SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Dsui_0083 FitnessBrowser__PS:Dsui_0083 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

2gnaA Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-gal (see paper)
55% identity, 97% coverage: 1:322/332 of query aligns to 3:329/329 of 2gnaA

query
sites
2gnaA

M

M

L

L

T

D

N

N

T

Q

S

T

I

I

L

L

I

I

T

T

G
|
G

G

G

T
|
T

G
|
G

S
|
S

F
|
F

G

G

N

K

T

C

F

F

V

V

P

R

M

K

T

V

L

L

A

D

K

T

F

T

N

N

P

A

K

K

K

K

I

I

V

I

I

V

F

Y

S
|
S

R
|
R

D
|
D

E

E

M

L

K
|
K

Q

Q

W

S

E

E

M

M

A

A

K

M

K

E

F

F

G

N

G

-

D

D

E

P

R

R

V

M

R

R

F

F

F

F

I

I

G
|
G

D
|
D

V
|
V

R

R

D

D

R

L

E

E

R

R

L

L

Y

N

R

Y

A

A

L

L

D

E

G

G

I

V

D

D

Y

I

V

C

V

I

H

H

A
|
A

A
|
A

A
|
A

T

L

K
|
K

I
x
H

V
|
V

P
|
P

T

I

A

A

E

E

Y

Y

N

N

P

P

F

L

E

E

C

C

V

I

K

K

T
|
T

N

N

I

I

N

M

G

G

A

A

M

S

N

N

L

V

I

I

D

N

A

A

C

C

I

L

D

K

K

N

G

A

V

I

K

S

R

Q

V

V

V

I

A

A

L
|
L

S
|
S

T

T

D

D

K

K

A

A

S

A

S

N

P

P

V

I

N

N

L

L

Y
|
Y

G

G

A

A

T

T

K
|
K

L

L

A

C

S

S

D

D

K

K

L

L

F

F

V

V

A

S

G

A

N

N

S

N

Y

F

A

K

G

G

G

S

H

S

D

Q

T

T

R

Q

F

F

A

S

V

V

V

V

R

R

Y
|
Y

G
|
G

N
|
N

V
|
V

M

V

G

G

S
|
S

R
|
R

G
|
G

S
|
S

V
|
V

I

V

P

P

F

F

F
|
F

M

K

S

K

-

L

I

V

K

Q

D

N

K

K

G

A

V

S

-

E

L

I

P
|
P

I
|
I

T
|
T

D

D

E

I

R

R

M
|
M

T

T

R
|
R

F

F

M

W

I

I

S

T

L

L

E

D

Q

E

G

G

V

V

E

S

L

F

V

V

W

L

H

K

A

S

F

L

G

K

D

R

M

M

E

H

G

G

G

G

E

E

I

I

Y

F

V

V

K

P

K

K

I

I

P

P

S

S

M

M

K

K

V
x
M

T

T

D

D

L

L

A

A

R

K

A

A

I

L

A

A

P

P

N

N

A

T

S

P

L

T

E

K

Y

I

V

I

G

G

I

I

R
|
R

P

P

G

G

E
|
E

K

K

L

L

H

H

E

E

Q

V

M

M

I

I

S

P

E

K

E

D

D

E

A

S

L

H

Y

L

S

A

Y

L

E

E

Y

F

P

E

E

D

H

F

F

F

K

I

I

I

L

Q

P

P

A

T

I

I

-

S

-

F

-

Q

-

T

-

P

H

K

N

D

W

Y

H

T

L

L

S

T

P

K

G

L

R

H

I

E

K

K

D

-

G

G

K

Q

K

K

V

V

P

A

E

P

G

D

F

F

S

E

Y

Y

T

S

S

S

D

H

N

N

N

N

S

N

E

Q

W

W

M

L

G

E

I

P

E

D

E

D

L

L

Q

L

R

K

W

L

I

L

binding galactose-uridine-5'-diphosphate: K87 (= K86), H88 (≠ I87), V89 (= V88), P90 (= P89), N169 (= N168), S173 (= S172), R174 (= R173), G175 (= G174), S176 (= S175), V177 (= V176), F181 (= F180), P193 (= P190), I194 (= I191), T195 (= T192), M199 (= M196), R201 (= R198), M235 (≠ V232), R254 (= R251), E257 (= E254)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G11), T15 (= T13), G16 (= G14), S17 (= S15), F18 (= F16), S39 (= S37), R40 (= R38), D41 (= D39), K44 (= K42), G62 (= G61), D63 (= D62), V64 (= V63), A83 (= A82), A84 (= A83), A85 (= A84), K87 (= K86), T102 (= T101), L125 (= L124), S126 (= S125), Y137 (= Y136), K141 (= K140), Y167 (= Y166), G168 (= G167), V170 (= V169), S173 (= S172), R174 (= R173)

2gn9A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-glc (see paper)
55% identity, 97% coverage: 1:322/332 of query aligns to 3:329/329 of 2gn9A

query
sites
2gn9A

M

M

L

L

T

D

N

N

T

Q

S

T

I

I

L

L

I

I

T

T

G
|
G

G

G

T
|
T

G
|
G

S
|
S

F
|
F

G

G

N

K

T

C

F

F

V

V

P

R

M

K

T

V

L

L

A

D

K

T

F

T

N

N

P

A

K

K

K

K

I

I

V

I

I

V

F

Y

S
|
S

R
|
R

D
|
D

E

E

M

L

K
|
K

Q

Q

W

S

E

E

M

M

A

A

K

M

K

E

F

F

G

N

G

-

D

D

E

P

R

R

V

M

R

R

F

F

F

F

I

I

G
|
G

D
|
D

V
|
V

R

R

D

D

R

L

E

E

R

R

L

L

Y

N

R

Y

A

A

L

L

D

E

G

G

I

V

D

D

Y

I

V

C

V

I

H

H

A
|
A

A
|
A

A
|
A

T

L

K
|
K

I
x
H

V

V

P

P

T

I

A

A

E

E

Y

Y

N

N

P

P

F

L

E

E

C

C

V

I

K

K

T
|
T

N

N

I

I

N

M

G

G

A

A

M

S

N

N

L

V

I

I

D

N

A

A

C

C

I

L

D

K

K

N

G

A

V

I

K

S

R

Q

V

V

V

I

A

A

L
|
L

S
|
S

T
|
T

D

D

K
|
K

A

A

S

A

S

N

P

P

V

I

N

N

L

L

Y
|
Y

G

G

A

A

T

T

K
|
K

L

L

A

C

S

S

D

D

K

K

L

L

F

F

V

V

A

S

G

A

N

N

S

N

Y

F

A

K

G

G

G

S

H

S

D

Q

T

T

R

Q

F

F

A

S

V

V

V

V

R

R

Y
|
Y

G
|
G

N
|
N

V
|
V

M

V

G

G

S
|
S

R
|
R

G

G

S
|
S

V
|
V

I

V

P

P

F

F

F

F

M

K

S

K

-

L

I

V

K

Q

D

N

K

K

G

A

V

S

-

E

L

I

P
|
P

I
|
I

T
|
T

D

D

E

I

R

R

M
|
M

T

T

R
|
R

F

F

M

W

I

I

S

T

L

L

E

D

Q

E

G

G

V

V

E

S

L

F

V

V

W

L

H

K

A

S

F

L

G

K

D

R

M

M

E

H

G

G

G

G

E

E

I

I

Y

F

V

V

K

P

K

K

I

I

P

P

S

S

M

M

K

K

V
x
M

T

T

D

D

L

L

A

A

R

K

A

A

I

L

A

A

P

P

N

N

A

T

S

P

L

T

E

K

Y

I

V

I

G

G

I

I

R
|
R

P

P

G

G

E
|
E

K

K

L

L

H

H

E

E

Q

V

M

M

I

I

S

P

E

K

E

D

D

E

A

S

L

H

Y

L

S

A

Y

L

E

E

Y

F

P

E

E

D

H

F

F

F

K

I

I

I

L

Q

P

P

A

T

I

I

-

S

-

F

-

Q

-

T

-

P

H

K

N

D

W

Y

H

T

L

L

S

T

P

K

G

L

R

H

I

E

K

K

D

-

G

G

K

Q

K

K

V

V

P

A

E

P

G

D

F

F

S

E

Y

Y

T

S

S

S

D

H

N

N

N

N

S

N

E

Q

W

W

M

L

G

E

I

P

E

D

E

D

L

L

Q

L

R

K

W

L

I

L

binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G11), T15 (= T13), G16 (= G14), S17 (= S15), F18 (= F16), S39 (= S37), R40 (= R38), D41 (= D39), K44 (= K42), G62 (= G61), D63 (= D62), V64 (= V63), A83 (= A82), A84 (= A83), A85 (= A84), K87 (= K86), T102 (= T101), L125 (= L124), S126 (= S125), T127 (= T126), Y137 (= Y136), K141 (= K140), Y167 (= Y166), G168 (= G167), V170 (= V169), S173 (= S172), R174 (= R173)
binding uridine-5'-diphosphate-glucose: K87 (= K86), H88 (≠ I87), T127 (= T126), K129 (= K128), Y137 (= Y136), N169 (= N168), S176 (= S175), V177 (= V176), P193 (= P190), I194 (= I191), T195 (= T192), M199 (= M196), R201 (= R198), M235 (≠ V232), R254 (= R251), E257 (= E254)

2gn6A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-glcnac (see paper)
55% identity, 97% coverage: 1:322/332 of query aligns to 3:329/329 of 2gn6A

query
sites
2gn6A

M

M

L

L

T

D

N

N

T

Q

S

T

I

I

L

L

I

I

T

T

G
|
G

G

G

T
|
T

G
|
G

S
|
S

F
|
F

G

G

N

K

T

C

F

F

V

V

P

R

M

K

T

V

L

L

A

D

K

T

F

T

N

N

P

A

K

K

K

K

I

I

V

I

I

V

F

Y

S
|
S

R
|
R

D
|
D

E

E

M

L

K
|
K

Q

Q

W

S

E

E

M

M

A

A

K

M

K

E

F

F

G

N

G

-

D

D

E

P

R

R

V

M

R

R

F

F

F

F

I

I

G
|
G

D
|
D

V
|
V

R

R

D

D

R

L

E

E

R

R

L

L

Y

N

R

Y

A

A

L

L

D

E

G

G

I

V

D

D

Y

I

V

C

V

I

H

H

A
|
A

A
|
A

A
|
A

T

L

K
|
K

I
x
H

V

V

P

P

T

I

A

A

E

E

Y

Y

N

N

P

P

F

L

E

E

C

C

V

I

K

K

T
|
T

N

N

I

I

N

M

G

G

A

A

M

S

N

N

L

V

I

I

D

N

A

A

C

C

I

L

D

K

K

N

G

A

V

I

K

S

R

Q

V

V

V

I

A

A

L
|
L

S
|
S

T
|
T

D
|
D

K
|
K

A

A

S

A

S

N

P

P

V

I

N

N

L

L

Y
|
Y

G

G

A

A

T

T

K
|
K

L

L

A

C

S

S

D

D

K

K

L

L

F

F

V

V

A

S

G

A

N

N

S

N

Y

F

A

K

G

G

G

S

H

S

D

Q

T

T

R

Q

F

F

A

S

V

V

V

V

R

R

Y
|
Y

G
|
G

N
|
N

V
|
V

M

V

G

G

S
|
S

R
|
R

G
|
G

S
|
S

V
|
V

I

V

P

P

F

F

F

F

M

K

S

K

-

L

I

V

K

Q

D

N

K

K

G

A

V

S

-

E

L

I

P
|
P

I
|
I

T
|
T

D

D

E

I

R

R

M
|
M

T

T

R
|
R

F

F

M

W

I

I

S

T

L

L

E

D

Q

E

G

G

V

V

E

S

L

F

V

V

W

L

H

K

A

S

F

L

G

K

D

R

M

M

E

H

G

G

G

G

E

E

I

I

Y

F

V

V

K

P

K

K

I

I

P

P

S

S

M

M

K

K

V
x
M

T

T

D

D

L

L

A

A

R

K

A

A

I

L

A

A

P

P

N

N

A

T

S

P

L

T

E

K

Y

I

V

I

G

G

I

I

R
|
R

P

P

G

G

E
|
E

K

K

L

L

H

H

E

E

Q

V

M

M

I

I

S

P

E

K

E

D

D

E

A

S

L

H

Y

L

S

A

Y

L

E

E

Y

F

P

E

E

D

H

F

F

F

K

I

I

I

L

Q

P

P

A

T

I

I

-

S

-

F

-

Q

-

T

-

P

H

K

N

D

W

Y

H

T

L

L

S

T

P

K

G

L

R

H

I

E

K

K

D

-

G

G

K

Q

K

K

V

V

P

A

E

P

G

D

F

F

S

E

Y

Y

T

S

S

S

D

H

N

N

N

N

S

N

E

Q

W

W

M

L

G

E

I

P

E

D

E

D

L

L

Q

L

R

K

W

L

I

L

binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G11), T15 (= T13), G16 (= G14), S17 (= S15), F18 (= F16), S39 (= S37), R40 (= R38), D41 (= D39), K44 (= K42), G62 (= G61), D63 (= D62), V64 (= V63), A83 (= A82), A84 (= A83), A85 (= A84), K87 (= K86), T102 (= T101), L125 (= L124), S126 (= S125), T127 (= T126), Y137 (= Y136), K141 (= K140), Y167 (= Y166), G168 (= G167), N169 (= N168), V170 (= V169), S173 (= S172), R174 (= R173)
binding uridine-diphosphate-n-acetylglucosamine: K87 (= K86), H88 (≠ I87), T127 (= T126), D128 (= D127), K129 (= K128), Y137 (= Y136), N169 (= N168), G175 (= G174), S176 (= S175), V177 (= V176), P193 (= P190), I194 (= I191), T195 (= T192), M199 (= M196), R201 (= R198), M235 (≠ V232), R254 (= R251), E257 (= E254)

2gn4A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADPH and udp-glcnac (see paper)
55% identity, 97% coverage: 1:322/332 of query aligns to 3:329/329 of 2gn4A

query
sites
2gn4A

M

M

L

L

T

D

N

N

T

Q

S

T

I

I

L

L

I

I

T

T

G
|
G

G

G

T
|
T

G
|
G

S
|
S

F
|
F

G

G

N

K

T

C

F

F

V

V

P

R

M

K

T

V

L

L

A

D

K

T

F

T

N

N

P

A

K

K

K

K

I

I

V

I

I

V

F

Y

S
|
S

R
|
R

D
|
D

E

E

M

L

K
|
K

Q

Q

W

S

E

E

M

M

A

A

K

M

K

E

F

F

G

N

G

-

D

D

E

P

R

R

V

M

R

R

F

F

F

F

I

I

G
|
G

D
|
D

V
|
V

R

R

D

D

R

L

E

E

R

R

L

L

Y

N

R

Y

A

A

L

L

D

E

G

G

I

V

D

D

Y

I

V

C

V

I

H

H

A
|
A

A
|
A

A
|
A

T

L

K
|
K

I

H

V

V

P

P

T

I

A

A

E

E

Y

Y

N

N

P

P

F

L

E

E

C

C

V

I

K

K

T
|
T

N

N

I

I

N

M

G

G

A

A

M

S

N

N

L

V

I

I

D

N

A

A

C

C

I

L

D

K

K

N

G

A

V

I

K

S

R

Q

V

V

V

I

A

A

L
|
L

S
|
S

T
|
T

D
|
D

K
|
K

A

A

S

A

S

N

P

P

V

I

N

N

L

L

Y
|
Y

G

G

A

A

T

T

K
|
K

L

L

A

C

S

S

D

D

K

K

L

L

F

F

V

V

A

S

G

A

N

N

S

N

Y

F

A

K

G

G

G

S

H

S

D

Q

T

T

R

Q

F

F

A

S

V

V

V

V

R

R

Y
|
Y

G
|
G

N
|
N

V
|
V

M

V

G

G

S
|
S

R
|
R

G

G

S
|
S

V
|
V

I

V

P

P

F
|
F

F
|
F

M

K

S

K

-

L

I

V

K

Q

D

N

K

K

G

A

V

S

-

E

L

I

P
|
P

I
|
I

T
|
T

D

D

E

I

R

R

M
|
M

T

T

R
|
R

F

F

M

W

I

I

S

T

L

L

E

D

Q

E

G

G

V

V

E

S

L

F

V

V

W

L

H

K

A

S

F

L

G

K

D

R

M

M

E

H

G

G

G

G

E

E

I

I

Y

F

V

V

K

P

K

K

I

I

P

P

S

S

M

M

K

K

V
x
M

T

T

D

D

L

L

A

A

R

K

A

A

I

L

A

A

P

P

N

N

A

T

S

P

L

T

E

K

Y

I

V

I

G

G

I

I

R
|
R

P

P

G

G

E
|
E

K

K

L

L

H

H

E

E

Q

V

M

M

I

I

S

P

E

K

E

D

D

E

A

S

L

H

Y

L

S

A

Y

L

E

E

Y

F

P

E

E

D

H

F

F

F

K

I

I

I

L

Q

P

P

A

T

I

I

-

S

-

F

-

Q

-

T

-

P

H

K

N

D

W

Y

H

T

L

L

S

T

P

K

G

L

R

H

I

E

K

K

D

-

G

G

K

Q

K

K

V

V

P

A

E

P

G

D

F

F

S

E

Y

Y

T

S

S

S

D

H

N

N

N

N

S

N

E

Q

W

W

M

L

G

E

I

P

E

D

E

D

L

L

Q

L

R

K

W

L

I

L

binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G13 (= G11), T15 (= T13), G16 (= G14), S17 (= S15), F18 (= F16), S39 (= S37), R40 (= R38), D41 (= D39), K44 (= K42), G62 (= G61), D63 (= D62), V64 (= V63), A83 (= A82), A84 (= A83), A85 (= A84), K87 (= K86), T102 (= T101), L125 (= L124), S126 (= S125), T127 (= T126), Y137 (= Y136), K141 (= K140), Y167 (= Y166), G168 (= G167), N169 (= N168), V170 (= V169), S173 (= S172), R174 (= R173)
binding uridine-diphosphate-n-acetylglucosamine: K87 (= K86), T127 (= T126), D128 (= D127), K129 (= K128), Y137 (= Y136), G168 (= G167), N169 (= N168), S176 (= S175), V177 (= V176), F180 (= F179), F181 (= F180), P193 (= P190), I194 (= I191), T195 (= T192), M199 (= M196), R201 (= R198), M235 (≠ V232), R254 (= R251), E257 (= E254)

2gn8A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp (see paper)
55% identity, 97% coverage: 1:322/332 of query aligns to 1:327/327 of 2gn8A

query
sites
2gn8A

M

M

L

L

T

D

N

N

T

Q

S

T

I

I

L

L

I

I

T

T

G
|
G

G

G

T
|
T

G
|
G

S
|
S

F
|
F

G

G

N

K

T

C

F

F

V

V

P

R

M

K

T

V

L

L

A

D

K

T

F

T

N

N

P

A

K

K

K

K

I

I

V

I

I

V

F

Y

S
|
S

R
|
R

D
|
D

E

E

M

L

K
|
K

Q

Q

W

S

E

E

M

M

A

A

K

M

K

E

F

F

G

N

G

-

D

D

E

P

R

R

V

M

R

R

F

F

F

F

I

I

G
|
G

D
|
D

V
|
V

R

R

D

D

R

L

E

E

R

R

L

L

Y

N

R

Y

A

A

L

L

D

E

G

G

I

V

D

D

Y

I

V

C

V

I

H

H

A
|
A

A
|
A

A
|
A

T

L

K
|
K

I

H

V

V

P

P

T

I

A

A

E

E

Y

Y

N

N

P

P

F

L

E

E

C

C

V

I

K

K

T
|
T

N

N

I

I

N

M

G

G

A

A

M

S

N

N

L

V

I

I

D

N

A

A

C

C

I

L

D

K

K

N

G

A

V

I

K

S

R

Q

V

V

V

I

A

A

L
|
L

S
|
S

T
|
T

D

D

K
|
K

A

A

S

A

S

N

P

P

V

I

N

N

L

L

Y
|
Y

G

G

A

A

T

T

K
|
K

L

L

A

C

S

S

D

D

K

K

L

L

F

F

V

V

A

S

G

A

N

N

S

N

Y

F

A

K

G

G

G

S

H

S

D

Q

T

T

R

Q

F

F

A

S

V

V

V

V

R

R

Y
|
Y

G
|
G

N
|
N

V
|
V

M

V

G

G

S
|
S

R
|
R

G

G

S
|
S

V
|
V

I

V

P

P

F

F

F

F

M

K

S

K

-

L

I

V

K

Q

D

N

K

K

G

A

V

S

-

E

L

I

P
|
P

I
|
I

T
|
T

D

D

E

I

R

R

M
|
M

T

T

R
|
R

F

F

M

W

I

I

S

T

L

L

E

D

Q

E

G

G

V

V

E

S

L

F

V

V

W

L

H

K

A

S

F

L

G

K

D

R

M

M

E

H

G

G

G

G

E

E

I

I

Y

F

V

V

K

P

K

K

I

I

P

P

S

S

M

M

K

K

V
x
M

T

T

D

D

L

L

A

A

R

K

A

A

I

L

A

A

P

P

N

N

A

T

S

P

L

T

E

K

Y

I

V

I

G

G

I

I

R
|
R

P

P

G

G

E
|
E

K

K

L

L

H

H

E

E

Q

V

M

M

I

I

S

P

E

K

E

D

D

E

A

S

L

H

Y

L

S

A

Y

L

E

E

Y

F

P

E

E

D

H

F

F

F

K

I

I

I

L

Q

P

P

A

T

I

I

-

S

-

F

-

Q

-

T

-

P

H

K

N

D

W

Y

H

T

L

L

S

T

P

K

G

L

R

H

I

E

K

K

D

-

G

G

K

Q

K

K

V

V

P

A

E

P

G

D

F

F

S

E

Y

Y

T

S

S

S

D

H

N

N

N

N

S

N

E

Q

W

W

M

L

G

E

I

P

E

D

E

D

L

L

Q

L

R

K

W

L

I

L

binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G11), T13 (= T13), G14 (= G14), S15 (= S15), F16 (= F16), S37 (= S37), R38 (= R38), D39 (= D39), K42 (= K42), G60 (= G61), D61 (= D62), V62 (= V63), A81 (= A82), A82 (= A83), A83 (= A84), K85 (= K86), T100 (= T101), L123 (= L124), S124 (= S125), T125 (= T126), Y135 (= Y136), K139 (= K140), Y165 (= Y166), G166 (= G167), V168 (= V169), S171 (= S172), R172 (= R173)
binding uridine-5'-diphosphate: K127 (= K128), N167 (= N168), S174 (= S175), V175 (= V176), P191 (= P190), I192 (= I191), T193 (= T192), M197 (= M196), R199 (= R198), M233 (≠ V232), R252 (= R251), E255 (= E254)

O25511 UDP-N-acetylglucosamine 4,6-dehydratase (inverting); Pseudaminic acid biosynthesis protein B; UDP-GlcNAc-inverting 4,6-dehydratase; EC 4.2.1.115 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
55% identity, 97% coverage: 1:322/332 of query aligns to 7:333/333 of O25511

query
sites
O25511

M

M

L

L

T

D

N

N

T

Q

S

T

I

I

L

L

I

I

T

T

G

G

G

G

T
|
T

G
|
G

S
|
S

F
|
F

G

G

N

K

T

C

F

F

V

V

P

R

M

K

T

V

L

L

A

D

K

T

F

T

N

N

P

A

K

K

K

K

I

I

V

I

I

V

F

Y

S
|
S

R
|
R

D
|
D

E
|
E

M
x
L

K
|
K

Q

Q

W

S

E

E

M

M

A

A

K

M

K

E

F

F

G

N

G

-

D

D

E

P

R

R

V

M

R

R

F

F

F

F

I

I

G

G

D
|
D

V
|
V

R

R

D

D

R

L

E

E

R

R

L

L

Y

N

R

Y

A

A

L

L

D

E

G

G

I

V

D

D

Y

I

V

C

V

I

H

H

A
|
A

A

A

A

A

T

L

K
|
K

I

H

V

V

P

P

T

I

A

A

E

E

Y

Y

N

N

P

P

F

L

E

E

C

C

V

I

K

K

T

T

N

N

I

I

N

M

G

G

A

A

M

S

N

N

L

V

I

I

D

N

A

A

C

C

I

L

D

K

K

N

G

A

V

I

K

S

R

Q

V

V

V

I

A

A

L
|
L

S
|
S

T

T

D

D

K
|
K

A

A

S

A

S

N

P

P

V

I

N

N

L

L

Y
|
Y

G

G

A

A

T

T

K
|
K

L

L

A

C

S

S

D

D

K

K

L

L

F

F

V

V

A

S

G

A

N

N

S

N

Y

F

A

K

G

G

G

S

H

S

D

Q

T

T

R

Q

F

F

A

S

V

V

V

V

R

R

Y

Y

G

G

N

N

V
|
V

M
x
V

G
|
G

S
|
S

R
|
R

G

G

S

S

V

V

I

V

P

P

F

F

F

F

M

K

S

K

-

L

I

V

K

Q

D

N

K

K

G

A

V

S

-

E

L

I

P

P

I

I

T

T

D

D

E

I

R

R

M

M

T

T

R

R

F

F

M

W

I

I

S

T

L

L

E

D

Q

E

G

G

V

V

E

S

L

F

V

V

W

L

H

K

A

S

F

L

G

K

D

R

M

M

E

H

G

G

G

G

E

E

I

I

Y

F

V

V

K

P

K

K

I

I

P

P

S

S

M

M

K

K

V

M

T

T

D

D

L

L

A

A

R

K

A

A

I

L

A

A

P

P

N

N

A

T

S

P

L

T

E

K

Y

I

V

I

G

G

I

I

R

R

P

P

G

G

E

E

K

K

L

L

H

H

E

E

Q

V

M

M

I

I

S

P

E

K

E

D

D

E

A

S

L

H

Y

L

S

A

Y

L

E

E

Y

F

P

E

E

D

H

F

F

F

K

I

I

I

L

Q

P

P

A

T

I

I

-

S

-

F

-

Q

-

T

-

P

H

K

N

D

W

Y

H

T

L

L

S

T

P

K

G

L

R

H

I

E

K

K

D

-

G

G

K

Q

K

K

V

V

P

A

E

P

G

D

F

F

S

E

Y

Y

T

S

S

S

D

H

N

N

N

N

S

N

E

Q

W

W

M

L

G

E

I

P

E

D

E

D

L

L

Q

L

R

K

W

L

I

L

TGSF 19:22 (= TGSF 13:16) binding
SRDELK 43:48 (≠ SRDEMK 37:42) binding
DV 67:68 (= DV 62:63) binding
A87 (= A82) binding
K91 (= K86) binding
LS 129:130 (= LS 124:125) binding
K133 (= K128) mutation K->A,E: Loss of activity.
Y141 (= Y136) binding
K145 (= K140) binding
VVGSR 174:178 (≠ VMGSR 169:173) binding

3w1vA Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in complex with inihibitor (see paper)
43% identity, 95% coverage: 7:322/332 of query aligns to 16:333/347 of 3w1vA

query
sites
3w1vA

I

L

L

L

I

I

T

T

G

G

G

G

T

T

G

G

S

S

F

F

G

G

N

N

T

A

F

V

V

M

P

K

M

R

T

F

L

L

A

D

K

S

F

-

N

N

P

I

K

K

K

E

I

I

V

R

I

I

F

F

S

S

R

R

D

D

E

E

M

K

K

K

Q

Q

W

D

E

D

M

I

A

R

K

K

K

K

F

Y

G

N

G

-

D

N

E

S

R

K

V

L

R

K

F

F

F

Y

I

I

G

G

D

D

V

V

R

R

D

D

R

S

E

Q

R

S

L

V

Y

E

R

T

A

A

L

M

D

R

G

D

I

V

D

D

Y

Y

V

V

V

F

H

H

A

A

A

A

A

A

T

L

K
|
K

I
x
Q

V
|
V

P
|
P

T

S

A

C

E

E

Y

F

N

F

P

P

F

V

E

E

C

A

V

V

K

K

T

T

N

N

I

I

N

I

G

G

A

T

M

E

N

N

L

V

I

L

D

Q

A

S

C

A

I

I

D

H

K

Q

G

N

V

V

K

K

R

K

V

V

V

I

A

C

L

L

S

S

T

T

D

D

K
|
K

A

A

S

A

S

Y

P

P

V

I

N

N

L

A

Y

M

G

G

A

I

T

S

K

K

L

A

A

M

S

M

D

E

K

K

L

V

F

F

V

V

A

A

G

K

N

S

S

R

Y

N

A

I

G

R

G

S

H

E

D

Q

T

T

R

L

F

I

A

C

V

G

V

T

R

R

Y

Y

G

G

N
|
N

V

V

M

M

G

A

S
|
S

R
|
R

G
|
G

S
|
S

V
|
V

I

I

P

P

F
x
L

F
|
F

M

I

S

D

-

K

I

I

K

K

D

A

K

G

G

E

V

P

L

L

P
x
T

I
|
I

T
|
T

D

D

E

P

R

D

M
|
M

T

T

R
|
R

F

F

M

L

I

M

S

S

L

L

E

E

Q

D

G

A

V

V

E

E

L

L

V

V

W

V

H

H

A

A

F

F

G

K

D

H

M

A

E

E

G

T

G

G

E

D

I

I

Y

M

V

V

K

Q

K

K

I

A

P

P

S

S

M

S

K

T

V
|
V

T

G

D

D

L

L

A

A

R

T

A

A

I

L

-

L

-

E

-

L

-

F

-

E

A

A

P

D

N

N

A

A

S

-

L

I

E

E

Y

I

V

I

G

G

I

T

R
|
R

P

H

G

G

E
|
E

K

K

L

K

H

A

E

E

Q

T

M

L

I

L

S

T

E

R

E

E

D

E

A

Y

L

A

Y

Q

S

C

Y

E

E

D

Y

M

P

G

E

D

H

Y

F

F

K

R

I

V

L

P

P

A

A

D

I

S

H

R

N

D

W

L

H

N

L

Y

S

S

P

N

G
x
Y

R
x
V

I

E

K

T

D

G

G

N

K

E

K

K

V

I

P

T

E

Q

G

S

F

Y

S

E

Y

Y

T

N

S

S

D

D

N

-

N

N

S

T

E

H

W

I

M

L

G

T

I

V

E

E

E

E

L

I

Q

K

R

E

W

K

I

L

binding [(2R,3S,4R,5R,6R)-5-acetamido-6-[[[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,4-bis(oxidanyl)oxan-2-yl]methylimino-azanylidene-azanium: K93 (= K86), Q94 (≠ I87), V95 (= V88), P96 (= P89), K135 (= K128), N175 (= N168), S179 (= S172), R180 (= R173), G181 (= G174), S182 (= S175), V183 (= V176), L186 (≠ F179), F187 (= F180), T198 (≠ P190), I199 (= I191), T200 (= T192), M204 (= M196), R206 (= R198), V240 (= V232), R263 (= R251), E266 (= E254), Y302 (≠ G290), V303 (≠ R291)

4g5hA Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in complex with by-product (see paper)
43% identity, 95% coverage: 7:322/332 of query aligns to 16:333/346 of 4g5hA

query
sites
4g5hA

I

L

L

L

I

I

T

T

G
|
G

G

G

T
|
T

G
|
G

S
|
S

F
|
F

G

G

N

N

T

A

F

V

V

M

P

K

M

R

T

F

L

L

A

D

K

S

F

-

N

N

P

I

K

K

K

E

I

I

V

R

I

I

F
|
F

S
|
S

R
|
R

D
|
D

E

E

M

K

K
|
K

Q

Q

W

D

E

D

M

I

A

R

K

K

K

K

F

Y

G

N

G

-

D

N

E

S

R

K

V

L

R

K

F

F

F

Y

I

I

G

G

D
|
D

V
|
V

R

R

D

D

R

S

E

Q

R

S

L

V

Y

E

R

T

A

A

L

M

D

R

G

D

I

V

D

D

Y

Y

V

V

V

F

H

H

A
|
A

A
|
A

A
|
A

T

L

K
|
K

I
x
Q

V
|
V

P
|
P

T

S

A

C

E

E

Y

F

N

F

P

P

F

V

E

E

C

A

V

V

K

K

T
|
T

N

N

I

I

N

I

G

G

A

T

M

E

N

N

L

V

I

L

D

Q

A

S

C

A

I

I

D

H

K

Q

G

N

V

V

K

K

R

K

V

V

V

I

A

C

L
|
L

S
|
S

T
|
T

D

D

K
|
K

A

A

S

A

S

Y

P

P

V

I

N

N

L

A

Y

M

G

G

A

I

T

S

K
|
K

L

A

A

M

S

M

D

E

K

K

L

V

F

F

V

V

A

A

G

K

N

S

S

R

Y

N

A

I

G

R

G

S

H

E

D

Q

T

T

R

L

F

I

A

C

V

G

V

T

R

R

Y
|
Y

G
|
G

N
|
N

V

V

M

M

G

A

S
|
S

R

R

G

G

S
|
S

V
|
V

I

I

P

P

F
x
L

F
|
F

M

I

S

D

-

K

I

I

K

K

D

A

K

G

G

E

V

P

L

L

P
x
T

I
|
I

T
|
T

D

D

E

P

R

D

M
|
M

T

T

R
|
R

F

F

M

L

I

M

S

S

L

L

E

E

Q

D

G

A

V

V

E

E

L

L

V

V

W

V

H

H

A

A

F

F

G

K

D

H

M

A

E

E

G

T

G

G

E

D

I

I

Y

M

V

V

K

Q

K

K

I

A

P

P

S

S

M

S

K

T

V
|
V

T

G

D

D

L

L

A

A

R

T

A

A

I

L

-

L

-

E

-

L

-

F

-

E

A

A

P

D

N

N

A

A

S

-

L

I

E

E

Y

I

V

I

G

G

I

T

R
|
R

P

H

G

G

E
|
E

K

K

L

K

H

A

E

E

Q

T

M

L

I

L

S

T

E

R

E

E

D

E

A
x
Y

L

A

Y

Q

S

C

Y

E

E

D

Y

M

P

G

E

D

H

Y

F

F

K

R

I

V

L

P

P

A

A

D

I

S

H

R

N

D

W

L

H

N

L

Y

S

S

P

N

G

Y

R

V

I

E

K

T

D

G

G

N

K

E

K

K

V

I

P

T

E

Q

G
x
S

F
x
Y

S
x
E

Y
|
Y

T

N

S

S

D

D

N

-

N
|
N

S
x
T

E

H

W

I

M

L

G

T

I

V

E

E

E

E

L

I

Q

K

R

E

W

K

I

L

binding nadp nicotinamide-adenine-dinucleotide phosphate: G20 (= G11), T22 (= T13), G23 (= G14), S24 (= S15), F25 (= F16), F44 (= F36), S45 (= S37), R46 (= R38), D47 (= D39), K50 (= K42), D69 (= D62), V70 (= V63), A89 (= A82), A90 (= A83), A91 (= A84), K93 (= K86), T108 (= T101), L131 (= L124), S132 (= S125), T133 (= T126), K147 (= K140), Y173 (= Y166), G174 (= G167), S179 (= S172)
binding [(2R,3R,4R,6R)-3-acetamido-6-methyl-4-oxidanyl-5-oxidanylidene-oxan-2-yl] [[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate: K93 (= K86), Q94 (≠ I87), V95 (= V88), P96 (= P89), K135 (= K128), N175 (= N168), S182 (= S175), V183 (= V176), L186 (≠ F179), F187 (= F180), T198 (≠ P190), I199 (= I191), T200 (= T192), M204 (= M196), R206 (= R198), V240 (= V232), R263 (= R251), E266 (= E254), Y278 (≠ A266), S313 (≠ G301), Y314 (≠ F302), E315 (≠ S303), Y316 (= Y304), N320 (= N309), T321 (≠ S310)

6bwcC X-ray structure of pen from bacillus thuringiensis (see paper)
39% identity, 97% coverage: 6:327/332 of query aligns to 7:324/327 of 6bwcC

query
sites
6bwcC

S

N

I

V

L

L

I

I

T

I

G
|
G

G
|
G

T
|
T

G
|
G

S
x
T

F
x
I

G

G

N

K

T

S

F

I

V

L

P

S

M

N

T

V

L

L

A

Q

K

E

F

-

N

K

P

P

K

K

K

V

I

V

V

R

I

V

F
|
F

S
|
S

R
|
R

D
x
S

E

E

M

Y

K
x
N

Q

Q

W

F

E

L

M

L

A

Q

K

E

K

E

F

F

G

R

G

D

D

K

E

N

R

R

-

N

V

I

R

R

F

Y

F

L

I

I

G
|
G

D
|
D

V
x
I

R

R

D

N

R

Y

E

D

R

R

L

V

Y

F

R

S

A

A

L

M

D

E

G

N

I

I

D

D

Y

Y

V

V

V

F

H

H

A
x
V

A
|
A

A
|
A

T

M

K
|
K

I
x
H

V

V

P

S

T

F

A

C

E

E

Y

Y

N

N

P

P

F

F

E

E

C

A

V

V

K

L

T
|
T

N

N

I

I

N

F

G

G

A

T

M

Q

N

N

L

V

I

I

D

K

A

A

C

A

I

I

D

A

K

Q

G

K

V

V

K

K

R

K

V

V

V

V

A

F

L
x
T

S
|
S

T
x
S

D
x
N

K

A

A

A

S

I

S

S

P

P

V

T

N

N

L

N

Y
|
Y

G

G

A

A

T

T

K
|
K

L

L

A

T

S

A

D

E

K

R

L

L

F

I

V

T

A

S

G

A

N

E

S

Y

Y

S

A

K

G

G

G

S

H

S

D

E

T

T

R

T

F

F

A

T

V

S

V

V

R

R

Y
x
F

G
|
G

N
|
N

V
|
V

M

M

G

G

S
|
S

R
|
R

G
|
G

S
|
S

V
|
V

I

I

P

P

F
x
L

F
|
F

M

E

S

N

-

Q

I

I

K

K

D

E

K

N

G

Q

V

K

L

I

P
x
T

I
x
V

T
|
T

D

D

E

L

R

S

M
|
M

T

S

R
|
R

F

F

M

M

I

M

S

T

L

L

E

N

Q

Q

G

A

V

T

E

M

L

L

V

T

W

I

H

E

A

A

F

M

G

K

D

I

M

A

E

K

G

G

G

G

E

E

I

T

Y

F

V

I

K

L

K

K

I

M

P

P

S

V

M

I

K

S

V
x
L

T

N

D

D

L

L

A

S

R

E

A

V

I

M

-

I

-

E

-

E

-

V

-

T

-

K

-

L

-

Y

-

G

A

L

P

E

N

N

A

I

S

K

L

I

E

E

Y

E

V

I

G

G

I

L

R
x
K

P

P

G

G

E
|
E

K

K

L

M

H

Y

E
|
E

Q

E

M

L

I

M

S

T

E

H

E

D

D

E

A

S

L

L

Y

Q

S

A

Y

F

E

E

Y

L

P

P

E

D

H

M

F

F

K

-

I

I

L

I

P

P

A

-

I

-

H

-

N

-

W

-

H

-

L

-

S

S

P

P

G

L

R

K

I

A

K

K

D

R

G

A

K

K

K

A

V

-

P

-

E

-

G

G

F

F

S

-

Y

Y

T

R

S

S

D

D

N

N

N

Q

S

N

E

-

W

A

M

I

G

S

I

K

E

E

E

E

L

L

Q

R

R

N

W

L

I

I

A

-

I

L

N

N

Q

Q

E

Q

binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G11), G13 (= G12), T14 (= T13), G15 (= G14), T16 (≠ S15), I17 (≠ F16), F36 (= F36), S37 (= S37), R38 (= R38), S39 (≠ D39), N42 (≠ K42), G62 (= G61), D63 (= D62), I64 (≠ V63), V83 (≠ A82), A84 (= A83), A85 (= A84), K87 (= K86), T102 (= T101), T125 (≠ L124), S126 (= S125), S127 (≠ T126), Y137 (= Y136), K141 (= K140), F167 (≠ Y166), G168 (= G167), N169 (= N168), V170 (= V169), S173 (= S172), R174 (= R173)
binding uridine-diphosphate-n-acetylglucosamine: K87 (= K86), H88 (≠ I87), S127 (≠ T126), N128 (≠ D127), Y137 (= Y136), G168 (= G167), N169 (= N168), G175 (= G174), S176 (= S175), V177 (= V176), L180 (≠ F179), F181 (= F180), T192 (≠ P190), V193 (≠ I191), T194 (= T192), M198 (= M196), R200 (= R198), L234 (≠ V232), K262 (≠ R251), E265 (= E254), E269 (= E258)

4j2oC Crystal structure of NADP-bound wbjb from a. Baumannii community strain d1279779 (see paper)
44% identity, 86% coverage: 1:286/332 of query aligns to 1:289/316 of 4j2oC

query
sites
4j2oC

M

M

L

F

T

K

N

D

T

K

S

V

I

L

L

L

I

I

T

T

G
|
G

G

G

T
|
T

G
|
G

S
|
S

F
|
F

G

G

N

N

T

A

F

V

V

L

P

K

M

R

T

F

L

L

A

-

K

E

F

T

N

D

P

I

K

K

K

E

I

I

V

R

I

I

F

F

S
|
S

R
|
R

D
|
D

E

E

M

K

K
|
K

Q

Q

W

D

E

D

M

M

A

R

K

K

K

K

F

Y

G

H

G

S

D

-

E

A

R

K

V

L

R

K

F

F

F

Y

I

I

G
|
G

D
|
D

V
|
V

R

R

D

D

R

Y

E

N

R

S

L

I

Y

L

R

N

A

A

L

T

D

R

G

G

I

V

D

D

Y

Y

V

I

V

Y

H

H

A
|
A

A
|
A

A
|
A

T

L

K
|
K

I

Q

V

V

P

P

T

S

A

C

E

E

Y

F

N

H

P

P

F

M

E

E

C

A

V

V

K

K

T
|
T

N

N

I

V

N

L

G

G

A

T

M

E

N

N

L

V

I

L

D

E

A

A

C

A

I

I

D

Q

K

N

G

H

V

V

K

K

R

R

V

V

V

V

A

C

L
|
L

S

S

T
|
T

D

D

K

K

A

A

S

V

S

Y

P

P

V

I

N

N

L

A

Y

M

G

G

A

I

T

S

K
|
K

L

A

A

M

S

M

D

E

K

K

L

V

F

M

V

V

A

A

G

K

N

S

S

R

Y

N

A

L

G

E

G

G

H

L

D

D

T

T

R

V

F

I

A

C

V

G

V

T

R

R

Y
|
Y

G
|
G

N
|
N

V
|
V

M

M

G

A

S

S

R

R

G

G

S

S

V

V

I

I

P

P

F

L

F

F

M

V

-

D

S

Q

I

I

K

R

D

Q

K

G

G

K

V

P

L

L

P

T

I

I

T

T

D

D

E

P

R

N

M

M

T

T

R

R

F

F

M

M

I

M

S

T

L

L

E

E

Q

D

G

A

V

V

E

D

L

L

V

V

W

L

H

Y

A

A

F

F

G

E

D

H

M

G

E

E

G

N

G

G

E

D

I

I

Y

F

V

V

K

Q

K

K

I

A

P

P

S

A

M

A

K

T

V

I

T

A

D

V

L

L

A

A

R

E

A

A

I

L

A

K

P

Q

N

L

A

L

S

N

L

V

E

E

-

D

-

H

-

P

-

I

-

S

Y

I

V

M

G

G

I

T

R

R

P

H

G

G

E

E

K

K

L

A

H

F

E

E

Q

A

M

L

I

L

S

S

E

R

E

E

D

E

A

M

L

V

Y

H

S

A

Y

F

E

D

Y

Q

P

G

E

D

H

Y

F

F

K

R

I

V

L

-

P

P

A

A

I

D

H

E

N

D

W

Y

H

N

binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G11), T13 (= T13), G14 (= G14), S15 (= S15), F16 (= F16), S36 (= S37), R37 (= R38), D38 (= D39), K41 (= K42), G59 (= G61), D60 (= D62), V61 (= V63), A80 (= A82), A81 (= A83), A82 (= A84), K84 (= K86), T99 (= T101), L122 (= L124), T124 (= T126), K138 (= K140), Y164 (= Y166), G165 (= G167), N166 (= N168), V167 (= V169)

3vvcA Crystal structure of capsular polysaccharide synthesizing enzyme cape , k126e, in apo form (see paper)
43% identity, 95% coverage: 7:322/332 of query aligns to 8:305/318 of 3vvcA

query
sites
3vvcA

I

L

L

L

I

I

T

T

G
|
G

G

G

T
|
T

G
|
G

S
|
S

F
|
F

G

G

N

N

T

A

F

V

V

M

P

K

M

R

T

F

L

L

A

D

K

S

F

-

N

N

P

I

K

K

K

E

I

I

V

R

I

I

F
|
F

S
|
S

R
|
R

D
|
D

E

E

M

K

K
|
K

Q

Q

W

D

E

D

M

I

A

R

K

K

K

K

F

Y

G

N

G

-

D

N

E

S

R

K

V

L

R

K

F

F

F

Y

I

I

G

G

D
|
D

V
|
V

R
|
R

D

D

R

S

E

Q

R

S

L

V

Y

E

R

T

A

A

L

M

D

R

G

D

I

V

D

D

Y

Y

V

V

V

F

H

H

A
|
A

A
|
A

A
|
A

T

L

K
|
K

I

Q

V

V

P

P

T

S

A

C

E

E

Y

F

N

F

P

P

F

V

E

E

C

A

V

V

K

K

T
|
T

N

N

I

I

N

I

G

G

A

T

M

E

N

N

L

V

I

L

D

Q

A

S

C

A

I

I

D

H

K

Q

G

N

V

V

K

K

R

K

V

V

V

I

A

C

L
|
L

S
|
S

T
|
T

D

D

K

E

A

A

S

A

S

Y

P

P

V

I

N

N

L

A

Y

M

G

G

A

I

T

S

K
|
K

L

A

A

M

S

M

D

E

K

K

L

V

F

F

V

V

A

A

G

K

N

S

S

R

Y

N

A

I

G

R

G

S

H

E

D

Q

T

T

R

L

F

I

A

C

V

G

V

T

R

R

Y
|
Y

G
|
G

N

N

V
|
V

M

M

G

A

S

S

R

R

G

G

S

S

V

V

I

I

P

P

F

L

F

F

M

I

S

D

-

K

I

I

K

K

D

A

K

G

G

E

V

P

L

L

P

T

I

I

T

T

D

D

E

P

R

D

M

M

T

T

R

R

F

F

M

L

I

M

S

S

L

L

E

E

Q

D

G

A

V

V

E

E

L

L

V

V

W

V

H

H

A

A

F

F

G

K

D

H

M

A

E

E

G

T

G

G

E

D

I

I

Y

M

V

V

K

Q

K

K

I

A

P

P

S

S

M

S

K

T

V

V

T

G

D

D

L

L

A

A

R

T

A

A

I

L

-

L

-

E

-

L

-

F

-

E

A

A

P

D

N

N

A

A

S

-

L

I

E

E

Y

I

V

I

G

G

I

T

R

R

P

H

G

G

E

E

K

K

L

K

H

A

E

E

Q

T

M

L

I

L

S

T

E

R

E

E

D

E

A

Y

L

A

Y

Q

S

C

Y

E

E

D

Y

M

P

G

E

D

H

Y

F

F

K

-

I

-

L

-

P

-

A

-

I

-

H

-

N

-

W

-

H

-

L

-

S

-

P

-

G

-

R

-

I

-

K

-

D

-

G

-

K

-

K

R

V

V

P

P

E

A

G

D

F

Y

S

E

Y

Y

T

N

S

S

D

D

N

-

N

N

S

T

E

H

W

I

M

L

G

T

I

V

E

E

E

E

L

I

Q

K

R

E

W

K

I

L

binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G11), T14 (= T13), G15 (= G14), S16 (= S15), F17 (= F16), F36 (= F36), S37 (= S37), R38 (= R38), D39 (= D39), K42 (= K42), D61 (= D62), V62 (= V63), R63 (= R64), A81 (= A82), A82 (= A83), A83 (= A84), K85 (= K86), T100 (= T101), L123 (= L124), S124 (= S125), T125 (= T126), K139 (= K140), Y165 (= Y166), G166 (= G167), V168 (= V169)

3vvbA Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in apo form (see paper)
37% identity, 95% coverage: 7:322/332 of query aligns to 6:260/270 of 3vvbA

query
sites
3vvbA

I

L

L

L

I

I

T

T

G
|
G

G

G

T
|
T

G
|
G

S
|
S

F
|
F

G

G

N

N

T

A

F

V

V

M

P

K

M

R

T

F

L

L

A

D

K

S

F

-

N

N

P

I

K

K

K

E

I

I

V

R

I

I

F
|
F

S
|
S

R
|
R

D
|
D

E

E

M

K

K
|
K

Q

Q

W

D

E

D

M

I

A

R

K

K

K

K

F

Y

G

N

G

-

D

N

E

S

R

K

V

L

R

K

F

F

F

Y

I

I

G

G

D
|
D

V
|
V

R

R

D

D

R

S

E

Q

R

S

L

V

Y

E

R

T

A

A

L

M

D

R

G

D

I

V

D

D

Y

Y

V

V

V

F

H

H

A
|
A

A
|
A

A
|
A

T

L

K
|
K

I

Q

V

V

P

P

T

S

A

C

E

E

Y

F

N

F

P

P

F

V

E

E

C

A

V

V

K

K

T
|
T

N

N

I

I

N

I

G

G

A

T

M

E

N

N

L

V

I

L

D

Q

A

S

C

A

I

I

D

H

K

Q

G

N

V

V

K

K

R

K

V

V

V

I

A

C

L
|
L

S
|
S

T
|
T

D

D

K

K

A

A

S

A

S

Y

P

P

V

I

N

N

L

A

Y

M

G

G

A

I

T

S

K
|
K

L

A

A

M

S

M

D

E

K

K

L

V

F

F

V

V

A

A

G

K

N

S

S

R

Y

N

A

I

G

R

G

S

H

E

D

Q

T

T

R

L

F

I

A

C

V

G

V

T

R

R

Y
|
Y

G
|
G

N
|
N

V
|
V

M

M

G

P

S

D

R

-

G

-

S

-

V

-

I

-

P

-

F

-

F

-

M

-

S

-

I

-

K

-

D

-

K

-

G

-

V

-

L

-

P

-

I

-

T

-

D

-

E

-

R

-

M

M

T

T

R

R

F

F

M

L

I

M

S

S

L

L

E

E

Q

D

G

A

V

V

E

E

L

L

V

V

W

V

H

H

A

A

F

F

G

K

D

H

M

A

E

E

G

T

G

G

E

D

I

I

Y

M

V

V

K

Q

K

K

I

A

P

P

S

S

M

S

K

T

V

V

T

G

D

D

L

L

A

A

R

T

A

A

I

L

A

-

P

-

N

-

A

-

S

-

L

-

E

-

Y

-

V

-

G

-

I

-

R

-

P

-

G

-

E

-

K

-

L

L

H

A

E

E

Q

T