SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing CA265_RS04990 FitnessBrowser__Pedo557:CA265_RS04990 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

A0A140FAN3 11-beta-hydroxysteroid dehydrogenase; 17-beta-hydroxysteroid dehydrogenase; Steroleosin; EC 1.1.1.146; EC 1.1.1.62 from Pinus massoniana (Chinese red pine) (see paper)
34% identity, 92% coverage: 2:250/272 of query aligns to 44:292/356 of A0A140FAN3

query
sites
A0A140FAN3

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Sites not aligning to the query:

206:356 mutation Missing: Loss of binding to plant derived cholesterol, cholest-5-en-3beta-ol.

Q9P7B4 NADP-dependent 3-hydroxy acid dehydrogenase; L-allo-threonine dehydrogenase; EC 1.1.1.381 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
33% identity, 86% coverage: 3:235/272 of query aligns to 4:238/259 of Q9P7B4

query
sites
Q9P7B4

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S42 (≠ V40) modified: Phosphoserine
T43 (= T41) modified: Phosphothreonine

H9XP47 Meso-2,3-butanediol dehydrogenase; BDH; meso-2,3-BDH; (R,S)-butane-2,3-diol dehydrogenase; NAD(H)-dependent meso-2,3-BDH; SmBdh; EC 1.1.1.- from Serratia marcescens (see paper)
33% identity, 70% coverage: 1:191/272 of query aligns to 1:188/251 of H9XP47

query
sites
H9XP47

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N15 (≠ S15) binding
M17 (≠ I17) binding
D36 (≠ A36) binding
D60 (= D63) binding
V61 (= V64) binding
N87 (= N90) binding
S138 (= S141) binding ; binding
V139 (≠ I142) mutation to Q: Retains 50% of activity with acetoin as substrate; when associated with A-247.
S140 (≠ A143) binding
Y151 (= Y154) binding ; binding ; binding
K155 (= K158) binding
V184 (≠ T187) binding
T186 (≠ S189) binding

Sites not aligning to the query:

197:199 RDK→SEAAGKPLGYGTET: Mimics longer alpha6 helix. Retains 3% of activity with acetoin as substrate.
247 Q→A: Retains 10% of activity with acetoin as substrate. Retains 50% of activity with acetoin as substrate; when associated with Q-139.

1edoA The x-ray structure of beta-keto acyl carrier protein reductase from brassica napus complexed with NADP+ (see paper)
36% identity, 68% coverage: 7:191/272 of query aligns to 3:188/244 of 1edoA

query
sites
1edoA

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active site: G12 (= G16), S138 (= S141), Y151 (= Y154), K155 (= K158)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G12), S10 (= S14), R11 (≠ S15), I13 (= I17), N31 (≠ L34), Y32 (≠ A35), A33 (= A36), R34 (= R37), S35 (≠ Q38), D59 (= D63), V60 (= V64), N86 (= N90), A87 (= A91), S138 (= S141), Y151 (= Y154), K155 (= K158), P181 (= P184), G182 (= G185), I184 (≠ T187), S186 (= S189), M188 (≠ I191)

4nbuB Crystal structure of fabg from bacillus sp (see paper)
32% identity, 69% coverage: 3:189/272 of query aligns to 5:187/244 of 4nbuB

query
sites
4nbuB

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active site: G18 (= G16), N111 (= N114), S139 (= S141), Q149 (≠ R151), Y152 (= Y154), K156 (= K158)
binding acetoacetyl-coenzyme a: D93 (≠ R96), K98 (≠ D101), S139 (= S141), N146 (≠ L148), V147 (≠ P149), Q149 (≠ R151), Y152 (= Y154), F184 (= F186)
binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G12), N17 (≠ S15), G18 (= G16), I19 (= I17), D38 (≠ T41), F39 (≠ L42), V59 (≠ A62), D60 (= D63), V61 (= V64), N87 (= N90), A88 (= A91), G89 (= G92), I90 (≠ L93), T137 (≠ V139), S139 (= S141), Y152 (= Y154), K156 (= K158), P182 (= P184), F184 (= F186), T185 (= T187), T187 (≠ S189)

Sites not aligning to the query:

P73574 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-acyl carrier protein reductase; EC 1.1.1.100 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
36% identity, 69% coverage: 3:191/272 of query aligns to 4:193/247 of P73574

query
sites
P73574

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I

L

I

V

T

T

G

G

A
|
A

S

S

S

R

G

G

I

I

G

G

K

K

A

A

C

T

A

A

E

L

E

A

F

L

A

A

K

A

R

T

G

G

A

M

N

K

L

V

V

V

L

V

A

N

A

Y

R

A

Q

Q

Y

S

V

S

T

T

L

A

C

A

E

D

I

A

T

V

A

V

D

A

L

E

E

I

K

I

K

A

Y

N

N

G

I

G

R

E

A

A

V

I

A

A

V

V

Q

Q

A

A

D

N

V

V

S

A

K

N

E

A

T

D

D

E

C

V

E

D

L

Q

I

L

I

I

K

K

Q

T

A

T

L

L

V

D

S

K

F

F

Q

S

K

R

I

I

D

D

V

V

L

L

V

V

N

N

A

A

G

G

L

I

S

T

M

R

R

D

A

T

L

L

F

L

N

L

D

R

L

M

D

K

L

L

S

E

V

D

L

W

K

Q

N

A

L

V

M

I

D

D

V

L

N

N

F

L

W

T

G

G

T

V

V

F

Y

L

C

C

T

T

K

K

Y

A

A

V

L

S

P

K

E

L

I

M

L

L

K

K

T

Q

K

K

-

S

G

G

T

R

V

I

G

N

V

I

S

T

S

S

I

V

A

A

G

G

F

M

R

M

G

G

L

N

P
|
P

G

G

R

Q

T

A

G

N

Y

Y

S

S

A

A

S

A

K
|
K

F

A

A

G

M

V

N

I

G

G

F

F

M

T

E

K

S

T

L

V

R

A

T

K

E

E

L

L

L

A

K

S

T

R

G

G

V

V

N

T

V

V

L

N

L

A

A

V

C

A

P

P

G

G

F
|
F

T

I

A

A

S

T

N

D

I

M

A14 (= A13) mutation to G: 4.2-fold increase in activity on acetoacetyl-CoA.
P151 (= P149) mutation to F: 2.7-fold increase in activity on acetoacetyl-CoA.; mutation to V: 5.7-fold increase in activity on acetoacetyl-CoA.
K160 (= K158) mutation to A: Almost no activity on acetoacetyl-CoA.
F188 (= F186) mutation to Y: 3.3-fold increase in activity on acetoacetyl-CoA.

Sites not aligning to the query:

198 N→R: 3.5-fold increase in activity on acetoacetyl-CoA.

6vspB Structure of serratia marcescens 2,3-butanediol dehydrogenase mutant q247a (see paper)
33% identity, 69% coverage: 3:191/272 of query aligns to 5:190/252 of 6vspB

query
sites
6vspB

L

F

K

D

E

N

K

K

V

V

I

V

I

I

T

T

G
|
G

A

A

S

G

S
x
N

G
|
G

I

M

G

G

K

E

A

A

C

A

A

A

E

R

F

F

A

S

K

A

R

E

G

G

A

A

N

I

L

V

V

V

L

L

A

A

A
x
D

R
x
W

Q

A

Y

K

V

E

T

A

L

V

C

D

E

K

I

V

T

A

A

A

D

S

L

L

E

P

K

K

K

G

Y

-

N

-

I

-

R

R

A

A

V

M

A

A

V

V

Q

H

A
x
I

D
|
D

V
|
V

S

S

K

D

E

H

T

V

D

A

C

V

E

E

L

K

I

M

K

N

Q

E

A

V

L

A

V

E

S

K

F

L

Q

G

K

R

I

I

D

D

V

V

L

L

V

L

N

N

A

A

G
|
G

L

V

S

H

M

V

R

A

A

G

L

S

F

V

N

L

D

E

L

T

D

S

L

I

S

D

V

D

L

W

K

R

N

R

L

I

M

A

D

G

V

V

N

D

F

I

W

D

G

G

T

V

V

V

Y

F

C

C

T

S

K

K

Y

F

A

A

L

L

P

P

E

H

I

L

L

L

K

K

T

T

K

K

G

G

T

C

V

I

V

V

G

N

V

T

S

A

S
|
S

I

V

A

S

G

G

F

L

R

G

G

G

L

D

P

W

G

G

R

A

T

A

G

Y

Y
|
Y

S

C

A

A

S

A

K

K

F

G

A

A

M

V

N

V

G

N

F

L

M

T

E

R

S

A

L

M

R

A

T

L

E

D

L

H

L

G

K

G

T

D

G

G

V

V

N

R

V

I

L

N

L

S

A

V

C

C

P

P

G

S

F

L

T

V

A

K

S

T

N

N

I

M

active site: G18 (= G16), S140 (= S141), Y153 (= Y154)
binding adenosine-5'-diphosphate: G14 (= G12), N17 (≠ S15), D38 (≠ A36), W39 (≠ R37), I61 (≠ A62), D62 (= D63), V63 (= V64), G91 (= G92)

6vspA Structure of serratia marcescens 2,3-butanediol dehydrogenase mutant q247a (see paper)
33% identity, 69% coverage: 3:191/272 of query aligns to 3:188/251 of 6vspA

query
sites
6vspA

L

F

K

D

E

N

K

K

V

V

I

V

I

I

T

T

G
|
G

A

A

S

G

S
x
N

G
|
G

I
x
M

G

G

K

E

A

A

C

A

A

A

E

R

F

F

A

S

K

A

R

E

G

G

A

A

N

I

L

V

V

V

L

L

A

A

A
x
D

R
x
W

Q
x
A

Y

K

V

E

T

A

L

V

C

D

E

K

I

V

T

A

A

A

D

S

L

L

E

P

K

K

K

G

Y

-

N

-

I

-

R

R

A

A

V

M

A

A

V

V

Q

H

A
x
I

D
|
D

V
|
V

S

S

K

D

E

H

T

V

D

A

C

V

E

E

L

K

I

M

K

N

Q

E

A

V

L

A

V

E

S

K

F

L

Q

G

K

R

I

I

D

D

V

V

L

L

V

L

N

N

N
|
N

A
|
A

G
|
G

L
x
V

S

H

M

V

R

A

A

G

L

S

F

V

N

L

D

E

L

T

D

S

L

I

S

D

V

D

L

W

K

R

N

R

L

I

M

A

D

G

V
|
V

N

D

F

I

W

D

G

G

T

V

V

V

Y

F

C

C

T

S

K

K

Y

F

A

A

L

L

P

P

E

H

I

L

L

L

K

K

T

T

K

K

G

G

T

C

V

I

V

V

G

N

V
x
T

S

A

S
|
S

I

V

A

S

G

G

F

L

R

G

G

G

L

D

P

W

G

G

R

A

T

A

G

Y

Y
|
Y

S

C

A

A

S

A

K
|
K

F

G

A

A

M

V

N

V

G

N

F

L

M

T

E

R

S

A

L

M

R

A

T

L

E

D

L

H

L

G

K

G

T

D

G

G

V

V

N

R

V

I

L

N

L

S

A

V

C

C

P
|
P

G
x
S

F
x
L

T
x
V

A

K

S
x
T

N
|
N

I
x
M

active site: G16 (= G16), S138 (= S141), Y151 (= Y154)
binding nicotinamide-adenine-dinucleotide: G12 (= G12), N15 (≠ S15), G16 (= G16), M17 (≠ I17), D36 (≠ A36), W37 (≠ R37), W37 (≠ R37), A38 (≠ Q38), I59 (≠ A62), D60 (= D63), V61 (= V64), N87 (= N90), A88 (= A91), G89 (= G92), V90 (≠ L93), V110 (= V113), T136 (≠ V139), S138 (= S141), Y151 (= Y154), K155 (= K158), P181 (= P184), S182 (≠ G185), L183 (≠ F186), V184 (≠ T187), T186 (≠ S189), N187 (= N190), M188 (≠ I191)

Sites not aligning to the query:

binding nicotinamide-adenine-dinucleotide: 189

6xewA Structure of serratia marcescens 2,3-butanediol dehydrogenase (see paper)
33% identity, 69% coverage: 3:191/272 of query aligns to 3:188/251 of 6xewA

query
sites
6xewA

L

F

K

D

E

N

K

K

V

V

I

V

I

I

T

T

G
|
G

A

A

S

G

S
x
N

G
|
G

I
x
M

G

G

K

E

A

A

C

A

A

A

E

R

F

F

A

S

K

A

R

E

G

G

A

A

N

I

L

V

V

V

L

L

A

A

A
x
D

R
x
W

Q
x
A

Y

K

V

E

T

A

L

V

C

D

E

K

I

V

T

A

A

A

D

S

L

L

E

P

K

K

K

G

Y

-

N

-

I

-

R

R

A

A

V

M

A

A

V

V

Q

H

A
x
I

D
|
D

V
|
V

S

S

K

D

E

H

T

V

D

A

C

V

E

E

L

K

I

M

K

N

Q

E

A

V

L

A

V

E

S

K

F

L

Q

G

K

R

I

I

D

D

V

V

L

L

V

L

N

N

N
|
N

A
|
A

G
|
G

L

V

S

H

M

V

R

A

A

G

L

S

F

V

N

L

D

E

L

T

D

S

L

I

S

D

V

D

L

W

K

R

N

R

L

I

M

A

D

G

V
|
V

N

D

F

I

W

D

G

G

T

V

V

V

Y

F

C

C

T

S

K

K

Y

F

A

A

L

L

P

P

E

H

I

L

L

L

K

K

T

T

K

K

G

G

T

C

V

I

V

V

G

N

V
x
T

S

A

S
|
S

I

V

A
x
S

G

G

F

L

R

G

G

G

L

D

P

W

G

G

R

A

T

A

G

Y

Y
|
Y

S

C

A

A

S

A

K
|
K

F

G

A

A

M

V

N

V

G

N

F

L

M

T

E

R

S

A

L

M

R

A

T

L

E

D

L

H

L

G

K

G

T

D

G

G

V

V

N

R

V

I

L

N

L

S

A

V

C

C

P

P

G
x
S

F
x
L

T
x
V

A

K

S
x
T

N
|
N

I
x
M

active site: G16 (= G16), S138 (= S141), Y151 (= Y154)
binding r,3-hydroxybutan-2-one: S138 (= S141), S140 (≠ A143), Y151 (= Y154)
binding s,3-hydroxybutan-2-one: S138 (= S141), Y151 (= Y154), S182 (≠ G185)
binding nicotinamide-adenine-dinucleotide: G12 (= G12), N15 (≠ S15), G16 (= G16), M17 (≠ I17), D36 (≠ A36), W37 (≠ R37), W37 (≠ R37), A38 (≠ Q38), I59 (≠ A62), D60 (= D63), V61 (= V64), N87 (= N90), A88 (= A91), G89 (= G92), V110 (= V113), T136 (≠ V139), S138 (= S141), Y151 (= Y154), K155 (= K158), S182 (≠ G185), L183 (≠ F186), V184 (≠ T187), T186 (≠ S189), N187 (= N190), M188 (≠ I191)

Sites not aligning to the query:

binding nicotinamide-adenine-dinucleotide: 189

4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
32% identity, 70% coverage: 1:191/272 of query aligns to 1:192/247 of 4jroC

query
sites
4jroC

M

M

N

T

L

L

K

Q

E

G

K

K

V

V

I

A

I

V

T

T

G
|
G

A

G

S
|
S

S
x
R

G
|
G

I
|
I

G

G

K

R

A

D

C

I

A

A

E

I

E

N

F

L

A

A

K

K

R

E

G

G

A

A

N

N

L

I

V

F

L

F

A
x
N

A
x
Y

R
x
N

Q
x
G

Y
x
S

V

P

T

E

L

A

C

A

E

E

I

E

T

T

A

A

D

K

L

L

E

V

K

A

K

E

Y

H

N

G

I

V

R

E

A

V

V

E

A

A

V

M

Q

K

A

A

D
x
N

V
|
V

S

A

K

I

E

A

T

E

D

D

C

V

E

D

L

A

I

F

K

K

Q

Q

A

A

L

I

V

E

S

R

F

F

Q

G

K

R

I

V

D

D

V

I

L

L

V

V

N

N

N
|
N

A
|
A

G

G

L
x
I

S

T

M

R

R

D

A

N

L

L

F

L

N

M

D

R

L

M

D

K

L

E

S

D

V

E

L

W

K

D

N

D

L

V

M

I

D

N

V
x
I

N

N

F

L

W

K

G

G

T

T

V

F

Y

L

C

C

T

T

K

K

Y

A

A

V

L

S

P

R

E

T

I

M

L

M

K

K

T

Q

K

R

-

A

G

G

T

K

V

I

G

N

V

M

S

A

S
|
S

I

V

A

V

G

G

F

L

R

I

G

G

L

N

P

A

G

G

R
x
Q

T

A

G

N

Y
|
Y

S

V

A

A

S

S

K
|
K

F

A

A

G

M

V

N

I

G

G

F

L

M

T

E

K

S

T

L

T

R

A

T

R

E

E

L

L

L

A

K

P

T

R

G

G

V

I

N

N

V

V

L

N

L

A

A

V

C

A

P
|
P

G

G

F

F

T
x
I

A

T

S
x
T

N

D

I

M

active site: G16 (= G16), S142 (= S141), Q152 (≠ R151), Y155 (= Y154), K159 (= K158)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G12), S14 (= S14), R15 (≠ S15), G16 (= G16), I17 (= I17), N35 (≠ A35), Y36 (≠ A36), N37 (≠ R37), G38 (≠ Q38), S39 (≠ Y39), N63 (≠ D63), V64 (= V64), N90 (= N90), A91 (= A91), I93 (≠ L93), I113 (≠ V113), S142 (= S141), Y155 (= Y154), K159 (= K158), P185 (= P184), I188 (≠ T187), T190 (≠ S189)

Q05016 NADP-dependent 3-hydroxy acid dehydrogenase; L-allo-threonine dehydrogenase; EC 1.1.1.-; EC 1.1.1.381 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
31% identity, 86% coverage: 3:235/272 of query aligns to 11:248/267 of Q05016

query
sites
Q05016

L

L

K

A

E

K

K

K

V

T

I

V

I

L

I

I

T

T

G

G

A

A

S

S

S

A

G

G

I

I

G

G

K

K

A

A

C

T

A

A

E

L

E

E

F

Y

-

L

-

E

A

A

K

S

R

N

G

G

-

D

A

M

N

K

L

L

V

I

L

L

A

A

R

R

Q

R

Y

L

V

E

T

K

L

L

C

E

E

E

I

L

T

K

A

K

D

T

L

I

E

D

K

Q

K

E

Y

F

-

P

N

N

I

A

R

K

A

V

V

H

A

V

V

A

Q

Q

A

L

D

D

V

I

S

T

K

Q

E

A

T

E

D

K

C

I

E

K

L

P

I

F

I

I

K

E

Q

N

A

L

L

P

V

Q

S

E

F

F

Q

K

K

D

I

I

D

D

V

I

L

L

V

V

N

N

N
|
N

A

A

G

G

L

-

S

-

M

-

R

K

A

A

L

L

F

G

N

S

D

D

-

R

-

V

-

G

-

Q

L

I

D

A

L

T

S

E

V

D

L

I

K

Q

N

D

L

V

M

F

D

D

V

T

N

N

F

V

W

T

G

A

T

L

V

I

Y

N

C

I

T

T

K

Q

Y

A

A

V

L

L

P

P

E

I

I

F

-

Q

L

A

K

K

T

N

K

S

G

G

T

D

V

I

V

V

G

N

V

L

S

G

S

S

I

I

A

A

G

G

F

R

R

D

G

A

L

Y

P

P

G

T

R

G

T

S

G

I

Y
|
Y

S

C

A

A

S

S

K
|
K

F

F

A

A

M

V

N

G

G

A

F

F

M

T

E

D

S

S

L

L

R

R

T

K

E

E

L

L

L

I

K

N

T

T

G

K

V

I

N

R

V

V

L

I

L

L

A

I

C

A

P

P

G

G

F

L

T

V

A

E

S

T

N

E

I

F

R

S

V

L

T

V

A

R

L

Y

S

R

K

G

D

N

G

E

A

E

A

Q

H

A

G

K

E

N

T

V

S

Y

M

K

D

D

E

T

G

T

K

P

M

L

M

M

T

-

S

A

E

D

V

V

A

A

S

D

I

L

I

I

A

V

D

Y

G

A

I

T

E

S

K

R

R

K

K

Q

R

N

T

T

L

V

I

I

N102 (= N90) binding
Y168 (= Y154) binding
K172 (= K158) binding

3rkuA Substrate fingerprint and the structure of NADP+ dependent serine dehydrogenase from saccharomyces cerevisiae complexed with NADP+
31% identity, 86% coverage: 3:235/272 of query aligns to 12:249/268 of 3rkuA

query
sites
3rkuA

L

L

K

A

E

K

K

K

V

T

I

V

I

L

I

I

T

T

G
|
G

A

A

S
|
S

S

A

G
|
G

I
|
I

G

G

K

K

A

A

C

T

A

A

E

L

E

E

F

Y

-

L

-

E

A

A

K

S

R

N

G

G

-

D

A

M

N

K

L

L

V

I

L

L

A

A

R
|
R

Q
x
R

Y

L

V

E

T

K

L

L

C

E

E

E

I

L

T

K

A

K

D

T

L

I

E

D

K

Q

K

E

Y

F

-

P

N

N

I

A

R

K

A

V

V

H

A

V

V

A

Q

Q

A

L

D
|
D

V
x
I

S

T

K

Q

E

A

T

E

D

K

C

I

E

K

L

P

I

F

I

I

K

E

Q

N

A

L

L

P

V

Q

S

E

F

F

Q

K

K

D

I

I

D

D

V

I

L

L

V

V

N

N

N
|
N

A
|
A

G
|
G

L

-

S

-

M

-

R
x
K

A
|
A

L

L

F

G

N

S

D

D

-

R

-

V

-

G

-

Q

L

I

D

A

L

T

S

E

V

D

L

I

K

Q

N

D

L

V

M

F

D

D

V

T

N
|
N

F

V

W

T

G

A

T

L

V

I

Y

N

C

I

T

T

K

Q

Y

A

A

V

L

L

P

P

E

I

I

F

-

Q

L

A

K

K

T

N

K

S

G

G

T

D

V

I

V

V

G

N

V

L

S

G

S
|
S

I

I

A

A

G

G

F

R

R

D

G

A

L

Y

P

P

G

T

R

G

T

S

G

I

Y
|
Y

S

C

A

A

S

S

K
|
K

F

F

A

A

M

V

N

G

G

A

F

F

M

T

E

D

S

S

L

L

R

R

T

K

E

E

L

L

L

I

K

N

T

T

G

K

V

I

N

R

V

V

L

I

L

L

A

I

C

A

P
|
P

G
|
G

F

L

T
x
V

A

E

S
x
T

N
x
E

I
x
F

R

S

V

L

T

V

A

R

L

Y

S

R

K

G

D
x
N

G

E

A

E

A

Q

H

A

G

K

E

N

T

V

S

Y

M

K

D

D

E

T

G

T

K

P

M

L

M

M

T

-

S

A

E

D

V

V

A

A

S

D

I

L

I

I

A

V

D

Y

G

A

I

T

E

S

K

R

R

K

K

Q

R

N

T

T

L

V

I

I

active site: A107 (= A97), N128 (= N114), S156 (= S141), Y169 (= Y154), K173 (= K158), N214 (≠ D199)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G21 (= G12), S23 (= S14), G25 (= G16), I26 (= I17), R49 (= R37), R50 (≠ Q38), D76 (= D63), I77 (≠ V64), N103 (= N90), A104 (= A91), G105 (= G92), K106 (≠ R96), S156 (= S141), Y169 (= Y154), K173 (= K158), P199 (= P184), G200 (= G185), V202 (≠ T187), T204 (≠ S189), E205 (≠ N190), F206 (≠ I191)

5itvA Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
32% identity, 68% coverage: 1:186/272 of query aligns to 3:186/255 of 5itvA

query
sites
5itvA

M

M

N

N

L

L

K

T

E

D

K

K

V

T

I

V

I

L

I

I

T

T

G
|
G

A

G

S

A

S
|
S

G
|
G

I
|
I

G

G

K

Y

A

A

C

A

A

V

E

Q

E

A

F

F

A

L

K

G

R

Q

G

Q

A

A

N

N

L

V

V

V

L

V

A

A

A
x
D

R

-

Q

-

Y

-

V
x
I

T

D

L

E

C

A

E

Q

I

G

T

E

A

A

D

M

L

V

E

R

K

K

K

E

Y

N

N

N

I

D

R

R

A

L

V

H

A

F

V

V

Q

Q

A
x
T

D

D

V
x
I

S

T

K

D

E

E

T

A

D

A

C

C

E

Q

L

H

I

A

I

V

K

E

Q

S

A

A

L

V

V

H

S

T

F

F

Q

G

K

G

I

L

D

D

V

V

L

L

V

I

N

N

N
|
N

A

A

G
|
G

L

I

S

E

M

I

R

V

A

A

L

P

F

I

N

H

D

E

L

M

D

E

L

L

S

S

V

D

L

W

K

N

N

K

L

V

M

L

D

Q

V

V

N

N

F

L

W

T

G

G

T

M

V

F

Y

L

C

M

T

S

K

K

Y

H

A

A

L

L

P

K

E

H

I

M

L

L

K

A

T

A

-

G

K

K

G

G

T

N

V

I

G

N

V
x
T

S

C

S
|
S

I

V

A

G

G

G

F

L

R

V

G

A

L

W

P

P

G

D

R

I

T

P

G

A

Y
|
Y

S

N

A

A

S

S

K
|
K

F

G

A

G

M

V

N

L

G

Q

F

L

M

T

E

K

S

S

L

M

R

A

T

V

E

D

L

Y

L

A

K

K

T

H

G

Q

V

I

N

R

V

V

L

N

L

C

A

V

C

C

P
|
P

G
|
G

F
x
I

active site: G18 (= G16), S141 (= S141), Y154 (= Y154), K158 (= K158)
binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G12), S17 (= S15), G18 (= G16), I19 (= I17), D38 (≠ A36), I39 (≠ V40), T61 (≠ A62), I63 (≠ V64), N89 (= N90), G91 (= G92), T139 (≠ V139), S141 (= S141), Y154 (= Y154), K158 (= K158), P184 (= P184), G185 (= G185), I186 (≠ F186)

Sites not aligning to the query:

binding 1,4-dihydronicotinamide adenine dinucleotide: 187

5itvD Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
32% identity, 68% coverage: 1:186/272 of query aligns to 3:186/227 of 5itvD

query
sites
5itvD

M

M

N

N

L

L

K

T

E

D

K

K

V

T

I

V

I

L

I

I

T

T

G
|
G

A

G

S

A

S
|
S

G
|
G

I
|
I

G

G

K

Y

A

A

C

A

A

V

E

Q

E

A

F

F

A

L

K

G

R

Q

G

Q

A

A

N

N

L

V

V

V

L

V

A

A

A
x
D

R

-

Q

-

Y

-

V
x
I

T

D

L

E

C

A

E

Q

I

G

T

E

A

A

D

M

L

V

E

R

K

K

K

E

Y

N

N

N

I

D

R

R

A

L

V

H

A

F

V

V

Q

Q

A
x
T

D
|
D

V
x
I

S

T

K

D

E

E

T

A

D

A

C

C

E

Q

L

H

I

A

I

V

K

E

Q

S

A

A

L

V

V

H

S

T

F

F

Q

G

K

G

I

L

D

D

V

V

L

L

V

I

N

N

N
|
N

A

A

G

G

L

I

S

E

M

I

R

V

A

A

L

P

F

I

N

H

D

E

L

M

D

E

L

L

S

S

V

D

L

W

K

N

N

K

L

V

M

L

D

Q

V

V

N

N

F

L

W

T

G

G

T

M

V

F

Y

L

C

M

T

S

K

K

Y

H

A

A

L

L

P

K

E

H

I

M

L

L

K

A

T

A

-

G

K

K

G

G

T

N

V

I

G

N

V
x
T

S

C

S
|
S

I

V

A

G

G

G

F

L

R

V

G

A

L

W

P

P

G

D

R

I

T

P

G

A

Y
|
Y

S

N

A

A

S

S

K
|
K

F

G

A

G

M

V

N

L

G

Q

F

L

M

T

E

K

S

S

L

M

R

A

T

V

E

D

L

Y

L

A

K

K

T

H

G

Q

V

I

N

R

V

V

L

N

L

C

A

V

C

C

P
|
P

G
|
G

F

I

active site: G18 (= G16), S141 (= S141), Y154 (= Y154), K158 (= K158)
binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G12), S17 (= S15), G18 (= G16), I19 (= I17), D38 (≠ A36), I39 (≠ V40), T61 (≠ A62), D62 (= D63), I63 (≠ V64), N89 (= N90), T139 (≠ V139), S141 (= S141), Y154 (= Y154), K158 (= K158), P184 (= P184), G185 (= G185)

Sites not aligning to the query:

binding 1,4-dihydronicotinamide adenine dinucleotide: 187

3pk0B Crystal structure of short-chain dehydrogenase/reductase sdr from mycobacterium smegmatis (see paper)
31% identity, 93% coverage: 2:255/272 of query aligns to 7:258/262 of 3pk0B

query
sites
3pk0B

N

D

L

L

K

Q

E

G

K

R

V

S

I

V

T

T

G

G

A

G

S

T

S

K

G
|
G

I

I

G

G

K

R

A

G

C

I

A

A

E

T

E

V

F

F

A

A

K

R

R

A

G

G

A

A

N

N

L

V

V

A

L

V

A

A

A

G

R

R

Q

S

Y

T

V

A

T

D

L

I

C

D

E

A

I

C

T

V

A

A

D

D

L

L

E
x
D

K

Q

K

L

Y
x
G

N

S

I
x
G

R

K

A

V

V

I

A

G

V

V

Q

Q

A

T

D

D

V

V

S

S

K

D

E

R

T

A

D

Q

C

C

E

D

L

A

I

L

I

A

K

G

Q

R

A

A

L

V

V

E

S

E

F

F

Q

G

K

G

I

I

D

D

V

V

L

V

V

C

N

A

N

N

A

A

G

G

L

V

S

F

M

P

R

D

A

A

L

P

F

L

N

A

D

T

L

M

D

T

L

P

S

E

V

Q

L

L

K

N

N

G

L

I

M

F

D

A

V

V

N

N

F

V

W

N

G

G

T

T

V

F

Y

Y

C

A

T

V

K

Q

Y

A

A

C

L

L

P

D

E

A

I

L

L

I

K

A

T

S

-

G

K

S

G

G

T

R

V

V

G

L

V

T

S

S

S
|
S

I

I

A

T

G

G

-

P

F

I

R

T

G

G

L

Y

P

P

G

G

R
x
W

T

S

G

H

Y
|
Y

S

G

A

A

S

T

K
|
K

F

A

A

A

M

Q

N

L

G

G

F

F

M

M

E

R

S

T

L

A

R

A

T

I

E

E

L

L

L

A

K

P

T

H

G

K

V

I

N

T

V

V

L

N

L

A

A

I

C

M

P

P

G

G

F

-

T

-

A

-

S

-

N

N

I

I

R

M

V

T

T

E

A

G

L

L

S

L

K

E

D

N

G

G

A

E

-

E

-

Y

-

I

A

A

H

S

G

M

E

A

T

R

S

S

M

I

D

P

E

A

G

G

K

A

M

L

M

G

T

T

S

P

E

E

E

D

V

I

A

G

S

H

I

L

I

A

A

A

D

-

G

-

I

F

E

L

K

A

R

T

K

K

R

E

T

A

L

G

I

Y

M

I

T

T

G

G

Q

Q

G

-

K

A

L

I

A

A

V

V

W

D

M

G

N

G

K

Q

L

V

F

L

P

P

A

E

F

S

V

L

D

D

active site: G21 (= G16), S147 (= S141), W158 (≠ R151), Y161 (= Y154), K165 (= K158)
binding calcium ion: D55 (≠ E50), G58 (≠ Y53), G60 (≠ I55)

2jahC Biochemical and structural analysis of the clavulanic acid dehydeogenase (cad) from streptomyces clavuligerus (see paper)
37% identity, 70% coverage: 3:192/272 of query aligns to 4:192/246 of 2jahC

query
sites
2jahC

L

L

K

Q

E

G

K

K

V

V

I

A

I

L

I

I

T

T

G
|
G

A

A

S
|
S

G
|
G

I
|
I

G

G

K

E

A

A

C

T

A

A

E

R

E

A

F

L

A

A

K

A

R

E

G

G

A

A

N

A

L

V

V

A

L

I

A

A

A
|
A

R
|
R

Q
x
R

Y

V

V

E

T

K

L

L

C

R

-

A

-

L

-

G

-

D

E

E

I

L

T

T

A

A

D

A

L

G

E

A

K

K

K

V

Y

H

N

-

I

-

R

-

A

-

V

-

A

V

V

L

Q

E

A

L

D
|
D

V
|
V

S

A

K

D

E

R

T

Q

D

G

C

V

E

D

L

A

I

A

I

V

K

A

Q

S

A

T

L

V

V

E

S

A

F

L

Q

G

K

G

I

L

D

D

V

I

L

L

V

V

N

N

N
|
N

A
|
A

G
|
G

L

I

S

M

M

L

R

L

A

G

L

P

F

V

N

E

D

D

L

A

D

D

L

T

S

T

V

D

L

W

K

T

N

R

L

M

M

I

D

D

V
x
T

N

N

F

L

W

L

G

G

T

L

V

M

Y

Y

C

M

T

T

K

R

Y

A

A

A

L

L

P

P

E

H

I

L

L

L

K

R

T

S

K

K

G

G

T

T

V

V

G

Q

V
x
M

S

S

S
|
S

I

I

A

A

G

G

F

R

R

V

G

N

L

V

P

R

G

N

R

A

T

A

G

V

Y
|
Y

S

Q

A

A

S

T

K
|
K

F

F

A

G

M

V

N

N

G

A

F

F

M

S

E

E

S

T

L

L

R

R

T

Q

E

E

L

V

L

T

K

E

T

R

G

G

V

V

N

R

V

V

L

V

A

I

C

E

P
|
P

G
|
G

F
x
T

T
|
T

A

D

S
x
T

N
x
E

I
x
L

R

R

active site: S141 (= S141), Y154 (= Y154), K158 (= K158)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G13 (= G12), S15 (= S14), S16 (= S15), G17 (= G16), I18 (= I17), A37 (= A36), R38 (= R37), R39 (≠ Q38), D63 (= D63), V64 (= V64), N90 (= N90), A91 (= A91), G92 (= G92), T113 (≠ V113), M139 (≠ V139), S141 (= S141), Y154 (= Y154), K158 (= K158), P184 (= P184), G185 (= G185), T186 (≠ F186), T187 (= T187), T189 (≠ S189), E190 (≠ N190), L191 (≠ I191)

Sites not aligning to the query:

active site: 199

2japA Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta- lactamase inhibitor clavulanic acid (see paper)
37% identity, 70% coverage: 3:192/272 of query aligns to 3:191/245 of 2japA

query
sites
2japA

L

L

K

Q

E

G

K

K

V

V

I

A

I

L

I

I

T

T

G
|
G

A

A

S
|
S

G
|
G

I
|
I

G

G

K

E

A

A

C

T

A

A

E

R

E

A

F

L

A

A

K

A

R

E

G

G

A

A

N

A

L

V

V

A

L

I

A

A

A
|
A

R
|
R

Q
x
R

Y

V

V

E

T

K

L

L

C

R

-

A

-

L

-

G

-

D

E

E

I

L

T

T

A

A

D

A

L

G

E

A

K

K

K

V

Y

H

N

-

I

-

R

-

A

-

V

-

A

V

V

L

Q

E

A
x
L

D
|
D

V
|
V

S

A

K

D

E

R

T

Q

D

G

C

V

E

D

L

A

I

A

I

V

K

A

Q

S

A

T

L

V

V

E

S

A

F

L

Q

G

K

G

I

L

D

D

V

I

L

L

V

V

N

N

N
|
N

A
|
A

G
|
G

L

I

S
x
M

M

L

R

L

A

G

L

P

F

V

N

E

D

D

L

A

D

D

L

T

S

T

V

D

L

W

K

T

N

R

L

M

M

I

D

D

V
x
T

N

N

F

L

W

L

G

G

T

L

V

M

Y

Y

C

M

T

T

K

R

Y

A

A

A

L

L

P

P

E

H

I

L

L

L

K

R

T

S

K

K

G

G

T

T

V

V

G

Q

V
x
M

S
|
S

I

I

A
|
A

G

G

F

R

R

V

G

N

L

V

P

R

G

N

R

A

T

A

G

V

Y
|
Y

S

Q

A

A

S

T

K
|
K

F

F

A

G

M

V

N

N

G

A

F

F

M

S

E

E

S

T

L

L

R

R

T

Q

E

E

L

V

L

T

K

E

T

R

G

G

V

V

N

R

V

V

L

V

A

I

C

E

P
|
P

G

G

F
x
T

T
|
T

A

D

S
x
T

N
x
E

I
x
L

R

R

active site: S140 (= S141), Y153 (= Y154), K157 (= K158)
binding (2r,3z,5r)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid: M93 (≠ S94), S140 (= S141), A142 (= A143), Y153 (= Y154), T185 (≠ F186)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G12 (= G12), S14 (= S14), S15 (= S15), G16 (= G16), I17 (= I17), A36 (= A36), R37 (= R37), R38 (≠ Q38), L61 (≠ A62), D62 (= D63), V63 (= V64), N89 (= N90), A90 (= A91), G91 (= G92), T112 (≠ V113), M138 (≠ V139), S139 (= S140), S140 (= S141), Y153 (= Y154), K157 (= K158), P183 (= P184), T185 (≠ F186), T186 (= T187), T188 (≠ S189), E189 (≠ N190), L190 (≠ I191)

Sites not aligning to the query:

A0A1U8QWA2 Glycine betaine reductase ATRR; Nonribosomal peptide synthetase-like protein ATRR; EC 1.2.1.-; EC 1.1.1.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
32% identity, 81% coverage: 3:223/272 of query aligns to 1027:1246/1270 of A0A1U8QWA2

query
sites
A0A1U8QWA2

L
|
L

K
x
S

E
x
G

K
|
K

V
|
V

I
x
A

I
x
V

T
|
T

G
|
G

A
|
A

S
|
S

G
|
G

I
|
I

G
|
G

K
x
A

A
|
A

C
x
V

A
|
A

E
x
T

E
x
A

F
x
L

A
|
A

K
x
R

R
x
E

G
|
G

A
|
A

N
x
H

L
x
V

V
x
A

L
|
L

A
x
G

A
|
A

R
|
R

Q
x
R

Y
x
L

V
x
D

T
x
A

L
|
L

C
x
E

E
x
S

I
x
L

T
x
K

A
x
E

D
x
K

L
|
L

E
x
S

K
x
A

K
x
S

Y

-

N
x
G

I
x
V

R
x
K

A
x
V

V
|
V

A
x
T

V
x
C

Q
x
K

A
x
T

D
|
D

V
|
V

S
x
T

K
x
D

E
x
R

T
x
K

D
x
Q

C
x
V

E
|
E

L
x
G

I
x
L

I
x
V

K
|
K

Q
x
A

A
|
A

L
x
T

V
x
E

S
x
E

F
x
L

Q
x
G

K
x
P

I
x
V

D
|
D

V
x
I

L
|
L

V
|
V

N
x
A

N
x
C

A
|
A

G
|
G

L
x
V

S
x
M

M
x
Y

R
x
F

A
x
T

L
x
M

F
x
M

N
x
A

D
x
N

L
x
T

D
x
Q

L
x
M

S
x
D

V
x
E

L
x
W

K
x
E

N
x
R

L
x
T

M
x
V

D
|
D

V
|
V

N
|
N

F
x
C

W
x
K

G
|
G

T
x
I

V
x
L

Y
x
N

C
x
S

T
x
L

K
x
A

Y
x
S

A
x
T

L
x
V

P
|
P

E
x
G

I
x
M

L
|
L

-
x
A

K
x
R

T
x
G

K
|
K

G
|
G

T
x
H

V
|
V

G
x
A

V
x
I

S
|
S

I
x
D

A
|
A

G
|
G

F
x
R

R
x
K

G
x
V

L
x
F

P
|
P

G
|
G

R
x
L

T
x
G

G
x
V

Y
|
Y

S
|
S

A
|
A

S
|
S

K
|
K

F
|
F

A
x
F

M
x
V

N
x
E

G
x
A

F
x
T

M
x
L

E
x
Q

S
x
A

L
|
L

R
|
R

T
x
L

E
|
E

L
x
T

L
x
A

K
x
G

T
x
Q

G
|
G

V
x
L

N
x
R

V
|
V

L
x
T

L
x
A

A
x
V

C
x
Q

P
|
P

G
|
G

F
x
N

T
|
T

A
|
A

S
x
T

N
x
D

I
x
L

R

-

V

-

T
x
L

A
x
G

L
x
M

S
|
S

K
x
T

D
|
D

G
x
A

A
x
E

A
|
A

-
x
I

-
x
K

H
x
Y

G
|
G

E
|
E

T
x
P

S
|
S

M

-

D

-

E
x
G

G
x
A

K
x
Q

M
x
I

M
x
L

T
x
D

S
x
P

E
|
E

E
x
D

V
|
V

A
|
A

S
x
N

I
x
S

I
|
I

G1036 (= G12) mutation to A: Compromises binding of the cosubstrate NADPH to aldehyde reductase domain R2. Decreases the aldehyde reductase activity by 4,000-fold; when associated with F-1178.
Y1178 (= Y154) mutation to F: Does not substantially affect carboxylic acid reductase activity but results to a 150-fold loss of aldehyde reductase activity and the accumulation of glycine betaine aldehyde intermediate. Further decreases the aldehyde reductase activity by 4,000-fold; when associated with F-1178.

Sites not aligning to the query:

14:418 Adenylation (A) domain
643:937 Carboxylic acid reductase domain R1
812 Y→F: Abolishes overall carboxylic acid reductase activity but does nor affect aldehyde reductase activity.
1026:1256 Aldehyde reductase domain R2

3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH (see paper)
30% identity, 68% coverage: 6:191/272 of query aligns to 2:188/239 of 3sj7A

query
sites
3sj7A

K

K

V

S

I

A

I

L

I

V

T

T

G
|
G

A

A

S
|
S

S
x
R

G
|
G

I
|
I

G

G

K

R

A

S

C

I

A

A

E

L

E

Q

F

L

A

A

K

E

R

E

G

G

A

Y

N

N

L

V

V

A

L

V

A
x
N

A
x
Y

R
x
A

Q
x
G

Y
x
S

V

K

T

E

L

K

C

A

E

E

I

A

T

V

A

V

D

E

L

E

E

I

K

K

K

A

Y

K

N

G

I

V

R

D

A

S

V

F

A

A

V

I

Q

Q

A
|
A

D
x
N

V
|
V

S

A

K

D

E

A

T

D

D

E

C

V

E

K

L

A

I

M

I

I

K

K

Q

E

A

V

L

V

V

S

S

Q

F

F

Q

G

K

S

I

L

D

D

V

V

L

L

V

V

N

N

N
|
N

A
|
A

G

G

L

I

S

T

M

R

R

D

A

N

L

L

F

L

N

M

D

R

L

M

D

K

L

E

S

Q

V

E

L

W

K

D

N

D

L

V

M

I

D

D

V
x
T

N

N

F

L

W

K

G

G

T

V

V

F

Y

N

C

C

T

I

K

Q

Y

K

A

A

L

T

P

P

E

Q

I

M

L

L

K

R

T

Q

K

R

-

S

G

G

T

A

V

I

G

N

V

L

S

S

S
|
S

I

V

A

V

G

G

F

A

R

V

G

G

L

N

P

P

G

G

R
x
Q

T

A

G

N

Y
|
Y

S

V

A

A

S

T

K
|
K

F

A

A

G

M

V

N

I

G

G

F

L

M

T

E

K

S

S

L

A

R

A

T

R

E

E

L

L

L

A

K

S

T

R

G

G

V

I

N

T

V

V

L

N

L

A

A

V

C

A

P
|
P

G
|
G

F

F

T

I

A

V

S

S

N

D

I

M

active site: G12 (= G16), S138 (= S141), Q148 (≠ R151), Y151 (= Y154), K155 (= K158)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G8 (= G12), S10 (= S14), R11 (≠ S15), I13 (= I17), N31 (≠ A35), Y32 (≠ A36), A33 (≠ R37), G34 (≠ Q38), S35 (≠ Y39), A58 (= A62), N59 (≠ D63), V60 (= V64), N86 (= N90), A87 (= A91), T109 (≠ V113), S138 (= S141), Y151 (= Y154), K155 (= K158), P181 (= P184), G182 (= G185)

3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
30% identity, 68% coverage: 6:191/272 of query aligns to 5:191/246 of 3osuA

query
sites
3osuA

K

K

V

S

I

A

I

L

I

V

T

T

G

G

A

A

S

S

S

R

G
|
G

I

I

G

G

K

R

A

S

C

I

A

A

E

L

E

Q

F

L

A

A

K

E

R

E

G

G

A

Y

N

N

L

V

V

A

L

V

A

N

A

Y

R

A

Q

G

Y

S

V

K

T

E

L

K

C

A

E

E

I

A

T

V

A

V

D

E

L

E

E

I

K

K

K

A

Y

K

N

G

I

V

R

D

A

S

V

F

A

A

V

I

Q

Q

A

A

D

N

V

V

S

A

K

D

E

A

T

D

D

E

C

V

E

K

L

A

I

M

I

I

K

K

Q

E

A

V

L

V

V

S

S

Q

F

F

Q

G

K

S

I

L

D

D

V

V

L

L

V

V

N

N

N
|
N

A

A

G

G

L

I

S

T

M

R

R

D

A

N

L

L

F

L

N

M

D

R

L

M

D

K

L

E

S

Q

V

E

L

W

K

D

N

D

L

V

M

I

D

D

V

T

N

N

F

L

W

K

G

G

T

V

V

F

Y

N

C

C

T

I

K

Q

Y

K

A

A

L

T

P

P

E

Q

I

M

L

L

K

R

T

Q

K

R

-

S

G

G

T

A

V

I

G

N

V

L

S

S

S
|
S

I

V

A

V

G

G

F

A

R

V

G

G

L

N

P

P

G

G

R
x
Q

T

A

G

N

Y
|
Y

S

V

A

A

S

T

K
|
K

F

A

A

G

M

V

N

I

G

G

F

L

M

T

E

K

S

S

L

A

R

A

T

R

E

E

L

L

L

A

K

S

T

R

G

G

V

I

N

T

V

V

L

N

L

A

A

V

C

A

P

P

G

G

F

F

T

I

A

V

S

S

N

D

I

M

active site: G15 (= G16), S141 (= S141), Q151 (≠ R151), Y154 (= Y154), K158 (= K158)
binding magnesium ion: N89 (= N90), K158 (= K158)

Query Sequence

>CA265_RS04990 FitnessBrowser__Pedo557:CA265_RS04990
MNLKEKVIIITGASSGIGKACAEEFAKRGANLVLAARQYVTLCEITADLEKKYNIRAVAV
QADVSKETDCELIIKQALVSFQKIDVLVNNAGLSMRALFNDLDLSVLKNLMDVNFWGTVY
CTKYALPEILKTKGTVVGVSSIAGFRGLPGRTGYSASKFAMNGFMESLRTELLKTGVNVL
LACPGFTASNIRVTALSKDGAAHGETSMDEGKMMTSEEVASIIADGIEKRKRTLIMTGQG
KLAVWMNKLFPAFVDKKVFDLFAKEKNPLIKG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory