SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing CCNA_01835 FitnessBrowser__Caulo:CCNA_01835 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
46% identity, 88% coverage: 28:227/228 of query aligns to 17:217/223 of 2pclA

query
sites
2pclA

N

E

I

I

L

L

R

K

G

G

V

I

D

S

L

L

V

S

V

V

N

K

P

K

G

G

E

E

R

F

V

V

A

S

I

I

I

I

G

G

P

A

S

S

G

G

S

S

G

G

K

K

S

S

S

T

L

L

I

L

A

Y

V

I

G

L

A

G

G

L

L

L

E

D

E

A

P

P

T

T

S

E

G

G

Q

K

V

V

R

F

L

L

F

E

G

G

Q

K

D

E

L

V

A

D

K

Y

L

T

N

N

E

E

D

K

G

E

R

L

A

S

R

L

L

L

R

R

R

N

G

R

R

K

A

L

A

G

L

F

V

V

F

F

Q

Q

S

F

F

H

H

Y

L

L

L

I

P

P

N

E

M

L

T

T

A

A

E

L

E

E

N

N

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V

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I

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V

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P

L

M

E

L

I

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D

M

G

G

A

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-

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-

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D

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Y

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L

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Q

Q

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R

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V

A

A

L

I

A

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R

R

A

A

L

L

A

A

A

N

R

E

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P

A

I

L

L

L

L

F

F

A

A

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D

E
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E

P
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P

T
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T

G

G

N

N

L

L

D

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S

A

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K

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L

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D

D

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G

R

K

I

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V

V

binding magnesium ion: E165 (= E174), P166 (= P175), T167 (= T176), T196 (= T206)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
42% identity, 95% coverage: 11:227/228 of query aligns to 5:222/648 of P75831

query
sites
P75831

L

L

V

E

L

L

D

K

A

D

V

I

A

R

L

R

T

S

L

Y

P

P

S

A

S

G

A

D

G

E

P

Q

V

V

N

E

I

V

L

L

R

K

G

G

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S

L

L

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D

V

I

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Y

P

A

G

G

E

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M

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A

A

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I

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G

P

A

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G

G

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G

K
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K

S

S

S

T

L

L

I

M

A

N

V

I

G

L

A

G

G

C

L

L

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S

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G

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Y

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R

L

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F

A

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G

Q

Q

D

D

L

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A

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K

T

L

L

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L

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G

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V

K47 (= K53) mutation to L: Lack of activity.
D169 (= D173) mutation to N: Lack of activity.

7mdyC Lolcde nucleotide-bound
46% identity, 89% coverage: 27:228/228 of query aligns to 19:222/226 of 7mdyC

query
sites
7mdyC

V

T

N

D

I

V

L

L

R

H

G

N

V

V

D

S

L

F

V

S

V

V

N

G

P

E

G

G

E

E

R

M

V

M

A

A

I

I

I

V

G

G

P

S

S

S

G
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G

S
|
S

G
|
G

K
|
K

S
|
S

S
x
T

L

L

I

L

A

H

V

L

G

L

A

G

G

G

L

L

E

D

E

T

P

P

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T

S

S

G

G

Q

D

V

V

R

I

L

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F

N

G

G

Q

Q

D

P

L

M

A

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K

K

L

L

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E

S

D

A

G

A

R

K

A

A

R

E

L

L

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R

R

N

G

Q

R

K

A

L

A

G

L

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V

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Q

S

F

F

H

H

H

L

L

L

L

P

P

N

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M

F

T

T

A

A

E

L

E

E

N

N

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V

A

A

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P

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L

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L

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A

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A

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A

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A

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R

R

-

A

-

L

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W

M

L

L

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K

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A

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V

G

G

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L

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G

H

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L

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H
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H

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R

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P

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x
E

L

L

S
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S

G
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G

G
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G

E

E

Q

R

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

L

A

V

A

N

R

N

P

P

A

R

L

L

L

V

F

L

A

A

D

D

E
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E

P

P

T

T

G

G

N
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N

L

L

D

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G

A

A

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H
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L

L

A

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L

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A

binding adp orthovanadate: G42 (= G50), S43 (= S51), G44 (= G52), K45 (= K53), S46 (= S54), T47 (≠ S55), Q91 (= Q99), H138 (= H144), E142 (≠ Q148), S144 (= S150), G145 (= G151), G146 (= G152), E168 (= E174), N172 (= N178), H201 (= H207)
binding magnesium ion: S46 (= S54), Q91 (= Q99)

Sites not aligning to the query:

binding adp orthovanadate: 12

7arlD Lolcde in complex with lipoprotein and adp (see paper)
46% identity, 89% coverage: 27:228/228 of query aligns to 19:222/222 of 7arlD

query
sites
7arlD

V

T

N

D

I

V

L

L

R

H

G

N

V

V

D

S

L

F

V

S

V

V

N

G

P

E

G

G

E

E

R

M

V

M

A

A

I

I

I

V

G

G

P

S

S

S

G
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G

S

S

G
|
G

K
|
K

S
|
S

S

T

L

L

I

L

A

H

V

L

G

L

A

G

G

G

L

L

E

D

E

T

P

P

T

T

S

S

G

G

Q

D

V

V

R

I

L

F

F

N

G

G

Q

Q

D

P

L

M

A

S

K

K

L

L

N

S

E

S

D

A

G

A

R

K

A

A

R

E

L

L

R

R

R

N

G

Q

R

K

A

L

A

G

L

F

V

I

F

Y

Q

Q

S

F

F

H

H

H

L

L

L

L

P

P

N

D

M

F

T

T

A

A

E

L

E

E

N

N

V

V

A

A

T

M

P

P

L

L

E

L

I

I

D

G

G

K

A

K

R

K

D

P

A

A

M

E

A

I

T

N

A

S

R

R

-

A

-

L

D

E

W

M

L

L

G

K

R

A

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V

G

G

L

L

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D

G

H

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L

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N

H

H

Y

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E

L

L

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S

G

G

G

G

E

E

Q

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Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

L

A

V

A

N

R

N

P

P

A

R

L

L

L

V

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

G

A

A

R

T

N

A

A

T

D

S

S

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I

A

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D

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L

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M

L

F

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N

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L

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G

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L

L

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M

A

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D

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G

R

R

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L

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T

S

A

binding adenosine-5'-diphosphate: G42 (= G50), G44 (= G52), K45 (= K53), S46 (= S54)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
46% identity, 89% coverage: 27:228/228 of query aligns to 22:225/233 of P75957

query
sites
P75957

V

T

N

D

I

V

L

L

R

H

G

N

V

V

D

S

L

F

V

S

V

V

N

G

P

E

G

G

E

E

R

M

V

M

A

A

I

I

I

V

G
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G

P

S

S

S

G

G

S

S

G

G

K

K

S

S

S

T

L

L

I

L

A

H

V

L

G

L

A

G

G

G

L

L

E

D

E

T

P

P

T

T

S

S

G

G

Q

D

V

V

R

I

L

F

F

N

G

G

Q

Q

D

P

L

M

A

S

K

K

L

L

N

S

E

S

D

A

G

A

R

K

A

A

R

E

L

L

R

R

R

N

G

Q

R

K

A

L

A

G

L

F

V

I

F

Y

Q

Q

S

F

F

H

H

H

L

L

L

L

P

P

N

D

M

F

T

T

A

A

E

L

E

E

N

N

V

V

A

A

T

M

P

P

L

L

E

L

I

I

D

G

G

K

A

K

R

K

D

P

A

A

M

E

A

I

T

N

A

S

R

R

-

A

-

L

D

E

W

M

L

L

G

K

R

A

V

V

G

G

L

L

S

D

G

H

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L

A

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H

H

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R

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P

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E

L

L

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S

G

G

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G

E

E

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Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

L

A

V

A

N

R

N

P

P

A

R

L

L

L

V

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

G

A

A

R

T

N

A

A

T

D

S

S

V

I

A

F

D

Q

L

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M

L

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G

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G

G

A

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A

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M

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M

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T

T

H

H

D

D

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L

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L

L

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K

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Q

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L

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E

M

M

A

R

D

D

G

G

R

R

I

L

V

T

S

A

G42 (= G47) mutation to D: Loss of lipoprotein release when overexpressed.

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
46% identity, 89% coverage: 27:228/228 of query aligns to 21:224/229 of 7v8iD

query
sites
7v8iD

V

T

N

D

I
x
V

L

L

R

H

G

N

V

V

D

S

L

F

V

S

V

V

N

G

P

E

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G

E

E

R

M

V

M

A

A

I

I

I

V

G

G

P

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

S
x
T

L

L

I

L

A

H

V

L

G

L

A

G

G

G

L

L

E

D

E

T

P

P

T

T

S

S

G

G

Q

D

V

V

R

I

L

F

F

N

G

G

Q

Q

D

P

L

M

A

S

K

K

L

L

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S

E

S

D

A

G

A

R

K

A

A

R

E

L

L

R

R

R

N

G

Q

R

K

A

L

A

G

L

F

V

I

F

Y

Q
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Q

S

F

F

H

H

H

L

L

L

L

P

P

N

D

M

F

T

T

A

A

E

L

E

E

N

N

V

V

A

A

T

M

P

P

L

L

E

L

I

I

D

G

G

K

A

K

R

K

D

P

A

A

M

E

A

I

T

N

A

S

R

R

-

A

-

L

D

E

W

M

L

L

G

K

R

A

V

V

G

G

L

L

S

D

G

H

R
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R

L

A

T

N

H
|
H

Y

R

P

P

H

S

Q
x
E

L

L

S
|
S

G

G

G
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G

E
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E

Q

R

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

L

A

V

A

N

R

N

P

P

A

R

L

L

L

V

F

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

N

L

L

D

D

G

A

A

R

T

N

A

A

T

D

S

S

V

I

A

F

D

Q

L

L

M

L

F

G

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E

L

L

V

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E

L

V

Q

G

G

A

T

A

A

M

F

V

L

M

V

V

V

T

T

H
|
H

D

D

P

L

V

Q

L

L

A

A

T

K

R

R

A

M

D

S

R

R

I

Q

V

L

R

E

M

M

A

R

D

D

G

G

R

R

I

L

V

T

S

A

binding phosphoaminophosphonic acid-adenylate ester: V23 (≠ I29), S43 (= S49), G44 (= G50), G46 (= G52), K47 (= K53), S48 (= S54), T49 (≠ S55), Q93 (= Q99), R137 (= R141), H140 (= H144), E144 (≠ Q148), S146 (= S150), G148 (= G152), E149 (= E153), H203 (= H207)
binding magnesium ion: S48 (= S54), Q93 (= Q99)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
43% identity, 89% coverage: 27:228/228 of query aligns to 20:222/226 of 5xu1B

query
sites
5xu1B

V

L

N

Q

I

V

L

L

R

K

G

N

V

I

D

N

L

L

V

E

V

V

N

N

P

E

G

G

E

E

R

F

V

V

A

A

I

I

I

M

G

G

P

P

S

S

G

G

S

S

G
|
G

K
|
K

S
|
S

S

T

L

L

I

M

A

N

V

T

G

I

A

G

G

M

L

L

E

D

E

T

P

P

T

T

S

S

G

G

Q

E

V

Y

R

Y

L

L

F

E

G

G

Q

Q

D

E

L

V

A

A

K

G

L

L

N

G

E

E

D

K

G

Q

R

L

A

A

R

K

L

V

R

R

R

N

G

Q

R

Q

A

I

A

G

L

F

V

V

F

F

Q

Q

S

Q

F

F

H

F

L

L

L

L

P

S

N

K

M

L

T

N

A

A

E

L

E

Q

N

N

V

V

A

E

T

L

P

P

L

L

E

I

I

Y

D

A

G

G

A

V

R

S

D

S

A

S

M

K

-

R

-

R

A

K

T

L

A

A

R

E

D

E

W

Y

L

L

G

D

R

K

V

V

G

E

L

L

S

T

G

E

R

R

L

S

T

H

H

H

Y

L

P

P

H

S

Q

E

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

L

A

V

A

N

R

N

P

P

A

S

L

I

L

I

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

G

T

A

K

T

T

A

G

T

N

S

Q

V

I

A

M

D

Q

L

L

M

L

F

V

N

D

L

L

V

N

T

K

E

E

V

-

G

G

A

K

A

T

M

I

V

I

M

M

V

V

T

T

H

H

D

E

P

P

V

E

L

I

A

A

T

A

R

Y

A

A

D

K

R

R

I

Q

V

I

R

V

M

I

A

R

D

D

G

G

R

V

I

I

V

S

S

S

binding magnesium ion: G45 (= G52), K46 (= K53), S47 (= S54)

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
41% identity, 92% coverage: 20:228/228 of query aligns to 14:223/650 of 5ws4A

query
sites
5ws4A

L

F

P

P

S

A

S

G

A

E

G

S

P

T

V

I

N

Q

I

I

L

L

R

K

G

G

V

I

D

D

L

L

V

T

V

I

N

Y

P

E

G

G

E

E

R

L

V

V

A

A

I

I

I

V

G

G

P

Q

S
|
S

G
|
G

S

S

G

G

K

K

S
|
S

S

T

L

L

I

M

A

N

V

I

G

L

A

G

G

C

L

L

E

D

E

R

P

P

T

T

S

S

G

G

Q

S

V

Y

R

K

L

V

F

N

G

G

Q

Q

D

E

L

T

A

G

K

K

L

L

N

E

E

P

D

D

G

Q

R

L

A

A

R

Q

L

L

R

R

R

R

G

E

R

Y

A

F

A

G

L

F

V

I

F

F

Q

Q

S

R

F

Y

H

H

L

L

L

L

P

G

N

D

M

L

T

S

A

A

E

E

E

G

N

N

V

V

A

E

T

V

P

P

L

A

E

V

I

Y

D

A

G

G

A

V

-

T

-

P

-

A

-

D

R

R

D

K

A

Q

M

R

A

A

T

T

A

A

R

-

D

-

W

L

L

L

G

T

R

E

V

L

G

G

L

L

S

G

G

T

R

K

L

T

T

Q

H

N

Y

R

P

P

H

S

Q

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

R

R

V

V

A

S

L

I

A

A

R

R

A

A

L

L

A

M

A

N

R

G

P

G

A

D

L

V

L

I

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

G

S

A

H

T

S

A

G

T

V

S

E

V

V

A

M

D

R

L

I

M

L

F

R

N

E

L

L

V

-

T

N

E

A

V

A

G

G

A

H

A

T

M

I

V

I

M

L

V

V

T

T

H

H

D

D

P

M

V

Q

L

V

A

A

T

K

R

N

A

A

D

T

R

R

I

I

V

I

R

E

M

I

A

S

D

D

G

G

R

E

I

I

V

I

S

S

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: S43 (= S49), G44 (= G50), S48 (= S54)

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
40% identity, 94% coverage: 13:226/228 of query aligns to 4:223/232 of 1f3oA

query
sites
1f3oA

L

L

D

K

A

N

V

V

A

T

L

K

T

T

L
x
Y

P

K

S

M

S

G

A

E

G

E

P

I

V

I

N

Y

I

A

L

L

R

K

G

N

V

V

D

N

L

L

V

N

V

I

N

K

P

E

G

G

E

E

R

F

V

V

A

S

I

I

I

M

G

G

P

P

S

S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

S
x
T

L

M

I

L

A

N

V

I

G

I

A

G

G

C

L

L

E

D

E

K

P

P

T

T

S

E

G

G

Q

E

V

V

R

Y

L

I

F

D

G

N

Q

I

D

K

L

T

A

N

K

D

L

L

N

D

E

D

D

D

G

E

R

L

A

T

R

K

L

I

R

R

R

R

G

D

R

K

A

I

A

G

L

F

V

V

F

F

Q

Q

S

Q

F

F

H

N

L

L

L

I

P

P

N

L

M

L

T

T

A

A

E

L

E

E

N

N

V

V

A

E

T

L

P

P

L

L

E

-

I

I

D

F

G

K

A

Y

R

R

D

G

A

A

M

M

A

S

-

G

-

E

-

E

-

R

-

R

-

K

T

R

A

A

R

L

D

E

W

C

L

L

G

K

R

M

V

A

G

E

L

L

S

E

G

E

R

R

L

F

-

A

T

N

H

H

Y

K

P

P

H

N

Q

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

L

A

A

A

N

R

N

P

P

A

P

L

I

L

I

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

G

S

A

K

T

T

A

G

T

E

S

K

V

I

A

M

D

Q

L

L

M

L

F

K

N

K

L

L

V

N

T

E

E

E

V

D

G

G

A

K

A

T

M

V

V

V

M

V

V

V

T

T

H

H

D

D

P

I

V

N

L

V

A

A

T

R

R

F

A

G

D

E

R

R

I

I

V

I

R

Y

M

L

A

K

D

D

G

G

R

E

I

V

binding adenosine-5'-diphosphate: Y11 (≠ L20), G41 (= G50), G43 (= G52), K44 (= K53), S45 (= S54), T46 (≠ S55)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
40% identity, 94% coverage: 13:226/228 of query aligns to 4:223/230 of 1l2tA

query
sites
1l2tA

L

L

D

K

A

N

V

V

A

T

L

K

T

T

L
x
Y

P

K

S

M

S

G

A

E

G

E

P

I

V

I

N

Y

I

A

L

L

R

K

G

N

V

V

D

N

L

L

V

N

V

I

N

K

P

E

G

G

E

E

R

F

V

V

A

S

I

I

I

M

G

G

P

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

S
x
T

L

M

I

L

A

N

V

I

G

I

A

G

G

C

L

L

E

D

E

K

P

P

T

T

S

E

G

G

Q

E

V

V

R

Y

L

I

F

D

G

N

Q

I

D

K

L

T

A

N

K

D

L

L

N

D

E

D

D

D

G

E

R

L

A

T

R

K

L

I

R

R

R

R

G

D

R

K

A

I

A

G

L

F

V

V

F

F

Q

Q

S

Q

F

F

H

N

L

L

L

I

P

P

N

L

M

L

T

T

A

A

E

L

E

E

N

N

V

V

A

E

T

L

P

P

L

L

E

-

I

I

D

F

G

K

A

Y

R

R

D

G

A

A

M

M

A

S

-

G

-

E

-

E

-

R

-

R

-

K

T

R

A

A

R

L

D

E

W

C

L

L

G

K

R

M

V

A

G

E

L

L

S

E

G

E

R

R

L
x
F

-

A

T

N

H

H

Y

K

P

P

H

N

Q
|
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

L

A

A

A

N

R

N

P

P

A

P

L

I

L

I

F

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

G

S

A

K

T

T

A

G

T

E

S

K

V

I

A

M

D

Q

L

L

M

L

F

K

N

K

L

L

V

N

T

E

E

E

V

D

G

G

A

K

A

T

M

V

V

V

M

V

V

V

T

T

H
|
H

D

D

P

I

V

N

L

V

A

A

T

R

R

F

A

G

D

E

R

R

I

I

V

I

R

Y

M

L

A

K

D

D

G

G

R

E

I

V

binding adenosine-5'-triphosphate: Y11 (≠ L20), S40 (= S49), G41 (= G50), S42 (= S51), G43 (= G52), K44 (= K53), S45 (= S54), T46 (≠ S55), F138 (≠ L142), Q145 (= Q148), S147 (= S150), G149 (= G152), Q150 (≠ E153), H204 (= H207)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
42% identity, 91% coverage: 22:228/228 of query aligns to 9:216/240 of 4ymuJ

query
sites
4ymuJ

S

K

S

N

A
x
F

G

G

P

S

V

L

N

E

I
x
V

L

L

R

K

G

G

V

V

D

T

L

L

V

K

V

V

N

N

P

K

G

G

E

E

R

V

V

V

A

V

I

I

I

I

G

G

P

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

S
x
T

L

L

I

L

A

R

V

C

G

I

A

N

G

L

L

L

E

E

E

E

P

P

T

T

S

K

G

G

Q

E

V

V

R

F

L

I

F

D

G

G

Q

-

D

-

L

-

A

V

K

K

L

I

N

N

E

-

D

N

G

G

R

K

A

V

R

N

L

I

R

N

-

K

-

V

R

R

G

Q

R

K

A

V

A

G

L

M

V

V

F

F

Q

Q

S

H

F

F

H

N

L

L

L

F

P

P

N

H

M

L

T

T

A

A

E

I

E

E

N

N

V

I

A

T

-

L

T

A

P

P

L

V

E

K

I

V

D

K

-

K

-

M

G

N

A

K

R

K

D

E

A

A

M

E

A

E

T

L

A

A

R

V

D

D

W

L

L

L

G

A

R

K

V

V

G

G

L

L

S

L

G

D

R

K

L

K

T

D

H

Q

Y

Y

P

P

H

I

Q

K

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

L

A

A

L

I

A

A

R

R

A

A

L

L

A

A

A

M

R

Q

P

P

A

E

L

V

L

M

F

L

A

F

D

D

E
|
E

P

P

T

T

G

S

N

A

L

L

D

D

G

P

A

E

T

M

A

V

T

K

S

E

V

V

A

L

D

N

L

V

M

M

F

K

N

Q

L

L

V

A

T

N

E

E

V

-

G

G

A

M

A

T

M

M

V

V

M

V

V

V

T

T

H
|
H

D

E

P

M

V

G

L

F

A

A

T

R

R

E

A

V

-

G

D

D

R

R

I

V

V

I

R

F

M

M

A

D

D

D

G

G

R

V

I

I

V

V

S

E

binding adenosine-5'-triphosphate: F11 (≠ A24), V16 (≠ I29), S36 (= S49), G37 (= G50), S38 (= S51), G39 (= G52), K40 (= K53), S41 (= S54), T42 (≠ S55), E162 (= E174), H194 (= H207)
binding magnesium ion: S41 (= S54), E162 (= E174)

8g4cB Bceabs atpgs high res tm (see paper)
33% identity, 88% coverage: 29:228/228 of query aligns to 22:223/248 of 8g4cB

query
sites
8g4cB

I

V

L

L

R

K

G

G

V

I

D

D

L

I

V

H

V

I

N

E

P

K

G

G

E

E

R

F

V

V

A

S

I

I

I

M

G

G

P

A

S
|
S

G

G

S
|
S

G

G

K

K

S
x
T

S

T

L

L

I

L

A

N

V

V

G

L

A

S

G

S

L

I

E

D

E

Q

P

V

T

S

S

H

G

G

Q

T

V

I

R

H

L

I

F

N

G

G

Q

N

D

D

L

M

A

T

K

A

L

M

N

K

E

E

D

K

G

Q

R

L

A

A

R

E

L

F

R

R

R

K

G

Q

R

H

A

L

A

G

L

F

V

I

F

F

Q

Q

S

D

F

Y

H

N

L

L

L

L

P

D

N

T

M

L

T

T

A

V

E

K

E

E

N

N

V

I

A

L

T

L

P

P

L

L

E

S

I

I

D

T

-

K

-

L

G

S

A

K

R

K

D

E

A

A

M

N

A

R

T

K

A

F

R

E

D

E

W

V

L

A

G

K

R

E

V

L

G

G

L

I

S

Y

G

E

R

L

L

R

T

D

H

K

Y

Y

P

P

H

N

Q

E

L

I

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

T

A

S

L

A

A

G

R

R

A

A

L

F

A

I

A

H

R

D

P

P

A

S

L

I

L

I

F

F

A

A

D
|
D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

G

S

A

K

T

S

A

A

T

S

S

D

V

L

A

L

D

N

L

K

M

L

F

S

N

Q

L

L

V

N

T

Q

E

K

V

R

G

N

A

A

A

T

M

I

V

I

M

M

V

V

T

T

H

H

D

D

P

P

V

V

L

A

A

A

T

S

R

Y

A

C

D

G

R

R

I

V

V

I

R

F

M

I

A

K

D

D

G

G

R

Q

I

M

V

Y

S

T

binding phosphothiophosphoric acid-adenylate ester: S42 (= S49), S44 (= S51), T47 (≠ S54), D168 (= D173)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 13

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
38% identity, 89% coverage: 27:228/228 of query aligns to 20:222/615 of 5lilA

query
sites
5lilA

V

V

N

H

I
x
V

L

L

R

K

G

D

V

I

D

S

L

L

V

S

V

I

N

E

P

R

G

G

E

D

R

F

V

V

A

A

I

I

I

M

G

G

P

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

S
x
T

L

L

I

M

A

N

V

I

G

I

A

G

G

C

L

L

E

D

E

T

P

A

T

T

S

G

G

G

Q

S

V

S

R

K

L

I

F

D

G

G

Q

K

D

E

L

T

A

I

K

E

L

L

N

T

E

N

D

D

G

Q

R

L

A

S

R

D

L

L

R

R

R

S

G

Q

R

K

A

F

A

G

L

F

V

I

F

F

Q
|
Q

S

R

F

Y

H

N

L

L

L

L

P

S

N

S

M

L

T

T

A

A

E

A

E

E

N

N

V

V

A

A

T

L

P

P

L

A

E

I

I

Y

D

A

G

G

-

M

-

P

A

Q

R

S

D

Q

A

R

M

L

A

E

T

R

A

A

R

K

D

Q

W

L

L

L

G

E

R

K

V

L

G

G

L

L

S

G

G

D

R
x
K

L

W

T

Q

H

N

Y

K

P

P

H

N

Q
|
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

A

S

L

I

A

A

R

R

A

A

L

L

A

M

A

N

R

G

P

G

A

E

L

I

L

I

F

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

G

S

A

H

T

S

A

G

T

E

S

N

V

V

A

M

D

E

L

I

M

L

F

R

N

Q

L

L

V

H

T

E

E

E

V

-

G

G

A

H

A

T

M

I

V

I

M

M

V

V

T

T

H

H

D

D

P

K

V

H

L

I

A

A

T

A

R

S

A

A

D

N

R

R

I

I

V

I

R

E

M

I

A

K

D

D

G

G

R

E

I

I

V

I

S

S

binding adenosine-5'-triphosphate: V22 (≠ I29), S42 (= S49), G43 (= G50), G45 (= G52), K46 (= K53), S47 (= S54), T48 (≠ S55), Q92 (= Q99), K136 (≠ R141), Q143 (= Q148), S145 (= S150), G147 (= G152), Q148 (≠ E153)
binding magnesium ion: S47 (= S54), Q92 (= Q99)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 13

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
38% identity, 89% coverage: 27:228/228 of query aligns to 20:222/592 of 5lj7A

query
sites
5lj7A

V

V

N

H

I
x
V

L

L

R

K

G

D

V

I

D

S

L

L

V

S

V

I

N

E

P

R

G

G

E

D

R

F

V

V

A

A

I

I

I

M

G

G

P

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

S
x
T

L

L

I

M

A

N

V

I

G

I

A

G

G

C

L

L

E

D

E

T

P

A

T

T

S

G

G

G

Q

S

V

S

R

K

L

I

F

D

G

G

Q

K

D

E

L

T

A

I

K

E

L

L

N

T

E

N

D

D

G

Q

R

L

A

S

R

D

L

L

R

R

R

S

G

Q

R

K

A

F

A

G

L

F

V

I

F

F

Q
|
Q

S

R

F

Y

H

N

L

L

L

L

P

S

N

S

M

L

T

T

A

A

E

A

E

E

N

N

V

V

A

A

T

L

P

P

L

A

E

I

I

Y

D

A

G

G

-

M

-

P

A

Q

R

S

D

Q

A

R

M

L

A

E

T

R

A

A

R

K

D

Q

W

L

L

L

G

E

R

K

V

L

G

G

L

L

S

G

G

D

R
x
K

L

W

T

Q

H

N

Y

K

P

P

H

N

Q
|
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

A

S

L

I

A

A

R

R

A

A

L

L

A

M

A

N

R

G

P

G

A

E

L

I

L

I

F

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

G

S

A

H

T

S

A

G

T

E

S

N

V

V

A

M

D

E

L

I

M

L

F

R

N

Q

L

L

V

H

T

E

E

E

V

-

G

G

A

H

A

T

M

I

V

I

M

M

V

V

T

T

H

H

D

D

P

K

V

H

L

I

A

A

T

A

R

S

A

A

D

N

R

R

I

I

V

I

R

E

M

I

A

K

D

D

G

G

R

E

I

I

V

I

S

S

binding adenosine-5'-triphosphate: V22 (≠ I29), S42 (= S49), G43 (= G50), G45 (= G52), K46 (= K53), S47 (= S54), T48 (≠ S55), Q92 (= Q99), K136 (≠ R141), Q143 (= Q148), S145 (= S150), G147 (= G152), Q148 (≠ E153)
binding magnesium ion: S47 (= S54), Q92 (= Q99)

7tchB Bceab e169q variant atp-bound conformation (see paper)
32% identity, 88% coverage: 29:228/228 of query aligns to 21:222/245 of 7tchB

query
sites
7tchB

I
x
V

L

L

R

K

G

G

V

I

D

D

L

I

V

H

V

I

N

E

P

K

G

G

E

E

R

F

V

V

A

S

I

I

I

M

G

G

P

A

S
|
S

G
|
G

S
|
S

G

G

K
|
K

S
x
T

S

T

L

L

I

L

A

N

V

V

G

L

A

S

G

S

L

I

E

D

E

Q

P

V

T

S

S

H

G

G

Q

T

V

I

R

H

L

I

F

N

G

G

Q

N

D

D

L

M

A

T

K

A

L

M

N

K

E

E

D

K

G

Q

R

L

A

A

R

E

L

F

R

R

R

K

G

Q

R

H

A

L

A

G

L

F

V

I

F

F

Q

Q

S

D

F

Y

H

N

L

L

L

L

P

D

N

T

M

L

T

T

A

V

E

K

E

E

N

N

V

I

A

L

T

L

P

P

L

L

E

S

I

I

D

T

-

K

-

L

G

S

A

K

R

K

D

E

A

A

M

N

A

R

T

K

A

F

R

E

D

E

W

V

L

A

G

K

R

E

V

L

G

G

L

I

S

Y

G

E

R

L

L

R

T

D

H

K

Y

Y

P

P

H

N

Q
x
E

L

I

S

S

G
|
G

G
|
G

E

Q

Q

K

Q

Q

R

R

V

T

A

S

L

A

A

G

R

R

A

A

L

F

A

I

A

H

R

D

P

P

A

S

L

I

L

I

F

F

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

G

S

A

K

T

S

A

A

T

S

S

D

V

L

A

L

D

N

L

K

M

L

F

S

N

Q

L

L

V

N

T

Q

E

K

V

R

G

N

A

A

A

T

M

I

V

I

M

M

V

V

T

T

H

H

D

D

P

P

V

V

L

A

A

A

T

S

R

Y

A

C

D

G

R

R

I

V

V

I

R

F

M

I

A

K

D

D

G

G

R

Q

I

M

V

Y

S

T

binding adenosine-5'-triphosphate: V21 (≠ I29), S41 (= S49), G42 (= G50), S43 (= S51), K45 (= K53), T46 (≠ S54), E142 (≠ Q148), G145 (= G151), G146 (= G152)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 12, 19

8igqA Cryo-em structure of mycobacterium tuberculosis adp bound ftsex/ripc complex in peptidisc (see paper)
42% identity, 95% coverage: 11:227/228 of query aligns to 3:218/227 of 8igqA

query
sites
8igqA

L

I

V

T

L

L

D

D

A

H

V

V

A

T

L

K

T

Q

L
x
Y

P

K

S

S

S

S

A

A

G

R

P

P

V

A

N

-

I

-

L

L

R

D

G

D

V

I

D

N

L

V

V

K

V

I

N

D

P

K

G

G

E

E

R

F

V

V

A

F

I

L

I

I

G

G

P

P

S

S

G
|
G

S
|
S

G

G

K
|
K

S
|
S

S

T

L

F

I

M

A

R

V

L

G

L

A

L

G

A

L

A

E

E

E

T

P

P

T

T

S

S

G

G

Q

D

V

V

R

R

L

V

F

S

G

K

Q

F

D

H

L

V

A

N

K

K

L

L

N

R

E

G

D

R

G

H

R

V

A

P

R

K

L

L

R

R

R

Q

G

V

R

-

A

I

A

G

L

C

V

V

F

F

Q

Q

S

D

F

F

H

R

L

L

L

L

P

Q

N

Q

M

K

T

T

A

V

E

Y

E

D

N

N

V

V

A

A

T

F

P

A

L

L

E

E

I

V

D

I

G

G

A

K

R

R

-

T

D

D

A

A

M

I

A

N

-

R

T

V

A

V

R

P

D

E

W

V

L

L

G

E

R

T

V

V

G

G

L

L

S

S

G

G

R

K

L

A

T

N

H

R

Y

L

P

P

H

D

Q

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

F

A

V

A

N

R

R

P

P

A

L

L

V

L

L

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

G

P

A

E

T

T

A

S

T

R

S

D

V

I

A

M

D

D

L

L

M

L

F

-

N

E

L

R

V

I

T

N

E

R

V

T

G

G

A

T

A

T

M

V

V

L

M

M

V

A

T

T

H

H

D

D

-

H

P

H

V

I

L

V

A

D

T

S

R

M

A

R

D

Q

R

R

I

V

V

V

R

E

M

L

A

S

D

L

G

G

R

R

I

L

V

V

binding adenosine-5'-diphosphate: Y12 (≠ L20), G40 (= G50), S41 (= S51), K43 (= K53), S44 (= S54)

8iddA Cryo-em structure of mycobacterium tuberculosis atp bound ftsex/ripc complex in peptidisc (see paper)
42% identity, 95% coverage: 11:227/228 of query aligns to 3:218/225 of 8iddA

query
sites
8iddA

L

I

V

T

L

L

D

D

A

H

V

V

A

T

L

K

T

Q

L
x
Y

P

K

S

S

S

S

A

A

G

R

P

P

V

A

N

-

I

-

L

L

R

D

G

D

V

I

D

N

L

V

V

K

V

I

N

D

P

K

G

G

E

E

R

F

V

V

A

F

I

L

I

I

G

G

P

P

S
|
S

G

G

S

S

G
|
G

K
|
K

S
|
S

S

T

L

F

I

M

A

R

V

L

G

L

A

L

G

A

L

A

E

E

E

T

P

P

T

T

S

S

G

G

Q

D

V

V

R

R

L

V

F

S

G

K

Q

F

D

H

L

V

A

N

K

K

L

L

N

R

E

G

D

R

G

H

R

V

A

P

R

K

L

L

R

R

R

Q

G

V

R

-

A

I

A

G

L

C

V

V

F

F

Q

Q

S

D

F

F

H

R

L

L

L

L

P

Q

N

Q

M

K

T

T

A

V

E

Y

E

D

N

N

V

V

A

A

T

F

P

A

L

L

E

E

I

V

D

I

G

G

A

K

R

R

-

T

D

D

A

A

M

I

A

N

-

R

T

V

A

V

R

P

D

E

W

V

L

L

G

E

R

T

V

V

G

G

L

L

S

S

G

G

R

K

L

A

T

N

H

R

Y

L

P

P

H

D

Q

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

F

A

V

A

N

R

R

P

P

A

L

L

V

L

L

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

G

P

A

E

T

T

A

S

T

R

S

D

V

I

A

M

D

D

L

L

M

L

F

-

N

E

L

R

V

I

T

N

E

R

V

T

G

G

A

T

A

T

M

V

V

L

M

M

V

A

T

T

H

H

D

D

-

H

P

H

V

I

L

V

A

D

T

S

R

M

A

R

D

Q

R

R

I

V

V

V

R

E

M

L

A

S

D

L

G

G

R

R

I

L

V

V

binding adenosine-5'-triphosphate: Y12 (≠ L20), S39 (= S49), G42 (= G52), K43 (= K53), S44 (= S54)

A5U7B7 Cell division ATP-binding protein FtsE from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) (see 2 papers)
42% identity, 95% coverage: 11:227/228 of query aligns to 2:217/229 of A5U7B7

query
sites
A5U7B7

L

I

V

T

L

L

D

D

A

H

V

V

A

T

L

K

T

Q

L

Y

P

K

S

S

S

S

A

A

G

R

P

P

V

A

N

-

I

-

L

L

R

D

G

D

V

I

D

N

L

V

V

K

V

I

N

D

P

K

G

G

E

E

R

F

V

V

A

F

I

L

I

I

G

G

P

P

S

S

G

G

S

S

G

G

K
|
K

S

S

S

T

L

F

I

M

A

R

V

L

G

L

A

L

G

A

L

A

E

E

E

T

P

P

T

T

S

S

G

G

Q

D

V

V

R

R

L

V

F

S

G

K

Q

F

D

H

L

V

A

N

K

K

L

L

N

R

E

G

D

R

G

H

R

V

A

P

R

K

L

L

R

R

R

Q

G

V

R

-

A

I

A

G

L
x
C

V

V

F

F

Q

Q

S

D

F

F

H

R

L

L

L

L

P

Q

N

Q

M

K

T

T

A

V

E

Y

E

D

N

N

V

V

A

A

T

F

P

A

L

L

E

E

I

V

D

I

G

G

A

K

R

R

-

T

D

D

A

A

M

I

A

N

-

R

T

V

A

V

R

P

D

E

W

V

L

L

G

E

R

T

V

V

G

G

L

L

S

S

G

G

R

K

L

A

T

N

H

R

Y

L

P

P

H

D

Q

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

F

A

V

A

N

R

R

P

P

A

L

L

V

L

L

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

G

P

A

E

T

T

A

S

T

R

S

D

V

I

A

M

D

D

L

L

M

L

F

-

N

E

L

R

V

I

T

N

E

R

V

T

G

G

A

T

A

T

M

V

V

L

M

M

V

A

T

T

H

H

D

D

-

H

P

H

V

I

L

V

A

D

T

S

R

M

A

R

D

Q

R

R

I

V

V

V

R

E

M

L

A

S

D

L

G

G

R

R

I

L

V

V

K42 (= K53) mutation to R: Does not bind ATP. Does not affect dimerization.
C84 (≠ L96) mutation to A: Does not affect ATPase activity.

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
43% identity, 92% coverage: 19:228/228 of query aligns to 7:216/241 of 4u00A

query
sites
4u00A

T

N

L

L

P

H

S

K

S

W

A
x
F

G

G

P

P

V

L

N

H

I
x
V

L

L

R

K

G

G

V

I

D

H

L

L

V

E

V

V

N

A

P

P

G

G

E

E

R

K

V

L

A

V

I

I

I

I

G

G

P

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

S
x
T

L

L

I

I

A

R

V

T

G

I

A

N

G

R

L

L

E

E

E

D

P

F

T

Q

S

E

G

G

Q

E

V

V

R

V

L

V

F

D

G

G

Q

-

D

-

L

-

A

L

K

S

L

V

N

K

E

D

D

D

G

R

R

A

A

L

R

R

L

E

R

I

R

R

G

R

R

E

A

V

A

G

L

M

V

V

F

F

Q

Q

S

Q

F

F

H

N

L

L

L

F

P

P

N

H

M

M

T

T

A

V

E

L

E

E

N

N

V

V

A

T

-

L

T

A

P

P

L

M

E

R

I

V

D

R

G

R

A

W

-

P

-

R

R

E

D

K

A

A

M

E

A

K

T

K

A

A

R

L

D

E

W

L

L

L

G

E

R

R

V

V

G

G

L

I

S

L

G

D

R

Q

L

A

T

R

H

K

Y

Y

P

P

H

A

Q

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

L

A

A

A

M

R

E

P

P

A

K

L

I

L

M

F

L

A

F

D

D

E

E

P

P

T

T

G

S

N

A

L

L

D

D

G

P

A

E

T

M

A

V

T

G

S

E

V

V

A

L

D

D

L

V

M

M

F

R

N

D

L

L

V

-

T

A

E

Q

V

G

G

G

A

M

A

T

M

M

V

V

M

V

V

V

T

T

H

H

D

E

P

M

V

G

L

F

A

A

T

R

R

E

-

V

A

A

D

D

R

R

I

V

V

V

R

F

M

M

A

D

D

G

G

G

R

Q

I

I

V

V

S

E

binding adenosine-5'-diphosphate: F12 (≠ A24), V17 (≠ I29), S37 (= S49), G38 (= G50), S39 (= S51), G40 (= G52), K41 (= K53), S42 (= S54), T43 (≠ S55)

8w6iD Cryo-em structure of escherichia coli str k12 ftsex complex with atp- gamma-s in peptidisc
41% identity, 86% coverage: 30:226/228 of query aligns to 18:215/219 of 8w6iD

query
sites
8w6iD

L

L

R

Q

G

G

V

V

D

T

L

F

V

H

V

M

N

Q

P

P

G

G

E

E

R

M

V

A

A

F

I

L

I

T

G

G

P

H

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

S
x
T

L

L

I

L

A

K

V

L

G

I

A

C

G

G

L

I

E

E

E

R

P

P

T

S

S

A

G

G

Q

K

V

I

R

W

L

F

F

S

G

G

Q

H

D

D

L

I

A

T

K

R

L

L

N

K

E

N

D

R

G

E

R

V

A

P

R

F

L

L

R

R

R

R

G

-

R

Q

A

I

A

G

L

M

V

I

F

F

Q
|
Q

S

D

F

H

H

H

L

L

L

L

P

M

N

D

M

R

T

T

A

V

E

Y

E

D

N

N

V

V

A

A

T

I

P

P

L

L

E

I

I

I

D

A

G

G

A

A

R

S

-

G

-

D

D

D

A

I

M

R

A

R

T

R

A

V

R

S

D

A

W

A

L

L

G

D

R

K

V

V

G

G

L

L

S

L

G

D

R
x
K

L

A

T

K

H

N

Y

F

P

P

H

I

Q
|
Q

L

L

S
|
S

G
|
G

G
|
G

E
|
E

Q

Q

Q

Q

R

R

V

V

A

G

L

I

A

A

R

R

A

A

L

V

A

V

A

N

R

K

P

P

A

A

L

V

L

L

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

G

D

A

A

T

L

A

S

T

E

S

G

V

I

A

L

D

R

L

L

M

-

F

F

N

E

L

E

V

F

T

N

E

R

V

V

G

G

A

V

A

T

M

V

V

L

M

M

V

A

T

T

H
|
H

D

D

-

I

P

N

V

L

L

I

A

S

T

R

R

R

A

S

D

Y

R

R

I

M

V

L

R

T

M

L

A

S

D

D

G

G

R

H

I

L

binding phosphothiophosphoric acid-adenylate ester: S37 (= S49), G38 (= G50), A39 (≠ S51), G40 (= G52), K41 (= K53), S42 (= S54), T43 (≠ S55), Q86 (= Q99), K130 (≠ R141), Q137 (= Q148), S139 (= S150), G140 (= G151), G141 (= G152), E142 (= E153), H195 (= H207)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 11

Query Sequence

>CCNA_01835 FitnessBrowser__Caulo:CCNA_01835
MSDDVTPAAPLVLDAVALTLPSSAGPVNILRGVDLVVNPGERVAIIGPSGSGKSSLIAVG
AGLEEPTSGQVRLFGQDLAKLNEDGRARLRRGRAALVFQSFHLLPNMTAEENVATPLEID
GARDAMATARDWLGRVGLSGRLTHYPHQLSGGEQQRVALARALAARPALLFADEPTGNLD
GATATSVADLMFNLVTEVGAAMVMVTHDPVLATRADRIVRMADGRIVS

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory