Comparing CA265_RS10640 CA265_RS10640 methylcrotonoyl-CoA carboxylase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3u9sF Crystal structure of p. Aeruginosa 3-methylcrotonyl-coa carboxylase (mcc) 750 kd holoenzyme, coa complex (see paper)
47% identity, 97% coverage: 4:531/542 of query aligns to 16:527/537 of 3u9sF
8f3dA 3-methylcrotonyl-coa carboxylase in filament, beta-subunit centered (see paper)
43% identity, 95% coverage: 15:530/542 of query aligns to 40:566/566 of 8f3dA
1vrgA Crystal structure of propionyl-coa carboxylase, beta subunit (tm0716) from thermotoga maritima at 2.30 a resolution
36% identity, 94% coverage: 16:524/542 of query aligns to 7:496/515 of 1vrgA
8pn7A Engineered glycolyl-coa carboxylase (g20r variant) with bound coa (see paper)
36% identity, 93% coverage: 18:523/542 of query aligns to 3:486/506 of 8pn7A
1on3C Transcarboxylase 12s crystal structure: hexamer assembly and substrate binding to a multienzyme core (with methylmalonyl-coenzyme a and methylmalonic acid bound) (see paper)
35% identity, 94% coverage: 16:524/542 of query aligns to 9:491/510 of 1on3C
1on3E Transcarboxylase 12s crystal structure: hexamer assembly and substrate binding to a multienzyme core (with methylmalonyl-coenzyme a and methylmalonic acid bound) (see paper)
36% identity, 94% coverage: 16:524/542 of query aligns to 13:501/520 of 1on3E
Q168G2 Propionyl-CoA carboxylase beta chain; EC 6.4.1.3 from Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans) (see paper)
33% identity, 97% coverage: 13:537/542 of query aligns to 2:508/510 of Q168G2
3n6rB Crystal structure of the holoenzyme of propionyl-coa carboxylase (pcc) (see paper)
34% identity, 96% coverage: 18:537/542 of query aligns to 3:504/506 of 3n6rB
3ib9A Propionyl-coa carboxylase beta subunit, d422l (see paper)
33% identity, 93% coverage: 18:523/542 of query aligns to 11:501/521 of 3ib9A
1xnyA Biotin and propionyl-coa bound to acyl-coa carboxylase beta subunit from s. Coelicolor (pccb) (see paper)
33% identity, 93% coverage: 18:523/542 of query aligns to 11:501/521 of 1xnyA
7ybuP Human propionyl-coenzyme a carboxylase
34% identity, 97% coverage: 11:537/542 of query aligns to 3:505/507 of 7ybuP
5iniF Structural basis for acyl-coa carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics (see paper)
31% identity, 92% coverage: 16:516/542 of query aligns to 6:484/511 of 5iniF
3gf3A Glutaconyl-coa decarboxylase a subunit from clostridium symbiosum co- crystallized with glutaconyl-coa (see paper)
30% identity, 97% coverage: 7:530/542 of query aligns to 24:541/563 of 3gf3A
3gmaB Glutaconyl-coa decarboxylase a subunit from clostridium symbiosum co- crystallized with glutaryl-coa (see paper)
30% identity, 97% coverage: 7:530/542 of query aligns to 24:545/566 of 3gmaB
8sgxE Leishmania tarentolae propionyl-coa carboxylase (alpha-4-beta-6) (see paper)
30% identity, 92% coverage: 38:537/542 of query aligns to 8:487/489 of 8sgxE
4g2rB Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor haloxyfop from mycobacterium tuberculosis (see paper)
28% identity, 88% coverage: 55:533/542 of query aligns to 1:440/441 of 4g2rB
6tzvA Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor phenyl-cyclodiaone from mycobacterium tuberculosis
27% identity, 89% coverage: 54:533/542 of query aligns to 1:425/426 of 6tzvA
6prwA Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor quizalofop-p derivative from mycobacterium tuberculosis
27% identity, 89% coverage: 54:533/542 of query aligns to 1:425/426 of 6prwA
6pk2A Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor quizalofop-p derivative from mycobacterium tuberculosis
27% identity, 89% coverage: 54:533/542 of query aligns to 1:425/426 of 6pk2A
6p7uA Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor quizalofop-p from mycobacterium tuberculosis
27% identity, 89% coverage: 54:533/542 of query aligns to 1:425/426 of 6p7uA
>CA265_RS10640 CA265_RS10640 methylcrotonoyl-CoA carboxylase
MNIEFNKNEDVNKQLVYELKTRLKKIYLGGGEKNAAKQKEKGKLLARERIAYLIDKDSNF
LEVGAFTADGMYAEQGGCPSAGVVCGIGYVSGRQCMIVANDATVKAGAWFPMTAKKNLRA
QEIAMENRLPVIYLVDSAGVYLPMQDEIFPDKEHFGRMFRNNAIMSSEGIVQISAIMGAC
VAGGAYLPIMSDEAMIVDKTGSVFLAGSYLVKSAIGEEVDNETLGGATTHCEISGVTDYK
HLNDQACLDSIRNIMSMLGAPQNAGFDRIKPAKPKEKEEELYGILPENRDKPYEIMDIIN
RLVDGSEFEEYKKGYGQSIVCGLGRIDGWAVGIVANQRKVVKSKKGEMQFGGVIYSDSAD
KATRFIMNCNQKKIPLVFLQDVTGFMVGSRSEHGGIIKDGAKMVNAVANSVVPKFTIVLG
NSYGAGNYAMCGKAYDPRLIYAWPTAKIAVMGGSQAAKTLLQIQEASLKAKGEVITPEKE
AELLKEITDRYDSQTTPYYAASRLWVDGIIDPLETRKVISMGIEAANQSPITKKFNVGVI
QT
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Lawrence Berkeley National Laboratory