SitesBLAST
Comparing CA265_RS23555 FitnessBrowser__Pedo557:CA265_RS23555 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4hea1 Crystal structure of the entire respiratory complex i from thermus thermophilus (see paper)
51% identity, 92% coverage: 4:422/455 of query aligns to 14:420/437 of 4hea1
- binding flavin mononucleotide: G63 (= G53), K74 (= K64), N91 (= N81), D93 (= D83), Y179 (= Y169), G182 (= G172), E183 (= E173), N218 (= N208), N219 (= N209), L401 (= L403)
- binding iron/sulfur cluster: I180 (= I170), P198 (= P188), S351 (= S354), C352 (= C355), G353 (= G356), K354 (≠ Q357), C355 (= C358), C358 (= C361), F398 (≠ I400), C399 (= C401), L401 (= L403)
2ybb1 Fitted model for bovine mitochondrial supercomplex i1iii2iv1 by single particle cryo-em (emd-1876) (see paper)
51% identity, 92% coverage: 4:422/455 of query aligns to 14:420/437 of 2ybb1
- binding flavin mononucleotide: G63 (= G53), G65 (= G55), N91 (= N81), D93 (= D83), G182 (= G172), E183 (= E173), E184 (= E174), N218 (= N208), N219 (= N209), T222 (≠ S212), P400 (= P402)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G65 (= G55), G66 (= G56), F69 (= F59), K74 (= K64), F77 (= F67), E96 (= E86), Y179 (= Y169), E184 (= E174), K201 (= K191), F204 (= F194), T324 (≠ S327)
- binding iron/sulfur cluster: S351 (= S354), C352 (= C355), K354 (≠ Q357), C355 (= C358), C358 (= C361), F398 (≠ I400), C399 (= C401), L401 (= L403), A402 (≠ G404)
Q56222 NADH-quinone oxidoreductase subunit 1; NADH dehydrogenase I chain 1; NDH-1 subunit 1; EC 7.1.1.- from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
51% identity, 92% coverage: 4:422/455 of query aligns to 15:421/438 of Q56222
8e9hF Mycobacterial respiratory complex i, fully-inserted quinone (see paper)
49% identity, 90% coverage: 17:427/455 of query aligns to 18:422/436 of 8e9hF
- binding flavin mononucleotide: G53 (= G53), R54 (= R54), G55 (= G55), A57 (= A57), K64 (= K64), N90 (= N81), D92 (= D83), Y178 (= Y169), G181 (= G172), E182 (= E173), E183 (= E174), N217 (= N208), N218 (= N209), S221 (= S212), L398 (= L403)
- binding iron/sulfur cluster: P197 (= P188), S349 (= S354), C350 (= C355), G351 (= G356), K352 (≠ Q357), C353 (= C358), C356 (= C361), S394 (≠ T399), F395 (≠ I400), C396 (= C401), L398 (= L403), G399 (= G404)
- binding zinc ion: C333 (= C338), E371 (= E376), H420 (= H425)
Sites not aligning to the query:
8b9zF Drosophila melanogaster complex i in the active state (dm1) (see paper)
47% identity, 90% coverage: 27:435/455 of query aligns to 45:441/441 of 8b9zF
- binding flavin mononucleotide: G69 (= G53), G71 (= G55), K80 (= K64), N98 (= N81), D100 (= D83), G189 (= G172), E191 (= E174), N226 (= N209), A408 (≠ P402), L409 (= L403)
- binding iron/sulfur cluster: P205 (= P188), C361 (= C355), G362 (= G356), Q363 (= Q357), C364 (= C358), C367 (= C361), T405 (= T399), C407 (= C401), L409 (= L403)
8eswV1 NADH dehydrogenase (Ubiquinone) 24 kDa subunit, isoform A (see paper)
47% identity, 90% coverage: 27:435/455 of query aligns to 43:439/439 of 8eswV1
- binding flavin mononucleotide: G67 (= G53), G69 (= G55), K78 (= K64), N96 (= N81), D98 (= D83), E99 (= E84), G187 (= G172), E188 (= E173), N224 (= N209), A406 (≠ P402)
- binding iron/sulfur cluster: I185 (= I170), P203 (= P188), C359 (= C355), Q361 (= Q357), C362 (= C358), C365 (= C361), T403 (= T399), I404 (= I400), C405 (= C401), L407 (= L403)
- binding : Y143 (≠ M128), N144 (≠ P129), Q150 (≠ E135), D174 (≠ E159)
7arcF Cryo-em structure of polytomella complex-i (peripheral arm) (see paper)
48% identity, 85% coverage: 42:427/455 of query aligns to 50:425/430 of 7arcF
- binding flavin mononucleotide: G61 (= G53), R62 (= R54), K72 (= K64), N90 (= N81), D92 (= D83), E93 (= E84), S94 (= S85), Y178 (= Y169), G181 (= G172), E182 (= E173), T217 (≠ N208), N218 (= N209), L401 (= L403)
- binding iron/sulfur cluster: S352 (= S354), C353 (= C355), G354 (= G356), Q355 (= Q357), C356 (= C358), C359 (= C361), T397 (= T399), C399 (= C401), L401 (= L403)
7aqrF Cryo-em structure of arabidopsis thaliana complex-i (peripheral arm) (see paper)
51% identity, 83% coverage: 42:418/455 of query aligns to 49:415/434 of 7aqrF
- binding flavin mononucleotide: G60 (= G53), R61 (= R54), G62 (= G55), K71 (= K64), N89 (= N81), D91 (= D83), Y177 (= Y169), G180 (= G172), E181 (= E173), E182 (= E174), T216 (≠ N208), N217 (= N209)
- binding iron/sulfur cluster: S351 (= S354), C352 (= C355), G353 (= G356), Q354 (= Q357), C355 (= C358), C358 (= C361), T396 (= T399), C398 (= C401), L400 (= L403)
7o6yB Cryo-em structure of respiratory complex i under turnover (see paper)
46% identity, 91% coverage: 14:428/455 of query aligns to 20:425/457 of 7o6yB
- binding flavin mononucleotide: G57 (= G53), G59 (= G55), K68 (= K64), N89 (= N81), D91 (= D83), E92 (= E84), G180 (= G172), E181 (= E173), E182 (= E174), T216 (≠ N208), N217 (= N209)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G59 (= G55), G60 (= G56), F63 (= F59), K68 (= K64), E94 (= E86), Y177 (= Y169), E182 (= E174), F202 (= F194), T324 (≠ S327)
- binding iron/sulfur cluster: P196 (= P188), S351 (= S354), C352 (= C355), G353 (= G356), Q354 (= Q357), C355 (= C358), C358 (= C361), T396 (= T399), C398 (= C401), L400 (= L403)
7b0nF 3.7-angstrom structure of Yarrowia lipolytica complex I with an R121M mutation in NUCM. (see paper)
46% identity, 91% coverage: 14:428/455 of query aligns to 21:426/460 of 7b0nF
- binding flavin mononucleotide: G60 (= G55), K69 (= K64), N90 (= N81), D92 (= D83), E93 (= E84), G94 (≠ S85), Y178 (= Y169), G181 (= G172), E182 (= E173), N218 (= N209)
- binding iron/sulfur cluster: P197 (= P188), S352 (= S354), C353 (= C355), Q355 (= Q357), C356 (= C358), C359 (= C361), T397 (= T399), C399 (= C401)
8gymv1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (see paper)
45% identity, 91% coverage: 23:435/455 of query aligns to 29:436/442 of 8gymv1
- binding flavin mononucleotide: G58 (= G53), G60 (= G55), N88 (= N81), D90 (= D83), Y176 (= Y169), E180 (= E173), E181 (= E174), T215 (≠ N208), N216 (= N209), T219 (≠ S212), A398 (≠ P402), L399 (= L403)
- binding iron/sulfur cluster: I177 (= I170), P195 (= P188), C351 (= C355), G352 (= G356), Q353 (= Q357), C354 (= C358), C357 (= C361), T395 (= T399), C397 (= C401), L399 (= L403), G400 (= G404)
7dgq8 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (see paper)
48% identity, 88% coverage: 27:428/455 of query aligns to 32:421/427 of 7dgq8
- binding flavin mononucleotide: G58 (= G55), K67 (= K64), N85 (= N81), D87 (= D83), E88 (= E84), G89 (≠ S85), C175 (= C171), G176 (= G172), A212 (≠ N208), N213 (= N209)
- binding iron/sulfur cluster: S347 (= S354), C348 (= C355), G349 (= G356), C351 (= C358), C354 (= C361), C394 (= C401), L396 (= L403)
- binding : R121 (≠ K117), Y132 (≠ M128), Q139 (≠ E135), R143 (≠ A139), Y146 (≠ K142), E147 (≠ A143), F165 (≠ Y161), R168 (≠ P164)
P25708 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Bos taurus (Bovine) (see paper)
48% identity, 87% coverage: 27:423/455 of query aligns to 63:447/464 of P25708
- C379 (= C355) binding
- C382 (= C358) binding
- C385 (= C361) binding
- C425 (= C401) binding
6zk91 Peripheral domain of open complex i during turnover (see paper)
48% identity, 87% coverage: 27:423/455 of query aligns to 35:419/430 of 6zk91
- binding flavin mononucleotide: G59 (= G53), G61 (= G55), K70 (= K64), N88 (= N81), D90 (= D83), E91 (= E84), G179 (= G172), E180 (= E173), A215 (≠ N208), N216 (= N209), A398 (≠ P402), L399 (= L403)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G61 (= G55), G62 (= G56), A63 (= A57), F65 (= F59), K70 (= K64), E93 (= E86), Y176 (= Y169), E181 (= E174), F201 (= F194), T323 (≠ S327)
- binding iron/sulfur cluster: I177 (= I170), P195 (= P188), C351 (= C355), G352 (= G356), Q353 (= Q357), C354 (= C358), C357 (= C361), T395 (= T399), C397 (= C401), L399 (= L403)
5lnk1 Entire ovine respiratory complex i (see paper)
48% identity, 87% coverage: 27:423/455 of query aligns to 37:421/432 of 5lnk1
- binding fe2/s2 (inorganic) cluster: P96 (= P87), G97 (= G88)
- binding flavin mononucleotide: G61 (= G53), R62 (= R54), K72 (= K64), N90 (= N81), D92 (= D83), E93 (= E84), G94 (≠ S85), Y178 (= Y169), G181 (= G172), E182 (= E173), V216 (= V207), A217 (≠ N208), N218 (= N209), T221 (≠ S212), L401 (= L403)
- binding iron/sulfur cluster: P197 (= P188), S352 (= S354), C353 (= C355), Q355 (= Q357), C356 (= C358), C359 (= C361), T397 (= T399), I398 (= I400), C399 (= C401)
7v2cA Active state complex i from q10 dataset (see paper)
48% identity, 88% coverage: 27:428/455 of query aligns to 38:427/433 of 7v2cA
- binding flavin mononucleotide: G62 (= G53), K73 (= K64), N91 (= N81), Y179 (= Y169), G182 (= G172), E183 (= E173), N219 (= N209), A401 (≠ P402), L402 (= L403)
- binding iron/sulfur cluster: P198 (= P188), C354 (= C355), G355 (= G356), Q356 (= Q357), C357 (= C358), C360 (= C361), T398 (= T399), C400 (= C401), L402 (= L403)
P49821 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Homo sapiens (Human) (see paper)
48% identity, 87% coverage: 27:423/455 of query aligns to 63:447/464 of P49821
- C379 (= C355) binding
- C382 (= C358) binding
- C385 (= C361) binding
- C425 (= C401) binding
Q91YT0 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Mus musculus (Mouse) (see 2 papers)
48% identity, 88% coverage: 22:423/455 of query aligns to 58:447/464 of Q91YT0
- C379 (= C355) binding
- C382 (= C358) binding
- C385 (= C361) binding
- C425 (= C401) binding
Sites not aligning to the query:
- 1:20 modified: transit peptide, Mitochondrion
7zm7B Cryoem structure of mitochondrial complex i from chaetomium thermophilum (inhibited by ddm) (see paper)
46% identity, 85% coverage: 42:428/455 of query aligns to 48:427/456 of 7zm7B
- binding flavin mononucleotide: G59 (= G53), G61 (= G55), K70 (= K64), N91 (= N81), D93 (= D83), G182 (= G172), E183 (= E173), E184 (= E174), A218 (≠ N208), N219 (= N209), A401 (≠ P402), L402 (= L403)
- binding iron/sulfur cluster: P198 (= P188), C354 (= C355), G355 (= G356), Q356 (= Q357), C357 (= C358), C360 (= C361), T398 (= T399), C400 (= C401), L402 (= L403)
7p61F Complex i from e. Coli, ddm-purified, with nadh, resting state (see paper)
46% identity, 93% coverage: 18:439/455 of query aligns to 26:436/442 of 7p61F
- binding flavin mononucleotide: G61 (= G53), G63 (= G55), K72 (= K64), N90 (= N81), D92 (= D83), G181 (= G172), E182 (= E173), N217 (= N208), N218 (= N209), A399 (≠ P402), H400 (≠ L403)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G63 (= G55), G64 (= G56), A65 (= A57), F67 (= F59), K72 (= K64), L75 (≠ F67), E95 (= E86), Y178 (= Y169), E183 (= E174), F203 (= F194), R320 (≠ A320), T323 (= T323)
- binding iron/sulfur cluster: S350 (= S354), C351 (= C355), W353 (≠ Q357), C354 (= C358), C357 (= C361), F397 (≠ I400), C398 (= C401), H400 (≠ L403)
Query Sequence
>CA265_RS23555 FitnessBrowser__Pedo557:CA265_RS23555
MSRKLLLEHINVPGINTLEVYRQKGGYRAVEKALKTLTPEEIVEEVKKSGLRGRGGAGFP
TGMKWSFLAKPEGVARYLVCNADESEPGTFKDRYLMTYIPHALIEGMIVSSFALGAKVSY
IYVRGEMMPQIRILEKAIAEAKAAGWLGKNILGTGYDLELYVQPGGGAYICGEETALLES
LEGKRGNPRIKPPFPAIAGLYGCPTVVNNVESIAAVVPIINDGGDEYAKIGIGRSTGTKL
ISASGNLVKPGVYEIELGLPVEEFIYSDEYCGGIANGKQLKATVAGGSSVPILPANLTLK
YANGEPRLMSYESLSEGGFATGTMMGSGGFIAFDEDQCIVRNTWNFSRFYHHESCGQCSP
CREGTGWMEKVLHKIEHGHGSMEDVDLLWDIQRKIEGNTICPLGDAAAWPVASAIRHFRD
EFEWHIKEPVKSQSQNYGIANYATPIEKAPVTEEK
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory