SitesBLAST
Comparing CA265_RS17845 FitnessBrowser__Pedo557:CA265_RS17845 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 15 hits to proteins with known functional sites (download)
6btmB Structure of alternative complex iii from flavobacterium johnsoniae (wild type) (see paper)
42% identity, 92% coverage: 71:1003/1010 of query aligns to 2:948/948 of 6btmB
- binding (2R)-3-{[(2R)-2-(decanoylamino)-3-hydroxypropyl]sulfanyl}propane-1,2-diyl ditetradecanoate: G2 (≠ A71)
- binding fe3-s4 cluster: C789 (= C846), C809 (= C866), V810 (= V867), T812 (= T869), C815 (= C872), M862 (= M919)
- binding iron/sulfur cluster: C777 (= C834), Q778 (= Q835), C780 (= C837), C785 (= C842), N802 (= N859), C819 (= C876), R824 (= R881)
Sites not aligning to the query:
6f0kB Alternative complex iii (see paper)
37% identity, 92% coverage: 72:1005/1010 of query aligns to 3:955/961 of 6f0kB
- binding fe3-s4 cluster: C803 (= C846), V805 (= V848), M818 (= M861), C823 (= C866), I824 (≠ V867), G825 (= G868), C829 (= C872), M869 (= M919)
- binding heme c: Y719 (vs. gap), N821 (= N864), R822 (= R865), R884 (≠ L934), N887 (≠ K937)
- binding iron/sulfur cluster: C733 (= C762), T734 (= T763), G735 (= G764), C736 (= C765), N737 (≠ G766), A738 (≠ S767), C739 (= C768), C743 (= C772), W765 (= W794), I768 (= I797), C791 (= C834), M792 (≠ Q835), H793 (= H836), C794 (= C837), P798 (= P841), C799 (= C842), N816 (= N859), C833 (= C876), C872 (= C922), Y874 (≠ M924), C875 (= C925), A901 (= A951), C902 (= C952), C906 (= C956)
6lodB Cryo-em structure of the air-oxidized photosynthetic alternative complex iii from roseiflexus castenholzii (see paper)
36% identity, 93% coverage: 68:1003/1010 of query aligns to 1:922/929 of 6lodB
- binding fe3-s4 cluster: V758 (= V845), C759 (= C846), P760 (= P847), C779 (= C866), V780 (= V867), G781 (= G868), T782 (= T869), C785 (= C872), M838 (= M919)
- binding heme c: N777 (= N864), R778 (= R865), R852 (≠ K933), I853 (≠ L934), R856 (≠ K937)
- binding iron/sulfur cluster: C692 (= C762), N693 (≠ T763), S694 (≠ G764), C695 (= C765), N696 (≠ G766), A697 (≠ S767), C698 (= C768), C702 (= C772), N706 (= N776), W724 (= W794), I727 (= I797), L746 (= L833), C747 (= C834), Q748 (= Q835), Q749 (≠ H836), C750 (= C837), P754 (= P841), C755 (= C842), N772 (= N859), C789 (= C876), Y791 (= Y878), V793 (= V880), R794 (= R881), K840 (= K921), C841 (= C922), F843 (≠ M924), C844 (= C925), T869 (≠ M950), C871 (= C952), C875 (= C956), I880 (= I961)
2vpyF Polysulfide reductase with bound quinone inhibitor, pentachlorophenol (pcp) (see paper)
29% identity, 24% coverage: 753:998/1010 of query aligns to 4:178/193 of 2vpyF
- binding pentachlorophenol: I91 (≠ V867), C93 (≠ T869)
- binding iron/sulfur cluster: C13 (= C762), G15 (= G764), C16 (= C765), C19 (= C768), C23 (= C772), N27 (= N776), L36 (≠ V786), I38 (= I795), P55 (= P831), Q57 (≠ L833), C58 (= C834), L59 (≠ Q835), C61 (= C837), P65 (= P841), C66 (= C842), C70 (= C846), P71 (= P847), V83 (≠ N859), C90 (= C866), I91 (≠ V867), A92 (≠ G868), C93 (≠ T869), G94 (≠ R870), C96 (= C872), C100 (= C876), P101 (= P877), Y102 (= Y878), R105 (= R893), V113 (≠ M919), C116 (= C922), F118 (≠ M924), C119 (= C925), P129 (≠ Q935), A130 (= A936), C131 (= C952), C135 (= C956), C139 (≠ A960), R140 (≠ I961)
Sites not aligning to the query:
2vpwF Polysulfide reductase with bound menaquinone (see paper)
29% identity, 24% coverage: 753:998/1010 of query aligns to 4:178/193 of 2vpwF
- binding iron/sulfur cluster: C13 (= C762), G15 (= G764), C16 (= C765), C19 (= C768), C23 (= C772), N27 (= N776), L36 (≠ V786), I38 (= I795), P55 (= P831), Q57 (≠ L833), C58 (= C834), L59 (≠ Q835), H60 (= H836), C61 (= C837), P65 (= P841), C66 (= C842), C70 (= C846), P71 (= P847), V83 (≠ N859), C90 (= C866), I91 (≠ V867), A92 (≠ G868), C93 (≠ T869), G94 (≠ R870), C96 (= C872), C100 (= C876), P101 (= P877), Y102 (= Y878), R105 (= R893), V113 (≠ M919), C116 (= C922), F118 (≠ M924), C119 (= C925), P129 (≠ Q935), A130 (= A936), C131 (= C952), C135 (= C956), C139 (≠ A960), R140 (≠ I961)
Sites not aligning to the query:
6cz7B The arsenate respiratory reductase (arr) complex from shewanella sp. Ana-3 (see paper)
28% identity, 24% coverage: 755:998/1010 of query aligns to 5:225/234 of 6cz7B
- binding iron/sulfur cluster: C12 (= C762), V13 (≠ T763), G14 (= G764), C15 (= C765), G16 (= G766), C18 (= C768), C22 (= C772), N26 (= N776), Y52 (≠ H829), P54 (= P831), C57 (= C834), N58 (≠ Q835), H59 (= H836), C60 (= C837), A63 (= A840), P64 (= P841), C65 (= C842), C69 (= C846), P70 (= P847), T82 (≠ N859), C89 (= C866), I90 (≠ V867), G91 (= G868), C92 (≠ T869), K93 (≠ R870), C95 (= C872), C99 (= C876), Y101 (= Y878), V103 (= V880), I104 (≠ R881), T161 (≠ M919), K163 (= K921), C164 (= C922), F166 (≠ M924), C167 (= C925), C179 (= C952), C183 (= C956), P184 (≠ S957), R188 (≠ I961)
Q7WTT9 Arsenate respiratory reductase iron-sulfur subunit ArrB; Arsenate respiratory reductase small subunit; ARR small subunit from Shewanella sp. (strain ANA-3) (see paper)
28% identity, 24% coverage: 755:998/1010 of query aligns to 5:225/234 of Q7WTT9
- C12 (= C762) binding
- C15 (= C765) binding
- C18 (= C768) binding
- C22 (= C772) binding
- C57 (= C834) binding
- C60 (= C837) binding
- C65 (= C842) binding
- C69 (= C846) binding
- C89 (= C866) binding
- C92 (≠ T869) binding
- C95 (= C872) binding
- C99 (= C876) binding
- C164 (= C922) binding
- C167 (= C925) binding
- C179 (= C952) binding
- C183 (= C956) binding
P18776 Anaerobic dimethyl sulfoxide reductase chain B; DMSO reductase iron-sulfur subunit from Escherichia coli (strain K12) (see 2 papers)
26% identity, 19% coverage: 757:948/1010 of query aligns to 9:152/205 of P18776
- C102 (≠ T869) mutation C->F,S,W,Y: Loss of electron transfer from menaquinol to DMSO.
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
2ivfB Ethylbenzene dehydrogenase from aromatoleum aromaticum (see paper)
23% identity, 25% coverage: 754:1001/1010 of query aligns to 5:261/337 of 2ivfB
- binding fe3-s4 cluster: C148 (= C846), T150 (≠ V848), I153 (≠ T851), C169 (= C866), K170 (≠ V867), G171 (= G868), H172 (≠ T869), R173 (= R870), H174 (≠ Y871), C175 (= C872), S193 (= S915)
- binding protoporphyrin ix containing fe: T150 (≠ V848), K170 (≠ V867), H172 (≠ T869)
- binding iron/sulfur cluster: C13 (= C762), L14 (≠ T763), G15 (= G764), C16 (= C765), Q17 (≠ G766), C19 (= C768), C23 (= C772), W27 (≠ E775), W38 (= W794), N39 (≠ I795), V41 (≠ I797), M135 (≠ L833), C136 (= C834), N137 (≠ Q835), H138 (= H836), C139 (= C837), P142 (≠ A840), C144 (= C842), V162 (≠ N859), C179 (= C876), A183 (≠ V880), I184 (≠ R881), K195 (= K921), C196 (= C922), I197 (≠ S923), L198 (≠ M924), C199 (= C925), N209 (≠ M950), C211 (= C952), C215 (= C956), V219 (≠ A960), R220 (≠ I961)
1kqfB Formate dehydrogenase n from e. Coli (see paper)
25% identity, 21% coverage: 757:964/1010 of query aligns to 33:186/289 of 1kqfB
- binding protoporphyrin ix containing fe: Y137 (= Y871)
- binding iron/sulfur cluster: C38 (= C762), I39 (≠ T763), G40 (= G764), C41 (= C765), K42 (≠ G766), C44 (= C768), C48 (= C772), N52 (= N776), T77 (≠ D809), M79 (≠ T811), C99 (= C834), M100 (≠ Q835), H101 (= H836), C102 (= C837), P105 (≠ A840), C107 (= C842), C111 (= C846), P112 (= P847), I117 (≠ T851), V125 (≠ N859), C132 (= C866), I133 (≠ V867), G134 (= G868), C135 (≠ T869), G136 (≠ R870), Y137 (= Y871), C138 (= C872), C142 (= C876), I146 (≠ V880), P147 (≠ R881), V156 (≠ L898), K158 (= K921), C159 (= C922), L161 (≠ M924), C162 (= C925), P172 (≠ M950), C174 (= C952), C178 (= C956), P179 (≠ S957), I183 (= I961)
Sites not aligning to the query:
P0AAJ3 Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit; Anaerobic formate dehydrogenase iron-sulfur subunit; Formate dehydrogenase-N subunit beta; FDH-N subunit beta from Escherichia coli (strain K12) (see paper)
25% identity, 21% coverage: 757:964/1010 of query aligns to 34:187/294 of P0AAJ3
- C39 (= C762) binding
- C42 (= C765) binding
- C45 (= C768) binding
- C49 (= C772) binding
- C100 (= C834) binding
- C103 (= C837) binding
- C108 (= C842) binding
- C112 (= C846) binding
- C133 (= C866) binding
- C136 (≠ T869) binding
- C139 (= C872) binding
- C143 (= C876) binding
- C160 (= C922) binding
- C163 (= C925) binding
- C175 (= C952) binding
- C179 (= C956) binding
3egwB The crystal structure of the narghi mutant narh - c16a
26% identity, 12% coverage: 817:933/1010 of query aligns to 167:255/509 of 3egwB
- binding fe3-s4 cluster: P181 (= P831), C196 (= C846), S198 (≠ V848), I201 (≠ T851), C217 (= C866), R218 (≠ V867), G219 (= G868), W220 (≠ T869), R221 (= R870), C223 (= C872), S241 (≠ M919)
- binding protoporphyrin ix containing fe: W220 (≠ T869), R221 (= R870)
- binding iron/sulfur cluster: C184 (= C834), E185 (≠ Q835), H186 (= H836), C187 (= C837), P190 (≠ A840), C192 (= C842), C227 (= C876), I232 (≠ R881), K243 (= K921), C244 (= C922), F246 (≠ M924), C247 (= C925)
Sites not aligning to the query:
- binding fe3-s4 cluster: 17, 18, 19, 20, 22, 263, 265, 268
- binding protoporphyrin ix containing fe: 88, 89
- binding iron/sulfur cluster: 26, 30, 41, 42, 257, 259
7z0sB Structure of the escherichia coli formate hydrogenlyase complex (anaerobic preparation, without formate dehydrogenase h) (see paper)
28% identity, 13% coverage: 751:884/1010 of query aligns to 2:100/170 of 7z0sB
- binding iron/sulfur cluster: C12 (= C762), I13 (≠ T763), G14 (= G764), C15 (= C765), H16 (≠ G766), T17 (≠ S767), C18 (= C768), C22 (= C772), H26 (≠ R787), R36 (≠ W794), L37 (≠ I795), P48 (= P831), L50 (= L833), C51 (= C834), H52 (≠ Q835), H53 (= H836), C54 (= C837), C59 (= C842), C63 (= C846), P64 (= P847), I68 (≠ V852), V75 (≠ N859), L77 (≠ M861), C82 (= C866), V83 (= V867), C85 (≠ T869), K86 (≠ R870), C88 (= C872), C92 (= C876), I97 (≠ R881)
Sites not aligning to the query:
- binding iron/sulfur cluster: 140, 142, 143, 144, 145, 146, 153, 155, 159, 160, 161, 164
P11349 Respiratory nitrate reductase 1 beta chain; Nitrate reductase A subunit beta; Quinol-nitrate oxidoreductase subunit beta; EC 1.7.5.1 from Escherichia coli (strain K12) (see 2 papers)
26% identity, 12% coverage: 817:933/1010 of query aligns to 167:255/512 of P11349
- C184 (= C834) binding
- C187 (= C837) binding
- C192 (= C842) binding
- C196 (= C846) binding
- C217 (= C866) binding
- C223 (= C872) binding
- C227 (= C876) binding
- C244 (= C922) binding
- C247 (= C925) binding
Sites not aligning to the query:
- 16 binding
- 19 binding
- 22 binding
- 26 binding
- 259 binding
- 263 binding
4v4cB Pyrogallol hydroxytransferase small subunit (see paper)
20% identity, 26% coverage: 753:1010/1010 of query aligns to 4:201/274 of 4v4cB
- binding calcium ion: I61 (≠ L822), N62 (≠ D823)
- binding iron/sulfur cluster: C13 (= C762), Q14 (≠ T763), D15 (≠ G764), C16 (= C765), N17 (≠ G766), N18 (≠ S767), C19 (= C768), C23 (= C772), C68 (= C834), M69 (≠ Q835), H70 (= H836), C71 (= C837), C76 (= C842), V92 (≠ N859), C109 (= C876), V113 (= V880), C126 (= C922), M128 (= M924), C129 (= C925), P143 (≠ E939), C145 (= C952), C149 (= C956), S151 (≠ A960), V153 (= V962), Y154 (≠ F963)
Query Sequence
>CA265_RS17845 FitnessBrowser__Pedo557:CA265_RS17845
MESNKKYWKGLEEYNNTPDFVKNNKNEFAEPLPIEDVLNEAGLSTVTPRRDFLKALGFGL
GAVTLAACQTAPVHKSIPYLVKPEEVTPGIPNYYTSSFNGQSILVKTREGRPIKIEPNPN
AGQFNCGTDARAQASVLDLYDVSKLKAPALVKDGKVEETTWAKIDSFVKGELAKAQAGGK
KIRIVSSTVNSPSTNAVIAQFIAKYPAAKLVQYDAVSYTGIIQANQNSFGKAVLPKYNFD
KADLIVSFSADFLGTWISGEEFTAQYTANRNYKSLENKKMSRHIQFESGMSLTGTNADTR
VPVKLSEEGPALIALYNAITGSALPGGTLGNNTTADKVIKLVAKELVQAKGKGLVVCGSN
DVSTQILVNAINAAIGSYGTTIDLDNPCYLYAGNDAEFNGLVAEMSRGEVGAVLFLNSNP
VYDAANAKAFTDALAKVPAKISFSDRADETATACDAIAINHNYLESWGDANAYEGYYSIV
QPTINPVFNSRQAEESLLTWADAPVKDYYQFVRSNWEAKMLPAVGLKWEEVLEKGVVTAT
AKTAGAYSFTQSLAQVATSIVSSSKALDKDIQLQVYENIPMRDGKNANNAFLQELPDPVS
KVTWDNYVALAPKFAEKLKVKEFDVVTVKASNGYSVDLPVLIQPGQAQQTASIALGYGRT
KVGKAGNDVGKNAFPFVSFINGTFQYATTVTITPTGGYYELAQTQTHHSFEGRAVIKEAT
FKEYLKNPGAGNEKGEHKDYDLWDQYEKPGNNWVMAIDLNACTGCGSCIVACNVENNIPV
VGRDEVRRRREMHWIRIDRYYSYETKDGDVTREKEIAKLEDLDHVSVVHQPMLCQHCDHA
PCETVCPVLATVHSSDGLNHMAYNRCVGTRYCANNCPYKVRRFNWFNYWNDSRFDNYLNN
EFTQLVLNPDVTTRSRGVMEKCSMCIQRIQGGKLQAKLEKRPLKDGDIKMACQEACSANA
IVFGDANDPNSEVSKALRSERIYYVLEEINVKPGIGYMTKIRNTDTTVQA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory