Comparing CA265_RS25185 FitnessBrowser__Pedo557:CA265_RS25185 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 10 hits to proteins with known functional sites (download)
4lhdA Crystal structure of synechocystis sp. Pcc 6803 glycine decarboxylase (p-protein), holo form with pyridoxal-5'-phosphate and glycine, closed flexible loop (see paper)
59% identity, 98% coverage: 9:946/958 of query aligns to 17:949/952 of 4lhdA
Sites not aligning to the query:
Q94B78 Glycine dehydrogenase (decarboxylating) 1, mitochondrial; Glycine cleavage system P protein 1; Glycine decarboxylase 1; Glycine decarboxylase P-protein 1; AtGLDP1; Glycine dehydrogenase (aminomethyl-transferring) 1; EC 1.4.4.2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
58% identity, 98% coverage: 9:950/958 of query aligns to 77:1028/1037 of Q94B78
6i34B Crystal structure of neanderthal glycine decarboxylase (p-protein)
53% identity, 98% coverage: 9:948/958 of query aligns to 11:954/954 of 6i34B
6i35A Crystal structure of human glycine decarboxylase (p-protein) bound with pyridoxyl-glycine-5'-monophosphate
53% identity, 98% coverage: 9:949/958 of query aligns to 13:953/953 of 6i35A
6i33A Crystal structure of human glycine decarboxylase (p-protein)
54% identity, 98% coverage: 9:949/958 of query aligns to 13:950/950 of 6i33A
P15505 Glycine dehydrogenase (decarboxylating), mitochondrial; Glycine cleavage system P protein; Glycine decarboxylase; Glycine dehydrogenase (aminomethyl-transferring); EC 1.4.4.2 from Gallus gallus (Chicken) (see paper)
53% identity, 99% coverage: 9:952/958 of query aligns to 51:992/1004 of P15505
6i33B Crystal structure of human glycine decarboxylase (p-protein)
52% identity, 98% coverage: 9:948/958 of query aligns to 11:925/925 of 6i33B
1wyuB Crystal structure of glycine decarboxylase (p-protein) of the glycine cleavage system, in holo form (see paper)
40% identity, 44% coverage: 480:904/958 of query aligns to 46:458/473 of 1wyuB
1wyvA Crystal structure of glycine decarboxylase (p-protein) of the glycine cleavage system, in inhibitor-bound form (see paper)
38% identity, 37% coverage: 19:372/958 of query aligns to 7:360/437 of 1wyvA
1wyuA Crystal structure of glycine decarboxylase (p-protein) of the glycine cleavage system, in holo form (see paper)
38% identity, 37% coverage: 19:372/958 of query aligns to 7:360/437 of 1wyuA
>CA265_RS25185 FitnessBrowser__Pedo557:CA265_RS25185
MSLNIHYKEDFQNRHIAPNEADTAEMLQTVGVNSIDELIEQTVPTAIRLKQPLNLPAAKS
ETEYLGALKQTSLLNKVFKSFIGQGYYDTITPGVILRNVFENPGWYTQYTPYQAEIAQGR
LQALLNFQTMVIDLTGMEIANASLLDEGTAAAEAMFMQYSLRKNQGAKKFFVSALLFPQT
IDILKTRANPYGIELVIGSHLDFVATEDFFGAIVQYPAGNGEVFDYKDFASALHNQNIKL
TVVADILSLTLLTPPGEWGADVVVGTTQRLGIPMGFGGPHAAFFATKEEYKRNIPGRIIG
VTIDSHGDYALRMALQTREQHIRRDKATSNICTAQALLAIMAGFYAAYHGPKGLKAIAER
THGLAISLASTLKGLGFEQLNSAYFDTIRFDLGDLKGGIHSGCIDNEINLNYVGNVATIS
FDETSTFEDVALIAKIFAKVKAIAADQVEVAENVETVIPSALQRTSAYLTHPIFNAHHSE
HEMLRYIKSLEAKDLSLCHSMIALGSCTMKLNATAEMIPVTWSHFGRIHPFAPADQVLGY
YSVFNELDKWLSEITGFAAMSLQPNAGAQGEYAGLMVIRAYHQDRGDFHRNVALIPASAH
GTNPASAAMADMKIVVVKSLENGNIDVEDLKAKAELHKDNLSCLMVTYPSTHGVFEESII
EICETIHANGGQVYMDGANMNAQVGLTSPANIGADVCHLNLHKTFCIPHGGGGPGMGPIG
VAKHLVPYLPGHAVVDIDKGKSISAVSSAPWGSASILIISHAYIAMMGAEGLTNATKYAI
LNANYMKARLEQHYPVLYSGAQGRCAHEMILDCRSFKAFGIEVTDIAKRLMDYGFHAPTV
SFPVAGTLMVEPTESEPKHELDRFCDALIAIKNEITAVENGTLDKVDNPLKNAPHTVSVI
TANEWDHAYSRQTAAFPLPYVLARKFWPSVGRVNDSHGDRALICACPPIESYLEEIVP
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory