SitesBLAST
Comparing CCNA_00864 FitnessBrowser__Caulo:CCNA_00864 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7wwxA Crystal structure of herbaspirillum huttiense l-arabinose 1- dehydrogenase (NAD bound form) (see paper)
53% identity, 98% coverage: 4:247/248 of query aligns to 4:253/254 of 7wwxA
- binding nicotinamide-adenine-dinucleotide: G18 (= G18), T21 (≠ S21), I23 (= I23), D42 (= D42), I43 (= I43), C68 (= C67), D69 (= D68), L70 (= L69), N96 (= N91), A98 (≠ G93), F146 (= F141), S147 (≠ G142), S148 (= S143), Y161 (= Y156), K165 (= K160), P191 (= P186), G192 (= G187), W193 (≠ N188), V194 (= V189), R198 (= R193)
9gwwA Crystal structure of sulfoquinovose-1-dehydrogenase from pseudomonas putida in complex with sulfoquinovose substrate (sulfo-ed pathway) (see paper)
48% identity, 97% coverage: 6:246/248 of query aligns to 12:253/257 of 9gwwA
9gwvA Crystal structure of sulfoquinovose-1-dehydrogenase from pseudomonas putida in complex with NAD+ (sulfo-ed pathway) (see paper)
48% identity, 97% coverage: 6:246/248 of query aligns to 10:249/253 of 9gwvA
- binding nicotinamide-adenine-dinucleotide: G22 (= G18), S25 (= S21), I27 (= I23), D46 (= D42), L47 (≠ I43), C68 (= C67), D69 (= D68), V70 (≠ L69), N96 (= N91), A98 (≠ G93), M146 (≠ F141), Y161 (= Y156), K165 (= K160), P191 (= P186), G192 (= G187), I194 (≠ V189)
5wjsA Crystal structure of oxidoreductase (short chain dehydrogenase/reductase family) from burkholderia thailandensis complexed with nadh
48% identity, 98% coverage: 4:247/248 of query aligns to 9:257/258 of 5wjsA
- active site: G27 (= G22), S152 (= S143), Y162 (≠ L153), Y165 (= Y156), K169 (= K160)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G23 (= G18), T26 (≠ S21), I28 (= I23), D47 (= D42), L48 (≠ I43), D73 (= D68), L74 (= L69), N100 (= N91), A102 (≠ G93), L150 (≠ F141), G151 (= G142), S152 (= S143), K169 (= K160), P195 (= P186), G196 (= G187), W197 (≠ N188), V198 (= V189), K202 (≠ R193)
7pcsB Structure of the heterotetrameric sdr family member bbscd (see paper)
36% identity, 96% coverage: 9:246/248 of query aligns to 2:241/247 of 7pcsB
- binding nicotinamide-adenine-dinucleotide: G11 (= G18), M16 (≠ I23), D35 (= D42), I36 (= I43), I62 (≠ L69), N88 (= N91), G90 (= G93), I138 (≠ F141), S140 (= S143), Y152 (= Y156), K156 (= K160), I185 (≠ V189)
Q9KJF1 (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase subunit BbsD; (S,R)-2-(alpha-hydroxybenzyl)succinyl-CoA dehydrogenase subunit BbsD; EC 1.1.1.429 from Thauera aromatica (see 2 papers)
36% identity, 96% coverage: 9:246/248 of query aligns to 3:242/248 of Q9KJF1
- S15 (= S21) binding NAD(+)
- D36 (= D42) binding NAD(+)
- D62 (= D68) binding NAD(+)
- I63 (≠ L69) binding NAD(+)
- N89 (= N91) binding NAD(+)
- Y153 (= Y156) binding NAD(+)
- K157 (= K160) binding NAD(+)
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
4urfB Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1 (see paper)
33% identity, 96% coverage: 9:247/248 of query aligns to 3:245/248 of 4urfB
- active site: G16 (= G22), S142 (= S143), I152 (≠ L153), Y155 (= Y156), K159 (= K160)
- binding 3-pyridinium-1-ylpropane-1-sulfonate: L210 (= L212), R211 (≠ K213), R212 (≠ G214)
- binding bicarbonate ion: I92 (vs. gap), G94 (≠ D95), R109 (≠ E110), R179 (= R180), S228 (= S230)
- binding nicotinamide-adenine-dinucleotide: G12 (= G18), G14 (= G20), N15 (≠ S21), G16 (= G22), I17 (= I23), D36 (= D42), I37 (= I43), D62 (= D68), T63 (≠ L69), N89 (= N91), A90 (= A92), G91 (= G93), I140 (≠ F141), Y155 (= Y156), K159 (= K160), P185 (= P186), A186 (≠ G187), I188 (≠ V189), T190 (= T191)
4urfA Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1 (see paper)
33% identity, 96% coverage: 9:247/248 of query aligns to 3:245/248 of 4urfA
- active site: G16 (= G22), S142 (= S143), I152 (≠ L153), Y155 (= Y156), K159 (= K160)
- binding 3-pyridinium-1-ylpropane-1-sulfonate: I92 (vs. gap), S93 (≠ N94), G94 (≠ D95), E95 (≠ D96), T97 (≠ H98), E101 (≠ D102), T103 (= T104), Q106 (≠ Y107), R109 (≠ E110), S175 (≠ P176), G177 (≠ D178)
- binding magnesium ion: S237 (≠ H239), Y238 (≠ E240)
- binding nicotinamide-adenine-dinucleotide: G12 (= G18), G14 (= G20), N15 (≠ S21), G16 (= G22), I17 (= I23), D36 (= D42), I37 (= I43), W41 (≠ D47), D62 (= D68), T63 (≠ L69), N89 (= N91), A90 (= A92), G91 (= G93), I140 (≠ F141), Y155 (= Y156), K159 (= K160), P185 (= P186), I188 (≠ V189), T190 (= T191)
4ureB Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1 (see paper)
33% identity, 96% coverage: 9:247/248 of query aligns to 3:245/248 of 4ureB
- active site: G16 (= G22), S142 (= S143), I152 (≠ L153), Y155 (= Y156), K159 (= K160)
- binding 3-pyridinium-1-ylpropane-1-sulfonate: N15 (≠ S21), G16 (= G22), I17 (= I23), N89 (= N91), G91 (= G93), Y155 (= Y156), P185 (= P186), A186 (≠ G187)
4nbuB Crystal structure of fabg from bacillus sp (see paper)
34% identity, 96% coverage: 9:246/248 of query aligns to 5:241/244 of 4nbuB
- active site: G18 (= G22), N111 (= N115), S139 (= S143), Q149 (≠ L153), Y152 (= Y156), K156 (= K160)
- binding acetoacetyl-coenzyme a: D93 (≠ R97), K98 (≠ D102), S139 (= S143), N146 (≠ L150), V147 (≠ E151), Q149 (≠ L153), Y152 (= Y156), F184 (≠ N188), M189 (≠ R193), K200 (≠ I206)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G18), N17 (≠ S21), G18 (= G22), I19 (= I23), D38 (= D45), F39 (≠ E46), V59 (≠ C67), D60 (= D68), V61 (≠ L69), N87 (= N91), A88 (= A92), G89 (= G93), I90 (≠ N94), T137 (≠ F141), S139 (= S143), Y152 (= Y156), K156 (= K160), P182 (= P186), F184 (≠ N188), T185 (≠ V189), T187 (= T191), M189 (≠ R193)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
34% identity, 97% coverage: 8:247/248 of query aligns to 2:245/247 of 4jroC
- active site: G16 (= G22), S142 (= S143), Q152 (≠ L153), Y155 (= Y156), K159 (= K160)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G18), S14 (≠ G20), R15 (≠ S21), G16 (= G22), I17 (= I23), N35 (vs. gap), Y36 (vs. gap), N37 (vs. gap), G38 (vs. gap), S39 (≠ L41), N63 (≠ D68), V64 (≠ L69), N90 (= N91), A91 (= A92), I93 (≠ N94), I113 (≠ V114), S142 (= S143), Y155 (= Y156), K159 (= K160), P185 (= P186), I188 (≠ V189), T190 (= T191)
8y46B SDR family oxidoreductase (see paper)
33% identity, 96% coverage: 9:247/248 of query aligns to 2:246/248 of 8y46B
8y4jA SDR family oxidoreductase (see paper)
33% identity, 96% coverage: 9:247/248 of query aligns to 3:247/249 of 8y4jA
8y11A Crystal structure of l-2-keto-3-deoxyfuconate 4-dehydrogenase bound to NAD(h) and sulfate ion (see paper)
33% identity, 96% coverage: 9:247/248 of query aligns to 3:247/249 of 8y11A
- binding nicotinamide-adenine-dinucleotide: A12 (≠ G18), Q15 (≠ S21), G16 (= G22), I17 (= I23), D36 (= D42), I37 (= I43), D57 (= D68), V58 (≠ L69), C80 (≠ N91), I130 (≠ F141), Y146 (= Y156), K150 (= K160), P176 (= P186), G177 (= G187), T178 (≠ N188), I179 (≠ V189), S181 (≠ T191), P182 (≠ K192), S183 (≠ R193), R187 (≠ W197)
8y46A SDR family oxidoreductase (see paper)
33% identity, 96% coverage: 9:247/248 of query aligns to 5:249/251 of 8y46A
7tzpG Crystal structure of putataive short-chain dehydrogenase/reductase (fabg) from klebsiella pneumoniae subsp. Pneumoniae ntuh-k2044 in complex with nadh (see paper)
35% identity, 93% coverage: 9:239/248 of query aligns to 6:237/247 of 7tzpG
- binding 1,4-dihydronicotinamide adenine dinucleotide: G15 (= G18), R18 (≠ S21), G19 (= G22), I20 (= I23), D39 (= D42), R40 (≠ A44), C63 (= C67), I65 (≠ L69), N91 (= N91), G93 (= G93), I94 (≠ N94), V114 (= V114), Y155 (= Y156), K159 (= K160), I188 (≠ V189), T190 (= T191), T193 (≠ Q194)
4fn4A Short-chain NAD(h)-dependent dehydrogenase/reductase from sulfolobus acidocaldarius (see paper)
32% identity, 98% coverage: 6:247/248 of query aligns to 2:251/254 of 4fn4A
- active site: G18 (= G22), S144 (= S143), Y157 (= Y156), K161 (= K160), S202 (≠ E201)
- binding nicotinamide-adenine-dinucleotide: G14 (= G18), S17 (= S21), G18 (= G22), I19 (= I23), E38 (≠ D42), L39 (≠ I43), R43 (≠ D47), A63 (≠ C67), D64 (= D68), V65 (≠ L69), N91 (= N91), G93 (= G93), I94 (vs. gap), T142 (≠ F141), S144 (= S143), Y157 (= Y156), K161 (= K160), P187 (= P186), V190 (= V189), T192 (= T191), N193 (≠ K192), I194 (≠ R193)
4nbwA Crystal structure of fabg from plesiocystis pacifica (see paper)
36% identity, 95% coverage: 12:246/248 of query aligns to 1:248/253 of 4nbwA
- active site: G12 (= G22), S146 (= S143), Y159 (= Y156), K163 (= K160)
- binding nicotinamide-adenine-dinucleotide: G8 (= G18), N11 (≠ S21), G12 (= G22), I13 (= I23), D32 (= D42), L33 (≠ I43), V57 (≠ C67), D58 (= D68), V59 (≠ L69), N85 (= N91), A86 (= A92), G87 (= G93), S146 (= S143), Y159 (= Y156), K163 (= K160), I192 (≠ V189), T194 (= T191)
3rwbA Crystal structure of complex of 4pal (4-pyridoxolactone) and pldh (tetrameric pyridoxal 4-dehydrogenase) from mesorhizobium loti
36% identity, 96% coverage: 9:246/248 of query aligns to 4:243/247 of 3rwbA
- active site: G17 (= G22), S140 (= S143), Y153 (= Y156), K157 (= K160)
- binding 7-hydroxy-6-methylfuro[3,4-c]pyridin-1(3H)-one: S140 (= S143), N141 (≠ I144), T142 (≠ S145), M150 (≠ L153), Y153 (= Y156), L185 (≠ N188), H196 (≠ T199)
- binding nicotinamide-adenine-dinucleotide: G13 (= G18), Q16 (≠ S21), G17 (= G22), I18 (= I23), D37 (= D42), I38 (= I43), D60 (= D68), I61 (≠ L69), N87 (= N91), A88 (= A92), S89 (≠ G93), I138 (≠ F141), S140 (= S143), Y153 (= Y156), K157 (= K160), P183 (= P186), L185 (≠ N188), I186 (≠ V189), S188 (≠ T191), G190 (≠ R193), V191 (≠ Q194)
3ndrA Crystal structure of tetrameric pyridoxal 4-dehydrogenase from mesorhizobium loti
36% identity, 96% coverage: 9:246/248 of query aligns to 4:243/247 of 3ndrA
- active site: G17 (= G22), S140 (= S143), Y153 (= Y156), K157 (= K160)
- binding nicotinamide-adenine-dinucleotide: G13 (= G18), Q16 (≠ S21), G17 (= G22), I18 (= I23), D37 (= D42), I38 (= I43), D60 (= D68), I61 (≠ L69), N87 (= N91), A88 (= A92), S89 (≠ G93), V110 (= V114), I138 (≠ F141), S140 (= S143), Y153 (= Y156), K157 (= K160), P183 (= P186), L185 (≠ N188), I186 (≠ V189), S188 (≠ T191), G190 (≠ R193), V191 (≠ Q194)
Query Sequence
>CCNA_00864 FitnessBrowser__Caulo:CCNA_00864
MSSAIYPSLKGKRVVITGGGSGIGAGLTAGFARQGAEVIFLDIADEDSRALEAELAGSPI
PPVYKRCDLMNLEAIKAVFAEIGDVDVLVNNAGNDDRHKLADVTGAYWDERINVNLRHML
FCTQAVAPGMKKRGGGAVINFGSISWHLGLEDLVLYETAKAGIEGMTRALARELGPDDIR
VTCVVPGNVKTKRQEKWYTPEGEAQIVAAQCLKGRIVPENVAALVLFLASDDASLCTGHE
YWIDAGWR
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory