SitesBLAST
Comparing CCNA_02352 FitnessBrowser__Caulo:CCNA_02352 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
8gy3C Large subunit of aldehyde dehydrogenase
30% identity, 93% coverage: 44:719/724 of query aligns to 18:718/732 of 8gy3C
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): M38 (≠ V64), G39 (= G65), Q40 (= Q66), H41 (≠ G67), V42 (≠ I68), A45 (= A71), G79 (= G105), G80 (= G106), S81 (= S107), S83 (≠ A109), V84 (≠ T110), Q344 (= Q368), G373 (= G397), G374 (= G398), F375 (= F399), G376 (= G400), L379 (= L403), L499 (= L506), R500 (= R507), T622 (≠ Q623), I623 (= I624), V624 (= V625), D625 (≠ N626), G628 (= G629), A629 (= A630), Q632 (= Q633), P686 (= P687), T687 (= T688), G688 (= G689), L689 (= L690), G690 (= G691), E691 (= E692)
5y6qC Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
26% identity, 46% coverage: 247:578/724 of query aligns to 95:411/748 of 5y6qC
Sites not aligning to the query:
- active site: 715, 716
- binding pterin cytosine dinucleotide: 461, 462, 463, 464, 465, 468, 499, 500, 502, 503, 504, 505, 638, 639, 640, 641, 644, 645, 648, 710, 711, 713, 714, 715
3hrdE Crystal structure of nicotinate dehydrogenase (see paper)
25% identity, 49% coverage: 185:537/724 of query aligns to 2:380/420 of 3hrdE
- active site: Q207 (= Q368), L242 (= L403), R318 (≠ N478), H322 (≠ P483), R350 (= R507)
- binding calcium ion: T206 (= T367), N208 (= N369), D212 (≠ G373), K241 (≠ R402), L242 (= L403), D243 (≠ M404)
- binding pterin cytosine dinucleotide: G236 (= G397), G237 (= G398), F238 (= F399), R350 (= R507)
- binding nicotinic acid: V14 (≠ Q197), D15 (≠ N198), E18 (≠ A201)
- binding selenium atom: F238 (= F399), G239 (= G400), A348 (≠ F505), F349 (≠ L506), R350 (= R507)
3hrdA Crystal structure of nicotinate dehydrogenase (see paper)
25% identity, 49% coverage: 185:537/724 of query aligns to 2:380/420 of 3hrdA
- active site: Q207 (= Q368), L242 (= L403), R318 (≠ N478), H322 (≠ P483), R350 (= R507)
- binding pterin cytosine dinucleotide: G236 (= G397), G237 (= G398), F238 (= F399), R350 (= R507)
- binding magnesium ion: T206 (= T367), N208 (= N369), D212 (≠ G373), K241 (≠ R402), L242 (= L403), D243 (≠ M404), T305 (≠ F465), Y308 (≠ G468), A309 (≠ E469), S310 (≠ T470), S346 (≠ T503)
- binding nicotinic acid: Y311 (≠ F471), A314 (= A474), R318 (≠ N478), F352 (≠ P509)
- binding selenium atom: F238 (= F399), G239 (= G400), A348 (≠ F505), F349 (≠ L506), R350 (= R507)
Q0QLF2 Nicotinate dehydrogenase large molybdopterin subunit; NDH; Nicotinic acid hydroxylase large molybdopterin subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see 2 papers)
25% identity, 49% coverage: 185:537/724 of query aligns to 3:381/425 of Q0QLF2
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2:425 modified: mature protein, Nicotinate dehydrogenase large molybdopterin subunit
5g5gC Escherichia coli periplasmic aldehyde oxidase (see paper)
27% identity, 40% coverage: 245:537/724 of query aligns to 91:380/731 of 5g5gC
Sites not aligning to the query:
- active site: 692, 693
- binding pterin cytosine dinucleotide: 468, 469, 470, 471, 472, 475, 506, 507, 508, 509, 510, 511, 512, 615, 616, 617, 618, 621, 622, 625, 688, 689, 690, 691, 692
P77489 Aldehyde oxidoreductase molybdenum-binding subunit PaoC; EC 1.2.99.6 from Escherichia coli (strain K12) (see 2 papers)
27% identity, 40% coverage: 245:537/724 of query aligns to 91:380/732 of P77489
Sites not aligning to the query:
- 440 mutation R->H,K: Decrease in catalytic efficiency.
- 468:470 binding
- 511:512 binding
- 615:621 binding
- 625 binding
- 688:691 binding
- 692 E→Q: Loss of activity.
1t3qB Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
22% identity, 53% coverage: 190:571/724 of query aligns to 14:436/786 of 1t3qB
Sites not aligning to the query:
- active site: 743, 744
- binding pterin cytosine dinucleotide: 506, 507, 508, 509, 510, 513, 544, 545, 546, 547, 548, 549, 550, 666, 668, 669, 670, 671, 674, 675, 678, 739, 740, 741, 742, 743
3zyvB Crystal structure of the mouse liver aldehyde oxidase 3 (maox3) (see paper)
27% identity, 35% coverage: 181:432/724 of query aligns to 523:782/1262 of 3zyvB
Sites not aligning to the query:
- active site: 829, 833, 861, 1207, 1208
- binding flavin-adenine dinucleotide: 44, 226, 227, 228, 229, 230, 231, 232, 233, 234, 267, 303, 304, 308, 312, 313, 316, 317, 319, 325, 326, 365, 366, 392, 393
- binding fe2/s2 (inorganic) cluster: 39, 41, 42, 44, 45, 46, 47, 49, 69, 71, 111, 112, 114, 146, 147, 148
O33819 4-hydroxybenzoyl-CoA reductase subunit alpha; 4-HBCR subunit alpha; EC 1.1.7.1 from Thauera aromatica (see paper)
27% identity, 20% coverage: 575:719/724 of query aligns to 606:753/769 of O33819
Sites not aligning to the query:
- 214 binding
- 244:245 binding
- 522:526 binding
1rm6A Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
27% identity, 20% coverage: 575:719/724 of query aligns to 598:745/761 of 1rm6A
- active site: E718 (vs. gap), G719 (vs. gap)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): V642 (= V620), K644 (≠ R622), A645 (≠ Q623), L646 (≠ I624), N647 (= N626), A650 (≠ G629), V651 (≠ A630), Q654 (= Q633), A713 (≠ L690), K714 (≠ G691), E715 (= E692), A716 (≠ P693), S717 (≠ A694), E718 (vs. gap)
Sites not aligning to the query:
- active site: 206, 241, 318, 322, 350
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 206, 235, 236, 237, 238, 348, 349, 350, 473, 474, 475, 476, 477, 480, 513, 514, 515, 516, 517, 518
G3X982 Aldehyde oxidase 3; Aldehyde oxidase homolog 1; Azaheterocycle hydroxylase 3; EC 1.2.3.1; EC 1.17.3.- from Mus musculus (Mouse) (see paper)
27% identity, 35% coverage: 181:432/724 of query aligns to 576:838/1335 of G3X982