SitesBLAST
Comparing CCNA_02024 FitnessBrowser__Caulo:CCNA_02024 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7aqrF Cryo-em structure of arabidopsis thaliana complex-i (peripheral arm) (see paper)
74% identity, 93% coverage: 3:412/439 of query aligns to 6:415/434 of 7aqrF
- binding flavin mononucleotide: G60 (= G57), R61 (= R58), G62 (= G59), K71 (= K68), N89 (= N87), D91 (= D89), Y177 (= Y174), G180 (= G177), E181 (= E178), E182 (= E179), T216 (≠ N213), N217 (= N214)
- binding iron/sulfur cluster: S351 (= S348), C352 (= C349), G353 (= G350), Q354 (= Q351), C355 (= C352), C358 (= C355), T396 (= T393), C398 (= C395), L400 (= L397)
7arcF Cryo-em structure of polytomella complex-i (peripheral arm) (see paper)
70% identity, 96% coverage: 3:422/439 of query aligns to 7:426/430 of 7arcF
- binding flavin mononucleotide: G61 (= G57), R62 (= R58), K72 (= K68), N90 (= N87), D92 (= D89), E93 (= E90), S94 (= S91), Y178 (= Y174), G181 (= G177), E182 (= E178), T217 (≠ N213), N218 (= N214), L401 (= L397)
- binding iron/sulfur cluster: S352 (= S348), C353 (= C349), G354 (= G350), Q355 (= Q351), C356 (= C352), C359 (= C355), T397 (= T393), C399 (= C395), L401 (= L397)
8gymv1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (see paper)
66% identity, 98% coverage: 3:434/439 of query aligns to 4:436/442 of 8gymv1
- binding flavin mononucleotide: G58 (= G57), G60 (= G59), N88 (= N87), D90 (= D89), Y176 (= Y174), E180 (= E178), E181 (= E179), T215 (≠ N213), N216 (= N214), T219 (≠ S217), A398 (= A396), L399 (= L397)
- binding iron/sulfur cluster: I177 (= I175), P195 (= P193), C351 (= C349), G352 (= G350), Q353 (= Q351), C354 (= C352), C357 (= C355), T395 (= T393), C397 (= C395), L399 (= L397), G400 (= G398)
8b9zF Drosophila melanogaster complex i in the active state (dm1) (see paper)
67% identity, 95% coverage: 3:420/439 of query aligns to 15:432/441 of 8b9zF
- binding flavin mononucleotide: G69 (= G57), G71 (= G59), K80 (= K68), N98 (= N87), D100 (= D89), G189 (= G177), E191 (= E179), N226 (= N214), A408 (= A396), L409 (= L397)
- binding iron/sulfur cluster: P205 (= P193), C361 (= C349), G362 (= G350), Q363 (= Q351), C364 (= C352), C367 (= C355), T405 (= T393), C407 (= C395), L409 (= L397)
7v2cA Active state complex i from q10 dataset (see paper)
67% identity, 96% coverage: 3:423/439 of query aligns to 8:428/433 of 7v2cA
- binding flavin mononucleotide: G62 (= G57), K73 (= K68), N91 (= N87), Y179 (= Y174), G182 (= G177), E183 (= E178), N219 (= N214), A401 (= A396), L402 (= L397)
- binding iron/sulfur cluster: P198 (= P193), C354 (= C349), G355 (= G350), Q356 (= Q351), C357 (= C352), C360 (= C355), T398 (= T393), C400 (= C395), L402 (= L397)
6zk91 Peripheral domain of open complex i during turnover (see paper)
67% identity, 96% coverage: 3:423/439 of query aligns to 5:425/430 of 6zk91
- binding flavin mononucleotide: G59 (= G57), G61 (= G59), K70 (= K68), N88 (= N87), D90 (= D89), E91 (= E90), G179 (= G177), E180 (= E178), A215 (≠ N213), N216 (= N214), A398 (= A396), L399 (= L397)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G61 (= G59), G62 (= G60), A63 (= A61), F65 (= F63), K70 (= K68), E93 (= E92), Y176 (= Y174), E181 (= E179), F201 (= F199), T323 (= T321)
- binding iron/sulfur cluster: I177 (= I175), P195 (= P193), C351 (= C349), G352 (= G350), Q353 (= Q351), C354 (= C352), C357 (= C355), T395 (= T393), C397 (= C395), L399 (= L397)
Q91YT0 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Mus musculus (Mouse) (see 2 papers)
67% identity, 96% coverage: 3:423/439 of query aligns to 33:453/464 of Q91YT0
- C379 (= C349) binding
- C382 (= C352) binding
- C385 (= C355) binding
- C425 (= C395) binding
Sites not aligning to the query:
- 1:20 modified: transit peptide, Mitochondrion
7dgq8 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (see paper)
67% identity, 96% coverage: 3:423/439 of query aligns to 2:422/427 of 7dgq8
- binding flavin mononucleotide: G58 (= G59), K67 (= K68), N85 (= N87), D87 (= D89), E88 (= E90), G89 (≠ S91), C175 (= C176), G176 (= G177), A212 (≠ N213), N213 (= N214)
- binding iron/sulfur cluster: S347 (= S348), C348 (= C349), G349 (= G350), C351 (= C352), C354 (= C355), C394 (= C395), L396 (= L397)
- binding : R121 (≠ H123), Y132 (≠ V134), Q139 (≠ E141), R143 (≠ K145), Y146 (= Y148), E147 (= E149), F165 (≠ Y166), R168 (≠ H169)
5lnk1 Entire ovine respiratory complex i (see paper)
67% identity, 96% coverage: 3:423/439 of query aligns to 7:427/432 of 5lnk1
- binding fe2/s2 (inorganic) cluster: P96 (= P93), G97 (= G94)
- binding flavin mononucleotide: G61 (= G57), R62 (= R58), K72 (= K68), N90 (= N87), D92 (= D89), E93 (= E90), G94 (≠ S91), Y178 (= Y174), G181 (= G177), E182 (= E178), V216 (= V212), A217 (≠ N213), N218 (= N214), T221 (≠ S217), L401 (= L397)
- binding iron/sulfur cluster: P197 (= P193), S352 (= S348), C353 (= C349), Q355 (= Q351), C356 (= C352), C359 (= C355), T397 (= T393), I398 (= I394), C399 (= C395)
8eswV1 NADH dehydrogenase (Ubiquinone) 24 kDa subunit, isoform A (see paper)
67% identity, 95% coverage: 3:420/439 of query aligns to 13:430/439 of 8eswV1
- binding flavin mononucleotide: G67 (= G57), G69 (= G59), K78 (= K68), N96 (= N87), D98 (= D89), E99 (= E90), G187 (= G177), E188 (= E178), N224 (= N214), A406 (= A396)
- binding iron/sulfur cluster: I185 (= I175), P203 (= P193), C359 (= C349), Q361 (= Q351), C362 (= C352), C365 (= C355), T403 (= T393), I404 (= I394), C405 (= C395), L407 (= L397)
- binding : Y143 (≠ V134), N144 (≠ F135), Q150 (≠ E141), D174 (= D164)
P25708 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Bos taurus (Bovine) (see paper)
68% identity, 95% coverage: 3:420/439 of query aligns to 33:450/464 of P25708
- C379 (= C349) binding
- C382 (= C352) binding
- C385 (= C355) binding
- C425 (= C395) binding
P49821 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Homo sapiens (Human) (see paper)
67% identity, 96% coverage: 3:423/439 of query aligns to 33:453/464 of P49821
- C379 (= C349) binding
- C382 (= C352) binding
- C385 (= C355) binding
- C425 (= C395) binding
7zm7B Cryoem structure of mitochondrial complex i from chaetomium thermophilum (inhibited by ddm) (see paper)
66% identity, 96% coverage: 3:423/439 of query aligns to 5:428/456 of 7zm7B
- binding flavin mononucleotide: G59 (= G57), G61 (= G59), K70 (= K68), N91 (= N87), D93 (= D89), G182 (= G177), E183 (= E178), E184 (= E179), A218 (≠ N213), N219 (= N214), A401 (= A396), L402 (= L397)
- binding iron/sulfur cluster: P198 (= P193), C354 (= C349), G355 (= G350), Q356 (= Q351), C357 (= C352), C360 (= C355), T398 (= T393), C400 (= C395), L402 (= L397)
7o6yB Cryo-em structure of respiratory complex i under turnover (see paper)
64% identity, 96% coverage: 3:423/439 of query aligns to 3:426/457 of 7o6yB
- binding flavin mononucleotide: G57 (= G57), G59 (= G59), K68 (= K68), N89 (= N87), D91 (= D89), E92 (= E90), G180 (= G177), E181 (= E178), E182 (= E179), T216 (≠ N213), N217 (= N214)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G59 (= G59), G60 (= G60), F63 (= F63), K68 (= K68), E94 (= E92), Y177 (= Y174), E182 (= E179), F202 (= F199), T324 (= T321)
- binding iron/sulfur cluster: P196 (= P193), S351 (= S348), C352 (= C349), G353 (= G350), Q354 (= Q351), C355 (= C352), C358 (= C355), T396 (= T393), C398 (= C395), L400 (= L397)
7b0nF 3.7-angstrom structure of Yarrowia lipolytica complex I with an R121M mutation in NUCM. (see paper)
64% identity, 96% coverage: 3:423/439 of query aligns to 4:427/460 of 7b0nF
- binding flavin mononucleotide: G60 (= G59), K69 (= K68), N90 (= N87), D92 (= D89), E93 (= E90), G94 (≠ S91), Y178 (= Y174), G181 (= G177), E182 (= E178), N218 (= N214)
- binding iron/sulfur cluster: P197 (= P193), S352 (= S348), C353 (= C349), Q355 (= Q351), C356 (= C352), C359 (= C355), T397 (= T393), C399 (= C395)
Q56222 NADH-quinone oxidoreductase subunit 1; NADH dehydrogenase I chain 1; NDH-1 subunit 1; EC 7.1.1.- from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
49% identity, 90% coverage: 20:415/439 of query aligns to 26:420/438 of Q56222
4hea1 Crystal structure of the entire respiratory complex i from thermus thermophilus (see paper)
49% identity, 90% coverage: 20:415/439 of query aligns to 25:419/437 of 4hea1
- binding flavin mononucleotide: G63 (= G57), K74 (= K68), N91 (= N87), D93 (= D89), Y179 (= Y174), G182 (= G177), E183 (= E178), N218 (= N213), N219 (= N214), L401 (= L397)
- binding iron/sulfur cluster: I180 (= I175), P198 (= P193), S351 (= S348), C352 (= C349), G353 (= G350), K354 (≠ Q351), C355 (= C352), C358 (= C355), F398 (≠ I394), C399 (= C395), L401 (= L397)
2ybb1 Fitted model for bovine mitochondrial supercomplex i1iii2iv1 by single particle cryo-em (emd-1876) (see paper)
49% identity, 90% coverage: 20:415/439 of query aligns to 25:419/437 of 2ybb1
- binding flavin mononucleotide: G63 (= G57), G65 (= G59), N91 (= N87), D93 (= D89), G182 (= G177), E183 (= E178), E184 (= E179), N218 (= N213), N219 (= N214), T222 (≠ S217), P400 (≠ A396)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G65 (= G59), G66 (= G60), F69 (= F63), K74 (= K68), F77 (= F71), E96 (= E92), Y179 (= Y174), E184 (= E179), K201 (= K196), F204 (= F199), T324 (= T321)
- binding iron/sulfur cluster: S351 (= S348), C352 (= C349), K354 (≠ Q351), C355 (= C352), C358 (= C355), F398 (≠ I394), C399 (= C395), L401 (= L397), A402 (≠ G398)
8e9hF Mycobacterial respiratory complex i, fully-inserted quinone (see paper)
49% identity, 90% coverage: 21:415/439 of query aligns to 17:416/436 of 8e9hF
- binding flavin mononucleotide: G53 (= G57), R54 (= R58), G55 (= G59), A57 (= A61), K64 (= K68), N90 (= N87), D92 (= D89), Y178 (= Y174), G181 (= G177), E182 (= E178), E183 (= E179), N217 (= N213), N218 (= N214), S221 (= S217), L398 (= L397)
- binding iron/sulfur cluster: P197 (= P193), S349 (= S348), C350 (= C349), G351 (= G350), K352 (≠ Q351), C353 (= C352), C356 (= C355), S394 (≠ T393), F395 (≠ I394), C396 (= C395), L398 (= L397), G399 (= G398)
- binding zinc ion: C333 (≠ D332), E371 (≠ V370)
Sites not aligning to the query:
7p61F Complex i from e. Coli, ddm-purified, with nadh, resting state (see paper)
43% identity, 94% coverage: 21:434/439 of query aligns to 25:437/442 of 7p61F
- binding flavin mononucleotide: G61 (= G57), G63 (= G59), K72 (= K68), N90 (= N87), D92 (= D89), G181 (= G177), E182 (= E178), N217 (= N213), N218 (= N214), A399 (= A396), H400 (≠ L397)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G63 (= G59), G64 (= G60), A65 (= A61), F67 (= F63), K72 (= K68), L75 (≠ F71), E95 (= E92), Y178 (= Y174), E183 (= E179), F203 (= F199), R320 (≠ G318), T323 (= T321)
- binding iron/sulfur cluster: S350 (= S348), C351 (= C349), W353 (≠ Q351), C354 (= C352), C357 (= C355), F397 (≠ I394), C398 (= C395), H400 (≠ L397)
Query Sequence
>CCNA_02024 FitnessBrowser__Caulo:CCNA_02024
MVGILEDKDRIFTNLYGLHDWGLEGAKKRGCWNGTKDILDAGRDWIIENMKNSGLRGRGG
AGFSTGLKWSFMPKEVKDGRPHYLVVNADESEPGTCKDREIMRHDPHLLIEGCLIASRAM
LAHACYIYIRGEYVFERERLEAAIKQAYEAKLVGKNNVHGWDFDIYVHHGAGAYICGEET
ALLESLEGKKGQPRLKPPFPAGAGLYGMPTTVNNVESIAVAGTILRRGAAWFAGFGRPNN
AGTKLFCVSGHVNLPCNVEEAMSIPFRQLVEDHCGGIRGGWGNLKAVIPGGSSVPMIPAE
QCEDLPMDFDALRNLKSGLGTAAVIVMDKDTDLVRAIARLSYFYKHESCGQCTPCREGTG
WMWRVMERMVTGEADPKEIDTLLDVTTQVEGHTICALGDAAAWPIQGLFRHFRHEVEERI
ASYRSGRLHVQGAKLIAAE
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory