Comparing CA265_RS19880 FitnessBrowser__Pedo557:CA265_RS19880 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 6 hits to proteins with known functional sites (download)
7rk5B Mannitol-2-dehydrogenase bound to nadh from aspergillus fumigatus
27% identity, 77% coverage: 3:390/503 of query aligns to 5:399/501 of 7rk5B
4im7A Crystal structure of fructuronate reductase (ydfi) from e. Coli cft073 (efi target efi-506389) complexed with nadh and d-mannonate
25% identity, 69% coverage: 74:422/503 of query aligns to 66:411/483 of 4im7A
Sites not aligning to the query:
1m2wA Pseudomonas fluorescens mannitol 2-dehydrogenase ternary complex with NAD and d-mannitol (see paper)
23% identity, 99% coverage: 1:497/503 of query aligns to 1:488/492 of 1m2wA
1lj8A Crystal structure of mannitol dehydrogenase in complex with NAD (see paper)
23% identity, 99% coverage: 1:497/503 of query aligns to 1:488/492 of 1lj8A
P09424 Mannitol-1-phosphate 5-dehydrogenase; EC 1.1.1.17 from Escherichia coli (strain K12) (see paper)
26% identity, 34% coverage: 199:368/503 of query aligns to 134:287/382 of P09424
Q4X1A4 Mannitol-1-phosphate 5-dehydrogenase; M1PDH; MPD; MPDH; EC 1.1.1.17 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
23% identity, 30% coverage: 216:368/503 of query aligns to 153:288/388 of Q4X1A4
>CA265_RS19880 FitnessBrowser__Pedo557:CA265_RS19880
MILNKENLKNINGDKVIKPSAEILALPEKVIQFGTGVLLRGLPDYFIDKANQKGIFNGRV
LVVKSTSKGGADAFSKQDNLYTLCVKGIEDGAHVEENSINASISRVLSASQDWAEILKAA
HQPEMQVVISNTTEVGIVKSEDKITDNPPQSYPGKLLAFLHERYTAFNGSAESGMVIVPT
ELISDNADKLKEILLDLAIQNKLGWDFENWLKTANHFCKTLVDRIVPGKLPESAQKAIES
ELGYEDELMIMAEPFRLWAIESSSEKVKEILSFAKADKGVFIVPSIDKFKELKLRLLNGT
HTISCGLAILAGFNTVKEAMANEDFSANVLKLMKDEIAPVVVNEDITYDEAIAFAKSVVD
RFSNPSLEHQWQAITLNFTSKMQMRNMPLIRRYYALKNEVPQLTALGVAAYILFMNVNQD
GDTYTASANGKTYPVQDEFAEILYEYWKNPETVVDNTLGDRRLWDKNLNNYPGFNAAVKS
YVDLLQNKGAKETLSNLHSERTI
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory