SitesBLAST
Comparing CCNA_01357 FitnessBrowser__Caulo:CCNA_01357 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
24% identity, 100% coverage: 2:613/614 of query aligns to 3:579/582 of 1t9dB
- active site: Y28 (≠ H40), G30 (vs. gap), G31 (= G41), A32 (≠ N42), I33 (≠ V43), E54 (= E65), T77 (= T88), F116 (≠ L129), Q117 (= Q130), E118 (≠ Q131), K166 (≠ Q188), R213 (≠ A247), M249 (≠ V283), V276 (≠ T310), V392 (≠ L419), L417 (≠ F441), G418 (≠ S442), M420 (= M444), D445 (= D469), N472 (= N496), E474 (≠ G498), Q475 (≠ Y499), M477 (≠ C501), V478 (≠ I502), W481 (≠ L505), L503 (≠ H534), G508 (= G539), L509 (≠ A540), K542 (≠ P573)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (= G41), A32 (≠ N42), V106 (= V119), P107 (≠ Y120), F116 (≠ L129), K166 (≠ Q188), M249 (≠ V283), D274 (= D308), R275 (≠ F309), W481 (≠ L505)
- binding flavin-adenine dinucleotide: R156 (vs. gap), G202 (= G237), A203 (≠ G238), G204 (= G239), N207 (vs. gap), T229 (= T263), L230 (≠ Q264), Q231 (≠ G265), L247 (≠ V281), M249 (≠ V283), H250 (≠ T284), G269 (= G303), A270 (≠ T304), R271 (= R305), D273 (≠ Q307), R275 (≠ F309), V276 (≠ T310), E302 (≠ N328), V303 (= V329), N307 (≠ D333), G320 (= G344), D321 (= D345), A322 (= A346), Q396 (≠ K425), M397 (≠ L426), G415 (≠ Y439), G416 (= G440)
- binding magnesium ion: D445 (= D469), N472 (= N496), E474 (≠ G498)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E65), P80 (= P93), G418 (≠ S442), M420 (= M444), M450 (= M474)
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
24% identity, 100% coverage: 2:613/614 of query aligns to 4:580/583 of 1t9bA
- active site: Y29 (≠ H40), G31 (vs. gap), G32 (= G41), A33 (≠ N42), I34 (≠ V43), E55 (= E65), T78 (= T88), F117 (≠ L129), Q118 (= Q130), E119 (≠ Q131), K167 (≠ Q188), R214 (≠ A247), M250 (≠ V283), V277 (≠ T310), V393 (≠ L419), L418 (≠ F441), G419 (≠ S442), M421 (= M444), D446 (= D469), N473 (= N496), E475 (≠ G498), Q476 (≠ Y499), M478 (≠ C501), V479 (≠ I502), W482 (≠ L505), L504 (≠ H534), G509 (= G539), L510 (≠ A540), K543 (≠ P573)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V119), P108 (≠ Y120), F117 (≠ L129), D275 (= D308), R276 (≠ F309), M478 (≠ C501), W482 (≠ L505)
- binding flavin-adenine dinucleotide: R157 (vs. gap), G203 (= G237), A204 (≠ G238), G205 (= G239), N208 (vs. gap), T230 (= T263), L231 (≠ Q264), Q232 (≠ G265), M247 (≠ A280), L248 (≠ V281), M250 (≠ V283), H251 (≠ T284), G270 (= G303), A271 (≠ T304), R272 (= R305), D274 (≠ Q307), R276 (≠ F309), V277 (≠ T310), E303 (≠ N328), V304 (= V329), N308 (≠ D333), D322 (= D345), A323 (= A346), Q397 (≠ K425), M398 (≠ L426), G416 (≠ Y439), G417 (= G440)
- binding magnesium ion: D446 (= D469), N473 (= N496), E475 (≠ G498)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
24% identity, 100% coverage: 2:613/614 of query aligns to 4:593/596 of 1t9cA
- active site: Y29 (≠ H40), G31 (vs. gap), G32 (= G41), A33 (≠ N42), I34 (≠ V43), E55 (= E65), T78 (= T88), F117 (≠ L129), Q118 (= Q130), E119 (≠ Q131), K167 (≠ Q188), R227 (≠ A247), M263 (≠ V283), V290 (≠ T310), V406 (≠ L419), L431 (≠ F441), G432 (≠ S442), M434 (= M444), D459 (= D469), N486 (= N496), E488 (≠ G498), Q489 (≠ Y499), M491 (≠ C501), V492 (≠ I502), W495 (≠ L505), L517 (≠ H534), G522 (= G539), L523 (≠ A540), K556 (≠ P573)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G41), V107 (= V119), P108 (≠ Y120), F117 (≠ L129), K167 (≠ Q188), D288 (= D308), R289 (≠ F309), W495 (≠ L505)
- binding flavin-adenine dinucleotide: R157 (vs. gap), G216 (= G237), A217 (≠ G238), G218 (= G239), N221 (vs. gap), T243 (= T263), L244 (≠ Q264), Q245 (≠ G265), L261 (≠ V281), M263 (≠ V283), H264 (≠ T284), G283 (= G303), A284 (≠ T304), R285 (= R305), D287 (≠ Q307), R289 (≠ F309), V290 (≠ T310), E316 (≠ N328), V317 (= V329), N321 (≠ D333), G334 (= G344), D335 (= D345), A336 (= A346), M411 (≠ L426), G429 (≠ Y439), G430 (= G440)
- binding magnesium ion: D459 (= D469), N486 (= N496), E488 (≠ G498)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
24% identity, 100% coverage: 2:613/614 of query aligns to 5:594/597 of 1t9aA
- active site: Y30 (≠ H40), G32 (vs. gap), G33 (= G41), A34 (≠ N42), I35 (≠ V43), E56 (= E65), T79 (= T88), F118 (≠ L129), Q119 (= Q130), E120 (≠ Q131), K168 (≠ Q188), R228 (≠ A247), M264 (≠ V283), V291 (≠ T310), V407 (≠ L419), L432 (≠ F441), G433 (≠ S442), M435 (= M444), D460 (= D469), N487 (= N496), E489 (≠ G498), Q490 (≠ Y499), M492 (≠ C501), V493 (≠ I502), W496 (≠ L505), L518 (≠ H534), G523 (= G539), L524 (≠ A540), K557 (≠ P573)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G41), V108 (= V119), P109 (≠ Y120), F118 (≠ L129), K168 (≠ Q188), M264 (≠ V283), D289 (= D308), R290 (≠ F309), M492 (≠ C501), V493 (≠ I502), W496 (≠ L505)
- binding flavin-adenine dinucleotide: R158 (vs. gap), G217 (= G237), A218 (≠ G238), G219 (= G239), N222 (vs. gap), T244 (= T263), L245 (≠ Q264), Q246 (≠ G265), L262 (≠ V281), M264 (≠ V283), H265 (≠ T284), G284 (= G303), A285 (≠ T304), R286 (= R305), D288 (≠ Q307), R290 (≠ F309), V291 (≠ T310), E317 (≠ N328), V318 (= V329), N322 (≠ D333), G335 (= G344), D336 (= D345), A337 (= A346), Q411 (≠ K425), M412 (≠ L426), G430 (≠ Y439), G431 (= G440)
- binding magnesium ion: D460 (= D469), N487 (= N496), E489 (≠ G498)
- binding propyl trihydrogen diphosphate: V407 (≠ L419), G408 (= G421), Q409 (≠ E422), H410 (= H424), M435 (= M444), G459 (= G468), D460 (= D469), A461 (≠ G470), S462 (= S471), N487 (= N496), E489 (≠ G498), Q490 (≠ Y499), G491 (= G500), M492 (≠ C501)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (≠ S442), M435 (= M444), M465 (= M474)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
24% identity, 100% coverage: 2:613/614 of query aligns to 4:593/596 of 1t9dA
- active site: Y29 (≠ H40), G31 (vs. gap), G32 (= G41), A33 (≠ N42), I34 (≠ V43), E55 (= E65), T78 (= T88), F117 (≠ L129), Q118 (= Q130), E119 (≠ Q131), K167 (≠ Q188), R227 (≠ A247), M263 (≠ V283), V290 (≠ T310), V406 (≠ L419), L431 (≠ F441), G432 (≠ S442), M434 (= M444), D459 (= D469), N486 (= N496), E488 (≠ G498), Q489 (≠ Y499), M491 (≠ C501), V492 (≠ I502), W495 (≠ L505), L517 (≠ H534), G522 (= G539), L523 (≠ A540), K556 (≠ P573)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G41), A33 (≠ N42), V107 (= V119), P108 (≠ Y120), F117 (≠ L129), K167 (≠ Q188), M263 (≠ V283), D288 (= D308), R289 (≠ F309), W495 (≠ L505)
- binding flavin-adenine dinucleotide: R157 (vs. gap), G216 (= G237), A217 (≠ G238), G218 (= G239), N221 (vs. gap), T243 (= T263), L244 (≠ Q264), Q245 (≠ G265), M260 (≠ A280), L261 (≠ V281), H264 (≠ T284), G283 (= G303), A284 (≠ T304), R285 (= R305), D287 (≠ Q307), R289 (≠ F309), V290 (≠ T310), E316 (≠ N328), V317 (= V329), N321 (≠ D333), G334 (= G344), D335 (= D345), A336 (= A346), Q410 (≠ K425), M411 (≠ L426), G429 (≠ Y439), G430 (= G440)
- binding magnesium ion: D459 (= D469), N486 (= N496), E488 (≠ G498)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E65), P81 (= P93), Q118 (= Q130), G432 (≠ S442), M434 (= M444), M464 (= M474)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
24% identity, 100% coverage: 2:613/614 of query aligns to 4:592/595 of 1t9bB
- active site: Y29 (≠ H40), G31 (vs. gap), G32 (= G41), A33 (≠ N42), I34 (≠ V43), E55 (= E65), T78 (= T88), F117 (≠ L129), Q118 (= Q130), E119 (≠ Q131), K167 (≠ Q188), R226 (≠ A247), M262 (≠ V283), V289 (≠ T310), V405 (≠ L419), L430 (≠ F441), G431 (≠ S442), M433 (= M444), D458 (= D469), N485 (= N496), E487 (≠ G498), Q488 (≠ Y499), M490 (≠ C501), V491 (≠ I502), W494 (≠ L505), L516 (≠ H534), G521 (= G539), L522 (≠ A540), K555 (≠ P573)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V119), P108 (≠ Y120), D287 (= D308), R288 (≠ F309), M490 (≠ C501), W494 (≠ L505)
- binding flavin-adenine dinucleotide: R157 (vs. gap), G215 (= G237), A216 (≠ G238), G217 (= G239), N220 (vs. gap), T242 (= T263), L243 (≠ Q264), Q244 (≠ G265), M259 (≠ A280), L260 (≠ V281), M262 (≠ V283), H263 (≠ T284), G282 (= G303), A283 (≠ T304), R284 (= R305), D286 (≠ Q307), R288 (≠ F309), V289 (≠ T310), E315 (≠ N328), V316 (= V329), N320 (≠ D333), G333 (= G344), D334 (= D345), A335 (= A346), Q409 (≠ K425), M410 (≠ L426), G428 (≠ Y439), G429 (= G440)
- binding magnesium ion: D458 (= D469), N485 (= N496), E487 (≠ G498)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
24% identity, 100% coverage: 2:613/614 of query aligns to 6:596/599 of 1n0hA
- active site: Y31 (≠ H40), G33 (vs. gap), G34 (= G41), A35 (≠ N42), I36 (≠ V43), E57 (= E65), T80 (= T88), F119 (≠ L129), Q120 (= Q130), E121 (≠ Q131), K169 (≠ Q188), R230 (≠ A247), M266 (≠ V283), V293 (≠ T310), V409 (≠ L419), L434 (≠ F441), G435 (≠ S442), M437 (= M444), D462 (= D469), N489 (= N496), E491 (≠ G498), Q492 (≠ Y499), M494 (≠ C501), V495 (≠ I502), W498 (≠ L505), L520 (≠ H534), G525 (= G539), L526 (≠ A540), K559 (≠ P573)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (≠ L419), G410 (= G421), Q411 (≠ E422), H412 (= H424), G435 (≠ S442), M437 (= M444), G461 (= G468), D462 (= D469), A463 (≠ G470), S464 (= S471), M467 (= M474), N489 (= N496), E491 (≠ G498), Q492 (≠ Y499), G493 (= G500), V495 (≠ I502)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G41), A35 (≠ N42), V109 (= V119), P110 (≠ Y120), F119 (≠ L129), K169 (≠ Q188), M266 (≠ V283), D291 (= D308), R292 (≠ F309), V495 (≠ I502), W498 (≠ L505)
- binding flavin-adenine dinucleotide: R159 (vs. gap), G219 (= G237), A220 (≠ G238), G221 (= G239), N224 (vs. gap), T246 (= T263), L247 (≠ Q264), Q248 (≠ G265), L264 (≠ V281), G265 (= G282), M266 (≠ V283), H267 (≠ T284), G286 (= G303), A287 (≠ T304), R288 (= R305), D290 (≠ Q307), R292 (≠ F309), V293 (≠ T310), E319 (≠ N328), V320 (= V329), N324 (≠ D333), G337 (= G344), D338 (= D345), A339 (= A346), M414 (≠ L426), G432 (≠ Y439), G433 (= G440)
- binding magnesium ion: D462 (= D469), N489 (= N496), E491 (≠ G498)
- binding thiamine diphosphate: Y31 (≠ H40), E57 (= E65), P83 (= P93)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
24% identity, 100% coverage: 2:613/614 of query aligns to 4:588/591 of 5wkcA
- active site: Y29 (≠ H40), G31 (vs. gap), G32 (= G41), A33 (≠ N42), I34 (≠ V43), E55 (= E65), T78 (= T88), F117 (≠ L129), Q118 (= Q130), E119 (≠ Q131), K167 (≠ Q188), R222 (≠ A247), M258 (≠ V283), V285 (≠ T310), V401 (≠ L419), L426 (≠ F441), G427 (≠ S442), M429 (= M444), D454 (= D469), N481 (= N496), E483 (≠ G498), Q484 (≠ Y499), M486 (≠ C501), V487 (≠ I502), W490 (≠ L505), L512 (≠ H534), G517 (= G539), L518 (≠ A540), K551 (≠ P573)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (≠ L419), G402 (= G421), Q403 (≠ E422), H404 (= H424), G427 (≠ S442), M429 (= M444), G453 (= G468), D454 (= D469), A455 (≠ G470), S456 (= S471), M459 (= M474), N481 (= N496), E483 (≠ G498), Q484 (≠ Y499), G485 (= G500), M486 (≠ C501), V487 (≠ I502)
- binding ethaneperoxoic acid: G32 (= G41), Q118 (= Q130)
- binding flavin-adenine dinucleotide: R157 (vs. gap), G211 (= G237), A212 (≠ G238), G213 (= G239), N216 (vs. gap), T238 (= T263), L239 (≠ Q264), Q240 (≠ G265), L256 (≠ V281), M258 (≠ V283), G278 (= G303), A279 (≠ T304), R280 (= R305), R284 (≠ F309), V285 (≠ T310), E311 (≠ N328), V312 (= V329), N316 (≠ D333), D330 (= D345), A331 (= A346), M406 (≠ L426), G424 (≠ Y439)
- binding magnesium ion: D454 (= D469), N481 (= N496), E483 (≠ G498)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (= G41), A33 (≠ N42), V107 (= V119), F117 (≠ L129), K167 (≠ Q188), M258 (≠ V283), R284 (≠ F309), M486 (≠ C501), W490 (≠ L505)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (vs. gap), E55 (= E65)
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
23% identity, 100% coverage: 2:613/614 of query aligns to 8:604/607 of 6u9dB
- active site: Y33 (≠ H40), G35 (vs. gap), G36 (= G41), A37 (≠ N42), I38 (≠ V43), E59 (= E65), T82 (= T88), F121 (≠ L129), Q122 (= Q130), E123 (≠ Q131), K171 (≠ Q188), M274 (≠ V283), V301 (≠ T310), V417 (≠ L419), G443 (≠ S442), M445 (= M444), D470 (= D469), N497 (= N496), E499 (≠ G498), Q500 (≠ Y499), M502 (≠ C501), V503 (≠ I502), W506 (≠ L505)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G41), V111 (= V119), P112 (≠ Y120), F121 (≠ L129), K171 (≠ Q188), D299 (= D308), R300 (≠ F309), M502 (≠ C501), W506 (≠ L505)
- binding flavin-adenine dinucleotide: R161 (vs. gap), A228 (≠ G238), G229 (= G239), N232 (vs. gap), T254 (= T263), L255 (≠ Q264), Q256 (≠ G265), L272 (≠ V281), M274 (≠ V283), G294 (= G303), R296 (= R305), D298 (≠ Q307), R300 (≠ F309), V301 (≠ T310), E327 (≠ N328), V328 (= V329), N332 (≠ D333), D346 (= D345), A347 (= A346), M422 (≠ L426), G440 (≠ Y439), G441 (= G440)
- binding magnesium ion: D470 (= D469), N497 (= N496)
- binding thiamine diphosphate: E59 (= E65), P85 (= P93), V417 (≠ L419), G418 (= G421), Q419 (≠ E422), H420 (= H424), G443 (≠ S442), M445 (= M444), A471 (≠ G470), S472 (= S471), N497 (= N496), E499 (≠ G498), Q500 (≠ Y499), G501 (= G500), M502 (≠ C501), V503 (≠ I502)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
24% identity, 100% coverage: 2:613/614 of query aligns to 88:684/687 of P07342
- R241 (vs. gap) binding
- 355:376 (vs. 284:305, 36% identical) binding
- 407:426 (vs. 328:345, 30% identical) binding
6lpiB Crystal structure of ahas holo-enzyme (see paper)
25% identity, 82% coverage: 5:507/614 of query aligns to 5:466/539 of 6lpiB
- active site: I27 (≠ V28), G29 (≠ H40), G30 (= G41), S31 (≠ N42), I32 (≠ V43), E53 (= E65), C76 (≠ S90), F115 (≠ L129), Q116 (= Q130), E117 (≠ Q131), K165 (≠ Q188), M256 (≠ V283), A283 (≠ T310), V375 (≠ A416), G401 (≠ S442), M403 (= M444), D428 (= D469), N455 (= N496), A457 (≠ G498), L458 (≠ Y499), L460 (≠ C501), V461 (≠ I502), Q464 (≠ L505)
- binding flavin-adenine dinucleotide: R155 (≠ T178), G212 (= G237), G213 (= G238), G214 (= G239), T236 (= T263), L237 (≠ Q264), M238 (≠ G265), L254 (≠ V281), M256 (≠ V283), H257 (≠ T284), G276 (= G303), A277 (≠ T304), R278 (= R305), D280 (≠ Q307), R282 (≠ F309), A283 (≠ T310), D300 (≠ N328), I301 (≠ V329), D319 (≠ G338), V320 (≠ A339), M380 (≠ L426), G398 (≠ Y439)
- binding magnesium ion: D428 (= D469), N455 (= N496)
- binding thiamine diphosphate: E53 (= E65), C76 (≠ S90), P79 (= P93), G376 (= G417), Q377 (≠ G418), H378 (= H424), G401 (≠ S442), M403 (= M444), G427 (= G468), D428 (= D469), G429 (= G470), S430 (= S471), M433 (= M474), N455 (= N496), A457 (≠ G498), L458 (≠ Y499), G459 (= G500), L460 (≠ C501), V461 (≠ I502)
8beoB Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
27% identity, 84% coverage: 52:567/614 of query aligns to 41:546/592 of 8beoB
- binding methyl hydrogen (s)-acetylphosphonate: C490 (vs. gap), Q492 (≠ G511)
- binding flavin-adenine dinucleotide: R153 (≠ T178), P154 (≠ C179), G210 (= G237), G211 (= G238), G212 (= G239), N215 (≠ Y242), T236 (= T263), L237 (≠ Q264), M238 (≠ G265), V254 (= V281), G255 (= G282), Q257 (vs. gap), T258 (= T284), G277 (= G303), N278 (≠ T304), R279 (= R305), A281 (≠ Q307), R283 (≠ F309), H284 (≠ T310), D301 (≠ N328), I302 (≠ V329), Q306 (≠ D333), D320 (= D345), A321 (= A346), G415 (vs. gap)
- binding magnesium ion: D445 (= D469), F450 (≠ M474), L451 (= L475), E453 (≠ S477), N472 (= N496), Y474 (≠ G498)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1s)-1-hydroxy-1-[(r)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: R283 (≠ F309), G393 (= G417), L394 (= L423), S395 (≠ H424), L420 (≠ M444), G444 (= G468), D445 (= D469), F446 (≠ G470), D447 (≠ S471), N472 (= N496), Y474 (≠ G498), L475 (≠ Y499), G476 (= G500), L477 (≠ C501), I478 (= I502)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: Q352 (≠ D382), R356 (= R386)
Sites not aligning to the query:
8beoA Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
27% identity, 84% coverage: 52:567/614 of query aligns to 41:546/592 of 8beoA
- binding flavin-adenine dinucleotide: R153 (≠ T178), P154 (≠ C179), G210 (= G237), G211 (= G238), G212 (= G239), N215 (≠ Y242), T236 (= T263), L237 (≠ Q264), M238 (≠ G265), V254 (= V281), G255 (= G282), Q257 (vs. gap), T258 (= T284), G277 (= G303), N278 (≠ T304), R279 (= R305), A281 (≠ Q307), R283 (≠ F309), H284 (≠ T310), D301 (≠ N328), I302 (≠ V329), Q306 (≠ D333), D320 (= D345), A321 (= A346), I397 (≠ L426), G415 (vs. gap)
- binding magnesium ion: R384 (≠ D408), V405 (≠ G434), F406 (≠ Y435), H410 (≠ Y439), D445 (= D469), F450 (≠ M474), L451 (= L475), E453 (≠ S477), N472 (= N496), Y474 (≠ G498)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1s)-1-hydroxy-1-[(r)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: R283 (≠ F309), G393 (= G417), L394 (= L423), S395 (≠ H424), L420 (≠ M444), G444 (= G468), D445 (= D469), F446 (≠ G470), D447 (≠ S471), N472 (= N496), Y474 (≠ G498), L475 (≠ Y499), G476 (= G500), L477 (≠ C501), I478 (= I502)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: E248 (≠ P275), Q352 (≠ D382)
Sites not aligning to the query:
5imsA Saccharomyces cerevisiae acetohydroxyacid synthase
24% identity, 93% coverage: 2:572/614 of query aligns to 6:540/541 of 5imsA
- active site: Y31 (≠ H40), G33 (vs. gap), G34 (= G41), A35 (≠ N42), I36 (≠ V43), E57 (= E65), T80 (= T88), F119 (≠ L129), Q120 (= Q130), E121 (≠ Q131), K169 (≠ Q188), R229 (≠ A247), M265 (≠ V283), V292 (≠ T310), V408 (≠ L419), L433 (≠ F441), G434 (≠ S442), M436 (= M444), D461 (= D469), N488 (= N496), E490 (≠ G498), L502 (≠ H534), G507 (= G539), L508 (≠ A540)
- binding flavin-adenine dinucleotide: R159 (vs. gap), G218 (= G237), A219 (≠ G238), G220 (= G239), N223 (vs. gap), T245 (= T263), L246 (≠ Q264), L263 (≠ V281), G264 (= G282), H266 (≠ T284), G285 (= G303), A286 (≠ T304), R287 (= R305), D289 (≠ Q307), R291 (≠ F309), V292 (≠ T310), E318 (≠ N328), V319 (= V329), N323 (≠ D333), D337 (= D345), A338 (= A346)
- binding magnesium ion: D461 (= D469), N488 (= N496)
- binding oxygen molecule: G34 (= G41), T80 (= T88), Q120 (= Q130)
- binding thiamine diphosphate: P32 (vs. gap), E57 (= E65), V408 (≠ L419), G409 (= G421), Q410 (≠ E422), H411 (= H424), G434 (≠ S442), M436 (= M444), G460 (= G468), D461 (= D469), A462 (≠ G470), S463 (= S471), M466 (= M474), N488 (= N496)
Sites not aligning to the query:
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
23% identity, 85% coverage: 37:557/614 of query aligns to 28:537/593 of 6deoA
- active site: Y31 (≠ H40), G33 (vs. gap), G34 (= G41), A35 (≠ N42), I36 (≠ V43), E57 (= E65), T80 (= T88), F119 (≠ L129), Q120 (= Q130), E121 (≠ Q131), K169 (≠ Q188), K224 (≠ A247), M260 (≠ V283), V287 (≠ T310), V403 (≠ P420), L428 (≠ F441), G429 (≠ S442), M431 (= M444), D456 (= D469), N483 (= N496), E485 (≠ G498), Q486 (≠ Y499), M488 (≠ C501), V489 (≠ I502), W492 (≠ L505), L514 (≠ H534), N519 (≠ G539), V520 (≠ A540)
- binding flavin-adenine dinucleotide: R159 (vs. gap), G213 (= G237), A214 (≠ G238), G215 (= G239), N218 (≠ Y242), T240 (= T263), L241 (≠ Q264), Q242 (≠ G265), L258 (≠ V281), G280 (= G303), A281 (≠ T304), R282 (= R305), D284 (≠ Q307), R286 (≠ F309), V287 (≠ T310), E313 (≠ N328), I314 (≠ V329), N318 (≠ D333), D332 (= D345), V333 (≠ A346), M408 (≠ L426), G426 (≠ Y439)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (≠ V283), D285 (= D308), R286 (≠ F309), M488 (≠ C501), W492 (≠ L505)
- binding magnesium ion: D456 (= D469), N483 (= N496), E485 (≠ G498)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (≠ P420), G404 (= G421), Q405 (≠ E422), H406 (= H424), G429 (≠ S442), M431 (= M444), G455 (= G468), D456 (= D469), A457 (≠ G470), S458 (= S471), M461 (= M474), N483 (= N496), E485 (≠ G498), Q486 (≠ Y499), G487 (= G500), M488 (≠ C501), V489 (≠ I502)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
24% identity, 85% coverage: 37:557/614 of query aligns to 30:541/597 of 6demA
- active site: Y33 (≠ H40), G35 (vs. gap), G36 (= G41), A37 (≠ N42), I38 (≠ V43), E59 (= E65), T82 (= T88), F121 (≠ L129), Q122 (= Q130), E123 (≠ Q131), K171 (≠ Q188), K228 (≠ A247), M264 (≠ V283), V291 (≠ T310), V407 (≠ G417), L432 (≠ F441), G433 (≠ S442), M435 (= M444), D460 (= D469), N487 (= N496), E489 (≠ G498), Q490 (≠ Y499), M492 (≠ C501), V493 (≠ I502), W496 (≠ L505), L518 (≠ H534), N523 (≠ G539), V524 (≠ A540)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (≠ V283), D289 (= D308), R290 (≠ F309), M492 (≠ C501), W496 (≠ L505)
- binding flavin-adenine dinucleotide: R161 (vs. gap), G217 (= G237), A218 (≠ G238), G219 (= G239), N222 (≠ Y242), T244 (= T263), L245 (≠ Q264), Q246 (≠ G265), L262 (≠ V281), G284 (= G303), A285 (≠ T304), R286 (= R305), D288 (≠ Q307), R290 (≠ F309), V291 (≠ T310), E317 (≠ N328), I318 (≠ V329), N322 (≠ D333), D336 (= D345), V337 (≠ A346), M412 (≠ L426), G430 (≠ Y439)
- binding magnesium ion: D460 (= D469), N487 (= N496), E489 (≠ G498)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ G417), G408 (= G418), Q409 (≠ L423), H410 (= H424), M435 (= M444), G459 (= G468), D460 (= D469), A461 (≠ G470), S462 (= S471), M465 (= M474), N487 (= N496), E489 (≠ G498), Q490 (≠ Y499), G491 (= G500), M492 (≠ C501), V493 (≠ I502)
Sites not aligning to the query:
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
24% identity, 85% coverage: 37:557/614 of query aligns to 30:541/597 of 6delA
- active site: Y33 (≠ H40), G35 (vs. gap), G36 (= G41), A37 (≠ N42), I38 (≠ V43), E59 (= E65), T82 (= T88), F121 (≠ L129), Q122 (= Q130), E123 (≠ Q131), K171 (≠ Q188), K228 (≠ A247), M264 (≠ V283), V291 (≠ T310), V407 (≠ G417), L432 (≠ F441), G433 (≠ S442), M435 (= M444), D460 (= D469), N487 (= N496), E489 (≠ G498), Q490 (≠ Y499), M492 (≠ C501), V493 (≠ I502), W496 (≠ L505), L518 (≠ H534), N523 (≠ G539), V524 (≠ A540)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D308), R290 (≠ F309), W496 (≠ L505)
- binding flavin-adenine dinucleotide: R161 (vs. gap), G217 (= G237), A218 (≠ G238), G219 (= G239), N222 (≠ Y242), T244 (= T263), L245 (≠ Q264), Q246 (≠ G265), L262 (≠ V281), G284 (= G303), A285 (≠ T304), R286 (= R305), D288 (≠ Q307), R290 (≠ F309), V291 (≠ T310), E317 (≠ N328), I318 (≠ V329), N322 (≠ D333), D336 (= D345), V337 (≠ A346), M412 (≠ L426), G430 (≠ Y439)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (≠ G417), G408 (= G418), Q409 (≠ L423), H410 (= H424), G433 (≠ S442), M435 (= M444), G459 (= G468), D460 (= D469), A461 (≠ G470), S462 (= S471), M465 (= M474), N487 (= N496), E489 (≠ G498), Q490 (≠ Y499), G491 (= G500), M492 (≠ C501), V493 (≠ I502)
- binding magnesium ion: D460 (= D469), N487 (= N496), E489 (≠ G498)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ G417), G408 (= G418), Q409 (≠ L423), H410 (= H424), G433 (≠ S442), M435 (= M444), G459 (= G468), D460 (= D469), A461 (≠ G470), S462 (= S471), M465 (= M474), N487 (= N496), E489 (≠ G498), Q490 (≠ Y499), G491 (= G500), M492 (≠ C501), V493 (≠ I502)
6dekA Crystal structure of candida albicans acetohydroxyacid synthase catalytic subunit (see paper)
23% identity, 85% coverage: 37:557/614 of query aligns to 31:539/595 of 6dekA
- active site: Y34 (≠ H40), G36 (vs. gap), G37 (= G41), A38 (≠ N42), I39 (≠ V43), E60 (= E65), T83 (= T88), Q118 (= Q130), E119 (≠ Q131), K167 (≠ Q188), K226 (≠ A247), M262 (≠ V283), V289 (≠ T310), V405 (≠ G417), L430 (≠ F441), G431 (≠ S442), M433 (= M444), D458 (= D469), N485 (= N496), E487 (≠ G498), Q488 (≠ Y499), M490 (≠ C501), V491 (≠ I502), W494 (≠ L505), L516 (≠ H534), N521 (≠ G539), V522 (≠ A540)
- binding flavin-adenine dinucleotide: R157 (vs. gap), G215 (= G237), A216 (≠ G238), G217 (= G239), N220 (≠ Y242), T242 (= T263), L243 (≠ Q264), Q244 (≠ G265), L260 (≠ V281), M262 (≠ V283), G282 (= G303), A283 (≠ T304), R284 (= R305), D286 (≠ Q307), R288 (≠ F309), V289 (≠ T310), E315 (≠ N328), I316 (≠ V329), N320 (≠ D333), D334 (= D345), V335 (≠ A346), M410 (≠ L426), G428 (= G434)
- binding magnesium ion: D458 (= D469), N485 (= N496), E487 (≠ G498)
- binding thiamine diphosphate: V405 (≠ G417), G406 (= G418), Q407 (≠ L423), H408 (= H424), M433 (= M444), G457 (= G468), D458 (= D469), A459 (≠ G470), S460 (= S471), N485 (= N496), E487 (≠ G498), Q488 (≠ Y499), G489 (= G500), M490 (≠ C501), V491 (≠ I502)
6bd3A Saccharomyces cerevisiae acetohydroxyacid synthase
24% identity, 93% coverage: 2:572/614 of query aligns to 6:536/538 of 6bd3A
- active site: Y31 (≠ H40), G33 (vs. gap), G34 (= G41), A35 (≠ N42), I36 (≠ V43), E57 (= E65), T80 (= T88), F119 (≠ L129), Q120 (= Q130), E121 (≠ Q131), K169 (≠ Q188), R225 (≠ A247), M261 (≠ V283), V288 (≠ T310), V404 (≠ L419), L429 (≠ F441), G430 (≠ S442), M432 (= M444), D457 (= D469), N484 (= N496), L498 (≠ H534), G503 (= G539), L504 (≠ A540)
- binding flavin-adenine dinucleotide: R159 (vs. gap), G214 (= G237), A215 (≠ G238), G216 (= G239), N219 (vs. gap), T241 (= T263), L242 (≠ Q264), Q243 (≠ G265), L259 (≠ V281), G260 (= G282), H262 (≠ T284), G281 (= G303), A282 (≠ T304), R283 (= R305), D285 (≠ Q307), R287 (≠ F309), V288 (≠ T310), E314 (≠ N328), V315 (= V329), D333 (= D345), A334 (= A346)
- binding 2-acetyl-thiamine diphosphate: P32 (vs. gap), E57 (= E65), P83 (= P93)
- binding magnesium ion: D457 (= D469), N484 (= N496)
- binding oxygen molecule: A35 (≠ N42), T80 (= T88), S81 (≠ T89), Q120 (= Q130)
- binding thiamine diphosphate: V404 (≠ L419), G405 (= G421), Q406 (≠ E422), H407 (= H424), G430 (≠ S442), M432 (= M444), D457 (= D469), A458 (≠ G470), S459 (= S471), M462 (= M474), N484 (= N496)
Sites not aligning to the query:
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
23% identity, 85% coverage: 37:557/614 of query aligns to 32:543/599 of 6denA
- active site: Y35 (≠ H40), G37 (vs. gap), G38 (= G41), A39 (≠ N42), I40 (≠ V43), E61 (= E65), T84 (= T88), F123 (≠ L129), Q124 (= Q130), E125 (≠ Q131), K173 (≠ Q188), K230 (≠ A247), M266 (≠ V283), V293 (≠ T310), V409 (≠ G417), L434 (≠ F441), G435 (≠ S442), M437 (= M444), D462 (= D469), N489 (= N496), E491 (≠ G498), Q492 (≠ Y499), M494 (≠ C501), V495 (≠ I502), W498 (≠ L505), L520 (≠ H534), N525 (≠ G539), V526 (≠ A540)
- binding flavin-adenine dinucleotide: R163 (vs. gap), G219 (= G237), A220 (≠ G238), G221 (= G239), N224 (≠ Y242), T246 (= T263), L247 (≠ Q264), Q248 (≠ G265), L264 (≠ V281), G286 (= G303), A287 (≠ T304), R288 (= R305), D290 (≠ Q307), R292 (≠ F309), V293 (≠ T310), E319 (≠ N328), I320 (≠ V329), N324 (≠ D333), D338 (= D345), V339 (≠ A346), M414 (≠ L426), G432 (= G434)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (≠ V283), D291 (= D308), R292 (≠ F309), W498 (≠ L505)
- binding magnesium ion: D462 (= D469), N489 (= N496), E491 (≠ G498)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (≠ G417), G410 (= G418), Q411 (≠ L423), H412 (= H424), G435 (≠ S442), M437 (= M444), G461 (= G468), D462 (= D469), A463 (≠ G470), S464 (= S471), N489 (= N496), E491 (≠ G498), Q492 (≠ Y499), G493 (= G500), M494 (≠ C501), V495 (≠ I502)
Query Sequence
>CCNA_01357 FitnessBrowser__Caulo:CCNA_01357
MALVRLTAAQATVRWLAAQHVETSDGEVPYFAGVWAIFGHGNVAGLGEALHGVRDVLLTY
RAHNEQGMAHAAIAFAKQSRRERAMVCTTSIGPGATNMVTAAALAHVNRLPVLFLPGDVY
ASRRPDPVLQQIEDFGDGTISANECFKPVSRYFDRITRPEQILDALPRALAVMLDPATCG
PATLAFCQDVQAEAFDYPQAFFAKRVWRIRAPQPDPRELDDLVGLIKAAERPLIVAGGGV
LYARAEAALADLANDAGLPVVETQGGKGSLAWDHPLNLGAVGVTGTTASVAAAEAADLVI
GLGTRLQDFTTGSRALFGAEGRKLVQVNVAPHDAHKHGATSVVGDALAVLEALAERLDGW
RAPVAWTDQATSGVPAWNAIFDASTRADTRPLPTDAQVLGAVWRASSDDSVVVCAAGGLP
GELHKLWRTRMPGGYHVEYGFSCMGYEIAGAVGVKMAEPDREVHVMVGDGSYLMLNSELA
TSVMLGTKLIVTVLDNRGYGCINRLQAATGGAAFNNLLADTLHETLPDIDFAAHAASLGA
RSEKVGDLSSLEAALQRAKASDRTYVVVIDTDPMPTTEGGAWWDVAVPEVSVRPSVNAAR
ADYDLKIKQQRTGD
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory