Comparing CA265_RS07955 FitnessBrowser__Pedo557:CA265_RS07955 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 7 hits to proteins with known functional sites (download)
P22106 Asparagine synthetase B [glutamine-hydrolyzing]; AS-B; EC 6.3.5.4 from Escherichia coli (strain K12) (see 2 papers)
31% identity, 64% coverage: 1:391/613 of query aligns to 1:380/554 of P22106
1ct9A Crystal structure of asparagine synthetase b from escherichia coli (see paper)
32% identity, 63% coverage: 4:391/613 of query aligns to 3:363/497 of 1ct9A
Sites not aligning to the query:
P78753 Probable asparagine synthetase [glutamine-hydrolyzing]; Glutamine-dependent asparagine synthetase; EC 6.3.5.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
29% identity, 56% coverage: 22:367/613 of query aligns to 27:365/557 of P78753
Sites not aligning to the query:
6gq3A Human asparagine synthetase (asns) in complex with 6-diazo-5-oxo-l- norleucine (don) at 1.85 a resolution (see paper)
28% identity, 56% coverage: 22:367/613 of query aligns to 22:361/509 of 6gq3A
Sites not aligning to the query:
P08243 Asparagine synthetase [glutamine-hydrolyzing]; Cell cycle control protein TS11; Glutamine-dependent asparagine synthetase; EC 6.3.5.4 from Homo sapiens (Human) (see 7 papers)
27% identity, 60% coverage: 1:367/613 of query aligns to 1:374/561 of P08243
Sites not aligning to the query:
Q9XB61 Carbapenam-3-carboxylate synthase; Carbapenam-3-carboxylate ligase; EC 6.3.3.6 from Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. carotovora) (see 3 papers)
28% identity, 25% coverage: 254:407/613 of query aligns to 241:405/503 of Q9XB61
Sites not aligning to the query:
1q19A Carbapenam synthetase (see paper)
28% identity, 25% coverage: 254:407/613 of query aligns to 240:404/500 of 1q19A
Sites not aligning to the query:
>CA265_RS07955 FitnessBrowser__Pedo557:CA265_RS07955
MCGIYGTTIPYSDGIVREKMARISFRGPDYTGVQRYDQVIFAHNRLAIIDLDARSNQPFS
YMHLHIVFNGEIYNYKDIRRELERKNYQFNTSSDTEVICAAYLEYGAGCLTRFNGMFAFV
IYDTRKNELFGARDRFGKKPFYYAHDHSSFEFASQPSQINIDRGLSVNEEAINQYLIWGY
VPEPQSIYAEVKQLPAAHYFKYDLKSHKLKITEYWTLDYGWKNKFEGSYEEAKEALALIL
ADAVKIRMNADVPLGVFLSGGIDSSLIAALATKEIDHVKTFSIKFNEKGFDESAYASQVA
KHLGTDHYTIECNYNDGIELIENFNRFYDEPFADSSAIPTMLLSKNTRKHVTVALSGDAG
DEAFLGYHRYKWIKQVNSLFYAPHGVRKALAGLINQSPSYRHKLIAMGISMEDVEKLYVK
MFGNMENSWVKQPDLAKYNPLMHILANPSKPLLERISDFDIKTYLNGDINTKVDRASMAF
SLESRSPLMDYRVMEFSRSLPTAFKYTNGNQKRILKDLLFDHVPAHMFDRPKAGFTMPFQ
HWFRNELKDYVMDNLSADNLKNIPGIHLKRTQEIINEHMTGKWNRYPQIWKLLVLSQWLI
KNKSTTHKVSLVA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory