SitesBLAST

Q5Q0U0 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 (Anion/sugar transporter), member 5; Vesicular excitatory amino acid transporter; VEAT from Rattus norvegicus (Rat) (see 2 papers)
29% identity, 60% coverage: 120:382/438 of query aligns to 166:440/495 of Q5Q0U0

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R168 (= R122) mutation to C: Abolishes H(+)-coupled sialic acid transporter activity.
E171 (≠ L125) mutation to C: Decreases H(+)-coupled sialic acid transporter activity; when associated with C-175.
G172 (= G126) mutation to C: Decreases protein levels and alters subcellular localization.
E175 (= E129) mutation to C: Decreases H(+)-coupled sialic acid transporter activity; when associated with C-171.
G176 (= G130) mutation to C: Decreases protein levels and alters subcellular localization.
F179 (≠ Q133) mutation to C: Decreases the affinity and transport rate for D-glucuronate. Does not affect H(+)-coupled sialic acid transporter activity.
P180 (= P134) mutation to C: Decreases protein levels and alters subcellular localization.
H183 (≠ M137) mutation to R: Abolishes H(+)-coupled sialic acid transporter activity.
W186 (≠ V140) mutation to C: Abolishes H(+)-coupled sialic acid transporter activity.
SSLKN 268:272 (≠ AGQEA 221:225) mutation Missing: Abolishes H(+)-coupled sialic acid transporter activity.
P334 (= P288) mutation to R: Abolishes H(+)-coupled sialic acid transporter activity.
G371 (= G324) mutation to V: Remains in the endoplasmic reticulum.

Sites not aligning to the query:

22:23 Dileucine internalization motif; LL→AA: Targeted to plasma membrane; sialic acid uptake strongly activated at acidic pH.
39 R→C: Markedly decreases H(+)-coupled sialic acid transporter activity.
136 K→E: Markedly decreases H(+)-coupled sialic acid transporter activity.

Q8BN82 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Mus musculus (Mouse) (see paper)
29% identity, 60% coverage: 120:382/438 of query aligns to 166:440/495 of Q8BN82

query
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Q8BN82

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H183 (≠ M137) mutation to R: Abolishes sialic acid transporter activity. Does not affect L-aspartate and L-glutamate transporter activity.

Sites not aligning to the query:

39 R→C: Completely abolishes L-aspartate and L-glutamate transporter activity. Retains appreciable H(+)-coupled sialic acid transporter activity.

Q9NRA2 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Homo sapiens (Human) (see 8 papers)
27% identity, 72% coverage: 67:382/438 of query aligns to 110:440/495 of Q9NRA2

query
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Q9NRA2

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K136 (vs. gap) to E: in SD; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; completely devoid of L-aspartate and L-glutamate transporter activity, but retains appreciable H(+)-coupled sialic acid transporter activity; dbSNP:rs80338795
H183 (≠ M137) to R: in ISSD; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; abolishes H(+)-coupled sialic acid transporter activity; has normal L-aspartate and L-glutamate transporter activity; dbSNP:rs119491109
LL 198:199 (≠ AG 152:153) mutation to AA: Localizes in vesicular structures mainly concentrated in the perinuclear region.
IL 266:267 (≠ IA 219:220) mutation to LA: Localizes in vesicular structures mainly concentrated in the perinuclear region.
SSLRN 268:272 (≠ AGQEA 221:225) natural variant: Missing (in ISSD; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; abolishes H(+)-coupled sialic acid transporter activity; has normal L-aspartate and L-glutamate transporter activity)
G328 (≠ A282) to E: in ISSD; some patients may manifest a milder phenotype consistent with Salla disease; markedly decreases H(+)-coupled sialic acid transporter activity; abolishes L-aspartate and L-glutamate transporter activity; dbSNP:rs386833996
P334 (= P288) to R: in ISSD; does not affect intracellular localization, targeted to lysosomes; abolishes H(+)-coupled sialic acid transporter activity; abolishes L-aspartate and L-glutamate transporter activity; dbSNP:rs119491110
G371 (= G324) to V: in ISSD; abolishes H(+)-coupled sialic acid transporter activity; abolishes L-aspartate and L-glutamate transporter activity; dbSNP:rs777862172

Sites not aligning to the query:

22:23 Dileucine internalization motif; LL→AA: Targeted to plasma membrane.; LL→GG: Targeted to plasma membrane; sialic acid uptake strongly activated at acidic pH.
39 R → C: in SD; frequent variant in Finland; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; completely devoid of L-aspartate and L-glutamate transport activity, but retains appreciable H(+)-coupled sialic acid and nitrate transporter activity; dbSNP:rs80338794

Q9JI12 Vesicular glutamate transporter 2; VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6 from Rattus norvegicus (Rat) (see 2 papers)
25% identity, 64% coverage: 121:402/438 of query aligns to 183:470/582 of Q9JI12

query
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Q9JI12

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T

N

T

A

T

R

V

R

R

I

K

A

I

F

M

T

N

L

C

G

G

A

G

V

F

L

G

M

M

-

E

-

A

T

T

G

L

M

L

F

V

V

V

G

G

K

Y

V

S

E

H

S

T

A

R

Y

G

A

V

A

A

I

I

A

S

L

F

L

L

C

V

L

L

-

A

-

V

-

G

-

F

G

S

G

G

F

F

A

A

H

I

Q

S

T

G

L

F

S

N

V

V

T

N

V

H

I

L

T

D

M

I

A

A

S

P

D

R

L

Y

F

-

R

-

N

-

E

-

V

A

A

S

T

I

V

L

A

M

G

G

L

I

A

S

G

N

M

G

M

V

G

G

N

T

L

L

G

S

L

G

L

M

L

V

F

C

S

P

L

I

I

V

G

G

G

A

L

M

V

T

A

K

K

N

R184 (= R122) mutation R->A,E,K: Greatly lowers L-glutamate transport.
E191 (= E129) mutation to A: Greatly lowers L-glutamate transport.; mutation E->D,Q: Lowers L-glutamate transport.
R322 (≠ A255) mutation to A: Loss of L-glutamate release. Abolishes the chloride ion conductance.

Sites not aligning to the query:

88 R→A: Impairs synaptic transmission. Abolishes the chloride ion conductance.
128 H→A: Greatly lowers L-glutamate transport.

7t3nA R184q/e191q mutant of rat vesicular glutamate transporter 2 (vglut2)
25% identity, 63% coverage: 126:402/438 of query aligns to 130:412/452 of 7t3nA

query
sites
7t3nA

G

G

L

L

A

V

E

Q

G

G

S

V

A

T

Q
x
Y

P

P

A

A

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H

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G

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I

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A

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I

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W

W

F

A

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A

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E
|
E

R

R

G

S

F

R

A

L

G

A

G

T

V

T

F

S

N

F

I

C

G
|
G

A

S

S
x
Y

I

A

G

G

S

A

V

V

L

I

A

A

P

M

P

P

L

L

V

A

V

G

W

I

A

L

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V

L

Q

V

Y

W

T

N

G

W

W

R

S

A

S

A

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F

F

V

Y

L

V

T

Y

G

G

V

S

M

F

G

G

L

M

V

V

W

W

V

Y

V

M

L

F

W

W

-

L

L

L

A

V

F

S

Y

Y

R

E

S

S

P

P

E

A

K

K

H

H

P

P

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T

M

I

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T

D

D

E

E

R

R

A

R

V

Y

I

I

-

E

A

S

A

I

G

G

Q

E

E

S

A

A

H

N

L

L

E

L

A

G

V

A

A

M

A

E

R

K

P

F

S

K

I

T

-

P

-

W

L

R

S

K

I

F

L

F

K

T

Q

S

G

M

Q

P

F

V

W

Y

G

A

I

I

A

I

L

V

P

A

R

N

F

F

L

C

A
x
R

D

S

P

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T

T

W
x
F

G
x
Y

T

L

L

L

A

L

F

I

W

S

V

Q

P

P

L

A

Y

Y

L

F

S

E

Q

E

T

V

R

F

G

G

F

F

D

E

L

I

K

S

Q

K

I

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A

G

L

M

F

L

A

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W

A

M

V

P

P

F

H

V

L

A

V

A

M

D

T

L

I

G

I

C

V

M

P

A

I

G

G

P

G

V

Q

I

I

A

A

L

D

F

F

L

L

Q

R

K

S

R

K

G

Q

V

I

T

L

L

S

I

T

N

T

A

T

R

V

R

R

I

K

A

I

F

M

T

N

L

C

G

G

A

G

V

F

L

G

M

M

-

E

-

A

T

T

G

L

M

L

F

V

V

V

G

G

K

Y

V

S

E

H

S

T

A

R

Y

G

A

V

A

A

I

I

A

S

L

F

L

L

C

V

L

L

-

A

-

V

-

G

-

F

G

S

G

G

F

F

A

A

H

I

Q

S

T

G

L

F

S

N

V

V

T

N

V

H

I

L

T

D

M

I

A

A

S

P

D

R

L

Y

F

-

R

-

N

-

E

-

V

A

A

S

T

I

V

L

A

M

G

G

L

I

A

S

G

N

M

G

M

V

G

G

N

T

L

L

G

S

L

G

L

M

L

V

F

C

S

P

L

I

I

V

G

G

G

A

L

M

V

T

A

K

K

N

binding (1s,3r)-1-aminocyclopentane-1,3-dicarboxylic acid: Y137 (≠ Q133), Y165 (≠ S161), R264 (≠ A255), F268 (≠ W259), Y269 (≠ G260)
binding (2R)-2-(methoxymethyl)-4-{[(25R)-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside: E152 (= E148), G163 (= G159)

Sites not aligning to the query:

Q03567 Uncharacterized transporter slc-17.2 from Caenorhabditis elegans (see paper)
26% identity, 70% coverage: 15:320/438 of query aligns to 3:349/493 of Q03567

query
sites
Q03567

G

G

G

A

A

T

M

K

P

P

K

R

L

L

K

V

A

P

L

S

R

T

W

R

W

F

I

A

I

L

G

S

L

L

V

V

T

M

L

F

-

F

G

G

A

C

V

L

I

V

N

T

Y

Y

L

M

T

M

R

R

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T

T

N

M

M

G

S

V

F

A

A

A

V

P

V

T

C

L

M

L

V

K

N

E

E

-

N

-

K

-

T

-

D

-

T

-

G

-

V

-

E

-

K

-

V

-

S

-

R

L

C

G

G

I

K

S

E

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M

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T

-

P

-

V

-

E

-

S

-
x
N

-

S

-

V

-

I

-

G

E

E

Y

F

S

D

W

W

-

D

-

K

-

Q

-

T

-

G

-

M

I

V

T

L

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S

A

S

F

F

Q

F

L

Y

G

G

-

Y

I

I

M

G

L

S

Q

Q

P

I

I

I

C

G

G

G

Y

H

V

L

L

A

D

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T

R

L

Y

G

G

L

G

R

K

T

R

G

V

F

V

A

F

V

V

F

T

A

I

V

L

A

G

W

S

S

A

L

L

I

L

A

T

M

L

A

L

H

N

G

P

L

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A

A

-

A

-

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N

T

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S

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E

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Y

G

A

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L

A

A

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I

L

L

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R

G

A

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A

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G

L

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A

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E

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G

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M

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M

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E

E

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L

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A

L

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G

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I

A

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A

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I

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V

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L

I

A

V

P

L

P

P

L

L

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V

G

W

F

A

L

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C

-

E

-

Y

-

G

L

F

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D

W

G

N

G

W

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A

I

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F

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Y

L

I

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I

G

G

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V

M

F

G

G

L

V

V

L

W

W

V

T

-

A

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L

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L

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A

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Y

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S

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A

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P

E

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A

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I

I

A

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A

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E

E

A

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M

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D

A

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A

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R

K

-

V

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-

P

-

W

L

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I

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P

Q

A

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W

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A

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L

A

P

G

R

H

F

F

L

A

A

G

D

D

P

-

T

-

W

W

G

G

-

A

-

Y

T

T

L

M

A

L

F

V

W

S

V

L

P

P

L

S

Y

F

L

L

S

K

Q

D

T

V

R

L

G

G

F

L

D

N

L

L

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S

Q

S

I

L

A

G

L

A

F

V

A

A

W

S

M

I

P

P

F

Y

V

I

A

A

A

Y

D

F

L

L

G

A

C

I

M

N

A

A

G

G

P

G

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V

I

L

A

A

L

D

F

T

L

L

Q

R

K

S

R

K

G

G

V

I

-

L

T

S

L

T

I

L

N

N

A

T

R

R

I

A

A

A

N69 (vs. gap) modified: carbohydrate, N-linked (GlcNAc...) asparagine

Q9C0U9 Uncharacterized transporter PB1C11.03 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
26% identity, 37% coverage: 54:216/438 of query aligns to 128:296/570 of Q9C0U9

query
sites
Q9C0U9

L

L

L

F

K

D

E

D

L

V

G

H

I

I

S

T

V

S

T

N

E

Q

Y

Y

S

N

W

N

I

L

T

N

S

T

A

L

F

F

Q

Y

L

V

G

G

I

Y

M

I

L

V

Q

G

P

Q

I

F

C

P

G

G

-

H

Y

Y

V

I

L

M

D

Q

T

T

L

F

G

P

L

L

R

G

T

K

G

F

F

V

A

G

V

L

F

V

A

T

V

F

A

S

W

W

S

S

L

V

I

I

A

V

M

F

A

L

H

H

G

C

L

C

A

A

N

Y

S

N

W

Y

Q

G

G

G

F

L

A

I

V

A

L

L

R

R

G

F

F

F

L

L

G

G

L

F

A

T

E

E

G

S

S

C

A

L

Q

L

P

P

A

A

G

M

M

E

K

A

T

T

V

M

A

G

I

M

W

F

F

F

P

T

A

H

K

Q

E

E

R

Q

G

A

F

F

A

L

G

Q

G

P

V

V

F

F

N

W

I

I

G

S

A

C

-

L

S

S

I

C

G

G

-

I

-

P

-

A

S

G

V

F

L

I

A

A

P

Y

P

G

L

L

V

E

V

F

W

V

A

T

V

K

L

S

V

I

W

A

N

P

W

W

R

K

A

L

A

F

F

M

V

I

L

I

T

T

-

G

G

G

V

I

M

T

G

F

L

F

V

L

W

S

V

I

V

F

L

L

W

F

L

F

A

Y

F

Y

Y

P

R

D

S

N

P

P

E

S

K

K

H

A

P

R

S

F

M

L

T

T

D

D

E

E

R

K

Sites not aligning to the query:

14 modified: Phosphoserine

Q9Y2C5 Probable small intestine urate exporter; Solute carrier family 17 member 4 from Homo sapiens (Human) (see 2 papers)
23% identity, 64% coverage: 55:335/438 of query aligns to 93:384/497 of Q9Y2C5

query
sites
Q9Y2C5

L

L

K

K

E

E

L

F

G

K

I

A

S

M

V

A

T

P

E

A

Y

Y

S

D

W

W

-

S

-

P

-

E

-

I

-

Q

-

G

-

I

I

I

T

L

S

S

A

S

F

L

Q

N

L

Y

G

G

I

S

M

F

L

L

Q

A

P

P

I

I

-

P

C

S

G

G

Y

Y

V

V

L

A

D

G

T

I

L

F

G

G

L

A

R

K

-

Y

-

V

T

V

G

G

F

A

A

G

V

L

F

F

A

I

V

S

A

S

W

F

S

L

L

T

I

L

A

F

M

I

A

P

H

L

G

A

L

A

A

N

N

A

S

G

W

V

Q

A

G

L

F

L

A

I

V

V

L

L

R

R

G

I

F

V

L

Q

G

G

L

I

A

A

E

Q

G

V

S

M

A

V

Q

L

P

T

A

G

G

Q

M

Y

K

S

T

I

V

W

A

V

I

K

W

W

F

A

P

P

A

P

K

L

E

E

R

R

G

S

F

Q

A

L

G

T

V

I

F

A

N

G

I

S

G

G

A

S

S

M

I

L

G

G

S

S

-

F

-

I

-

V

V

L

L

L

A

A

P

G

L

L

V

L

V

C

W

Q

A

T

V

I

L

-

V

-

W

-

N

G

W

W

R

P

A

Y

A

V

F

F

V

Y

L

I

T

F

G

G

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G

M

I

G

G

L

C

V

A

W

C

V

C

V

P

L

L

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W

L

F

A

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F

L

-

I

Y

Y

R

D

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D

P

P

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V

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N

H

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M

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-

A

D

G

E

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A

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A

E

Q

A

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D

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R

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S

-

I

I

L

R

S

A

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M

L

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K

Q

S

G

L

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P

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L

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W

G

A

I

I

A

L

L

V

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R

Y

F

F

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C

A

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D

Y

P

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T

L

W

F

G

Y

T

T

L

I

A

M

F

A

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Y

V

T

P

P

L

T

Y

Y

L

I

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S

Q

S

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V

R

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G

Q

F

A

D

N

L

L

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R

Q

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I

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A

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L

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L

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P

F

F

V

V

A

V

A

G

D

C

L

I

G

C

C

I

M

I

A

L

G

G

P

G

V

L

I

L

A

A

L

D

F

F

L

L

Q

L

K

S

R

R

G

K

V

I

T

L

L

R

I

L

N

I

A

T

R

I

R

R

I

K

A

L

F

F

T

T

L
x
A

G

I

A

G

V

V

L

L

M

F

T

P

G

S

M

V

M

I

F

L

V

V

G

S

A372 (≠ L323) to T: in dbSNP:rs11754288

Sites not aligning to the query:

66 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N→A: Loss of glycosylation and significant reduction in the tranport of thyroid hormones T3 and T4; when associated with A-75 and A-90.
75 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N→A: Loss of glycosylation and significant reduction in the tranport of thyroid hormones T3 and T4; when associated with A-66 and A-90.
90 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N→A: Loss of glycosylation and significant reduction in the tranport of thyroid hormones T3 and T4; when associated with A-75 and A-90.

Query Sequence

>CCNA_01039 FitnessBrowser__Caulo:CCNA_01039
MAVAVPERAPEGSPGGAAMPKLKALRWWIIGLVTLGAVINYLTRSTMGVAAPTLLKELGI
SVTEYSWITSAFQLGIMLQPICGYVLDTLGLRTGFAVFAVAWSLIAMAHGLANSWQGFAV
LRGFLGLAEGSAQPAGMKTVAIWFPAKERGFAGGVFNIGASIGSVLAPPLVVWAVLVWNW
RAAFVLTGVMGLVWVVLWLAFYRSPEKHPSMTDEERAVIAAGQEAHLEAVAARPSILSIL
KQGQFWGIALPRFLADPTWGTLAFWVPLYLSQTRGFDLKQIALFAWMPFVAADLGCMAGP
VIALFLQKRGVTLINARRIAFTLGAVLMTGMMFVGKVESAYAAIALLCLGGFAHQTLSVT
VITMASDLFRRNEVATVAGLAGMMGNLGLLLFSLLIGGLVAKVGYDPFFIALGVLDILGA
ILLWTLVKDPAARAKAAA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory