Comparing CCNA_02616 FitnessBrowser__Caulo:CCNA_02616 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1cjxA Crystal structure of pseudomonas fluorescens hppd (see paper)
48% identity, 97% coverage: 7:354/357 of query aligns to 2:352/352 of 1cjxA
7xntA Crystal structure of pfhppd-y13161 complex
48% identity, 96% coverage: 7:347/357 of query aligns to 5:341/341 of 7xntA
7x8eA Crystal structure of pfhppd-y13287 complex
47% identity, 97% coverage: 7:351/357 of query aligns to 4:341/341 of 7x8eA
7xntC Crystal structure of pfhppd-y13161 complex
45% identity, 94% coverage: 7:342/357 of query aligns to 4:320/320 of 7xntC
1t47A Structure of fe2-hppd bound to ntbc (see paper)
36% identity, 78% coverage: 68:347/357 of query aligns to 74:360/362 of 1t47A
P32755 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; F Alloantigen; F protein; EC 1.13.11.27 from Rattus norvegicus (Rat) (see 2 papers)
28% identity, 85% coverage: 52:354/357 of query aligns to 63:382/393 of P32755
Sites not aligning to the query:
Q88JU3 3-dehydroshikimate dehydratase; DSD; EC 4.2.1.118 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
29% identity, 90% coverage: 13:335/357 of query aligns to 294:614/635 of Q88JU3
Sites not aligning to the query:
5hmqD Xylose isomerase-like tim barrel/4-hydroxyphenylpyruvate dioxygenase fusion protein
30% identity, 90% coverage: 13:335/357 of query aligns to 296:611/624 of 5hmqD
Sites not aligning to the query:
5ec3A Structural insight into the catalyitc mechanism of human 4- hydroxyphenylpyruvate dioxygenase
28% identity, 85% coverage: 52:354/357 of query aligns to 55:374/376 of 5ec3A
8im2A Crystal structure of human hppd complexed with ntbc (see paper)
28% identity, 84% coverage: 52:351/357 of query aligns to 57:373/374 of 8im2A
7yvvA Acmp1, r-4-hydroxymandelate synthase
31% identity, 76% coverage: 75:344/357 of query aligns to 70:331/335 of 7yvvA
8im3A Crystal structure of human hppd complexed with compound a10 (see paper)
28% identity, 83% coverage: 52:347/357 of query aligns to 57:369/371 of 8im3A
3zgjB S221m v223f y359a mutant of 4-hydroxymandelate synthase from streptomyces coelicolor (see paper)
29% identity, 91% coverage: 20:344/357 of query aligns to 12:339/343 of 3zgjB
Q02110 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Sus scrofa (Pig) (see paper)
28% identity, 81% coverage: 67:354/357 of query aligns to 81:382/393 of Q02110
Sites not aligning to the query:
1sqiA Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases (see paper)
27% identity, 80% coverage: 52:338/357 of query aligns to 56:343/343 of 1sqiA
O52791 4-hydroxymandelate synthase; HMS; HmaS; 4-hydroxyphenylpyruvate dioxygenase II; EC 1.13.11.46 from Amycolatopsis orientalis (Nocardia orientalis) (see paper)
28% identity, 90% coverage: 27:347/357 of query aligns to 19:346/357 of O52791
2r5vA Hydroxymandelate synthase crystal structure (see paper)
29% identity, 90% coverage: 27:347/357 of query aligns to 18:344/346 of 2r5vA
5yy6A Crystal structure of arabidopsis thaliana hppd truncated mutant complexed with benquitrione (see paper)
30% identity, 78% coverage: 66:344/357 of query aligns to 92:371/371 of 5yy6A
1sqdA Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases (see paper)
30% identity, 78% coverage: 66:343/357 of query aligns to 92:373/373 of 1sqdA
5ywhA Crystal structure of arabidopsis thaliana hppd complexed with y13508
31% identity, 78% coverage: 66:344/357 of query aligns to 91:370/372 of 5ywhA
>CCNA_02616 FitnessBrowser__Caulo:CCNA_02616
MTLVTDQNPLGLDGFEFVEFTSPDPAAMKALIEQLGFVAASKHPTKAATRYKQGRVNLIV
NEETTGQVADFRADHGPSANGMAFRVENAEQAYADAVKRGAKPADASRSLLGADAKVLEG
IGGSLLYLVDRYGDAGTIYDAWEQVPGAALAEAKNNVGLDLLDHLTHNVKRGQMRTWSTF
YNQIFGFEEQKYFDIKGQATGLFSQAMIAPDKAIRIPLNESQDDKSQIEEFIRQYNGEGI
QHLAMTTDNIYDTVEKLRARGVKLQDTIETYYELVDKRVPGHGEDLERLRKNRILIDGAV
GEEGLLLQIFTENLFGPIFFEIIQRKGNEGFGNGNFQALFESIELDQIRRGVITVDA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory