SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Dsui_0563 FitnessBrowser__PS:Dsui_0563 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 1 hits to proteins with known functional sites (download)

P68183 Maltose/maltodextrin transport system permease protein MalG from Escherichia coli (strain K12) (see 2 papers)
28% identity, 79% coverage: 8:186/226 of query aligns to 86:252/296 of P68183

query
sites
P68183

W

W

N

N

A

S

V

V

L

-

L

-

T

-

L

-

K

K

L

V

A

A

G

G

T

I

T

S

T

A

L

I

L

G

L

I

L

V

L

A

F

L

G

S

T

T

P

T

I

C

A

A

W

Y

W

A

L

F

A

A

R

R

T

M

R

R

-

F

-

P

-

G

-

K

-

A

S

T

W

L

L

L

K

K

G

G

P

-

V

-

G

-

A

-

A

-

V

-

A

M

L

L

P

I

L

F

V

Q

L

M

P

F

P

P

T

A

V

V

L

L

G

S

F

L

Y

V

L

A

L

L

V

Y

T

A

L

L

G

F

P

D

N

R

G

-

P

-

I

L

G

G

Q

E

L

Y

T

I

Q

P

S

F

L

I

G

G

L

L

G

N

L

-

L

-

P

-

F

-

T

T

F

H

P

G

G

G

L

V

V

I

L

F

A

A

S

-

V

Y

L

L

Y

G

S

G

M

I

P

A

F

L

V

H

V

V

Q

W

P

T

L

I

Q

K

Q

G

A

Y

F

F

E

E

S

T

L

I

G

D

E

S

R

S

P

L

L

E

E
|
E

A

A

A
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A

A

A

T

L

L

D

R
x
G

A

A

S

T

P

P

W

W

D

Q

T

A

F

F

F

R

S

L

V

V

V

L

L

L

P
|
P

L

L

A

S

R

V

P

P

G

I

F

L

V

A

T

V

A

V

T

F

I

I

L

L

G

S

F

F

A

I

H

A

T

A

V

I

G

T

E

E

F

V

G

P

V

V

V

A

L

S

M

L

I

L

G

L

G

R

N

D

I

V

P

N

E

S

K

Y

T

T

R

L

V

A

V

V

S

G

V

M

Q

Q

I

Q

Y

Y

E190 (= E124) mutation E->A,C,K,L: Reduction of transport rate.
A192 (= A126) mutation A->D,S,L: Loss of transport and MalK dissociation from the membrane.
G196 (≠ R130) mutation to A: No effect.; mutation to P: Loss of transport and MalK dissociation from the membrane.
P209 (= P143) mutation to A: No effect.

Query Sequence

>Dsui_0563 FitnessBrowser__PS:Dsui_0563
MPFGPDDWNAVLLTLKLAGTTTLLLLLFGTPIAWWLARTRSWLKGPVGAAVALPLVLPPT
VLGFYLLVTLGPNGPIGQLTQSLGLGLLPFTFPGLVLASVLYSMPFVVQPLQQAFESLGE
RPLEAAATLRASPWDTFFSVVLPLARPGFVTATILGFAHTVGEFGVVLMIGGNIPEKTRV
VSVQIYDHVEALEYTQAHWLAGGMLVFSFLVLLALYGSKARSRHGY

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory