Comparing CCNA_00752 CCNA_00752 3-hydroxybutyryl-CoA dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6aa8E Crystal structure of (s)-3-hydroxybutyryl-coenzymea dehydrogenase from clostridium acetobutylicum complexed with NAD+ (see paper)
55% identity, 96% coverage: 5:283/292 of query aligns to 1:279/281 of 6aa8E
4kuhA Crystal structure of 3-hydroxybutylryl-coa dehydrogenase with acetoacetyl-coa from clostridium butyricum
51% identity, 96% coverage: 4:283/292 of query aligns to 1:280/280 of 4kuhA
4kugA Crystal structure of 3-hydroxybutylryl-coa dehydrogenase with NAD from clostridium butyricum
51% identity, 96% coverage: 4:283/292 of query aligns to 1:280/282 of 4kugA
4pzeA Crystal structure of (s)-3-hydroxybutyryl-coa dehydrogenase paah1 in complex with acetoacetyl-coa (see paper)
47% identity, 96% coverage: 4:283/292 of query aligns to 2:281/283 of 4pzeA
4pzdA Crystal structure of (s)-3-hydroxybutyryl-coa dehydrogenase paah1 in complex with NAD+ (see paper)
47% identity, 96% coverage: 4:283/292 of query aligns to 2:281/283 of 4pzdA
1f17A L-3-hydroxyacyl-coa dehydrogenase complexed with nadh (see paper)
42% identity, 97% coverage: 4:286/292 of query aligns to 4:293/293 of 1f17A
1f12A L-3-hydroxyacyl-coa dehydrogenase complexed with 3-hydroxybutyryl-coa (see paper)
42% identity, 97% coverage: 4:286/292 of query aligns to 4:293/293 of 1f12A
Q16836 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35 from Homo sapiens (Human) (see 7 papers)
42% identity, 96% coverage: 4:284/292 of query aligns to 27:314/314 of Q16836
1f0yA L-3-hydroxyacyl-coa dehydrogenase complexed with acetoacetyl-coa and NAD+ (see paper)
42% identity, 96% coverage: 4:284/292 of query aligns to 4:291/291 of 1f0yA
P9WNP7 3-hydroxybutyryl-CoA dehydrogenase; Beta-hydroxybutyryl-CoA dehydrogenase; BHBD; EC 1.1.1.157 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
44% identity, 96% coverage: 4:283/292 of query aligns to 5:286/286 of P9WNP7
P00348 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; L-3-hydroxyacyl CoA dehydrogenase; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35 from Sus scrofa (Pig) (see paper)
42% identity, 96% coverage: 4:284/292 of query aligns to 27:314/314 of P00348
8oqsB Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-83
37% identity, 96% coverage: 4:283/292 of query aligns to 340:622/735 of 8oqsB
Sites not aligning to the query:
8oqlA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-1
37% identity, 96% coverage: 4:283/292 of query aligns to 333:615/728 of 8oqlA
Sites not aligning to the query:
8oqvA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-109
37% identity, 96% coverage: 4:283/292 of query aligns to 332:614/726 of 8oqvA
Sites not aligning to the query:
8oqoA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-49
37% identity, 96% coverage: 4:283/292 of query aligns to 333:615/727 of 8oqoA
Sites not aligning to the query:
8pf8A Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-72
37% identity, 96% coverage: 4:283/292 of query aligns to 334:616/729 of 8pf8A
Sites not aligning to the query:
8oquA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-92
37% identity, 96% coverage: 4:283/292 of query aligns to 335:617/730 of 8oquA
Sites not aligning to the query:
8oqtA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-91
37% identity, 96% coverage: 4:283/292 of query aligns to 334:616/729 of 8oqtA
Sites not aligning to the query:
8oqnA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-53
37% identity, 96% coverage: 4:283/292 of query aligns to 334:616/729 of 8oqnA
Sites not aligning to the query:
8opvA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with resveratrol (fragment-b-h11)
37% identity, 96% coverage: 4:283/292 of query aligns to 334:616/729 of 8opvA
Sites not aligning to the query:
>CCNA_00752 CCNA_00752 3-hydroxybutyryl-CoA dehydrogenase
MSEIKTVGVIGAGQMGSGIAHVVALGGYDVRLHDVSRERIDAGIAVIEKNMARQVGRGII
DDAAMKAALARIQPAEGLEAIGATDLAIEAATENEEVKKSIFRSLQPYLKPETLLASNTS
SISITRLASATDRPERFIGLHFMNPVPLMKLVEIIRGIATDVPTYERAVTFAQSLGKITS
NAEDFPAFIVNRVLVPMINEAIYTLYEGVGTVDAIDTAMKLGANHPMGPLELGDFIGLDT
VLSIMNVLHEGLADSKYRPCPLLVKYVEAGWLGKKTGRGFYDYRGETPVPTR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory