SitesBLAST
Comparing CCNA_03243 CCNA_03243 NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa (see paper)
57% identity, 98% coverage: 8:498/499 of query aligns to 5:495/495 of 5iuwA
- active site: N166 (= N169), K189 (= K192), E265 (= E268), C300 (= C303), E399 (= E402), D476 (= D479)
- binding 1h-indol-3-ylacetic acid: F167 (= F170), M170 (≠ H173), C300 (= C303), D457 (= D460), F465 (= F468)
- binding nicotinamide-adenine-dinucleotide: I162 (= I165), V163 (= V166), P164 (= P167), W165 (= W168), N166 (= N169), K189 (= K192), G222 (= G225), G226 (= G229), K227 (≠ E230), F240 (= F243), T241 (= T244), G242 (= G245), S243 (= S246), I246 (≠ V249), Y253 (= Y256), E265 (= E268), A266 (≠ L269), C300 (= C303), E399 (= E402), F401 (= F404)
5iuvA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
57% identity, 98% coverage: 8:498/499 of query aligns to 5:495/495 of 5iuvA
- active site: N166 (= N169), K189 (= K192), E265 (= E268), C300 (= C303), E399 (= E402), D476 (= D479)
- binding nicotinamide-adenine-dinucleotide: I162 (= I165), V163 (= V166), P164 (= P167), W165 (= W168), N166 (= N169), K189 (= K192), S191 (≠ A194), G222 (= G225), G226 (= G229), K227 (≠ E230), F240 (= F243), T241 (= T244), G242 (= G245), S243 (= S246), I246 (≠ V249), Y253 (= Y256), E265 (= E268), A266 (≠ L269), C300 (= C303), E399 (= E402), F401 (= F404)
7jsoA P. Syringae alda indole-3-acetaldehyde dehydrogenase c302a mutant in complex with NAD+ and iaa (see paper)
56% identity, 98% coverage: 8:498/499 of query aligns to 5:495/495 of 7jsoA
- active site: N166 (= N169), E265 (= E268), A300 (≠ C303), D476 (= D479)
- binding 1h-indol-3-ylacetic acid: F167 (= F170), W174 (= W177), V299 (= V302), A300 (≠ C303), T301 (= T304), D457 (= D460), F465 (= F468)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I162 (= I165), V163 (= V166), P164 (= P167), W165 (= W168), K189 (= K192), E192 (= E195), G222 (= G225), G226 (= G229), K227 (≠ E230), F240 (= F243), G242 (= G245), S243 (= S246), I246 (≠ V249), A266 (≠ L269), G267 (= G270), A300 (≠ C303), E399 (= E402), F401 (= F404)
7uyyA The crystal structure of the pseudomonas aeruginosa aldehyde dehydrogenase encoded by the pa4189 gene in complex with nadh (see paper)
48% identity, 96% coverage: 15:494/499 of query aligns to 15:491/496 of 7uyyA
- binding 1,4-dihydronicotinamide adenine dinucleotide: V165 (≠ I165), L166 (≠ V166), P167 (= P167), W168 (= W168), K192 (= K192), G225 (= G225), G229 (= G229), F243 (= F243), G245 (= G245), S246 (= S246), T249 (≠ V249), L252 (≠ R252), F253 (≠ L253), Y256 (= Y256), C269 (≠ L269), G270 (= G270), C303 (= C303), H350 (≠ Q350), K353 (≠ T353), F400 (= F404)
Q63639 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Rattus norvegicus (Rat) (see paper)
44% identity, 96% coverage: 21:498/499 of query aligns to 38:513/518 of Q63639
6b5hA Aldh1a2 liganded with NAD and 1-(4-cyanophenyl)-n-(3-fluorophenyl)-3- [4-(methylsulfonyl)phenyl]-1h-pyrazole-4-carboxamide (compound cm121) (see paper)
44% identity, 96% coverage: 21:498/499 of query aligns to 12:487/492 of 6b5hA
- active site: N161 (= N169), E260 (= E268), C294 (= C303), E468 (≠ D479)
- binding 1-(4-cyanophenyl)-N-(3-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-1H-pyrazole-4-carboxamide: V112 (= V120), G116 (≠ L124), F162 (= F170), W169 (= W177), Q284 (≠ W293), F288 (≠ Y297), T295 (= T304), N449 (≠ D460), L451 (≠ C462), N452 (≠ D463), F457 (= F468)
- binding nicotinamide-adenine-dinucleotide: I157 (= I165), I158 (≠ V166), W160 (= W168), N161 (= N169), K184 (= K192), G217 (= G225), G221 (= G229), F235 (= F243), T236 (= T244), G237 (= G245), S238 (= S246), V241 (= V249), E260 (= E268), L261 (= L269), C294 (= C303), F393 (= F404)
6b5gA Aldh1a2 liganded with NAD and (3-ethoxythiophen-2-yl){4-[4-nitro-3- (pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone (compound 6-118) (see paper)
44% identity, 96% coverage: 21:498/499 of query aligns to 12:487/492 of 6b5gA
- active site: N161 (= N169), E260 (= E268), C294 (= C303), E468 (≠ D479)
- binding (3-ethoxythiophen-2-yl){4-[4-nitro-3-(pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone: F162 (= F170), L165 (≠ H173), W169 (= W177), F288 (≠ Y297), C293 (≠ V302), C294 (= C303), T295 (= T304), N449 (≠ D460), L451 (≠ C462)
- binding nicotinamide-adenine-dinucleotide: I157 (= I165), I158 (≠ V166), P159 (= P167), W160 (= W168), N161 (= N169), M166 (= M174), K184 (= K192), E187 (= E195), G217 (= G225), G221 (= G229), F235 (= F243), T236 (= T244), G237 (= G245), S238 (= S246), V241 (= V249), E260 (= E268), L261 (= L269), C294 (= C303), E391 (= E402), F393 (= F404)
6aljA Aldh1a2 liganded with NAD and compound win18,446 (see paper)
44% identity, 96% coverage: 21:498/499 of query aligns to 12:487/492 of 6aljA
- active site: N161 (= N169), E260 (= E268), C294 (= C303), E468 (≠ D479)
- binding N,N'-(octane-1,8-diyl)bis(2,2-dichloroacetamide): G116 (≠ L124), F162 (= F170), L165 (≠ H173), M166 (= M174), W169 (= W177), E260 (= E268), C293 (≠ V302), C294 (= C303), L451 (≠ C462), N452 (≠ D463), A453 (≠ I464)
- binding nicotinamide-adenine-dinucleotide: I157 (= I165), I158 (≠ V166), P159 (= P167), W160 (= W168), N161 (= N169), K184 (= K192), E187 (= E195), G217 (= G225), G221 (= G229), F235 (= F243), G237 (= G245), S238 (= S246), V241 (= V249), Q341 (= Q350), K344 (≠ T353), E391 (= E402), F393 (= F404)
O94788 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Homo sapiens (Human) (see 6 papers)
44% identity, 96% coverage: 21:498/499 of query aligns to 38:513/518 of O94788
- E50 (≠ A33) to G: in dbSNP:rs34266719
- A110 (= A92) to V: in dbSNP:rs35365164
- Q182 (≠ A164) to K: in DIH4; decreased retinoic acid biosynthetic process
- IPW 184:186 (≠ VPW 166:168) binding
- KPAE 210:213 (= KPAE 192:195) binding
- STE 264:266 (≠ SGP 246:248) binding
- C320 (= C303) active site, Nucleophile
- R347 (≠ M330) to H: in DIH4; decreased expression; dbSNP:rs141245344
- V348 (≠ K331) to I: in dbSNP:rs4646626
- KQYNK 366:370 (≠ RQMNT 349:353) binding
- A383 (= A366) to T: in DIH4; uncertain significance; dbSNP:rs749124508
- E417 (= E402) binding
- E436 (≠ R421) to K: in dbSNP:rs34744827
- S461 (≠ A446) to Y: in DIH4; decreased retinoic acid biosynthetic process
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
48% identity, 96% coverage: 21:499/499 of query aligns to 11:489/494 of 4pz2B
- active site: N159 (= N169), K182 (= K192), E258 (= E268), C292 (= C303), E392 (= E402), D469 (= D479)
- binding nicotinamide-adenine-dinucleotide: I155 (= I165), I156 (≠ V166), P157 (= P167), W158 (= W168), N159 (= N169), M164 (= M174), K182 (= K192), A184 (= A194), E185 (= E195), G215 (= G225), G219 (= G229), F233 (= F243), T234 (= T244), G235 (= G245), S236 (= S246), V239 (= V249), E258 (= E268), L259 (= L269), C292 (= C303), E392 (= E402), F394 (= F404)
P51977 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Ovis aries (Sheep) (see 2 papers)
43% identity, 100% coverage: 1:498/499 of query aligns to 6:496/501 of P51977
5ac0A Ovis aries aldehyde dehydrogenase 1a1 in complex with a duocarmycin analog (see paper)
43% identity, 99% coverage: 6:498/499 of query aligns to 2:489/494 of 5ac0A
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding 1-[(1S)-1-methyl-5-oxidanyl-1,2-dihydrobenzo[e]indol-3-yl]hexan-1-one: M114 (≠ V120), F164 (= F170), W171 (= W177), Y290 (= Y297), C295 (≠ V302), C296 (= C303)
- binding nicotinamide-adenine-dinucleotide: I159 (= I165), I160 (≠ V166), P161 (= P167), W162 (= W168), K186 (= K192), E189 (= E195), G219 (= G225), G223 (= G229), A224 (≠ E230), F237 (= F243), G239 (= G245), S240 (= S246), V243 (= V249), G264 (= G270), C296 (= C303), Q343 (= Q350), K346 (≠ T353), E393 (= E402)
5abmA Sheep aldehyde dehydrogenase 1a1 (see paper)
43% identity, 99% coverage: 6:498/499 of query aligns to 2:489/494 of 5abmA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I159 (= I165), I160 (≠ V166), P161 (= P167), W162 (= W168), K186 (= K192), E189 (= E195), G219 (= G225), G223 (= G229), F237 (= F243), G239 (= G245), S240 (= S246), V243 (= V249), G264 (= G270), Q343 (= Q350), K346 (≠ T353), E393 (= E402), F395 (= F404)
1bxsA Sheep liver class 1 aldehyde dehydrogenase with NAD bound (see paper)
43% identity, 99% coverage: 6:498/499 of query aligns to 2:489/494 of 1bxsA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding nicotinamide-adenine-dinucleotide: I159 (= I165), I160 (≠ V166), P161 (= P167), W162 (= W168), K186 (= K192), E189 (= E195), G219 (= G225), G223 (= G229), F237 (= F243), G239 (= G245), S240 (= S246), V243 (= V249), L263 (= L269), C296 (= C303), Q343 (= Q350), K346 (≠ T353), E393 (= E402), F395 (= F404)
7jwwA Crystal structure of human aldh1a1 bound to compound (r)-28 (see paper)
43% identity, 96% coverage: 21:498/499 of query aligns to 14:489/494 of 7jwwA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding 5-{4-[(Z)-2-hydroxyethenyl]phenyl}-1-methyl-6-{[(1R)-1-phenylethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: G118 (≠ L124), T122 (= T128), F164 (= F170), M168 (= M174), Y290 (= Y297), C295 (≠ V302), C296 (= C303), I297 (≠ T304), V453 (≠ C462), F459 (= F468)
7jwvA Crystal structure of human aldh1a1 bound to compound (r)-28 (see paper)
43% identity, 96% coverage: 21:498/499 of query aligns to 14:489/494 of 7jwvA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding 5-[4-(hydroxymethyl)phenyl]-1-methyl-6-{[(1R)-1-phenylethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: G118 (≠ L124), T122 (= T128), F164 (= F170), M168 (= M174), Y290 (= Y297), C295 (≠ V302), I297 (≠ T304), V453 (≠ C462), F459 (= F468)
7jwuA Crystal structure of human aldh1a1 bound to compound (r)-28 (see paper)
43% identity, 96% coverage: 21:498/499 of query aligns to 14:489/494 of 7jwuA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding nicotinamide-adenine-dinucleotide: I159 (= I165), I160 (≠ V166), P161 (= P167), W162 (= W168), N163 (= N169), K186 (= K192), E189 (= E195), G219 (= G225), G223 (= G229), A224 (≠ E230), F237 (= F243), T238 (= T244), G239 (= G245), S240 (= S246), V243 (= V249), L263 (= L269), C296 (= C303), Q343 (= Q350), K346 (≠ T353), E393 (= E402), F395 (= F404)
- binding 1-methyl-5-phenyl-6-{[(1R)-1-(pyridin-2-yl)ethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: T122 (= T128), F164 (= F170), W171 (= W177), Y290 (= Y297), C295 (≠ V302), I297 (≠ T304), V453 (≠ C462), F459 (= F468)
7jwtA Crystal structure of human aldh1a1 bound to compound (r)-28 (see paper)
43% identity, 96% coverage: 21:498/499 of query aligns to 14:489/494 of 7jwtA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding 6-{[(1R)-1-(3-hydroxyphenyl)ethyl]sulfanyl}-1-methyl-5-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: G118 (≠ L124), T122 (= T128), F164 (= F170), M168 (= M174), W171 (= W177), Y290 (= Y297), C295 (≠ V302), V453 (≠ C462), F459 (= F468)
P15437 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Equus caballus (Horse) (see paper)
43% identity, 96% coverage: 21:498/499 of query aligns to 21:496/501 of P15437
Sites not aligning to the query:
- 2 modified: N-acetylserine
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
44% identity, 96% coverage: 21:498/499 of query aligns to 6:480/486 of 4pxlA
- active site: N154 (= N169), K177 (= K192), E253 (= E268), C287 (= C303), E384 (= E402), D461 (= D479)
- binding nicotinamide-adenine-dinucleotide: I150 (= I165), V151 (= V166), P152 (= P167), W153 (= W168), K177 (= K192), E180 (= E195), G210 (= G225), G214 (= G229), A215 (≠ E230), F228 (= F243), G230 (= G245), S231 (= S246), V234 (= V249), E253 (= E268), G255 (= G270), C287 (= C303), Q334 (= Q350), K337 (≠ T353), E384 (= E402), F386 (= F404)
Query Sequence
>CCNA_03243 CCNA_03243 NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase
MPRVTLPADMTERLAKLAPPSQAVIDGDLVEAASGATFHNVSPRDGQVLNLVTACQADDV
ERAVAGARAAFEDGRWRDQGPRQKKAVLFRLAELMERDADELALLESLDVGKPISDARNV
DIPLAINTCRWYAEALDKVYGEVGTSPADRLSYAVHEPLGVIGAIVPWNFPLHMAMWKVA
PALAMGNSVVLKPAEQSPLTALKLGALALEAGLPPGVLNVIPGLGGVAGEALALSMDVDM
IAFTGSGPVGRRLMEYSARSNLKRVSLELGGKSPQIVFADCPDLEAAAQAAAWGVFYNQG
EVCTAASRLLVEAPIKDAFLARVIEVAKGMKVGDPLDPSTQFGAMVSERQMNTALDYIAT
ADSQGARRVLGGQRVRQEAGGFYVEPTIFDQVRPDQTLAREEVFGPVLGVMTFSSEDEAM
RLANDTVYGLAAGLWTADVSKALRGARRLKAGLVWVNGWDACDITMPFGGFKQSGFGRDR
SLHALHKYADLKSVSVTLR
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory