SitesBLAST
Comparing CCNA_02215 FitnessBrowser__Caulo:CCNA_02215 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
I6YCA3 Acyl-CoA dehydrogenase FadE26; ACAD; 3-oxocholest-4-en-26-oyl-CoA dehydrogenase alpha subunit; EC 1.3.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
33% identity, 100% coverage: 1:403/403 of query aligns to 1:395/400 of I6YCA3
- IGYS 127:130 (≠ QGYS 128:131) binding
- T136 (≠ S137) binding
- S162 (≠ T163) binding
- E247 (= E250) mutation to A: Loss of dehydrogenase activity.
- TNE 380:382 (≠ SNE 388:390) binding
4x28A Crystal structure of the chse4-chse5 complex from mycobacterium tuberculosis (see paper)
34% identity, 100% coverage: 1:403/403 of query aligns to 1:382/386 of 4x28A
- active site: Y122 (= Y130), S123 (= S131), E240 (= E250), G365 (≠ A386), M377 (≠ K398)
- binding dihydroflavine-adenine dinucleotide: I120 (≠ Q128), Y122 (= Y130), S123 (= S131), G128 (= G136), T129 (≠ S137), W153 (= W161), S155 (≠ T163), F363 (≠ I384), T367 (≠ S388), E369 (= E390), V370 (≠ I391)
P71858 Acyl-CoA dehydrogenase FadE29; ACAD; 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA dehydrogenase beta subunit; 3-oxo-4-pregnene-20-carboxyl-CoA dehydrogenase beta subunit; EC 1.3.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
32% identity, 88% coverage: 1:355/403 of query aligns to 1:344/387 of P71858
- E241 (= E250) mutation to Q: Unable to dehydrogenate pregnene-carboxyl-CoA ester.
P96855 Acyl-CoA dehydrogenase FadE34; ACAD; 3-oxochol-4-en-24-oyl-CoA dehydrogenase; EC 1.3.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
31% identity, 89% coverage: 47:403/403 of query aligns to 383:709/711 of P96855
- E581 (= E250) mutation to Q: Displays less than 1% activity with cholyl-CoA as substrate. Still binds FAD.
Sites not aligning to the query:
- 236 R→A: Displays less than 2% activity with cholyl-CoA as substrate. Cannot bind FAD.
6wy8B Tcur3481-tcur3483 steroid acad (see paper)
34% identity, 75% coverage: 1:301/403 of query aligns to 1:288/384 of 6wy8B
Sites not aligning to the query:
6wy9A Tcur3481-tcur3483 steroid acad g363a variant (see paper)
36% identity, 63% coverage: 50:301/403 of query aligns to 43:284/380 of 6wy9A
Sites not aligning to the query:
2pg0A Crystal structure of acyl-coa dehydrogenase from geobacillus kaustophilus
26% identity, 87% coverage: 51:400/403 of query aligns to 44:378/380 of 2pg0A
- active site: M124 (≠ Y130), T125 (≠ S131), E243 (= E250), A364 (= A386), R376 (≠ K398)
- binding flavin-adenine dinucleotide: I122 (≠ Q128), M124 (≠ Y130), T125 (≠ S131), G130 (= G136), S131 (= S137), F155 (≠ W161), I156 (≠ T162), T157 (= T163), R269 (= R274), F272 (≠ D277), F279 (≠ D284), Q337 (≠ E342), L338 (≠ A343), G340 (= G345), G341 (≠ N346), V359 (≠ K381), I362 (= I384), Y363 (= Y385), T366 (≠ S388), E368 (= E390), M369 (≠ I391)
6es9A Methylsuccinyl-coa dehydrogenase of paracoccus denitrificans with bound flavin adenine dinucleotide (see paper)
28% identity, 87% coverage: 50:401/403 of query aligns to 200:544/545 of 6es9A
- active site: F281 (≠ Y130), T282 (≠ S131), A408 (≠ G252), R541 (≠ K398)
- binding coenzyme a: F467 (= F309), W470 (vs. gap)
- binding flavin-adenine dinucleotide: A279 (≠ Q128), F281 (≠ Y130), T282 (≠ S131), G287 (= G136), S288 (= S137), W312 (= W161), I313 (≠ T162), T314 (= T163), E374 (vs. gap), R434 (= R274), Q436 (≠ D276), F437 (≠ D277), L441 (= L281), F444 (≠ D284), Q502 (≠ E342), I503 (≠ A343), G505 (= G345), G506 (≠ N346), F528 (≠ Y385), A531 (≠ S388), E533 (= E390), I534 (= I391)
Sites not aligning to the query:
1ukwB Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
28% identity, 90% coverage: 41:401/403 of query aligns to 32:377/379 of 1ukwB
- active site: L124 (≠ Y130), S125 (= S131), T241 (≠ E250), E362 (≠ A386), R374 (≠ K398)
- binding cobalt (ii) ion: D145 (= D151), H146 (≠ D152)
- binding flavin-adenine dinucleotide: F122 (≠ Q128), L124 (≠ Y130), S125 (= S131), G130 (= G136), S131 (= S137), W155 (= W161), S157 (≠ T163), K200 (≠ L207), L357 (≠ K381), Y361 (= Y385), E362 (≠ A386), T364 (≠ S388), E366 (= E390), L370 (≠ N394)
1ukwA Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
28% identity, 90% coverage: 41:401/403 of query aligns to 32:377/379 of 1ukwA
- active site: L124 (≠ Y130), S125 (= S131), T241 (≠ E250), E362 (≠ A386), R374 (≠ K398)
- binding flavin-adenine dinucleotide: F122 (≠ Q128), L124 (≠ Y130), S125 (= S131), G130 (= G136), S131 (= S137), W155 (= W161), S157 (≠ T163), L357 (≠ K381), Y361 (= Y385), E362 (≠ A386), T364 (≠ S388), E366 (= E390), L370 (≠ N394)
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
28% identity, 87% coverage: 50:401/403 of query aligns to 72:407/412 of P15651
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
27% identity, 97% coverage: 12:401/403 of query aligns to 14:380/384 of 1jqiA
- active site: G377 (≠ K398)
- binding acetoacetyl-coenzyme a: L95 (≠ M98), F125 (≠ Q128), S134 (= S137), F234 (≠ W240), M238 (≠ K244), Q239 (≠ Y245), L241 (= L247), D242 (≠ E248), R245 (= R251), Y364 (= Y385), E365 (≠ A386), G366 (= G387)
- binding flavin-adenine dinucleotide: F125 (≠ Q128), L127 (≠ Y130), S128 (= S131), G133 (= G136), S134 (= S137), W158 (= W161), T160 (= T163), R270 (= R274), F273 (≠ D277), L280 (≠ D284), Q338 (≠ E342), I339 (≠ A343), G342 (vs. gap), I360 (≠ K381), T367 (≠ S388), E369 (= E390), I370 (= I391)
8hk0B Crystal structure of fic32-33 complex from streptomyces ficellus nrrl 8067 (see paper)
27% identity, 62% coverage: 1:251/403 of query aligns to 1:244/379 of 8hk0B
Sites not aligning to the query:
7w0jE Acyl-coa dehydrogenase, tfu_1647
26% identity, 86% coverage: 57:401/403 of query aligns to 52:381/382 of 7w0jE
- binding [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-azanyl-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate: S127 (= S131), W157 (= W161), R270 (= R274), Q272 (≠ D276), F273 (≠ D277), I277 (≠ L281), F280 (≠ D284), I283 (≠ F287), Q339 (≠ E342), L340 (≠ A343), G343 (≠ N346), Y365 (= Y385), E366 (≠ A386), T368 (≠ S388), Q370 (≠ E390), I371 (= I391)
3pfdC Crystal structure of an acyl-coa dehydrogenase from mycobacterium thermoresistibile bound to reduced flavin adenine dinucleotide solved by combined iodide ion sad mr (see paper)
27% identity, 87% coverage: 52:401/403 of query aligns to 37:368/369 of 3pfdC
- active site: L116 (≠ Y130), S117 (= S131), T233 (≠ E250), E353 (≠ A386), R365 (≠ K398)
- binding dihydroflavine-adenine dinucleotide: Y114 (≠ Q128), L116 (≠ Y130), S117 (= S131), G122 (= G136), S123 (= S137), W147 (= W161), I148 (≠ T162), T149 (= T163), R259 (= R274), F262 (≠ D277), V266 (≠ L281), N269 (≠ D284), Q326 (≠ E342), L327 (≠ A343), G330 (≠ N346), I348 (≠ K381), Y352 (= Y385), T355 (≠ S388), Q357 (≠ E390)
8i4rA Crystal structure of acyl-coa dehydrogenase complexed with acetyl-coa from thermobifida fusca
26% identity, 86% coverage: 57:401/403 of query aligns to 51:380/381 of 8i4rA
- binding acetyl coenzyme *a: S132 (= S137), T134 (≠ L139), R180 (≠ E185), R234 (≠ T241), L237 (≠ K244), R238 (≠ Y245), L240 (= L247), D241 (≠ E248), R244 (= R251), E365 (≠ A386), G366 (= G387), R377 (≠ K398)
- binding flavin-adenine dinucleotide: Y123 (≠ Q128), L125 (≠ Y130), S126 (= S131), G131 (= G136), S132 (= S137), W156 (= W161), I157 (≠ T162), T158 (= T163), I360 (≠ K381), T367 (≠ S388), Q369 (≠ E390)
8i4pA Crystal structure of acyl-coa dehydrogenase from thermobifida fusca
26% identity, 86% coverage: 57:401/403 of query aligns to 51:380/381 of 8i4pA
- binding flavin-adenine dinucleotide: Y123 (≠ Q128), L125 (≠ Y130), S126 (= S131), G131 (= G136), S132 (= S137), W156 (= W161), I157 (≠ T162), T158 (= T163), I360 (≠ K381), Y364 (= Y385), T367 (≠ S388), Q369 (≠ E390)
4iv6B X-ray crystal structure of an isovaleryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
27% identity, 79% coverage: 83:401/403 of query aligns to 78:376/383 of 4iv6B
- active site: L121 (≠ Y130), T122 (≠ S131), G240 (= G252), E361 (≠ A386), K373 (= K398)
- binding dihydroflavine-adenine dinucleotide: L121 (≠ Y130), T122 (≠ S131), G126 (≠ S135), G127 (= G136), S128 (= S137), W152 (= W161), I153 (≠ T162), S154 (≠ T163), R266 (= R274), S268 (≠ D276), F269 (≠ D277), I273 (≠ L281), H276 (≠ D284), V279 (≠ F287), R334 (≠ E342), V335 (≠ A343), G338 (≠ N346), L356 (≠ A375), G360 (≠ Y385), T363 (≠ S388), E365 (= E390), I366 (= I391)
3r7kA Crystal structure of a probable acyl coa dehydrogenase from mycobacterium abscessus atcc 19977 / dsm 44196 (see paper)
26% identity, 92% coverage: 29:400/403 of query aligns to 9:377/378 of 3r7kA
- active site: V126 (≠ Y130), T127 (≠ S131), E242 (= E250), G363 (≠ A386), K375 (= K398)
- binding dihydroflavine-adenine dinucleotide: V126 (≠ Y130), T127 (≠ S131), G132 (= G136), S133 (= S137), F157 (≠ W161), I158 (≠ T162), T159 (= T163), R268 (= R274), T270 (≠ D276), F271 (≠ D277), L275 (= L281), R278 (≠ D284), I281 (≠ F287), Q336 (≠ E342), I337 (≠ A343), G340 (≠ N346), I358 (≠ K381), T365 (≠ S388), E367 (= E390)
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
25% identity, 88% coverage: 47:401/403 of query aligns to 40:378/380 of 4l1fA
- active site: L125 (≠ Y130), T126 (≠ S131), G242 (≠ E250), E363 (≠ A386), R375 (≠ K398)
- binding coenzyme a persulfide: T132 (≠ S137), H179 (≠ E185), F232 (≠ W240), M236 (≠ K244), E237 (≠ Y245), L239 (= L247), D240 (≠ E248), R243 (= R251), Y362 (= Y385), E363 (≠ A386), G364 (= G387), R375 (≠ K398)
- binding flavin-adenine dinucleotide: F123 (≠ Q128), L125 (≠ Y130), T126 (≠ S131), G131 (= G136), T132 (≠ S137), F156 (≠ W161), I157 (≠ T162), T158 (= T163), R268 (= R274), Q270 (≠ D276), F271 (≠ D277), I275 (≠ L281), F278 (≠ D284), L281 (≠ F287), Q336 (≠ E342), I337 (≠ A343), G340 (≠ N346), I358 (≠ K381), Y362 (= Y385), T365 (≠ S388), Q367 (≠ E390)
Sites not aligning to the query:
Query Sequence
>CCNA_02215 FitnessBrowser__Caulo:CCNA_02215
MDLAFSAEDLAFQQEVRDWIATAYDDDLRRQMSQSKNGYLDKAGQVKWQKKLAERGWAAP
DWPVELGGAGFTPSQRYIFNMEMSLAGVPTSSPMGLKMVAPVIMAFGSDAQKAQHLPPIL
NSDIWWCQGYSEPGSGSDLASLQMRAVRDGDDYVLNGSKIWTTHAQWADWMFCLVRTSTE
GKPQEGISFLLLRMDTPGIQIKPLPTLDGPPDNEQEINQVFFDNVRVPVANRIGEENKGW
TYAKYLLEFERGNAYAPGLMNMLKKVKRIAALERADDGGRLIDDPDFRSKIANLEIQVEA
LNASELRIFSGRGAGKNIGPASSMLKCVGSEHQQAITELTLEAVGNYATPFVRDTWSPAN
DGRAGPDYAGPAAPAYFNYRKASIYAGSNEIQRNIMAKMVLGL
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory