I

F

A

E

D

S

L

L

L

V

H

R

A

Q

D

D

S

P

D

R

F

F

E

E

L

I

M

C

N

V

E

E

S

V

D

I

I

L

S

G

A

L

L

V

V

C

F

F

R

R

Y

L

R

K

P

G

K

S

N

N

V

-

Q

-

L

-

D

-

V

-

C

-

A

K

M

V

N

N

Q

E

Y

A

I

L

K

L

K

Q

A

R

M

I

F

N

N

S

Q

A

G

K

K

K

A

I

L

H

V

L

A

V

G

P

T

C

K

H

I

L

N

R

Q

D

Q

K

F

F

Y

V

L

L

K

R

F

F

T

A

L

I

L

C

N

S

P

R

L

T

T

V

T

E

I

S

S

A

D

H

I

V

E

Q

N

R

I

A

I

W

K

E

I

H

I

I

K

K

K

E

H

L

G

A

N

A

E

D

Y

V

V

L

R

R

binding pyridoxal-5'-phosphate: F80 (≠ L105), S147 (≠ G164), A148 (≠ G165), S149 (≠ T166), H192 (= H210), T246 (= T267), D271 (= D292), A273 (= A294), N300 (≠ D321), H302 (= H323), K303 (= K324)
binding methyl (2~{R})-2-azanyl-3-[3,4-bis(oxidanyl)phenyl]propanoate: Y79 (≠ H104), H192 (= H210), T246 (= T267), K303 (= K324)

P20711 Aromatic-L-amino-acid decarboxylase; AADC; DOPA decarboxylase; DDC; EC 4.1.1.28 from Homo sapiens (Human) (see 8 papers)
24% identity, 88% coverage: 49:502/513 of query aligns to 25:476/480 of P20711

query
sites
P20711

N

E

N

G

Q

R

Q

Q

P

V

F

Y

S

P

G

D

V

V

S

E

P

P

S

G

K

Y

L

L

R

R

P

P

L

L

F

I

D

P

S

A

I

A

E

A

F

P

E

Q

K

E

T

P

H

-

D

D

N

T

Y

F

D

E

A

D

L

I

L

I

K

N

E

D

V

V

E
|
E

Q

K

L

I

Y

I

T

M

S

P

H

G

A

V

V

T

A

H

F

W

H

H

H

S

P

P

A

Y

Y

F

I

F

A

A

H

Y

L

F

N

P

C

T

P

A

I

S

V

S

I

Y

P

P

A

A

V

M

A

L

A

A

E

D

V

M

M

L

I

C

S

G

A

A

I

I

N

G

S

C

S

I

I

G

D

F

T

S

W

W

D

A

Q

A

S

S

A

P

G

A

G

C

T

T

L

E

I

L

E

E

Q

T

K

V

L

M

I

M

E

D

W

W

T

L

C

G

D

K

Q

M

I

L

G

E

Y

L

S

P

K

K

-

A

-

F

-

L

-

N

-

E

-

K

-

A

-

G

K

E

S

G

D

G

G

G

I

V

F

I

T

Q

S

G

G

S

G
x
A

T
x
S

Q

E

S

A

N

T

L

L

M

V

G

A

L

L

L

L

L

A

A

A

R

R

D

-

H

-

Y

-

S

-

I

-

T

T

A

K

L

V

N

I

H

H

N

R

I

L

K

Q

V

A

E

A

G

S

-

P

-

E

L

L

P

T

Q

Q

E

A

A

A

-

I

-

M

S

E

R

K

F

L

R

V

I

A

F

Y

V

S

S

S

E

D

K

Q

A

A

H

H

F

S

S

S

I

V

Q

E

K

R

N

A

A

G

S

L

L

I

L

G

G

G

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E

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A

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-

I

-

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x
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A

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F

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Y

L

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P

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S

N

N

V

-

Q

-

L

-

D

-

V

-

C

-

A

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M

V

N

N

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E

Y

A

I

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A

R

M

I

F

N

N

S

Q

A

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A

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V

L

A

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G

P

T

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H

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N

R

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D

Q

K

F

F

Y

V

L

L

K

R

F

F

T

A

L

I

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N

S

P

R

L

T

T

V

T

E

I

S

S

A

D

H

I

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E

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x
R

I

A

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E61 (= E86) to D: in dbSNP:rs11575292
A148 (≠ G165) binding
S149 (≠ T166) binding
P210 (≠ K231) to L: in dbSNP:rs6262
M217 (= M238) to V: in dbSNP:rs6263
M239 (≠ I260) to I: in dbSNP:rs11575377; to L: in dbSNP:rs11575376
T246 (= T267) binding
N300 (≠ D321) binding
K303 (= K324) modified: N6-(pyridoxal phosphate)lysine
R462 (≠ N488) to Q: in dbSNP:rs11575542

Sites not aligning to the query:

17 M → V: in dbSNP:rs6264

P05031 Aromatic-L-amino-acid decarboxylase; AADC; DOPA decarboxylase; DDC; EC 4.1.1.28 from Drosophila melanogaster (Fruit fly) (see 3 papers)
26% identity, 89% coverage: 43:499/513 of query aligns to 52:505/510 of P05031

query
sites
P05031

V

I

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Y

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F

F

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E

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S

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A

L

L

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V

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F

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R

Y

L

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P

G

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S

N

N

V

E

Q

R

L

-

D

-

V

-

C

-

A

-

M

-

N

N

Q

E

Y

A

I

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K

L

K

K

A

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M

I

F

N

N

G

Q

R

G

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L

A

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P

T

A

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N

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D

Q

V

F

Y

Y

F

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A

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C

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S

P

R

L

F

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I
x
S

S

E

D

D

I

M

E

E

N

Y

I

S

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S

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A

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A

G

A

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D

E

E

T117 (≠ C107) binding ; mutation to A: Decreased specific activity to L-DOPA. Increased specific activity to 5-HTP. Decreased ligand binding affinity.; mutation to S: Increased specific activity to L-DOPA and 5-HTP. Decreased ligand binding affinity.
A183 (≠ G165) binding
S184 (≠ T166) binding
K197 (≠ N186) to N: in allele Ddc-R9
H227 (= H210) active site; binding ; binding ; mutation to N: Enzymatic shift from L-dopa decarboxylation of to L-Dopa decarboxylation-oxidative deamination.; mutation to W: Decreased specific activity to L-DOPA and 5-HTP. Decreased ligand binding affinity.
V264 (≠ I251) to M: in allele Ddc-R11 and allele Ddc-R18
D305 (= D292) binding
N334 (≠ D321) binding
358:384 (vs. 344:372, 27% identical) Disordered
R390 (≠ D378) to M: in allele Ddc-Ore
S428 (= S416) to F: in allele Ddc-R33
S489 (≠ I483) to A: in allele Ddc-2b

Sites not aligning to the query:

12 T → P: in allele Ddc-R6, allele Ddc-R9, allele Ddc-R16, allele Ddc-R20, allele Ddc-R25 and allele Ddc-R30

7xinA Crystal structure of dodc from pseudomonas
25% identity, 86% coverage: 57:496/513 of query aligns to 33:469/470 of 7xinA

query
sites
7xinA

V

V

S

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P

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A

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A

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x
F

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A

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A

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L

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G

K

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D

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x
T

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x
A

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x
S

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T

L

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H

H

binding pyridoxal-5'-phosphate: F80 (≠ L105), T139 (≠ G164), A140 (≠ G165), S141 (≠ T166), H181 (= H210), T238 (= T267), D263 (= D292), A265 (= A294), N292 (≠ D321), H294 (= H323), K295 (= K324)

Query Sequence

>CA265_RS04075 FitnessBrowser__Pedo557:CA265_RS04075
MFTSDLEKHELIDFLTESPTKEIFHHENEAEYLHAVGKVTQAVKKFLNNNQQPFSGVSPS
KLRPLFDSIEFEKTHDNYDALLKEVEQLYTSHAVAFHHPAYIAHLNCPIVIPAVAAEVMI
SAINSSIDTWDQSAGGTLIEQKLIEWTCDQIGYSKKSDGIFTSGGTQSNLMGLLLARDHY
SITALNHNIKVEGLPQEASRFRIFVSEKAHFSIQKNASLLGLGEKSVIKIKTDRSFRMNT
VLLEDAIKREIAQGNIPIAIVGTAGTTDFGNVDPLKELASISKKYHTWFHIDAAYGCGLL
LTDKYRSLLNGIELAHSVTVDYHKSFFQPVSSSGFLVRDKNFFNLITHHADYLNPKDHDE
DGLPNQVNKSIQTTRRFDALKLWFTLRMMGRNKLGGYFDTIIETAAKIADLLHADSDFEL
MNESDISALVFRYRPKNVQLDVCAMNQYIKKAMFNQGKALVAGTKINQQFYLKFTLLNPL
TTISDIENIIKIIKKHGNEYVRLNQASADFRRN

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory