Comparing CCNA_03465 FitnessBrowser__Caulo:CCNA_03465 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P48728 Aminomethyltransferase, mitochondrial; Glycine cleavage system T protein; GCVT; EC 2.1.2.10 from Homo sapiens (Human) (see 4 papers)
45% identity, 98% coverage: 6:371/375 of query aligns to 28:399/403 of P48728
1wsvA Crystal structure of human t-protein of glycine cleavage system (see paper)
45% identity, 96% coverage: 11:371/375 of query aligns to 2:368/371 of 1wsvA
1worA Crystal structure of t-protein of the glycine cleavage system (see paper)
36% identity, 95% coverage: 11:366/375 of query aligns to 1:355/362 of 1worA
1wopA Crystal structure of t-protein of the glycine cleavage system (see paper)
36% identity, 95% coverage: 11:366/375 of query aligns to 1:355/362 of 1wopA
Sites not aligning to the query:
1wooA Crystal structure of t-protein of the glycine cleavage system (see paper)
36% identity, 95% coverage: 11:366/375 of query aligns to 1:355/362 of 1wooA
Sites not aligning to the query:
3a8iA Crystal structure of et-ehred-5-ch3-thf complex (see paper)
37% identity, 95% coverage: 12:369/375 of query aligns to 2:358/363 of 3a8iA
Q46337 Sarcosine oxidase subunit alpha; Sarcosine oxidase subunit A; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit alpha; Tetrameric sarcosine oxidase subunit alpha; TSOX subunit alpha; EC 1.5.3.24 from Corynebacterium sp. (strain P-1) (see 2 papers)
29% identity, 92% coverage: 12:355/375 of query aligns to 577:946/967 of Q46337
Sites not aligning to the query:
Q50LF0 Sarcosine oxidase subunit alpha; Sarcosine oxidase subunit A; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit alpha; Tetrameric sarcosine oxidase subunit alpha; TSOX subunit alpha; EC 1.5.3.24 from Corynebacterium sp. (strain U-96) (see 2 papers)
28% identity, 93% coverage: 12:361/375 of query aligns to 575:950/965 of Q50LF0
Sites not aligning to the query:
3ad7A Heterotetrameric sarcosine oxidase from corynebacterium sp. U-96 in complex with methylthio acetate (see paper)
28% identity, 93% coverage: 12:361/375 of query aligns to 574:949/963 of 3ad7A
Sites not aligning to the query:
1vrqA Crystal structure of heterotetrameric sarcosine oxidase from corynebacterium sp. U-96 in complex with folinic acid (see paper)
28% identity, 93% coverage: 12:361/375 of query aligns to 574:949/963 of 1vrqA
Sites not aligning to the query:
2gagA Heteroteterameric sarcosine: structure of a diflavin metaloenzyme at 1.85 a resolution (see paper)
29% identity, 91% coverage: 12:352/375 of query aligns to 575:941/965 of 2gagA
Sites not aligning to the query:
3tfjA Dmsp-dependent demethylase from p. Ubique - with cofactor thf (see paper)
23% identity, 93% coverage: 19:367/375 of query aligns to 28:369/369 of 3tfjA
3tfiA Dmsp-dependent demethylase from p. Ubique - with substrate dmsp (see paper)
23% identity, 93% coverage: 19:367/375 of query aligns to 28:369/369 of 3tfiA
Q4FP21 Dimethylsulfonioproprionate demethylase DmdA; EC 2.1.1.269 from Pelagibacter ubique (strain HTCC1062) (see paper)
23% identity, 93% coverage: 19:367/375 of query aligns to 28:369/369 of Q4FP21
1pj6A Crystal structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folic acid (see paper)
23% identity, 98% coverage: 7:373/375 of query aligns to 424:825/828 of 1pj6A
Sites not aligning to the query:
Q9AGP8 Dimethylglycine oxidase; DMGO; EC 1.5.3.10 from Arthrobacter globiformis (see 2 papers)
23% identity, 98% coverage: 7:373/375 of query aligns to 426:827/830 of Q9AGP8
Sites not aligning to the query:
1pj7A Structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folinic acid (see paper)
23% identity, 98% coverage: 7:373/375 of query aligns to 423:824/827 of 1pj7A
Sites not aligning to the query:
3gsiA Crystal structure of d552a dimethylglycine oxidase mutant of arthrobacter globiformis in complex with tetrahydrofolate (see paper)
23% identity, 98% coverage: 7:373/375 of query aligns to 423:824/827 of 3gsiA
Sites not aligning to the query:
Q9UI17 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Homo sapiens (Human) (see 4 papers)
24% identity, 83% coverage: 58:367/375 of query aligns to 533:848/866 of Q9UI17
Sites not aligning to the query:
Q63342 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Rattus norvegicus (Rat) (see 2 papers)
24% identity, 84% coverage: 52:367/375 of query aligns to 520:841/857 of Q63342
Sites not aligning to the query:
>CCNA_03465 FitnessBrowser__Caulo:CCNA_03465
MSSQDSSDQDLKKTPLYDAHVAAGARMVPFAGYSMPVQYKDGVLKEHLWTREHAGLFDVS
HMGQARIRGENPAKSFEKVVSADYQGLKAGKQRYGVLLNADGGIVDDLMTARPDEDGLFV
VVNGACKDNDYAIIARELAGEATVTRLEDRALLALQGPEAAAVLAAHVPEAAQMVFMDAK
ALSAFGVDAIISRSGYTGEDGYEISVPADAAERVWNTLLADERVKPIGLGARDSLRLEAG
LPLYGHDLDETVSPIEAGLNFAVGRSRREAGDYLGAARIAKELAGELSRVRVNLKVLEGA
PAREGAEIADEAGNVIGKVTSGGFAPSLGFPIAIGFAPPAYAAVGTKLKVIVRGKPAAAE
VVASPFVPNRYVRKL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory