SitesBLAST
Comparing CCNA_02479 FitnessBrowser__Caulo:CCNA_02479 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5tnxA Crystal structure of alcohol dehydrogenase zinc-binding domain protein from burkholderia ambifaria
56% identity, 96% coverage: 14:365/366 of query aligns to 16:368/370 of 5tnxA
- active site: C42 (= C40), H43 (= H41), T44 (= T42), I47 (≠ V45), H63 (= H61), E64 (= E62), C92 (= C90), C95 (= C93), C98 (= C96), C106 (= C104), F110 (= F108), C171 (= C168), T175 (= T172), K363 (= K360)
- binding zinc ion: C92 (= C90), C95 (= C93), C98 (= C96), C106 (= C104)
1f8fA Crystal structure of benzyl alcohol dehydrogenase from acinetobacter calcoaceticus
49% identity, 99% coverage: 3:366/366 of query aligns to 4:362/362 of 1f8fA
- active site: C41 (= C40), H42 (= H41), T43 (= T42), I46 (≠ V45), H62 (= H61), E63 (= E62), C91 (= C90), C94 (= C93), C97 (= C96), C105 (= C104), F109 (= F108), C164 (= C168), T168 (= T172), K356 (= K360)
- binding nicotinamide-adenine-dinucleotide: H42 (= H41), C164 (= C168), G191 (= G195), V193 (= V197), D213 (= D217), R218 (= R222), S256 (≠ T260), T257 (= T261), V279 (= V283), V306 (= V310), E307 (= E311)
- binding zinc ion: C41 (= C40), H62 (= H61), C91 (= C90), C94 (= C93), C97 (= C96), C105 (= C104), C164 (= C168)
P00325 All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Alcohol dehydrogenase 1B; Alcohol dehydrogenase subunit beta; EC 1.1.1.105 from Homo sapiens (Human) (see 9 papers)
36% identity, 99% coverage: 1:363/366 of query aligns to 8:373/375 of P00325
- H48 (= H41) to R: in dbSNP:rs1229984
- N57 (≠ H50) to K: in dbSNP:rs1041969
- T60 (= T53) to S: in dbSNP:rs6413413
- R370 (≠ K360) to C: in beta-3/Indianapolis; allele ADH1B*3; decreased NAD(H) binding; dbSNP:rs2066702
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylserine
1u3vA Crystal structure of human alcohol dehydrogenase beta-1-beta-1 isoform complexed with n-heptylformamide determined to 1.65 angstrom resolution (see paper)
35% identity, 99% coverage: 1:363/366 of query aligns to 7:372/374 of 1u3vA
- active site: C46 (= C40), R47 (≠ H41), T48 (= T42), H51 (≠ V45), H67 (= H61), E68 (= E62), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), D115 (≠ F108), C174 (= C168), T178 (= T172), R369 (≠ K360)
- binding heptylformamide: T48 (= T42), H67 (= H61), F93 (= F87), L116 (≠ P109), C174 (= C168)
- binding nicotinamide-adenine-dinucleotide: R47 (≠ H41), T48 (= T42), H51 (≠ V45), C174 (= C168), T178 (= T172), G199 (= G193), L200 (≠ A194), G201 (= G195), V203 (= V197), D223 (= D217), I224 (= I218), V268 (≠ T260), I269 (≠ T261), R271 (≠ N263), V292 (= V283), G293 (= G284), V294 (≠ A285), V318 (= V310)
- binding zinc ion: C46 (= C40), H67 (= H61), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), C174 (= C168)
1u3uA Crystal structure of human alcohol dehydrogenase beta-1-beta-1 isoform complexed with n-benzylformamide determined to 1.6 angstrom resolution (see paper)
35% identity, 99% coverage: 1:363/366 of query aligns to 7:372/374 of 1u3uA
- active site: C46 (= C40), R47 (≠ H41), T48 (= T42), H51 (≠ V45), H67 (= H61), E68 (= E62), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), D115 (≠ F108), C174 (= C168), T178 (= T172), R369 (≠ K360)
- binding n-benzylformamide: T48 (= T42), H67 (= H61), F93 (= F87), C174 (= C168), V294 (≠ A285)
- binding nicotinamide-adenine-dinucleotide: R47 (≠ H41), T48 (= T42), H51 (≠ V45), C174 (= C168), T178 (= T172), G199 (= G193), L200 (≠ A194), G201 (= G195), V203 (= V197), D223 (= D217), I224 (= I218), K228 (≠ R222), V268 (≠ T260), I269 (≠ T261), R271 (≠ N263), V292 (= V283), G293 (= G284), V294 (≠ A285), V318 (= V310), R369 (≠ K360)
- binding zinc ion: C46 (= C40), H67 (= H61), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), C174 (= C168)
1hdxB Three-dimensional structures of three human alcohol dehydrogenase variants: correlations with their functional differences (see paper)
35% identity, 99% coverage: 1:363/366 of query aligns to 7:372/374 of 1hdxB
- active site: C46 (= C40), R47 (≠ H41), T48 (= T42), H51 (≠ V45), H67 (= H61), E68 (= E62), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), D115 (≠ F108), C174 (= C168), T178 (= T172), R369 (≠ K360)
- binding cyclohexanol: L116 (≠ P109), V318 (= V310)
- binding nicotinamide-adenine-dinucleotide: C46 (= C40), R47 (≠ H41), H51 (≠ V45), T178 (= T172), L200 (≠ A194), G201 (= G195), G202 (≠ A196), V203 (= V197), D223 (= D217), I269 (≠ T261), R271 (≠ N263), V292 (= V283), G293 (= G284), V294 (≠ A285), R369 (≠ K360)
- binding zinc ion: C46 (= C40), H67 (= H61), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), C174 (= C168)
1dehA Crystallization of human beta1 alcohol dehydrogenase (15 mg/ml) in 50 mm sodium phosphate (ph 7.5), 2.0 mm NAD+ and 1 mm 4-iodopyrazole at 25 oc, 13% (w/v) peg 8000 (see paper)
35% identity, 99% coverage: 1:363/366 of query aligns to 7:372/374 of 1dehA
- active site: C46 (= C40), R47 (≠ H41), T48 (= T42), H51 (≠ V45), H67 (= H61), E68 (= E62), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), D115 (≠ F108), C174 (= C168), T178 (= T172), R369 (≠ K360)
- binding nicotinamide-adenine-dinucleotide: C46 (= C40), R47 (≠ H41), T48 (= T42), H51 (≠ V45), C174 (= C168), T178 (= T172), G201 (= G195), V203 (= V197), D223 (= D217), I224 (= I218), V268 (≠ T260), I269 (≠ T261), V292 (= V283), V294 (≠ A285)
- binding 4-iodopyrazole: T48 (= T42), H67 (= H61), F93 (= F87), L116 (≠ P109), C174 (= C168)
- binding zinc ion: C46 (= C40), H67 (= H61), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104)
P23991 Alcohol dehydrogenase 1; ADH-1; Alcohol dehydrogenase I; EC 1.1.1.1 from Gallus gallus (Chicken) (see paper)
35% identity, 99% coverage: 1:363/366 of query aligns to 8:374/376 of P23991
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylserine
P19631 Alcohol dehydrogenase 1; ADH3; Alcohol dehydrogenase subunit alpha; EC 1.1.1.1 from Coturnix japonica (Japanese quail) (Coturnix coturnix japonica) (see paper)
36% identity, 99% coverage: 1:363/366 of query aligns to 7:373/375 of P19631
Sites not aligning to the query:
- 1 modified: N-acetylserine
1u3tA Crystal structure of human alcohol dehydrogenase alpha-alpha isoform complexed with n-cyclopentyl-n-cyclobutylformamide determined to 2.5 angstrom resolution (see paper)
34% identity, 99% coverage: 1:363/366 of query aligns to 7:372/374 of 1u3tA
- active site: C46 (= C40), G47 (≠ H41), T48 (= T42), H51 (≠ V45), H67 (= H61), E68 (= E62), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), D115 (≠ F108), C174 (= C168), T178 (= T172), R369 (≠ K360)
- binding cyclobutyl(cyclopentyl)formamide: T48 (= T42), H67 (= H61), A93 (≠ T86), I94 (≠ F87), I318 (≠ V310)
- binding nicotinamide-adenine-dinucleotide: C46 (= C40), T48 (= T42), H51 (≠ V45), C174 (= C168), T178 (= T172), L200 (≠ A194), G201 (= G195), V203 (= V197), D223 (= D217), I224 (= I218), I269 (≠ T261), V292 (= V283), G293 (= G284), V294 (≠ A285)
- binding zinc ion: C46 (= C40), H67 (= H61), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), C174 (= C168)
P07327 Alcohol dehydrogenase 1A; Alcohol dehydrogenase subunit alpha; EC 1.1.1.1 from Homo sapiens (Human) (see 3 papers)
34% identity, 99% coverage: 1:363/366 of query aligns to 8:373/375 of P07327
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylserine
P00326 Alcohol dehydrogenase 1C; Alcohol dehydrogenase subunit gamma; EC 1.1.1.1 from Homo sapiens (Human) (see 5 papers)
34% identity, 99% coverage: 1:363/366 of query aligns to 8:373/375 of P00326
- C47 (= C40) binding
- R48 (≠ H41) to H: in dbSNP:rs35385902
- H68 (= H61) binding
- C98 (= C90) binding
- C101 (= C93) binding
- C104 (= C96) binding
- C112 (= C104) binding
- P166 (= P159) to S: in dbSNP:rs34195308
- C175 (= C168) binding
- GLGGVG 200:205 (≠ GAGAVG 193:198) binding
- D224 (= D217) binding
- K229 (≠ R222) binding
- R272 (≠ N263) to Q: in allele ADH3*2/gamma-2; dbSNP:rs1693482
- VGV 293:295 (≠ VGA 283:285) binding
- AIF 318:320 (≠ VVE 309:311) binding
- I350 (≠ F340) to V: in allele ADH3*2/gamma-2; dbSNP:rs698
- P352 (= P342) to T: in dbSNP:rs35719513
- R370 (≠ K360) binding
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylserine
1u3wA Crystal structure of human alcohol dehydrogenase gamma-2-gamma-2 isoform complexed with n-1-methylheptylformamide determined to 1.45 angstrom resolution (see paper)
34% identity, 99% coverage: 1:363/366 of query aligns to 7:372/374 of 1u3wA
- active site: C46 (= C40), R47 (≠ H41), S48 (≠ T42), H51 (≠ V45), H67 (= H61), E68 (= E62), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), D115 (≠ F108), C174 (= C168), T178 (= T172), R369 (≠ K360)
- binding 1-methylheptylformamide: S48 (≠ T42), H67 (= H61), F93 (= F87), C174 (= C168)
- binding nicotinamide-adenine-dinucleotide: C46 (= C40), R47 (≠ H41), S48 (≠ T42), H51 (≠ V45), C174 (= C168), T178 (= T172), G199 (= G193), G201 (= G195), V203 (= V197), D223 (= D217), I224 (= I218), K228 (≠ R222), V268 (≠ T260), I269 (≠ T261), T274 (≠ V266), V292 (= V283), G293 (= G284), V294 (≠ A285), I318 (≠ V310)
- binding zinc ion: C46 (= C40), H67 (= H61), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), C174 (= C168)
P06757 Alcohol dehydrogenase 1; Alcohol dehydrogenase A subunit; EC 1.1.1.1 from Rattus norvegicus (Rat) (see paper)
35% identity, 100% coverage: 1:365/366 of query aligns to 8:376/376 of P06757
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylserine
P80338 Alcohol dehydrogenase 1; Alcohol dehydrogenase I; EC 1.1.1.1 from Struthio camelus (Common ostrich) (see 2 papers)
35% identity, 99% coverage: 1:363/366 of query aligns to 7:372/374 of P80338
Sites not aligning to the query:
- 1 modified: N-acetylserine
P81600 Alcohol dehydrogenase class-3 chain H; Alcohol dehydrogenase class-III chain H; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase; EC 1.1.1.1; EC 1.1.1.-; EC 1.1.1.284 from Gadus morhua (Atlantic cod) (see 2 papers)
34% identity, 100% coverage: 1:365/366 of query aligns to 7:375/375 of P81600
Sites not aligning to the query:
- 1 modified: N-acetylalanine
1qv6A Horse liver alcohol dehydrogenase his51gln/lys228arg mutant complexed with NAD+ and 2,4-difluorobenzyl alcohol (see paper)
33% identity, 99% coverage: 1:363/366 of query aligns to 7:372/374 of 1qv6A
- active site: C46 (= C40), R47 (≠ H41), S48 (≠ T42), Q51 (≠ V45), H67 (= H61), E68 (= E62), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), D115 (vs. gap), C174 (= C168), T178 (= T172), R369 (≠ K360)
- binding (2,4-difluorophenyl)methanol: S48 (≠ T42), H67 (= H61), F93 (= F87), L116 (vs. gap), V294 (≠ A285)
- binding nicotinamide-adenine-dinucleotide: C46 (= C40), R47 (≠ H41), Q51 (≠ V45), C174 (= C168), T178 (= T172), G199 (= G193), G201 (= G195), V203 (= V197), D223 (= D217), I224 (= I218), V268 (≠ T260), I269 (≠ T261), V292 (= V283), G293 (= G284), V294 (≠ A285), I318 (≠ V310)
- binding zinc ion: C46 (= C40), H67 (= H61), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), C174 (= C168)
8eiwA Cobalt(ii)-substituted horse liver alcohol dehydrogenase in complex with nadh and n-cyclohexylformamide (see paper)
33% identity, 99% coverage: 1:363/366 of query aligns to 7:372/374 of 8eiwA
- binding cobalt (ii) ion: C46 (= C40), H67 (= H61), C174 (= C168)
- binding cyclohexylformamide: S48 (≠ T42), H67 (= H61), F93 (= F87), L116 (vs. gap), C174 (= C168), V294 (≠ A285)
- binding 1,4-dihydronicotinamide adenine dinucleotide: C46 (= C40), R47 (≠ H41), S48 (≠ T42), H51 (≠ V45), C174 (= C168), T178 (= T172), G199 (= G193), G201 (= G195), V203 (= V197), D223 (= D217), I224 (= I218), I269 (≠ T261), R271 (≠ N263), V292 (= V283), G293 (= G284), V294 (≠ A285), I318 (≠ V310), F319 (≠ E311)
- binding zinc ion: C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104)
7k35A Eqadh-nadh-4-methylbenzyl alcohol, p21 (see paper)
33% identity, 99% coverage: 1:363/366 of query aligns to 7:372/374 of 7k35A
- active site: C46 (= C40), R47 (≠ H41), S48 (≠ T42), H51 (≠ V45), H67 (= H61), E68 (= E62), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), D115 (vs. gap), C174 (= C168), T178 (= T172), R369 (≠ K360)
- binding 1,4-dihydronicotinamide adenine dinucleotide: C46 (= C40), R47 (≠ H41), S48 (≠ T42), H51 (≠ V45), C174 (= C168), T178 (= T172), G199 (= G193), G201 (= G195), V203 (= V197), D223 (= D217), I224 (= I218), I269 (≠ T261), V292 (= V283), V294 (≠ A285), I318 (≠ V310), R369 (≠ K360)
- binding (4-methylphenyl)methanol: S48 (≠ T42), L57 (= L51), H67 (= H61), F93 (= F87), L116 (vs. gap), V294 (≠ A285)
- binding zinc ion: C46 (= C40), H67 (= H61), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), C174 (= C168)
7adhA Three-dimensional structure of isonicotinimidylated liver alcohol dehydrogenase (see paper)
33% identity, 99% coverage: 1:363/366 of query aligns to 7:372/374 of 7adhA
- active site: C46 (= C40), R47 (≠ H41), S48 (≠ T42), H51 (≠ V45), H67 (= H61), E68 (= E62), C97 (= C90), C100 (= C93), C103 (= C96), C111 (= C104), D115 (vs. gap), C174 (= C168), T178 (= T172), R369 (≠ K360)
- binding isonicotinamidine: K18 (≠ S12), S54 (≠ D48), T82 (≠ K76), D87 (= D81), K88 (≠ H82), K159 (= K153), A163 (≠ T157), P165 (= P159), K168 (≠ R162), K188 (= K182), N225 (= N219), K228 (≠ R222), K231 (≠ L225), K315 (≠ R307), K325 (≠ D317), D326 (≠ V318), K330 (≠ E322), I346 (= I338), V349 (≠ F340), K354 (≠ E345), E357 (≠ Q348), E366 (≠ R357)
- binding zinc ion: C46 (= C40), H67 (= H61), C103 (= C96), C111 (= C104), C174 (= C168)
Query Sequence
>CCNA_02479 FitnessBrowser__Caulo:CCNA_02479
MQVTAAVTRSPSGPFSLEALDIEPPRAGEILVRVVATGVCHTDMVMRDQHLPTPQPVVLG
HEGAGVVEQVGPGVAKVAVGDHVVMTFNSCGRCPSCSDHAPTYCHEFFPRNFMGAREDGS
SGLSKGSEVIHANIFGQSSFATYALCHERNAVKVDKTAPLERLGPLGCGVMTGAGAVMNA
LKVPAGRSLVVFGAGAVGLSAVLAAKAIGAGPIIAIDINPERLALALELGADHALNGAEG
GVVEKIQAITGTGAHFSIDTTANLKVMRQAVDCLGARGVCGLVGASKMGDELPLDAVSVM
SGGKVVRGVVEGDADPDVFIPELIALHLAGRFPFDRLIQFYPLAEINQAVSDGETGRVIK
PVVRMS
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory