Comparing CCNA_01554 FitnessBrowser__Caulo:CCNA_01554 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 12 hits to proteins with known functional sites (download)
4im7A Crystal structure of fructuronate reductase (ydfi) from e. Coli cft073 (efi target efi-506389) complexed with nadh and d-mannonate
39% identity, 94% coverage: 27:481/482 of query aligns to 9:468/483 of 4im7A
7rk5B Mannitol-2-dehydrogenase bound to nadh from aspergillus fumigatus
37% identity, 95% coverage: 25:481/482 of query aligns to 21:485/501 of 7rk5B
1m2wA Pseudomonas fluorescens mannitol 2-dehydrogenase ternary complex with NAD and d-mannitol (see paper)
36% identity, 98% coverage: 11:481/482 of query aligns to 1:476/492 of 1m2wA
1lj8A Crystal structure of mannitol dehydrogenase in complex with NAD (see paper)
36% identity, 98% coverage: 11:481/482 of query aligns to 1:476/492 of 1lj8A
P09424 Mannitol-1-phosphate 5-dehydrogenase; EC 1.1.1.17 from Escherichia coli (strain K12) (see paper)
28% identity, 50% coverage: 176:416/482 of query aligns to 104:334/382 of P09424
Q4X1A4 Mannitol-1-phosphate 5-dehydrogenase; M1PDH; MPD; MPDH; EC 1.1.1.17 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
22% identity, 51% coverage: 172:416/482 of query aligns to 104:335/388 of Q4X1A4
7ocnA Crystal structure of the bifunctional mannitol-1-phosphate dehydrogenase/phosphatase mtld from acinetobacter baumannii (see paper)
27% identity, 22% coverage: 285:390/482 of query aligns to 510:634/690 of 7ocnA
Sites not aligning to the query:
7ocpA NADPH bound to the dehydrogenase domain of the bifunctional mannitol- 1-phosphate dehydrogenase/phosphatase mtld from acinetobacter baumannii (see paper)
27% identity, 22% coverage: 285:390/482 of query aligns to 510:634/688 of 7ocpA
Sites not aligning to the query:
7ocqA Nadh bound to the dehydrogenase domain of the bifunctional mannitol-1- phosphate dehydrogenase/phosphatase mtld from acinetobacter baumannii (see paper)
27% identity, 22% coverage: 285:390/482 of query aligns to 506:630/686 of 7ocqA
Sites not aligning to the query:
7ocsA Mannitol-1-phosphate bound to the phosphatase domain of the bifunctional mannitol-1-phosphate dehydrogenase/phosphatase mtld-d16a from acinetobacter baumannii (see paper)
27% identity, 22% coverage: 285:390/482 of query aligns to 502:626/682 of 7ocsA
Sites not aligning to the query:
7ocrB NADPH and fructose-6-phosphate bound to the dehydrogenase domain of the bifunctional mannitol-1-phosphate dehydrogenase/phosphatase mtld from acinetobacter baumannii (see paper)
27% identity, 22% coverage: 285:390/482 of query aligns to 495:619/675 of 7ocrB
Sites not aligning to the query:
7ocqB Nadh bound to the dehydrogenase domain of the bifunctional mannitol-1- phosphate dehydrogenase/phosphatase mtld from acinetobacter baumannii (see paper)
27% identity, 22% coverage: 285:390/482 of query aligns to 499:623/679 of 7ocqB
Sites not aligning to the query:
>CCNA_01554 FitnessBrowser__Caulo:CCNA_01554
MTANSATSPALRLNATSYPGVVPGVAIPTYDRDKLQIGVVHFGPGAFHRAHQAHYFDQLL
AHDPRWGVCAVSLKSPGVRDALKPQDGLYTLAQLDAETTFRIVGSILEVLVAPEDPPSVF
ARLAAPTTRLVTLTVTEKGYTLSANGGLDESHPDIVHDLANPREPRSAVGYLVEGLRRRF
AAGLAPYAVVACDNLADNGWRLKAAVVAYAAKLDESLAAWIDREGRFPRTMVDSITPATD
DALRARTLAATGLEDAWPIQREAFAQWVVEDVLPADGPDLASVGVIMTDDVRGFERAKLR
LLNGVHSTLAYVGILRGHETVFEAVSDPTLAALASDMMAKDIIPTLTPPRGLDLQAYADA
ILGRFRNPEIRHLLAQIAWDGSQKLPFRILGTLTETLEAGRSIERLAVPLAAWMRFVALR
AKAGEAIVDPLQDRLLALGLAATGEASADVAAFLALDSVFPASLAGDPRFVSALEKAYAD
LG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory