SitesBLAST
Comparing CA265_RS09620 FitnessBrowser__Pedo557:CA265_RS09620 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
38% identity, 99% coverage: 1:464/467 of query aligns to 1:463/467 of 7qh2C
- binding flavin-adenine dinucleotide: V73 (≠ P73), G75 (= G75), S76 (≠ G76), G77 (= G77), T78 (= T78), G79 (= G79), L80 (= L80), A83 (= A83), C84 (≠ A84), P137 (= P137), G138 (≠ S138), E139 (≠ S139), A142 (≠ C143), T143 (≠ F144), G146 (= G147), N147 (= N148), S149 (≠ A150), T150 (≠ H151), A152 (≠ S153), G153 (= G154), E203 (= E204), G204 (= G205), I209 (≠ V210), E422 (= E423), H423 (= H424)
- binding fe (iii) ion: H377 (= H378), H384 (= H385), E422 (= E423)
P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
36% identity, 98% coverage: 9:467/467 of query aligns to 3:458/459 of P9WIT1
- K354 (= K357) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
8jdeA Crystal structure of mldhd in complex with d-lactate (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:455/455 of 8jdeA
- binding flavin-adenine dinucleotide: P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), W322 (vs. gap), E413 (= E423), H414 (= H424), N450 (= N460)
- binding lactic acid: R318 (= R330), H369 (= H378), H376 (= H385), H414 (= H424)
- binding manganese (ii) ion: H369 (= H378), H376 (= H385), E413 (= E423)
8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:455/455 of 8jdxA
- binding flavin-adenine dinucleotide: E32 (= E37), P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), W322 (vs. gap), E413 (= E423), H414 (= H424), N450 (= N460)
- binding 3-methyl-2-oxobutanoic acid: R318 (= R330), H369 (= H378), H376 (= H385), H414 (= H424)
- binding manganese (ii) ion: H369 (= H378), H376 (= H385), E413 (= E423)
8jdsA Crystal structure of mldhd in complex with pyruvate (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:456/456 of 8jdsA
- binding flavin-adenine dinucleotide: E32 (= E37), P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), W323 (vs. gap), E414 (= E423), H415 (= H424), N451 (= N460)
- binding manganese (ii) ion: H370 (= H378), H377 (= H385), E414 (= E423)
- binding pyruvic acid: R319 (= R330), H370 (= H378), H377 (= H385), H415 (= H424)
8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:455/455 of 8jdtA
- binding 2-ketobutyric acid: R318 (= R330), H369 (= H378), H376 (= H385), H414 (= H424)
- binding flavin-adenine dinucleotide: P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), W322 (vs. gap), E413 (= E423), H414 (= H424), N450 (= N460)
- binding manganese (ii) ion: H369 (= H378), H376 (= H385), E413 (= E423)
8jdzA Crystal structure of mldhd in complex with 2-keto-3-methylvaleric acid (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:454/454 of 8jdzA
- binding (3S)-3-methyl-2-oxopentanoic acid: R318 (= R330), W322 (vs. gap), H369 (= H378), H376 (= H385), H413 (= H424)
- binding flavin-adenine dinucleotide: E32 (= E37), P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), W322 (vs. gap), E412 (= E423), H413 (= H424), N449 (= N460)
- binding manganese (ii) ion: H369 (= H378), H376 (= H385), E412 (= E423)
8jdyA Crystal structure of mldhd in complex with 2-ketoisocaproic acid (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:454/454 of 8jdyA
- binding 2-oxo-4-methylpentanoic acid: R318 (= R330), W322 (vs. gap), S336 (≠ E345), H369 (= H378), H376 (= H385), H413 (= H424)
- binding flavin-adenine dinucleotide: P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), E412 (= E423), N449 (= N460)
- binding manganese (ii) ion: H369 (= H378), H376 (= H385), E412 (= E423)
8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:454/454 of 8jdvA
- binding 2-Ketohexanoic acid: V75 (≠ L80), R317 (= R330), W321 (vs. gap), H368 (= H378), H375 (= H385), H413 (= H424)
- binding flavin-adenine dinucleotide: P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), W321 (vs. gap), Y322 (vs. gap), E412 (= E423), H413 (= H424), N449 (= N460)
- binding manganese (ii) ion: H368 (= H378), H375 (= H385), E412 (= E423)
8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:455/455 of 8jduA
- binding 2-oxopentanoic acid: R318 (= R330), W322 (vs. gap), H369 (= H378), H376 (= H385), H414 (= H424)
- binding flavin-adenine dinucleotide: P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), W322 (vs. gap), E413 (= E423), N450 (= N460)
- binding manganese (ii) ion: H369 (= H378), H376 (= H385), E413 (= E423)
8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:456/456 of 8jdrA
- binding flavin-adenine dinucleotide: P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), Y324 (vs. gap), H370 (= H378), E414 (= E423), N451 (= N460)
- binding (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid: R319 (= R330), W323 (vs. gap), H415 (= H424)
8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:456/456 of 8jdqA
- binding (2R)-2-hydroxy-4-methylpentanoic acid: R319 (= R330), W323 (vs. gap), H370 (= H378), H415 (= H424)
- binding flavin-adenine dinucleotide: P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), H370 (= H378), E414 (= E423), N451 (= N460)
8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:456/456 of 8jdoA
- binding (2R)-2-hydroxyhexanoic acid: R319 (= R330), W323 (vs. gap), H415 (= H424)
- binding flavin-adenine dinucleotide: P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), Y324 (vs. gap), H370 (= H378), E414 (= E423), N451 (= N460)
8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:456/456 of 8jdnA
- binding flavin-adenine dinucleotide: P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), H370 (= H378), E414 (= E423), N451 (= N460)
- binding (2R)-2-oxidanylpentanoic acid: R319 (= R330), W323 (vs. gap), H415 (= H424)
8jdgA Crystal structure of h405a mldhd in complex with d-2-hydroxybutanoic acid (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:456/456 of 8jdgA
- binding flavin-adenine dinucleotide: P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), H370 (= H378), E414 (= E423), N451 (= N460)
- binding (2R)-2-oxidanylbutanoic acid: R319 (= R330), H415 (= H424)
8jdbA Crystal structure of h405a mldhd in complex with d-2-hydroxyoctanoic acid (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:456/456 of 8jdbA
- binding flavin-adenine dinucleotide: P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), Y324 (vs. gap), H370 (= H378), E414 (= E423), N451 (= N460)
- binding (2R)-2-oxidanyloctanoic acid: V75 (≠ L80), R319 (= R330), W323 (vs. gap), H415 (= H424)
8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid (see paper)
31% identity, 99% coverage: 6:465/467 of query aligns to 1:455/455 of 8jdpA
- binding flavin-adenine dinucleotide: P68 (= P73), G70 (= G75), T71 (≠ G76), G72 (= G77), T73 (= T78), G74 (= G79), G78 (≠ A83), V79 (≠ A84), L90 (≠ M95), P132 (= P137), G133 (≠ S138), A134 (≠ S139), G140 (= G147), M141 (≠ N148), A143 (= A150), T144 (≠ H151), A146 (≠ S153), S147 (≠ G154), E200 (= E204), G201 (= G205), I206 (≠ V210), H369 (= H378), E413 (= E423), N450 (= N460)
- binding deaminohydroxyvaline: R319 (= R330), H414 (= H424)
3pm9A Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
30% identity, 99% coverage: 6:465/467 of query aligns to 2:465/465 of 3pm9A
- active site: A149 (≠ S153), L159 (≠ T163)
- binding flavin-adenine dinucleotide: P69 (= P73), Q70 (≠ R74), G71 (= G75), G72 (= G76), N73 (≠ G77), T74 (= T78), G75 (= G79), L76 (= L80), G79 (≠ A83), Q80 (≠ A84), L91 (≠ M95), L133 (≠ P137), G134 (≠ S138), A135 (≠ S139), C139 (= C143), T140 (≠ F144), G142 (= G146), G143 (= G147), S146 (≠ A150), T147 (≠ H151), A149 (≠ S153), G150 (= G154), E200 (= E204), G201 (= G205), I205 (≠ V209), I206 (≠ V210), E423 (= E423)
6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
30% identity, 100% coverage: 1:467/467 of query aligns to 4:466/466 of 6lpxA
- binding 2-oxoglutaric acid: R333 (= R330), T337 (≠ A334), K348 (≠ E345), Y379 (= Y376), H381 (= H378), H388 (= H385), H423 (= H424)
- binding flavin-adenine dinucleotide: W39 (≠ E37), P75 (= P73), Q76 (≠ R74), G77 (= G75), G78 (= G76), N79 (≠ G77), T80 (= T78), G81 (= G79), M82 (≠ L80), G85 (≠ A83), S86 (≠ A84), L139 (≠ P137), G140 (≠ S138), A141 (≠ S139), C145 (= C143), G149 (= G147), N150 (= N148), A152 (= A150), T153 (≠ H151), G157 (= G155), G207 (= G205), I212 (≠ V210), E422 (= E423), N459 (= N460)
- binding zinc ion: H381 (= H378), H388 (= H385), E422 (= E423)
6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg) (see paper)
30% identity, 100% coverage: 1:467/467 of query aligns to 4:466/466 of 6lpuA
- binding flavin-adenine dinucleotide: W39 (≠ E37), P75 (= P73), G77 (= G75), G78 (= G76), N79 (≠ G77), T80 (= T78), G81 (= G79), G85 (≠ A83), S86 (≠ A84), L139 (≠ P137), G140 (≠ S138), A141 (≠ S139), C145 (= C143), H146 (≠ F144), G148 (= G146), G149 (= G147), N150 (= N148), A152 (= A150), T153 (≠ H151), A155 (≠ S153), E206 (= E204), G207 (= G205), I211 (≠ V209), I212 (≠ V210), E422 (= E423), N459 (= N460)
- binding (2s)-2-hydroxypentanedioic acid: R333 (= R330), T337 (≠ A334), K348 (≠ E345), Y379 (= Y376), H381 (= H378), H388 (= H385), H423 (= H424)
- binding zinc ion: H381 (= H378), H388 (= H385), E422 (= E423)
Query Sequence
>CA265_RS09620 FitnessBrowser__Pedo557:CA265_RS09620
MNFTKINPEILAEIKAAVGAEKVFTDADSLENYSHDETEDLRYQPEVVVKPTTPEEVSAL
LKICNAHHVPVTPRGGGTGLSGAALPIYGGISLSMEKFKAILDIDTENLQATVEPGVITE
EFINAVAEKGLLYPVDPSSKGSCFIGGNVAHGSGGPRVVKYGTIREYILNLEVVLPNGDI
IWTGANTLKYASGYNLTQLMIGSEGTLAVVTKIVTKLLPKPSQSVLMMGSFSTNEDACAA
VSAIFRAGVTPSALEFMERKGVEWVIKFDDIKFDLKDDVAALLMIEFDGDDLDDIFKNCE
KTNIVLEEHNCTEVLFADTAAQKEELWRMRRTMAESVKSNSVYKEEDTVVPRAALPKLVN
GIKEIGAKYGFESVCYGHAGDGNLHVNIIKAGMSDEDWKNKLKFGIAEIFELTTALGGTL
SGEHGIGLVQKEFMPIKYSEIHLNLMRGIKNIFDPKGILNPGKIMPD
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory