SitesBLAST
Comparing CCNA_00074 CCNA_00074 multifunctional fatty acid oxidation complex subunit alpha FadJ to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
4b3iA Crystal structure of mycobacterium tuberculosis fatty acid beta-oxidation complex with coenzymea bound at the hydratase active sites (see paper)
47% identity, 96% coverage: 9:711/733 of query aligns to 22:729/731 of 4b3iA
- active site: G79 (≠ A66), E100 (≠ F96), R104 (≠ K100), G127 (= G123), E130 (= E126), P151 (= P147), E152 (= E148), G160 (= G156), S452 (= S439), H473 (= H460), E485 (= E472), S523 (= S510)
- binding adenosine-5'-diphosphate: Q640 (= Q628), P641 (≠ A629), P642 (≠ L630), L643 (≠ I631), Q644 (= Q632)
- binding coenzyme a: S37 (= S24), T38 (≠ M25), V40 (≠ T27), A77 (= A64), G79 (≠ A66), D80 (= D67), V81 (≠ L68), K82 (≠ G69), L125 (≠ M121), P151 (= P147), E152 (= E148), R186 (≠ S181), F315 (= F302), Q319 (= Q306)
7o4uA Structure of the alpha subunit of mycobacterium tuberculosis beta- oxidation trifunctional enzyme in complex with oxidized nicotinamide adenine dinucleotide (see paper)
47% identity, 96% coverage: 9:711/733 of query aligns to 9:709/711 of 7o4uA
- binding nicotinamide-adenine-dinucleotide: G323 (= G330), A324 (= A331), G325 (= G332), M326 (= M333), M327 (= M334), K345 (≠ I352), D346 (= D353), V347 (≠ Q354), A402 (= A409), V403 (= V410), F404 (= F411), E405 (= E412), N430 (= N437), S432 (= S439), H453 (= H460), S456 (= S463)
6yswA E. Coli anaerobic trifunctional enzyme subunit-alpha in complex with coenzyme a
38% identity, 98% coverage: 4:722/733 of query aligns to 4:703/707 of 6yswA
- active site: A66 (= A66), I71 (≠ A78), A84 (≠ F92), Q88 (≠ F96), G112 (= G123), E115 (= E126), P136 (= P147), E137 (= E148), G145 (= G156), D264 (= D275), S422 (= S439), H443 (= H460), E455 (= E472), N493 (≠ S510)
- binding coenzyme a: E23 (≠ R23), M25 (= M25), T27 (= T27), A64 (= A64), A66 (= A66), D67 (= D67), I68 (≠ L68), N69 (≠ G69), P136 (= P147), E137 (= E148), L140 (≠ V151), F286 (= F302), F287 (≠ L303), T290 (≠ Q306), K293 (≠ G309)
P40939 Trifunctional enzyme subunit alpha, mitochondrial; 78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Homo sapiens (Human) (see 5 papers)
34% identity, 97% coverage: 13:722/733 of query aligns to 49:762/763 of P40939
- V282 (= V240) to D: in MTPD; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852773
- I305 (≠ L263) to N: in MTPD; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852774
- L342 (≠ F302) to P: in LCHAD deficiency; dbSNP:rs137852772
- E510 (= E472) active site, For hydroxyacyl-coenzyme A dehydrogenase activity; to Q: in AFLP and LCHAD deficiency; loss of long-chain-3-hydroxyacyl-CoA dehydrogenase activity; dbSNP:rs137852769
1wdmA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form i (native3) (see paper)
36% identity, 97% coverage: 12:723/733 of query aligns to 16:707/707 of 1wdmA
- active site: A69 (= A66), N89 (≠ G95), N93 (= N99), G117 (= G123), E120 (= E126), P139 (= P147), E140 (= E148), P147 (= P155), G148 (= G156), S430 (= S439), H451 (= H460), E463 (= E472), N501 (≠ S510)
- binding acetyl coenzyme *a: K142 (= K150), D297 (≠ L305), M459 (= M468), N501 (≠ S510), P534 (= P543), M535 (≠ R544), V544 (= V553), V651 (≠ I666), Y652 (≠ L667), G655 (= G670), L658 (≠ P673)
- binding nicotinamide-adenine-dinucleotide: G321 (= G330), A322 (= A331), I324 (≠ M333), M325 (= M334), K343 (≠ I352), D344 (= D353), I345 (≠ Q354), A400 (= A409), V401 (= V410), E403 (= E412), K408 (= K417), N428 (= N437), T429 (= T438), S430 (= S439), F452 (= F461), N454 (≠ S463)
1wdlA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form ii (native4) (see paper)
36% identity, 97% coverage: 12:723/733 of query aligns to 16:715/715 of 1wdlA
- active site: A69 (= A66), N89 (≠ G95), N93 (= N99), G117 (= G123), E120 (= E126), P139 (= P147), E140 (= E148), P147 (= P155), G148 (= G156), S430 (= S439), H451 (= H460), E463 (= E472), N501 (≠ S510)
- binding nicotinamide-adenine-dinucleotide: G321 (= G330), A322 (= A331), I324 (≠ M333), M325 (= M334), D344 (= D353), I345 (≠ Q354), A400 (= A409), V401 (= V410), V402 (≠ F411), E403 (= E412), K408 (= K417), V411 (= V420), N428 (= N437), T429 (= T438), S430 (= S439)
P28793 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Pseudomonas fragi (see paper)
36% identity, 97% coverage: 12:723/733 of query aligns to 16:715/715 of P28793