Comparing CA265_RS19745 FitnessBrowser__Pedo557:CA265_RS19745 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q5HNV1 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Staphylococcus epidermidis (strain ATCC 35984 / RP62A) (see paper)
34% identity, 98% coverage: 4:245/247 of query aligns to 3:247/269 of Q5HNV1
Q58484 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
36% identity, 99% coverage: 2:245/247 of query aligns to 7:262/282 of Q58484
1nvtB Crystal structure of shikimate dehydrogenase (aroe or mj1084) in complex with NADP+ (see paper)
36% identity, 99% coverage: 2:245/247 of query aligns to 12:267/287 of 1nvtB
1nvtA Crystal structure of shikimate dehydrogenase (aroe or mj1084) in complex with NADP+ (see paper)
36% identity, 99% coverage: 2:245/247 of query aligns to 12:267/287 of 1nvtA
2hk9B Crystal structure of shikimate dehydrogenase from aquifex aeolicus in complex with shikimate and NADP+ at 2.2 angstrom resolution (see paper)
35% identity, 98% coverage: 4:246/247 of query aligns to 9:251/267 of 2hk9B
O67049 Shikimate dehydrogenase (NADP(+)); SD; SDH; EC 1.1.1.25 from Aquifex aeolicus (strain VF5) (see paper)
35% identity, 98% coverage: 4:246/247 of query aligns to 9:251/269 of O67049
2hk9A Crystal structure of shikimate dehydrogenase from aquifex aeolicus in complex with shikimate and NADP+ at 2.2 angstrom resolution (see paper)
35% identity, 98% coverage: 4:246/247 of query aligns to 9:251/269 of 2hk9A
3dooA Crystal structure of shikimate dehydrogenase from staphylococcus epidermidis complexed with shikimate (see paper)
32% identity, 98% coverage: 4:245/247 of query aligns to 3:238/258 of 3dooA
2cy0A Crystal structure of shikimate 5-dehydrogenase (aroe) from thermus thermophilus hb8 in complex with NADP (see paper)
34% identity, 100% coverage: 1:246/247 of query aligns to 1:244/262 of 2cy0A
2ev9B Crystal structure of shikimate 5-dehydrogenase (aroe) from thermus thermophilus hb8 in complex with NADP(h) and shikimate (see paper)
34% identity, 100% coverage: 1:246/247 of query aligns to 1:244/263 of 2ev9B
Q5SJF8 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
34% identity, 100% coverage: 1:246/247 of query aligns to 1:244/263 of Q5SJF8
2gptA Crystal structure of arabidopsis dehydroquinate dehydratase-shikimate dehydrogenase in complex with tartrate and shikimate (see paper)
32% identity, 99% coverage: 2:246/247 of query aligns to 235:473/498 of 2gptA
Sites not aligning to the query:
2o7qA Crystal structure of the a. Thaliana dhq-dehydroshikimate-sdh- shikimate-NADP(h)
33% identity, 99% coverage: 2:246/247 of query aligns to 235:476/501 of 2o7qA
Sites not aligning to the query:
2o7sA Crystal structure of the a. Thaliana dhq-dehydroshikimate-sdh- shikimate-NADP(h)
31% identity, 99% coverage: 2:246/247 of query aligns to 235:475/500 of 2o7sA
Sites not aligning to the query:
6bmqA Crystal structure of arabidopsis dehydroquinate dehydratase-shikimate dehydrogenase (t381g mutant) in complex with tartrate and shikimate (see paper)
32% identity, 99% coverage: 2:246/247 of query aligns to 235:473/498 of 6bmqA
Sites not aligning to the query:
3tozA 2.2 angstrom crystal structure of shikimate 5-dehydrogenase from listeria monocytogenes in complex with NAD.
29% identity, 98% coverage: 5:246/247 of query aligns to 17:277/291 of 3tozA
Q8Y9N5 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
29% identity, 98% coverage: 5:246/247 of query aligns to 17:277/291 of Q8Y9N5
3tnlA 1.45 angstrom crystal structure of shikimate 5-dehydrogenase from listeria monocytogenes in complex with shikimate and NAD.
29% identity, 98% coverage: 5:246/247 of query aligns to 14:274/288 of 3tnlA
1nytA Shikimate dehydrogenase aroe complexed with NADP+ (see paper)
32% identity, 100% coverage: 1:246/247 of query aligns to 1:253/271 of 1nytA
P15770 Shikimate dehydrogenase (NADP(+)); SD; SDH; EC 1.1.1.25 from Escherichia coli (strain K12) (see paper)
32% identity, 100% coverage: 1:246/247 of query aligns to 1:253/272 of P15770
>CA265_RS19745 FitnessBrowser__Pedo557:CA265_RS19745
MKTYGLIGYPLSHSFSKKYFTEKFQNEGIAGHQYELFPIADIKSLPDLLNENPSLCGLNV
TIPHKVNVLCYLNEVDEAAEKIGAVNCISIKSFEGKNYLKGYNTDAYGFEESLKPLLGPQ
HTKALVFGDGGAAKAVKYVLEKLNIQYQLVVRTAVPGAILYSEVSPEILASHQLLINTTP
LGMSPNVDTFPEIDYSLLGPGYLAYDLVYNPLETAFLAKAAERGAAIKNGLEMLYKQAEK
AWAIWNK
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory