Comparing Dsui_0323 Dsui_0323 3-hydroxyacyl-CoA dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6yswA E. Coli anaerobic trifunctional enzyme subunit-alpha in complex with coenzyme a
34% identity, 98% coverage: 14:642/645 of query aligns to 4:665/707 of 6yswA
P40939 Trifunctional enzyme subunit alpha, mitochondrial; 78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Homo sapiens (Human) (see 5 papers)
30% identity, 98% coverage: 9:639/645 of query aligns to 36:720/763 of P40939
6tnmA E. Coli aerobic trifunctional enzyme subunit-alpha (see paper)
32% identity, 97% coverage: 15:639/645 of query aligns to 9:674/719 of 6tnmA
P21177 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Escherichia coli (strain K12) (see 2 papers)
32% identity, 97% coverage: 15:639/645 of query aligns to 9:674/729 of P21177
1wdlA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form ii (native4) (see paper)
32% identity, 96% coverage: 22:642/645 of query aligns to 16:677/715 of 1wdlA
P28793 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Pseudomonas fragi (see paper)
32% identity, 96% coverage: 22:642/645 of query aligns to 16:677/715 of P28793
1wdmA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form i (native3) (see paper)
32% identity, 96% coverage: 22:642/645 of query aligns to 16:669/707 of 1wdmA
7o4uA Structure of the alpha subunit of mycobacterium tuberculosis beta- oxidation trifunctional enzyme in complex with oxidized nicotinamide adenine dinucleotide (see paper)
30% identity, 97% coverage: 13:639/645 of query aligns to 5:673/711 of 7o4uA
8oqvA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-109
30% identity, 98% coverage: 10:639/645 of query aligns to 2:689/726 of 8oqvA
8oqrA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-80
30% identity, 97% coverage: 13:639/645 of query aligns to 16:691/728 of 8oqrA
8pf8A Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-72
30% identity, 97% coverage: 13:639/645 of query aligns to 16:691/729 of 8pf8A
Sites not aligning to the query:
8oquA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-92
30% identity, 97% coverage: 13:639/645 of query aligns to 17:692/730 of 8oquA
8oqtA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-91
30% identity, 97% coverage: 13:639/645 of query aligns to 16:691/729 of 8oqtA
Sites not aligning to the query:
8oqnA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-53
30% identity, 97% coverage: 13:639/645 of query aligns to 16:691/729 of 8oqnA
8opvA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with resveratrol (fragment-b-h11)
30% identity, 97% coverage: 13:639/645 of query aligns to 16:691/729 of 8opvA
8opuA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with sulfamethoxazole (fragment-b-e1)
30% identity, 97% coverage: 13:639/645 of query aligns to 16:691/729 of 8opuA
8oqoA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-49
30% identity, 97% coverage: 13:639/645 of query aligns to 15:690/727 of 8oqoA
8oqqA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-79
30% identity, 97% coverage: 13:639/645 of query aligns to 10:685/723 of 8oqqA
8oqpA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-76
30% identity, 97% coverage: 13:639/645 of query aligns to 10:685/723 of 8oqpA
Sites not aligning to the query:
8oqlA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-1
30% identity, 97% coverage: 13:639/645 of query aligns to 15:690/728 of 8oqlA
>Dsui_0323 Dsui_0323 3-hydroxyacyl-CoA dehydrogenase
MNMHTQTSLTQQHWHLTREADGLAWLSLDKAGESANSLSKAVMAELSGVLDELDRQPPKA
LIIRSAKSAGFIAGADISEFDQLDSPEAAKAMVARGWELFNRLAAVPYPTLALVRGHCLG
GGLELALACRTLLVVDEPGTKLGLPEVMLGIFPGWGGMLRLPRRVGPAVALDLMLAGKTV
DAKKAKRLGLADECVPPRVMESAARQLALNPPSRKPLPLLQRLFLGPLRGVVAGQARKQV
AKRARPEHYPAPYAIIDLWAKYDGNALAAPEITDRIVRSATARNLVRVFHLQERLKAFGK
DSAFVAKRVHVVGAGVMGGDIAAWCAGRGLTVTLQDQNVERIAPAIKRAHAGFARRIRDK
LQLRAVMDRLIPDPEGHGAAHADVVIEAIFENLEAKHSLLKGLEARMKPDAVLATNTSSL
KLEDIRTVLQRPERLVGIHFFNPVAKMPLVEVVTAAGGDAEVTRQACAFVRGIDKLPLPV
QSAPGFLVNAVLGPYLLEAMRCVDEGIAPETVDEAALAFGMPMGPIELADTVGLDIAMAA
GKALAGNGTEPPKCLVQRFERGDLGRKSGKGFYAYPAGKIQKGAAGAVPAGLAERLVQPL
LQRTQQLVDAGVVADAELADAGVIFGTGFAPFTGGPLNYARSRHA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory