SitesBLAST
Comparing CCNA_03695 FitnessBrowser__Caulo:CCNA_03695 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P37685 Aldehyde dehydrogenase B; Acetaldehyde dehydrogenase; EC 1.2.1.4 from Escherichia coli (strain K12) (see paper)
72% identity, 97% coverage: 15:506/506 of query aligns to 21:512/512 of P37685
- R197 (≠ E191) mutation to E: Less than 10% of wild-type acetaldehyde dehydrogenase activity.
6b5hA Aldh1a2 liganded with NAD and 1-(4-cyanophenyl)-n-(3-fluorophenyl)-3- [4-(methylsulfonyl)phenyl]-1h-pyrazole-4-carboxamide (compound cm121) (see paper)
44% identity, 97% coverage: 13:501/506 of query aligns to 5:490/492 of 6b5hA
- active site: N161 (= N165), E260 (= E262), C294 (= C301), E468 (= E479)
- binding 1-(4-cyanophenyl)-N-(3-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-1H-pyrazole-4-carboxamide: V112 (≠ A116), G116 (≠ L120), F162 (= F166), W169 (= W173), Q284 (≠ E288), F288 (≠ L295), T295 (= T302), N449 (≠ H460), L451 (≠ Y462), N452 (≠ P463), F457 (= F468)
- binding nicotinamide-adenine-dinucleotide: I157 (= I161), I158 (= I162), W160 (= W164), N161 (= N165), K184 (= K188), G217 (= G220), G221 (= G224), F235 (= F238), T236 (= T239), G237 (= G240), S238 (≠ E241), V241 (≠ T244), E260 (= E262), L261 (= L263), C294 (= C301), F393 (= F404)
6b5gA Aldh1a2 liganded with NAD and (3-ethoxythiophen-2-yl){4-[4-nitro-3- (pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone (compound 6-118) (see paper)
44% identity, 97% coverage: 13:501/506 of query aligns to 5:490/492 of 6b5gA
- active site: N161 (= N165), E260 (= E262), C294 (= C301), E468 (= E479)
- binding (3-ethoxythiophen-2-yl){4-[4-nitro-3-(pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone: F162 (= F166), L165 (= L169), W169 (= W173), F288 (≠ L295), C293 (≠ V300), C294 (= C301), T295 (= T302), N449 (≠ H460), L451 (≠ Y462)
- binding nicotinamide-adenine-dinucleotide: I157 (= I161), I158 (= I162), P159 (= P163), W160 (= W164), N161 (= N165), M166 (= M170), K184 (= K188), E187 (= E191), G217 (= G220), G221 (= G224), F235 (= F238), T236 (= T239), G237 (= G240), S238 (≠ E241), V241 (≠ T244), E260 (= E262), L261 (= L263), C294 (= C301), E391 (= E402), F393 (= F404)
6aljA Aldh1a2 liganded with NAD and compound win18,446 (see paper)
44% identity, 97% coverage: 13:501/506 of query aligns to 5:490/492 of 6aljA
- active site: N161 (= N165), E260 (= E262), C294 (= C301), E468 (= E479)
- binding N,N'-(octane-1,8-diyl)bis(2,2-dichloroacetamide): G116 (≠ L120), F162 (= F166), L165 (= L169), M166 (= M170), W169 (= W173), E260 (= E262), C293 (≠ V300), C294 (= C301), L451 (≠ Y462), N452 (≠ P463), A453 (= A464)
- binding nicotinamide-adenine-dinucleotide: I157 (= I161), I158 (= I162), P159 (= P163), W160 (= W164), N161 (= N165), K184 (= K188), E187 (= E191), G217 (= G220), G221 (= G224), F235 (= F238), G237 (= G240), S238 (≠ E241), V241 (≠ T244), Q341 (= Q348), K344 (= K351), E391 (= E402), F393 (= F404)
O94788 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Homo sapiens (Human) (see 6 papers)
44% identity, 97% coverage: 13:501/506 of query aligns to 31:516/518 of O94788
- E50 (≠ A31) to G: in dbSNP:rs34266719
- A110 (= A88) to V: in dbSNP:rs35365164
- Q182 (= Q160) to K: in DIH4; decreased retinoic acid biosynthetic process
- IPW 184:186 (= IPW 162:164) binding
- KPAE 210:213 (= KPAE 188:191) binding
- STE 264:266 (≠ ETS 241:243) binding
- C320 (= C301) active site, Nucleophile
- R347 (≠ V328) to H: in DIH4; decreased expression; dbSNP:rs141245344
- V348 (= V329) to I: in dbSNP:rs4646626
- KQYNK 366:370 (≠ EQLNK 347:351) binding
- A383 (= A364) to T: in DIH4; uncertain significance; dbSNP:rs749124508
- E417 (= E402) binding
- E436 (= E421) to K: in dbSNP:rs34744827
- S461 (≠ G446) to Y: in DIH4; decreased retinoic acid biosynthetic process
Q63639 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Rattus norvegicus (Rat) (see paper)
43% identity, 97% coverage: 13:501/506 of query aligns to 31:516/518 of Q63639
5l13A Structure of aldh2 in complex with 2p3 (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 5l13A
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (= F166), M168 (= M170), W171 (= W173), F290 (≠ L295), C295 (≠ V300), C296 (= C301), C297 (≠ T302), D451 (≠ H460), F453 (≠ Y462)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 4kwgA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (= F166), M168 (= M170), C295 (≠ V300), C296 (= C301), C297 (≠ T302), D451 (≠ H460), F453 (≠ Y462)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 4kwfA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (= F166), M168 (= M170), W171 (= W173), E262 (= E262), C295 (≠ V300), C296 (= C301), C297 (≠ T302), D451 (≠ H460), F453 (≠ Y462), F459 (= F468)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 3sz9A
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (= F166), C295 (≠ V300), C296 (= C301), D451 (≠ H460), F453 (≠ Y462), F459 (= F468)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 3injA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ L120), F164 (= F166), L167 (= L169), F286 (= F290), F290 (≠ L295), D451 (≠ H460), F453 (≠ Y462)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 2vleA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding daidzin: M118 (≠ L120), F164 (= F166), M168 (= M170), W171 (= W173), F286 (= F290), F290 (≠ L295), C295 (≠ V300), C296 (= C301), D451 (≠ H460), V452 (≠ A461), F453 (≠ Y462)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 1o01B
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding (2e)-but-2-enal: C296 (= C301), C297 (≠ T302), F453 (≠ Y462)
- binding nicotinamide-adenine-dinucleotide: I159 (= I161), I160 (= I162), P161 (= P163), W162 (= W164), K186 (= K188), E189 (= E191), G219 (= G220), G223 (= G224), A224 (≠ K225), F237 (= F238), G239 (= G240), S240 (≠ E241), I243 (≠ T244), L263 (= L263), G264 (= G264), C296 (= C301), Q343 (= Q348), E393 (= E402), F395 (= F404)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 1cw3A
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding magnesium ion: V34 (≠ S39), D103 (= D105), Q190 (= Q192)
- binding nicotinamide-adenine-dinucleotide: I159 (= I161), I160 (= I162), P161 (= P163), W162 (= W164), K186 (= K188), G219 (= G220), G223 (= G224), A224 (≠ K225), F237 (= F238), G239 (= G240), S240 (≠ E241), I243 (≠ T244), L263 (= L263), G264 (= G264), C296 (= C301), Q343 (= Q348), K346 (= K351), E393 (= E402), F395 (= F404)
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 19:494/496 of 4fr8C
- active site: N165 (= N165), K188 (= K188), Q264 (≠ E262), C298 (= C301), E395 (= E402), E472 (= E479)
- binding nicotinamide-adenine-dinucleotide: I161 (= I161), I162 (= I162), W164 (= W164), K188 (= K188), G221 (= G220), G225 (= G224), A226 (≠ K225), F239 (= F238), G241 (= G240), S242 (≠ E241), I245 (≠ T244), Q345 (= Q348), E395 (= E402), F397 (= F404)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 16:491/493 of 4fr8A
- active site: N162 (= N165), K185 (= K188), Q261 (≠ E262), C295 (= C301), E392 (= E402), E469 (= E479)
- binding nicotinamide-adenine-dinucleotide: I158 (= I161), I159 (= I162), W161 (= W164), K185 (= K188), G218 (= G220), G222 (= G224), A223 (≠ K225), F236 (= F238), G238 (= G240), S239 (≠ E241), I242 (≠ T244), Q342 (= Q348), K345 (= K351), E392 (= E402), F394 (= F404)
- binding propane-1,2,3-triyl trinitrate: F163 (= F166), L166 (= L169), W170 (= W173), F289 (≠ L295), S294 (≠ V300), C295 (= C301), D450 (≠ H460), F452 (≠ Y462)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
43% identity, 94% coverage: 22:497/506 of query aligns to 7:478/489 of 4o6rA
- active site: N150 (= N165), K173 (= K188), E248 (= E262), C282 (= C301), E383 (= E402), E460 (= E479)
- binding adenosine monophosphate: I146 (= I161), V147 (≠ I162), K173 (= K188), G206 (= G220), G210 (= G224), Q211 (≠ K225), F224 (= F238), G226 (= G240), S227 (≠ E241), T230 (= T244), R233 (≠ L247)
1nzwA Cys302ser mutant of human mitochondrial aldehyde dehydrogenase complexed with nadh and mg2+ (see paper)
44% identity, 95% coverage: 22:501/506 of query aligns to 17:492/494 of 1nzwA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), S296 (≠ T302), E393 (= E402), E470 (= E479)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I159 (= I161), I160 (= I162), P161 (= P163), K186 (= K188), E189 (= E191), G219 (= G220), P220 (≠ L221), G223 (= G224), A224 (≠ K225), F237 (= F238), G239 (= G240), S240 (≠ E241), I243 (≠ T244), E262 (= E262), G264 (= G264), S296 (≠ T302), Q343 (= Q348), E393 (= E402), F395 (= F404)
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
43% identity, 95% coverage: 22:501/506 of query aligns to 43:518/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
2onmA Human mitochondrial aldehyde dehydrogenase asian variant, aldh2 2, Complexed with NAD+ (see paper)
44% identity, 92% coverage: 22:488/506 of query aligns to 17:479/494 of 2onmA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding adenosine-5'-diphosphate: E189 (= E191), G219 (= G220), G223 (= G224), A224 (≠ K225), F237 (= F238), G239 (= G240), S240 (≠ E241), I243 (≠ T244)
Query Sequence
>CCNA_03695 FitnessBrowser__Caulo:CCNA_03695
MTKPEFIESLSRPPFKARYDNFIGGQWVAPADGRYFDNSSPIHGRKICEIARSQAIDIER
ALDAAHAAKAGWARTSAADRSRILLRIADRMEENLAALATAETWDNGKPIRETLAADIPL
AIDHFRYFAGCLRSQEGSISEIDHDTIAYHFHEPLGVVGQIIPWNFPLLMACWKLAPALA
AGNCVVLKPAEQTPASIMVWAEMIGDLLPAGVLNIVNGFGLEAGKPLASSPRIAKIAFTG
ETSTGRLIMQYAAQNLIPVTLELGGKSPNIFFDDVAREDDDYLDKALEGFTMFALNQGEV
CTCPSRALVQESIYEKFMERALKRVNAVVQGSPLDPATMIGAQASEEQLNKILGYMDIGR
NEGAKLLAGGQRKILPGQLADGYYVEPTVFEGHNKMRIFQEEIFGPVLAVTTFKTEEEAL
EIANDTAFGLGAGVWSRDANRCYRFGRGIEAGRVWTNCYHAYPAHAAFGGYKQSGVGRET
HKMMLDHYQQTKNMLVSYSPKALGFF
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory