Comparing CA265_RS09660 FitnessBrowser__Pedo557:CA265_RS09660 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P18159 Phosphoglucomutase; PGM; Alpha-phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Bacillus subtilis (strain 168) (see paper)
48% identity, 88% coverage: 40:548/578 of query aligns to 34:549/581 of P18159
O74478 Probable phosphoribomutase; PRM; Phosphoglucomutase 3 homolog; PGM 3 homolog; EC 5.4.2.7 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
35% identity, 95% coverage: 4:554/578 of query aligns to 1:560/587 of O74478
Q96G03 Phosphopentomutase; Glucose phosphomutase 2; Phosphodeoxyribomutase; Phosphoglucomutase-2; EC 5.4.2.7; EC 5.4.2.2 from Homo sapiens (Human) (see 2 papers)
33% identity, 98% coverage: 4:572/578 of query aligns to 15:595/612 of Q96G03
Sites not aligning to the query:
Q03262 Phosphoribomutase; PRM; Phosphoglucomutase 3; PGM 3; EC 5.4.2.7 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
32% identity, 97% coverage: 1:558/578 of query aligns to 6:597/622 of Q03262
1wqaA Crystal structure of pyrococcus horikoshii phosphomannomutase/phosphoglucomutase complexed with mg2+
27% identity, 87% coverage: 50:550/578 of query aligns to 5:435/455 of 1wqaA
2fuvA Phosphoglucomutase from salmonella typhimurium.
25% identity, 89% coverage: 46:559/578 of query aligns to 37:531/545 of 2fuvA
2h5aX Complex of the enzyme pmm/pgm with xylose 1-phosphate (see paper)
28% identity, 45% coverage: 55:312/578 of query aligns to 11:242/455 of 2h5aX
Sites not aligning to the query:
2h4lX Complex of pmm/pgm with ribose 1-phosphate (see paper)
28% identity, 45% coverage: 55:312/578 of query aligns to 11:242/455 of 2h4lX
Sites not aligning to the query:
2fkfA Phosphomannomutase/phosphoglucomutase from pseudomonas aeruginosa with alpha-d-glucose 1,6-bisphosphate bound (see paper)
28% identity, 45% coverage: 55:312/578 of query aligns to 11:242/455 of 2fkfA
Sites not aligning to the query:
1pcmX Enzyme-ligand complex of p. Aeruginosa pmm/pgm (see paper)
28% identity, 45% coverage: 55:312/578 of query aligns to 11:242/455 of 1pcmX
Sites not aligning to the query:
1p5gX Enzyme-ligand complex of p. Aeruginosa pmm/pgm (see paper)
28% identity, 45% coverage: 55:312/578 of query aligns to 11:242/455 of 1p5gX
Sites not aligning to the query:
1p5dX Enzyme-ligand complex of p. Aeruginosa pmm/pgm (see paper)
28% identity, 45% coverage: 55:312/578 of query aligns to 11:242/455 of 1p5dX
Sites not aligning to the query:
4il8A Crystal structure of an h329a mutant of p. Aeruginosa pmm/pgm (see paper)
28% identity, 45% coverage: 55:312/578 of query aligns to 15:246/459 of 4il8A
Sites not aligning to the query:
P26276 Phosphomannomutase/phosphoglucomutase; PMM / PGM; EC 5.4.2.2; EC 5.4.2.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 10 papers)
28% identity, 45% coverage: 55:312/578 of query aligns to 19:250/463 of P26276
Sites not aligning to the query:
Q02E40 Phosphomannomutase/phosphoglucomutase; PMM / PGM; EC 5.4.2.2; EC 5.4.2.8 from Pseudomonas aeruginosa (strain UCBPP-PA14) (see paper)
28% identity, 45% coverage: 55:312/578 of query aligns to 19:250/463 of Q02E40
1pcjX Enzyme-ligand complex of p. Aeruginosa pmm/pgm (see paper)
28% identity, 45% coverage: 55:312/578 of query aligns to 14:245/458 of 1pcjX
Sites not aligning to the query:
1k2yX Crystal structure of phosphomannomutase/phosphoglucomutase s108a mutant from p. Aeruginosa (see paper)
28% identity, 45% coverage: 55:312/578 of query aligns to 15:246/459 of 1k2yX
Sites not aligning to the query:
3i3wA Structure of a phosphoglucosamine mutase from francisella tularensis
27% identity, 62% coverage: 50:409/578 of query aligns to 3:326/441 of 3i3wA
P31120 Phosphoglucosamine mutase; EC 5.4.2.10 from Escherichia coli (strain K12) (see 3 papers)
27% identity, 49% coverage: 124:409/578 of query aligns to 75:331/445 of P31120
Sites not aligning to the query:
3uw2A X-ray crystal structure of phosphoglucomutase/phosphomannomutase family protein (bth_i1489)from burkholderia thailandensis (see paper)
26% identity, 39% coverage: 144:369/578 of query aligns to 102:298/458 of 3uw2A
Sites not aligning to the query:
>CA265_RS09660 FitnessBrowser__Pedo557:CA265_RS09660
MQAIDQSTQATINQWLSGNYDENTKAEIQALVDKDATTELTDAFYRSLEFGTGGLRGIMG
AGSNRINKYTIGTATQGLANYLNNKYPNEKIKVAIAHDSRNNSDYFAKITADVFSANGIH
VYFFSALRPTPELSFAVRHFGCKSGVMLTASHNPKEYNGYKAYGADGGQFTSPDDKLVID
EVNKIKNIDEVKFDRVEANIELIGEEVDKLYLDGITALSISPEAIKRQHDLKIVYSPIHG
TGITLVPKALAQFGFTNVTLVEEQSTPDGNFPTVVYPNPEEKDALTLAMNKAKEIDADLV
LATDPDADRVGIAVKDNNGEWVLLNGNQTGCLLINYLLSAWEANGKLDGNQFIVKTIVTS
NLIEEIAKKKDVTYYNTLTGFKYIGQLMTELEGKKYFIGGGEESYGYLIGDLVRDKDAVV
SAAFISEMTAYYKDKGASLYNALLDMYVEYGLYKEDLVSLTKKGKSGAEEIKAMMVKFRE
NPPATLGGSKVSVLKDYELSQETDLTTGKVSKLDYPTSDVLQFITEDGSIVSARPSGTEP
KIKFYCSVNAPLADRKDFESVNAQLGDKIKAVMADLQA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory